Improvement in relaxation response in corpus cavernosum from trained rats

Urology

Volumn 63, Issue 5, 2004, Pages 1004-1008

  Claudino, Mário A ^b   Priviero, Fernanda B M ^b   Teixeira, Cleber E ^b   De Nucci, Gilberto ^b   Antunes, Edson ^b   Zanesco, Angelina ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ENDOTHELIN; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTRIC FIELD; ELECTROSTIMULATION; ENDOTHELIUM; ERECTILE DYSFUNCTION; ISOLATION PROCEDURE; MALE; NITRERGIC NERVE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; TRAINING;

ACETYLCHOLINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELINS; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; MALE; NITRIC OXIDE; NITROPRUSSIDE; PENIS; PHENYLEPHRINE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 2342519417     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.urology.2003.11.034     Document Type: Article

References (27)

1. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide physiology, pathophysiology, and pharmacology. Pharmacol Rev. 43:1991;109-142
2. Ignarro L.J. Nitric oxide a unique endogenous signaling molecule in vascular biology. Biosci Rep. 19:1999;51-71
3. Rajfer J., Aronson W.J., Bush P.A., et al. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. 326:1992;90-94
4. Delp M.D., McAllister R.M., Laughlin M.H. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol. 75:1993;1354-1363
5. Wang J., Wolin M.S., Hintze T.H. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res. 73:1993;829-838
6. Sessa W.C., Pritchard K., Seyedi N., et al. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 74:1994;349-353
7. Shen W., Lundborg M., Wang J., et al. Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J Appl Physiol. 77:1994;165-172
8. Woodman C.R., Muller J.M., Laughlin M.H., et al. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol. 273:1997;H2575-H2579
9. Krieger E.M., Brum P.C., Negrão C.E. Role of arterial baroreceptor function on cardiovascular adjustments to acute and chronic dynamic exercise. Biological Res. 31:1998;273-279
10. Simoes H.G., Campbell G., Kokubun E., et al. Blood pressure responses in human mirror lactate responses for individual anaerobic threshold and for lactate minimum in track tests. Eur J Appl Physiol Occup Physiol. 80:1999;34-40
11. Pilis W., Zarzeczny R., Langfort J., et al. Anaerobic threshold in rats. Comp Biochem Physiol. 106A:1993;285-289
12. ACSM. ACSM Position Stand on the Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Adults. Med Sci Sports Exerc. 30:1998;975-991
13. Hedlund P., Alm P., Anderson K.-E. NO synthase in cholinergic nerves and NO-induced relaxations in the rat isolated corpus cavernosum. Br J Pharmacol. 126:1999;349-360
14. Matsunaga K., Furchgott R.F. Interactions of light and sodium nitrite in producing relaxant of rabbit aorta. J Pharmacol Exp Ther. 248:1989;687-695
15. Schifter S., Breum L., Niclasen B., et al. Calcitonin gene related peptide during exercise and training. Horm Metab Res. 27:1995;473-475
16. Gharakhanlou R., Chadan S., Gardiner P. Increased activity of endurance training increases calcitonin gene-related peptide content in lumbar motoneuron cell bodies and in sciatic nerve in the rat. Neuroscience. 89:1999;1229-1239
17. Andersson K.E., Wagner G. Physiology of penile erection. Physiol Rev. 75:1995;191-236
18. Bivalacqua T.J., Champion H.C., Hellstrom W.J., et al. Pharmacotherapy for erectile dysfunction. Trends Pharmacol Sci. 21:2000;484-489
19. Andersson K.E. Pharmacology of penile erection. Pharmacol Rev. 53:2001;417-450
20. Denninger J.W., Marletta M.A. Guanylate cyclase and the NO/cGMP signaling pathway. Biochim Biophys Acta. 1411:1999;334-350
21. Hurt K.J., Musicki B., Palese M.A., et al. Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci USA. 99:2002;4061-4066
22. Ignarro L.J., Bush P.A., Buga G.M., et al. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun. 170:1990;843-850
23. Wiegman D.L., Harris P.D., Joshua I.G., et al. Decreased vascular sensitivity to norepinephrine following exercise training. J Appl Physiol. 51:1981;282-287
24. Oltman C.L., Parker J.L., Adams H.R., et al. Effects of exercise training on vasomotor reactivity of porcine coronary arteries. Am J Physiol. 263:1992;H372-H382
25. Chen H.I., Li H.T., Chen C.C. Physical conditioning decreases norepinephrine-induced vasoconstriction in rabbits possible roles of norepinephrine-evoked endothelium-derived relaxing factor. Circulation. 90:1994;970-975
26. Johnson L.R., Parker J.L., Laughlin M.H. Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs. J Appl Physiol. 88:2000;443-451
27. Wingard C.J., Husain S., Williams J., et al. RhoA/rho-kinase mediates synergistic ET-1 and phenylephrine contraction of rat corpus cavernosum. Am J Physiol. 283:2003;R1145-R1152