α-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32491-32501

  Mandal, Md Nawajes A ^a,b   Moiseyev, Gennadiy P ^b,c   Elliott, Michael H ^a,b   Kasus Jacobi, Anne ^a,b   Li, Xiaoman ^a   Chen, Hui ^a,e   Zheng, Lixin ^a   Nikolaeva, Olga ^b,c   Floyd, Robert A ^b,d   Ma, Jian Xing ^b,c   Anderson, Robert E ^a,b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^e SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; IN-VIVO; KEY ENZYMES; NEURODEGENERATION; NITRONES; PHOTORESPONSES; RADICAL TRAPPING; RETINAL CELLS; RETINAL DISEASE; RETINOL DEHYDROGENASE; RHODOPSIN REGENERATION; SPIN TRAP; STARGARDT DISEASE; THERAPEUTIC BENEFITS; TOXIC BYPRODUCTS; VISUAL CYCLE;

BYPRODUCTS; CATALYSTS; ENZYMES; FREE RADICALS; OPHTHALMOLOGY; PHOSPHOLIPIDS; PLANTS (BOTANY);

ALDEHYDES;

AGENTS ACTING ON THE EYE; LECITHIN RETINOL ACYLTRANSFERASE; N TERT BUTYL ALPHA (2 SULFOPHENYL)NITRONE; N TERT BUTYL ALPHA PHENYLNITRONE; NITRONE DERIVATIVE; RETINAL PIGMENT EPITHELIUM SPECIFIC PROTEIN 65; RETINOL DEHYDROGENASE; RHODOPSIN; UNCLASSIFIED DRUG; VISUAL PIGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EYE PROTECTION; IC 50; IN VIVO STUDY; LIGHT DAMAGE; LIGHT EXPOSURE; LIGHT INTENSITY; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; RETINA INJURY; RETINA ROD;

ACYLTRANSFERASES; ALCOHOL OXIDOREDUCTASES; ANIMALS; CARRIER PROTEINS; CIS-TRANS-ISOMERASES; CYCLIC N-OXIDES; EYE PROTEINS; LIGHT; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RETINAL DEGENERATION; RETINAL ROD PHOTORECEPTOR CELLS; RHODOPSIN;

RATTUS;

EID: 80052757041     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.255877     Document Type: Article

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