Correction of endothelial dysfunction in chronic heart failure: Additional effects of exercise training and oral L-arginine supplementation

Journal of the American College of Cardiology

Volumn 35, Issue 3, 2000, Pages 706-713

  Hambrecht, Rainer ^a   Hilbrich, Lutz ^a   Erbs, Sandra ^a   Gielen, Stephan ^a   Fiehn, Eduard ^a   Schoene, Nina ^a   Schuler, Gerhard ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARGININE; GLYCERYL TRINITRATE;

A SCAN; ADULT; ARTERY DIAMETER; ARTICLE; BRACHIAL ARTERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOPPLER FLOWMETER; DOSE RESPONSE; DRUG BLOOD LEVEL; ENDOTHELIUM LESION; EXERCISE; HAND GRIP; HEART FAILURE; HUMAN; MALE; PLASMA HALF LIFE; PRIORITY JOURNAL; RADIAL ARTERY; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

EID: 0034162915     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(99)00602-6     Document Type: Article

References (37)

1. Minotti J.R., Christoph I., Oka R., et al. Impaired skeletal muscle function in patients with congestive heart failure relationship to systemic exercise performance . J Clin Invest. 88:1991;2077-2082.
2. Massie B.M., Conway M., Yonge R., et al. Skeletal muscle metabolism in patients with congestive heart failure relation to clinical severity and blood flow . Circulation. 78:1987;1009-1019.
3. Zelis R., Longhurst J., Capone R.J., Mason D.T. A comparison of regional blood flow and oxygen utilization during dynamic forearm exercise in normal subjects and in patients with congestive heart failure. Circulation. 50:1974;137-143.
4. Kubo S.H., Rector T.C., Williams R.E., et al. Endothelium dependent vasodilation is attenuated in patients with heart failure. Circulation. 84:1991;1589-1596.
5. Katz S.D., Krum H., Kahn T., Knecht M. Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure role of endothelium-derived nitric oxide . J Am Coll Cardiol. 28:1996;585-590.
6. Rector T.S., Bank A.J., Mullen K.A., et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation. 93:1996;2135-2141.
7. + current in vascular endothelial cells. Nature. 331:1988;168-170.
8. Cooke J.P., Rossitch E., Andon N.A., et al. Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest. 88:1991;1663-1671.
9. 2+ signaling of vascular endothelial cells effects of shear stress and ATP . Am J Physiol. 260:1998;H1698-H1707.
10. Sessa W.C., Harrison J.K., Barber C.M., et al. Molecular cloning and expression of a cDNA encoding endothelial nitric oxide synthase. J Biol Chem. 267:1992;15274-15276.
11. Hornig B., Maier V., Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation. 93:1996;210-214.
12. Hambrecht R., Fiehn E., Weigl C., et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation. 98:1998;2709-2715.
13. Katz S.D., Yuen J., Bijou R., LeJemtel T.H. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J Appl Physiol. 82:1997;1488-1492.
14. Nugent A.G., McGurk C., McAuley D.F., et al. Physical training and endothelial function in patients with chronic heart failure. Letter to the editor. Circulation. 94:1996;2988-2989.
15. Hintze T.H., Vatner S.F. Reactive dilation of large coronary arteries in conscious dogs. Circ Res. 54:1984;50-57.
16. Drexler H., Hayoz D., Münzel T., et al. Endothelial function in chronic heart failure. Am J Cardiol. 69:1992;1596-1601.
17. Uehata A., Lieberman E.H., Gerhard M.D., et al. Noninvasive assessment of endothelium-dependent flow-mediated dilation of the brachial artery. Vasc Med. 2:1997;87-92.
18. Katz S.D., Yuen J., Bijou R., LeJemtel T.H. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J Appl Physiol. 82:1997;1488-1492.
19. Zelis R., Mason D.T., Braunwald E. A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest. 47:1968;960-970.
20. Hirooka Y., Imaizumi T., Tagawa T., et al. Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure. Circulation. 90:1994;658-668.
21. Chin-Dusting J.P.F., Kaye D.M., Lefkovits J., et al. Dietary supplementation with L-arginine fails to restore endothelial function in forearm resistance arteries of patients with severe heart failure. J Am Coll Cardiol. 27:1996;1207-1213.
22. Wang P., Zweier J.L. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem. 271:1996;29223-29230.
23. Drexler H., Zeiher A.M., Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet. 338:1991;1546-1550.
24. Kubo S.H., Rector T.S., Bank A.J. Endothelial nitric oxide pathway function in the peripheral vasculature of patients with heart failure. J Card Fail. 2:1996;S217-S223.
25. Williams S.B., Cusco J.A., Roddy M., et al. Impaired nitric-oxide mediated vasodilation in patients with noninsulin-dependent diabetes mellitus. J Am Coll Cardiol. 27:1996;567-574.
26. Cooke J.P., Dzau V.J. Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. Circulation. 96:1997;379-382.
27. Belch J.J.F., Bridges A.B., Scott N., Chopra M. Oxygen free radicals and congestive heart failure. Br Heart J. 65:1991;245-248.
28. Huk I., Nanobashvili J., Neumayer C., et al. L-Arginine treatment alters kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 96:1997;667-675.
29. Noris M., Morigr M., Donadelli R. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res. 76:1995;536-543.
30. Resnick N., Gimbrone M.A.J. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 9:1995;874-882.
31. Wang J., Wolin M.S., Hintze T. Chronic exercise exhances endothelium-mediated dilation of epicardial coronary arteries in conscious dogs. Circ Res. 73:1993;829-838.
32. Sessa W.C., Pritchard K., Seyedi N., et al. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 74:1994;349-353.
33. Koller A., Huang A., Sun D., Kaley G. Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles. Role of endothelial nitric oxide and prostaglandins. Circ Res. 76:1995;544-550.
34. Carlsson I., Sollevi A., Wennmalm A. The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperemia. J Physiol Lond. 389:1987;147-161.
35. Koller A., Kaley G. Role of endothelium in reactive dilation of skeletal muscle arterioles. Am J Physiol. 259:1990;H1313-H1316.
36. Engelke K.A., Halliwill J.R., Proctor D.N., et al. Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm. J Appl Physiol. 81:1996;1807-1814.
37. Franciosa J.A., Park M., Levine T.B. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol. 47:1981;33-39.