Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 41, 2012, Pages

  Kiser, Philip D ^a   Farquhar, Erik R ^b   Shi, Wuxian ^b   Sui, Xuewu ^b   Chance, Mark R ^b   Palczewski, Krzysztof ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Extended X ray absorption fine structure; Isomerohydrolase; Metalloprotein; Monotopic membrane protein

Indexed keywords

IRON; ISOMERASE; METALLOPROTEIN; PHOSPHOLIPID; RETINOID; RPE65 ISOMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ENZYME SUBSTRATE; ISOMERIZATION; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; VISION; X RAY ABSORPTION SPECTROSCOPY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CATTLE; CIS-TRANS-ISOMERASES; CRYSTALLOGRAPHY, X-RAY; IRON; LIPIDS; MICROSOMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOLIPIDS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RETINAL PIGMENT EPITHELIUM; SEQUENCE HOMOLOGY, AMINO ACID; X-RAY ABSORPTION SPECTROSCOPY;

EID: 84867345070     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212025109     Document Type: Article

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