Conformational effects on potency of thioimidazoles and dihydrothiazolines

MedChemComm

Volumn 2, Issue 4, 2011, Pages 261-269

  Selig, Roland ^a   Schattel, Verena ^a   Goettert, Marcia ^a   Schollmeyer, Dieter ^b   Albrecht, Wolfgang ^c   Laufer, Stefan ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c C a i r Biosciences GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 FLUOROPHENYL) N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL]ACETAMIDE; 2 (4 FLUOROPHENYL) N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL]ACETAMIDE; 2 (4 FLUOROPHENYL) N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL]ACETAMIDE; 3 FLUORO N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 4 METHYLBENZAMIDE; 3 FLUORO N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 4 METHYLBENZAMIDE; 3 FLUORO N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL] 4 METHYLBENZAMIDE; 4 FLUORO N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL]BENZAMIDE; 4 FLUORO N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL]BENZAMIDE; 4 FLUORO N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL]BENZAMIDE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; DIHYDROTHIAZOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 1 BENZOFURAN 2 CARBOXAMIDE; N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 2 FURAMIDE; N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 2 PHENYLACETAMIDE; N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 2 PHENYLCYCLOPROPANECARBOXAMIDE; N [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL]BENZAMIDE; N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 1 BENZOFURAN 2 CARBOXAMIDE; N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 2 FURAMIDE; N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 2 PHENYLACETAMIDE; N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL] 2 PHENYLCYCLOPROPANECARBOXAMIDE; N [4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]PYRIDIN 2 YL]BENZAMIDE; N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL] 1 BENZOFURAN 2 CARBOXAMIDE; N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL] 2 FURAMIDE; N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL] 2 PHENYLACETAMIDE; N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL] 2 PHENYLCYCLOPROPANECARBOXAMIDE; N [4 [6 (4 FLUOROPHENYL) 2,3 DIHYDROIMIDAZO[2,1 B][1,3]THIAZOL 5 YL]PYRIDIN 2 YL]BENZAMIDE; THIOIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 79953882511     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c0md00228c     Document Type: Article

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