L-arginine increases endothelial nitric oxide production and reduces blood pressure of rest without changing the exercise pressor response;L-arginina aumenta a produção endotelial de óxido nítrico e reduz a pressão arterial de repouso sem alterar as respostas pressóricas do exercício

Motricidade

Volumn 8, Issue 3, 2012, Pages 19-29

  Lima, J M ^a   Silva, A S ^a   Alves, N F ^b   Porpino, S K ^b   Almeida, A E ^a   Lima, R T ^a  

^a Departamento de Nutrição   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Arginine; Blood pressure; Nitric oxide; Physical exercise; Supplementation

Indexed keywords

EID: 84867345998     PISSN: 1646107X     EISSN: None     Source Type: Journal    
DOI: 10.6063/motricidade.8(3).1153     Document Type: Article

References (44)

1. Accorsi-Mendonça, D., Almado, C. E. L., Fernandes, L. G., & Machado, B. H. (2005). Controle neural da circulação e hipertensão arterial. Revista Brasileira de Hipertensão, 12(4), 235-241.
2. American College of Sports Medicine Position Stand (1998). The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in adults. Medicine and Science in Sports and Exercise, 30(6), 975-991.
3. Adams, M., Forsyth, C., Jessup, W., Robinson, J., & Celermajer, D. (1995). Oral L arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. Journal of the American College of Cardiology, 26(4), 1054-1061. doi: 10.1016/0735-1097(95)00257-9.
4. Araújo, C. G. S. (2001). Fisiologia do exercício físico e hipertensão arterial. Uma breve introdução. Revista Hipertensão, 4, 78-83.
5. Baster, T. & Baster-Brooks, C. (2005). Exercise and hypertension. Australian Family Physician, 34(6), 419-424.
6. Boo, Y. C., & Jo, H. (2003). Flow-dependent regulation of endothelial nitric oxide synthase: Role of protein kinases. American journal of physiology: Cell physiology, 285, 499-508. doi: 10,1152/ajpcell.00122.2003
7. Claudino, M. A., Priviero, F. B., Teixeira, C., De Nucci, G., Antunes, G., & Zanesco. A (2004). Improvement in relaxation response in corpus cavernosun from trained rats. Urology, 63, 1004-1008. doi: 10.1016/j.urology. 2003.11.034 (Pubitemid 38596705)
8. Consolim-Colombo, F., & Fiorino, P. (2005). Sistema nervoso simpático e hipertensão arterial sistêmica - aspectos clínicos. Revista Brasileira de Hipertensão, 12, 251-255.
9. Danson, E. J. & Paterson, D. J. (2005). Cardiac neurobiology of nitric oxide synthases. Annals of the New York Academy of Sciences, 1047(1), 183-196. doi: 10.1196/annals.1341.017 (Pubitemid 41123839)
10. Dequattro, V., & Feng, M. (2002). The sympathetic nervous system: the muse of primary hypertension. Journal of Human Hypertension, 16, 64-69. doi: 10.1038/sj/jhh/1001346 (Pubitemid 34441140)
11. Fayh, A. P. T. (2005). Efeito da suplementação de L-arginina e do exercício em cicloergômetro sobre a função endotelial e eestressee oxidativo em sujeitos com diabetes tipo I. MD Thesis, 2005. Universidade Federal do Rio Grande do Sul.
12. Fisberg, R. M., Slater, B., Marchioni, D. M. L., & Martini, L. A. Inquéritos alimentares: métodos e bases científicos. Barueri, SP: Manole, 2005.
13. Forjaz, C. L. M., Brandão-Rondon, U. M., & Negrão C. E. (2005). Efeitos hipotensores e simpatolíticos do exercício aeróbio na hipertensão arterial. Revista Brasileira de Hipertensão, 12(4), 245-250.
14. Green, D. J., Maiorana, A., O'driscoll, G., & Taylor, R. (2004). Effect of exercise training on endothelium-derived nitric oxide function in humans. The Journal of Physiology, 561, 1-25. doi: 10.1113/jphysiol.2004.068197 (Pubitemid 39549463)
15. Griffin, K. L., Laughlin, M. H., & Parker, J. L. (1999). Exercise training improves endothelium mediated vasorelaxation after chronic coronary occlusion. Journal of Applied Physiology, 87, 1948-1956.
16. Hambrecht, R., Hilbrich, L., Erbs, S., Gielen, S., Fiehn, E., Schoene, N., & Schuler G. (2000). Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral l-arginine supplementation. Journal of the American College of Cardiology, 35, 706-713. doi: 10.1016/S0735-1097(99)00602-6 (Pubitemid 30167028)
17. Higashi, Y., Oshima, T., Ozono, R., Matsuura, H., & Kajiyama, G. (1997). Aging and severity of hypertension attenuate endotheliumdependent renal vascular relaxation in humans. Hypertension, 30, 252-258. doi: 10.1161/01.HYP.30.2.252 (Pubitemid 27329006)
18. Higashi, Y. & Yoshizumi, M. (2004). Exercise and endothelial function: Role of endotheliumderived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacology & Therapeutics, 102(1), 87 - 96. http://dx.doi.org/10.1016/j.pharmthera.2004.02.003 (Pubitemid 38429987)
19. Irigoyen, M. C., Lacchini, S., Angelis, K., & Michelini, L. C. (2003). Fisiopatologia da hipertensão: O que avançamos? Revista da Sociedade de Cardiologia do Estado de São Paulo, 13, 20-45.
20. Jonh, S., & Schmieder, R. E. (2003). Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia. Current Hypertension Reports, 5, 199-207. doi: 10.1007/s11906-003-0021-1 (Pubitemid 38914962)
21. Joint National Committee on The Prevention, Detection, and Treatment of High Blood Pressure (1997). Sixth Report (JNC VI). Archives of Internal Medicine, 157, 2413-2446.
22. Kuru, O., Sentürk, U. K, Demir, N., Yesilkaya, A., Ergüler, G., & Erkiliç, M. (2002). Effect of exercise on blood pressure in rats with chronic NOS inhibition. European Journal of Applied Physiology, 87(2), 134-140. doi: 10.1007/s00421-002-0602-8 (Pubitemid 41399016)
23. Lassègue, B., & Clempus, R. (2003). Vascular NAD(P) H oxidases: Specific features, expression, and regulation. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 285, 277-297. doi: 10.1152/ajpregu.00758.2002
24. Lekakis, J. P, Papathanassiou, S., Papaioannou, T. G., Papamichael, C. M., Zakopoulos, N., Kotsis, V., Stamatelopoulos, S.F. (2002). Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. International Journal of Cardiology, 86, 317-323. doi: 10.1016/S0167-5273(02) 00413-8 (Pubitemid 35284824)
25. Lim, D. S., Mooradian, S. J., Goldberg, C. S., Gomez, C., Crowley, D. C, Rocchini, A. P., & Charpie, J.R. (2004). Effect of oral L-arginine on oxidant estresse, endothelial dysfunction, and systemic arterial pressure in young cardiac transplant recipients. American Journal of Cardiology, 94, 828-831. doi: 10.1016/j.amjcard.2004.05.073 (Pubitemid 39221515)
26. Lucotti, P., Setola, E., Monti, L. D., Galluccio, E., Costa, S., Sandoli, E. P.,Piatti, P. (2006). Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin resistant type 2 diabetic patients. American Journal of Physiology - Endocrinology and Metabolism, 291(5), 906-912. doi: 10.1152/ajpendo.00002.2006
27. Maeda, S., Miyauchi, T., Kakiyama, T., Sugawara, J., Iemitsu, M., Irukayama-Tomobe, Y.,Matsuda, M. (2001). Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sciences, 69(9), 1005-1016. doi: 10.1016/S0024-3205(01)01192-4 (Pubitemid 32701910)
28. Maeda, S., Tanabe, T., Otsuki, T., Sugawara, J., Iemitsu, M., Miyauchi, T.,Matsuda, M. (2004). Moderate Regular Exercise Increases Basal Production of Nitric Oxide in Elderly Women. Hypertension Research, 27(12), 947-953. doi: 10.1291/hypres.27.947 (Pubitemid 40425397)
29. Martina, V., Masha, A., Gigliardi, V. R., Brocato, L., Manzato, E., Berchior, A.,Iannone, A. (2008). Long-Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients With Type 2 Diabetes. Diabetes Care, 31(5), 940-944.
30. Moncada, S., Palmer, R. M., & Higgs., E. A. (1991). Nitric oxide: Physiology pathophysiology and pharmacology. Pharmacological Reviews, 43, 109-142.
31. Moncada, S. (1997). Nitric oxide in the vasculature: Physiology and pathophysiology. Annals of the New York Academy of Sciences, 811, 60-67. doi: 10.1111/j.1749-6632.1997.tb51989.x (Pubitemid 27308315)
32. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G.,Morgonato, A. (2004). Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. American journal of Cardiology, 93(7), 933-935. doi: 10.1016/j.amjcard.2003.12.040 (Pubitemid 38429612)
33. Perez, A. C., Oliveira, C., Prieto, J. G., Ferrando A.,Vila, L., & Alvarez, A. I. (2002). Quantitative assessment of nitric oxide in rat skeletal muscle and plasma after exercise. European Journal of Applied Physiology, 88, 189-191. doi 10.1007/s00421-002-0693-2 (Pubitemid 40826327)
34. Piccirilo, G., Munizzi, M. R., Fimognari, F. L., & Marigliano, V. (1996). Heart rate variability in hypertensive subjects. International Journal of Cardiology, 53(3), 291-298. doi: 10.1016/0167-5273(95)02538-3 (Pubitemid 26178162)
35. Rebelo, F. P. V., Benetti, M., Lemos L. S., & Carvalho T. (2001). Efeito agudo do exercício físico aeróbio sobre a pressão arterial de hipertensos controlados submetidos a diferentes volumes de treinamento. Revista Brasileira de Atividade Física e Saúde, 6(2), 28-37.
36. Rytlewski, K., Olszanecki, R., Korbut, R., & Zdebski, Z. (2005). Effects of prolonged oral supplementation with L-arginine on blood pressure and nitric oxide synthesis in preeclampsia. European Journal of Clinical Investigation, 35(1), 32-37. doi: 10.1111/j.1365-2362.2005.01445.x (Pubitemid 40187952)
37. Sarri, K., Linardakis, M., Codrington, C., & Kafatos, A. (2007). Does the periodic vegetarianism of Greek Orthodox Christians benefit blood pressure? Preventive Medicine, 44(4), 341-348. doi: 10.1016/j.ypmed.2006.11.009 (Pubitemid 46550677)
38. Sociedade Brasileira de Cardiologia, Sociedade Brasileira de Hipertensão, & Sociedade Brasileira de Nefrologia. (2006). V Diretrizes Brasileiras de hipertensão arterial. Revista da Sociedade Brasileira de Hipertensão, 9(4), 256-312.
39. Sposito, A. C. (2004). Emerging insights into hypertension and dyslipidaemia synergies. European Heart Journal, 6, 8-12. doi: 10.1016/j.ehjsup.2004.10.003 (Pubitemid 39572509)
40. Tatchum-Talom, R., Schulz, R., Mcneill, J. R., & Khadour, F. H. (2000). Upregulation of neuronal nitric oxide synthase in skeletal muscle by swim training. American Journal of Physiology, 279, 1757-1766.
41. Touyz, R. M. (2005). Intracellular mechanisms involved in vascular remodeling of resistance arteries in hypertension: role of angiotensin II. Experimental Physiology, 90(4), 449-455. doi: 10.1113/expphysiol.2005.030080 (Pubitemid 40980144)
42. Vanhoutte, P. M. (2003). Endothelial control of vasomotor function: From health to coronary disease. Circulation Journal, 67(7), 572-575. doi: 10.1253/ circj.67.572 (Pubitemid 36834382)
43. Wang, J. S. (2005). Effects of exercise training and detraining on cutaneous microvascular function in man: The regulatory role of endotheliumdependent dilation in skin vasculature. European Journal of Applied Physiology, 93(4), 429-434. doi: 10.1007/s00421-004-1176-4 (Pubitemid 40074302)
44. Wilson, A. M., Harada, R., Nair, N., Balasubramanian, N., & Cooke, J. P. (2007). L-Arginine Supplementation in Peripheral Arterial Disease. No Benefit and Possible Harm. Circulation Journal, 116(2), 188-195. doi: 10.1161/circulationaha.106.683656 (Pubitemid 47057525)