Evaluating the links between schizophrenia and sleep and circadian rhythm disruption

Journal of Neural Transmission

Volumn 119, Issue 10, 2012, Pages 1061-1075

  Pritchett, David ^a   Wulff, Katharina ^a   Oliver, Peter L ^b   Bannerman, David M ^b   Davies, Kay E ^b   Harrison, Paul J ^a   Peirson, Stuart N ^a   Foster, Russell G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bipolar; Circadian; Mouse models; Neuropsychiatric; Schizophrenia; SCRD; Sleep

Indexed keywords

CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; COGNITION; COMORBIDITY; DISEASE ASSOCIATION; HUMAN; MENTAL DISEASE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SCHIZOPHRENIA; SLEEP QUALITY;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HUMANS; MICE; MUTATION; SCHIZOPHRENIA; SLEEP DISORDERS, CIRCADIAN RHYTHM;

EID: 84867337664     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0817-8     Document Type: Review

References (197)

1. Abraham D, Dallmann R, Steinlechner S, Albrecht U, Eichele G, Oster H (2006) Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light. J Biol Rhythms 21:169-176
2. Acheson A, Richards JB, de Wit H (2007) Effects of sleep deprivation on impulsive behaviors in men and women. Physiol Behav 91:579-587
3. Albrecht U, Foster RG (2002) Placing ocular mutants into a functional context: A chronobiological approach. Methods 28:465-477
4. Aleman A, Hijman R, de Haan EH, Kahn RS (1999) Memory impairment in schizophrenia: A meta-Analysis. Am J Psychiatry 156:1358-1366
5. Alhola P, Polo-Kantola P (2007) Sleep deprivation: Impact on cognitive performance. Neuropsychiatr Dis Treat 3:553-567
6. Andreasen NC (1995) Symptoms, signs, and diagnosis of schizophrenia. Lancet 346:477-481
7. Andreasen NC (1999) A unitary model of schizophrenia: Bleuler's ''fragmented phrene'' as schizencephaly. Arch Gen Psychiatry 56:781-787
8. Arguello PA, Gogos JA (2008) A signaling pathway AKTing up in schizophrenia. J Clin Invest 118:2018-2021
9. Arguello PA, Gogos JA (2010) Cognition in mouse models of schizophrenia susceptibility genes. Schizophr Bull 36:289-300
10. Auslander LA, Jeste DV (2002) Perceptions of problems and needs for service among middle-Aged and elderly outpatients with schizophrenia and related psychotic disorders. Community Ment Health J 38:391-402
11. Bachus SE, Hyde TM, Herman MM, Egan MF, Kleinman JE (1997) Abnormal cholecystokinin mRNA levels in entorhinal cortex of schizophrenics. J Psychiatr Res 31:233-256
12. Banks S, Dinges DF (2007) Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 3:519-528
13. Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E (1998) Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA 95:15020-15025
14. Baranski JV, Pigeau RA (1997) Self-monitoring cognitive performance during sleep deprivation: Effects of modafinil, d-Amphetamine and placebo. J Sleep Res 6:84-91
15. Baranski JV, Thompson MM, Lichacz FM, McCann C, Gil V, Pasto L, Pigeau RA (2007) Effects of sleep loss on team decision making: Motivational loss or motivational gain? Hum Factors 49:646-660
16. Basner M, Glatz C, Griefahn B, Penzel T, Samel A (2008a) Aircraft noise: Effects on macro-And microstructure of sleep. Sleep Med 9:382-387
17. Basner M, Muller U, Elmenhorst EM, Kluge G, Griefahn B (2008b) Aircraft noise effects on sleep: A systematic comparison of EEG awakenings and automatically detected cardiac activations. Physiol Meas 29:1089-1103
18. Bernstein HG, Lendeckel U, Bertram I, Bukowska A, Kanakis D, Dobrowolny H, Stauch R, Krell D, Mawrin C, Budinger E, Keilhoff G, Bogerts B (2006) Localization of neuregulin-1alpha (heregulin-Alpha) and one of its receptors, ErbB-4 tyrosinekinase, in developing and adult human brain. Brain Res Bull 69:546-559
19. Bissonette GB, Powell EM (2012) Reversal learning and attentional set-shifting in mice. Neuropharmacology 62:1168-1174
20. Boivin DB, Tremblay GM, James FO (2007) Working on atypical schedules. Sleep Med 8:578-589
21. Bradshaw NJ, Porteous DJ (2012) DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology 62:1230-1241
22. Brandon NJ, Sawa A (2011) Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 12:707-722
23. Bromundt V, Koster M, Georgiev-Kill A, Opwis K, Wirz-Justice A, Stoppe G, Cajochen C (2011) Sleep-wake cycles and cognitive functioning in schizophrenia. Br J Psychiatry 198:269-276
24. Brzozka MM, Radyushkin K, Wichert SP, Ehrenreich H, Rossner MJ (2010) Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain. Biol Psychiatry 68:33-40
25. Bussey TJ, Holmes A, Lyon L, Mar AC, McAllister KA, Nithianantharajah J, Oomen CA, Saksida LM (2012) New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats. Neuropharmacology 62:1191-1203
26. Chadman KK, Yang M, Crawley JN (2009) Criteria for validating mouse models of psychiatric diseases. Am J Med Genet B Neuropsychiatr Genet 150B:1-11
27. Chakravarti A (1999) Population genetics-making sense out of sequence. Nat Genet 21:56-60
28. Chee MW, Chuah LY (2008) Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition. Curr Opin Neurol 21:417-423
29. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D (2002) Genetic and physiological data implicating the new human gene G72 and the gene for D-Amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99:13675-13680
30. Cohrs S (2008) Sleep disturbances in patients with schizophrenia: Impact and effect of antipsychotics. CNS Drugs 22:939-962
31. Corradini I, Verderio C, Sala M, Wilson MC, Matteoli M (2009) SNAP-25 in neuropsychiatric disorders. Ann N Y Acad Sci 1152:93-99
32. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
33. Crow TJ (2008) The emperors of the schizophrenia polygene have no clothes. Psychol Med 38:1681-1685
34. Dahl RE, Lewin DS (2002) Pathways to adolescent health sleep regulation and behavior. J Adolesc Health 31:175-184
35. Davis JA, Gould TJ (2005) Rolipram attenuates MK-801-induced deficits in latent inhibition. Behav Neurosci 119:595-602
36. Davis S, Mirick DK (2006) Circadian disruption, shift work and the risk of cancer: A summary of the evidence and studies in Seattle. Cancer Causes Control 17:539-545
37. Deakin IH, Law AJ, Oliver PL, Schwab MH, Nave KA, Harrison PJ, Bannerman DM (2009) Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice. Neuroreport 20:1523-1528
38. Dibner C, Schibler U, Albrecht U (2010) The mammalian circadian timing system: Organization and coordination of central and peripheral clocks. Annu Rev Physiol 72:517-549
39. Dinges DF, Pack F, Williams K, Gillen KA, Powell JW, Ott GE, Aptowicz C, Pack AI (1997) Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep 20:267-270
40. Duffield GE, Watson NP, Mantani A, Peirson SN, Robles-Murguia M, Loros JJ, Israel MA, Dunlap JC (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol 19:297-304
41. Dworak M, Schierl T, Bruns T, Struder HK (2007) Impact of singular excessive computer game and television exposure on sleep patterns and memory performance of school-Aged children. Pediatrics 120:978-985
42. Easton A, Arbuzova J, Turek FW (2003) The circadian clock mutation increases exploratory activity and escape-seeking behavior. Genes Brain Behav 2:11-19
43. Ebihara S, Marks T, Hudson DJ, Menaker M (1986) Genetic control of melatonin synthesis in the pineal gland of the mouse. Science 231:491-493
44. Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E (2008) The anatomy of first-episode and chronic schizophrenia: An anatomical likelihood estimation meta-Analysis. Am J Psychiatry 165:1015-1023
45. Elvevag B, Goldberg TE (2000) Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 14:1-21
46. Fatemi SH, King DP, Reutiman TJ, Folsom TD, Laurence JA, Lee S, Fan YT, Paciga SA, Conti M, Menniti FS (2008) PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. Schizophr Res 101:36-49
47. Fisher SP, Godinho SI, Pothecary CA, Hankins MW, Foster RG, Peirson SN (2012) Rapid assessment of sleep-wake behavior in mice. J Biol Rhythms 27:48-58
48. Forest G, Poulin J, Daoust AM, Lussier I, Stip E, Godbout R (2007) Attention and non-REM sleep in neuroleptic-naive persons with schizophrenia and control participants. Psychiatry Res 149:33-40
49. Foster RG, Helfrich-Forster C (2001) The regulation of circadian clocks by light in fruitflies and mice. Philos Trans R Soc Lond B Biol Sci 356:1779-1789
50. Gangwisch JE, Malaspina D, Boden-Albala B, Heymsfield SB (2005) Inadequate sleep as a risk factor for obesity: Analyses of the NHANES I. Sleep 28:1289-1296
51. Garner JP, Thogerson CM, Wurbel H, Murray JD, Mench JA (2006) Animal neuropsychology: Validation of the intra-dimensional extra-dimensional set shifting task for mice. Behav Brain Res 173:53-61
52. Goder R, Boigs M, Braun S, Friege L, Fritzer G, Aldenhoff JB, Hinze-Selch D (2004) Impairment of visuospatial memory is associated with decreased slow wave sleep in schizophrenia. J Psychiatr Res 38:591-599
53. Goder R, Scharffetter F, Aldenhoff JB, Fritzer G (2007) Visual declarative memory is associated with non-rapid eye movement sleep and sleep cycles in patients with chronic non-restorative sleep. Sleep Med 8:503-508
54. Goder R, Fritzer G, Gottwald B, Lippmann B, Seeck-Hirschner M, Serafin I, Aldenhoff JB (2008) Effects of olanzapine on slow wave sleep, sleep spindles and sleep-related memory consolidation in schizophrenia. Pharmacopsychiatry 41:92-99
55. Goldman M, Tandon R, DeQuardo JR, Taylor SF, Goodson J, McGrath M (1996) Biological predictors of 1-year outcome in schizophrenia in males and females. Schizophr Res 21:65-73
56. Goto M, Oshima I, Tomita T, Ebihara S (1989) Melatonin content of the pineal gland in different mouse strains. J Pineal Res 7:195-204
57. Gottlieb DJ, O'Connor GT, Wilk JB (2007) Genome-wide association of sleep and circadian phenotypes. BMC Med Genet 8(Suppl 1):S9
58. Grimes CA, Jope RS (2001) CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium. J Neurochem 78:1219-1232
59. Hansen J (2006) Risk of breast cancer after night-And shift work: Current evidence and ongoing studies in Denmark. Cancer Causes Control 17:531-537
60. Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Mol Psychiatry 10:40-68; image 5
61. Harrison PJ, Law AJ (2006) Neuregulin 1 and schizophrenia: Genetics, gene expression, and neurobiology. Biol Psychiatry 60:132-140
62. Harrison PJ, Lyon L, Sartorius LJ, Burnet PW, Lane TA (2008) The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): Expression, function and involvement in schizophrenia. J Psychopharmacol 22:308-322
63. Harrison PJ, Pritchett D, Stumpenhorst K, Betts JF, Nissen W, Schweimer J, Lane T, Burnet PW, Lamsa KP, Sharp T, Bannerman DM, Tunbridge EM (2012) Genetic mouse models relevant to schizophrenia: Taking stock and looking forward. Neuropharmacology 62:1164-1167
64. Harrison Y, Horne JA (2000) The impact of sleep deprivation on decision making: A review. J Exp Psychol Appl 6:236-249
65. Hashimoto R, Straub RE, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR (2004) Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol Psychiatry 9:299-307
66. Hofstetter JR, Lysaker PH, Mayeda AR (2005) Quality of sleep in patients with schizophrenia is associated with quality of life and coping. BMC Psychiatry 5:13
67. Horne JA (1988) Sleep loss and ''divergent'' thinking ability. Sleep 11:528-536
68. Horne JA (1993) Human sleep, sleep loss and behaviour. Implications for the prefrontal cortex and psychiatric disorder. Br J Psychiatry 162:413-419
69. Hughes AT, Piggins HD (2008) Behavioral responses of Vipr2-/-mice to light. J Biol Rhythms 23:211-219
70. Iitaka C, Miyazaki K, Akaike T, Ishida N (2005) A role for glycogen synthase kinase-3beta in the mammalian circadian clock. J Biol Chem 280:29397-29402
71. Irwin M (2002) Effects of sleep and sleep loss on immunity and cytokines. Brain Behav Immun 16:503-512
72. Jeans AF, Oliver PL, Johnson R, Capogna M, Vikman J, Molnar Z, Babbs A, Partridge CJ, Salehi A, Bengtsson M, Eliasson L, Rorsman P, Davies KE (2007) A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse. Proc Natl Acad Sci USA 104:2431-2436
73. Johnson EO, Roth T, Breslau N (2006) The association of insomnia with anxiety disorders and depression: Exploration of the direction of risk. J Psychiatr Res 40:700-708
74. Johnson MA, Devay P, Role LW (2002) The cystine-rich domain of the neuregulin-1 gene (crd-NRG-1) is required for survival of a subset of neurons in the suprachiasmatic nucleus (SCN). Society for Neuroscience, Washington DC (online). 2002 Abstract Viewer/Itinerary Planner, 2002
75. Johnstone M, Thomson PA, Hall J, McIntosh AM, Lawrie SM, Porteous DJ (2011) DISC1 in schizophrenia: Genetic mouse models and human genomic imaging. Schizophr Bull 37:14-20
76. Jones K, Harrison Y (2001) Frontal lobe function, sleep loss and fragmented sleep. Sleep Med Rev 5:463-475
77. Jud C, Schmutz I, Hampp G, Oster H, Albrecht U (2005) A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions. Biol Proced Online 7:101-116
78. Kaffman A, Krystal JJ (2012) New frontiers in animal research of psychiatric illness. Methods Mol Biol 829:3-30
79. Kahn-Greene ET, Killgore DB, Kamimori GH, Balkin TJ, Killgore WD (2007) The effects of sleep deprivation on symptoms of psychopathology in healthy adults. Sleep Med 8:215-221
80. Kahol K, Leyba MJ, Deka M, Deka V, Mayes S, Smith M, Ferrara JJ, Panchanathan S (2008) Effect of fatigue on psychomotor and cognitive skills. Am J Surg 195:195-204
81. Kantrowitz JT, Oakman E, Bickel S, Citrome L, Spielman A, Silipo G, Battaglia J, Javitt DC (2010) The importance of a good night's sleep: An open-label trial of the sodium salt of gammahydroxybutyric acid in insomnia associated with schizophrenia. Schizophr Res 120:225-226
82. Kapas L, Obal F Jr, Alfoldi P, Rubicsek G, Penke B, Obal F (1988) Effects of nocturnal intraperitoneal administration of cholecystokinin in rats: Simultaneous increase in sleep, increase inEEG slowwave activity, reduction of motor activity, suppression of eating, and decrease in brain temperature. Brain Res 438:155-164
83. Kelman BB (1999) The sleep needs of adolescents. J Sch Nurs 15:14-19
84. Killgore WD, Balkin TJ, Wesensten NJ (2006a) Impaired decision making following 49 h of sleep deprivation. J Sleep Res 15:7-13
85. Killgore WD, McBride SA, Killgore DB, Balkin TJ (2006b) The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation. Sleep 29:841-847
86. Killgore WD, Killgore DB, Day LM, Li C, Kamimori GH, Balkin TJ (2007) The effects of 53 hours of sleep deprivation on moral judgment. Sleep 30:345-352
87. Killgore WD, Kahn-Greene ET, Lipizzi EL, Newman RA, Kamimori GH, Balkin TJ (2008) Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. Sleep Med 9:517-526
88. Knutson KL, Spiegel K, Penev P, Van Cauter E (2007) The metabolic consequences of sleep deprivation. Sleep Med Rev 11:163-178
89. Koefoed P, Hansen TV, Woldbye DP, Werge T, Mors O, Hansen T, Jakobsen KD, Nordentoft M, Wang A, Bolwig TG, Rehfeld JF (2009) An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males. Acta Psychiatr Scand 120:281-287
90. Konradi C, Heckers S (2003) Molecular aspects of glutamate dysregulation: Implications for schizophrenia and its treatment. Pharmacol Ther 97:153-179
91. Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ (2001) Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294:2511-2515
92. Krystal AD, Thakur M, Roth T (2008) Sleep disturbance in psychiatric disorders: Effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. Ann Clin Psychiatry 20:39-46
93. Kundermann B, Krieg JC, Schreiber W, Lautenbacher S (2004) The effect of sleep deprivation on pain. Pain Res Manag 9:25-32
94. Kyriacou CP, Hastings MH (2010) Circadian clocks: Genes, sleep, and cognition. Trends Cogn Sci 14:259-267
95. Lamond N, Jay SM, Dorrian J, Ferguson SA, Jones C, Dawson D (2007) The dynamics of neurobehavioural recovery following sleep loss. J Sleep Res 16:33-41
96. Landis CA, Savage MV, Lentz MJ, Brengelmann GL (1998) Sleep deprivation alters body temperature dynamics to mild cooling and heating not sweating threshold in women. Sleep 21:101-108
97. Laposky AD, Bass J, Kohsaka A, Turek FW (2008) Sleep and circadian rhythms: Key components in the regulation of energy metabolism. FEBS Lett 582:142-151
98. Lee B, Li A, Hansen KF, Cao R, Yoon JH, Obrietan K (2010) CREB influences timing and entrainment of the SCN circadian clock. J Biol Rhythms 25:410-420
99. Lee PR, Brady DL, Shapiro RA, Dorsa DM, Koenig JI (2005) Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin. Neuropsychopharmacology 30:1883-1894
100. Leucht S, Kissling W, McGrath J (2004) Lithium for schizophrenia revisited: A systematic review and meta-Analysis of randomized controlled trials. J Clin Psychiatry 65:177-186
101. Lin HF, Liu YL, Liu CM, Hung SI, Hwu HG, Chen WJ (2005) Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents. Psychol Med 35:1589-1598
102. Lipina TV, Wang M, Liu F, Roder JC (2012) Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. Neuropharmacology 62:1252-1262
103. Lorton D, Lubahn CL, Estus C, Millar BA, Carter JL, Wood CA, Bellinger DL (2006) Bidirectional communication between the brain and the immune system: Implications for physiological sleep and disorders with disrupted sleep. Neuroimmunomodulation 13:357-374
104. Lowrey PL, Takahashi JS (2011) Genetics of circadian rhythms in mammalian model organisms. Adv Genet 74:175-230
105. Lucidi F, Russo PM, Mallia L, Devoto A, Lauriola M, Violani C (2006) Sleep-related car crashes: Risk perception and decisionmaking processes in young drivers. Accid Anal Prev 38:302-309
106. Lynn SJ, Lilienfeld SO, Merckelbach H, Giesbrecht T, van der Kloet D (2012) Dissociation and dissociative disorders. Curr Dir Psychol Sci 21:48-53
107. Maemura K, Takeda N, Nagai R (2007) Circadian rhythms in the CNS and peripheral clock disorders: Role of the biological clock in cardiovascular diseases. J Pharmacol Sci 103:134-138
108. Manoach DS, Cain MS, Vangel MG, Khurana A, Goff DC, Stickgold R (2004) A failure of sleep-dependent procedural learning in chronic, medicated schizophrenia. Biol Psychiatry 56:951-956
109. Manoach DS, Stickgold R (2009) Does abnormal sleep impair memory consolidation in schizophrenia? Front Hum Neurosci 3:21
110. Manoach DS, Thakkar KN, Stroynowski E, Ely A, McKinley SK, Wamsley E, Djonlagic I, Vangel MG, Goff DC, Stickgold R (2010) Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stages. J Psychiatr Res 44:112-120
111. Marshall FH, Barnes S, Hughes J, Woodruff GN, Hunter JC (1991) Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms. J Neurochem 56:917-922
112. Martin J, Jeste DV, Caliguiri MP, Patterson T, Heaton R, Ancoli-Israel S (2001) Actigraphic estimates of circadian rhythms and sleep/wake in older schizophrenia patients. Schizophr Res 47:77-86
113. Martin JL, Jeste DV, Ancoli-Israel S (2005) Older schizophrenia patients have more disrupted sleep and circadian rhythms than age-matched comparison subjects. J Psychiatr Res 39:251-259
114. Martinek S, Inonog S, Manoukian AS, Young MW (2001) A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105:769-779
115. Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, McMahon DG, Harmar AJ, Okamura H, Hastings MH (2006) Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling. Curr Biol 16:599-605
116. McKenna BS, Dicjinson DL, Orff HJ, Drummond SP (2007) The effects of one night of sleep deprivation on known-risk and ambiguous-risk decisions. J Sleep Res 16:245-252
117. Meerlo P, Sgoifo A, Suchecki D (2008) Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Med Rev 12:197-210
118. Mei L, Xiong WC (2008) Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci 9:437-452
119. Miller DD (2004) Atypical antipsychotics: Sleep, sedation, and efficacy. Prim Care Companion J Clin Psychiatry 6:3-7
120. Mistlberger RE, Skene DJ (2004) Social influences on mammalian circadian rhythms: Animal and human studies. Biol Rev Camb Philos Soc 79:533-556
121. Moore RY (1973) Retinohypothalamic projection in mammals: A comparative study. Brain Res 49:403-409
122. Moore RY, Klein DC (1974) Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-Acetyltransferase activity. Brain Res 71:17-33
123. Muecke S (2005) Effects of rotating night shifts: Literature review. J Adv Nurs 50:433-439
124. Murray G, Harvey A (2010) Circadian rhythms and sleep in bipolar disorder. Bipolar Disord 12:459-472
125. Myers E, Startup H, Freeman D (2011) Cognitive behavioural treatment of insomnia in individuals with persistent persecutory delusions: A pilot trial. J Behav Ther Exp Psychiatry 42:330-336
126. Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH, Turek FW (2000) The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci 20:8138-8143
127. Nestler EJ, Hyman SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161-1169
128. Nilsson M, Carlsson A, Carlsson ML (1997) Glycine and D-serine decrease MK-801-induced hyperactivity in mice. J Neural Transm 104:1195-1205
129. Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (1999) International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev 51:745-781
130. Numata S, Ueno S, Iga J, Song H, Nakataki M, Tayoshi S, Sumitani S, Tomotake M, Itakura M, Sano A, Ohmori T (2008) Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. J Psychiatr Res 43:7-12
131. O'Brien EM, Mindell JA (2005) Sleep and risk-taking behavior in adolescents. Behav Sleep Med 3:113-133
132. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Moller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nothen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40:1053-1055
133. O'Neill JS, Reddy AB (2012) The essential role of cAMP/Ca2? signalling in mammalian circadian timekeeping. Biochem Soc Trans 40:44-50
134. Oginska H, Pokorski J (2006) Fatigue and mood correlates of sleep length in three age-social groups: School children, students, and employees. Chronobiol Int 23:1317-1328
135. Oken BS, Salinsky MC, Elsas SM (2006) Vigilance, alertness, or sustained attention: Physiological basis and measurement. Clin Neurophysiol 117:1885-1901
136. Oliver PL, Davies KE (2009) Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25mousemutant blind-drunk.Hum Mol Genet 18:4576-4589
137. Oliver PL, Sobczyk MV, Maywood ES, Edwards B, Lee S, Livieratos A, Oster H, Butler R, Godinho SI, Wulff K, Peirson SN, Fisher SP, Chesham JE, Smith JW, Hastings MH, Davies KE, Foster RG (2009) Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet 18:4576-4589
138. Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH, Morton AJ (2007) Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J Neurosci 27:7869-7878
139. Papaleo F, Lipska BK, Weinberger DR (2012) Mouse models of genetic effects on cognition: Relevance to schizophrenia. Neuropharmacology 62:1204-1220
140. Philip P, Akerstedt T (2006) Transport and industrial safety, how are they affected by sleepiness and sleep restriction? Sleep Med Rev 10:347-356
141. Pilcher JJ, Huffcutt AI (1996) Effects of sleep deprivation on performance: A meta-Analysis. Sleep 19:318-326
142. Pilcher JJ, Lambert BJ, Huffcutt AI (2000) Differential effects of permanent and rotating shifts on self-report sleep length: A metaanalytic review. Sleep 23:155-163
143. Plante DT, Winkelman JW (2008) Sleep disturbance in bipolar disorder: Therapeutic implications. Am J Psychiatry 165:830-843
144. Power A, Hughes AT, Samuels RE, Piggins HD (2010) Rhythmpromoting actions of exercise in mice with deficient neuropeptide signaling. J Biol Rhythms 25:235-246
145. Randazzo AC, Muehlbach MJ, Schweitzer PK, Walsh JK (1998) Cognitive function following acute sleep restriction in children ages 10-14. Sleep 21:861-868
146. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418:935-941
147. Riemann D, Voderholzer U (2003) Primary insomnia: A risk factor to develop depression? J Affect Disord 76:255-259
148. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J, Ophoff RA, Andreassen OA, Scolnick E, Cichon S, St Clair D, Corvin A, Gurling H, Werge T, Rujescu D, Blackwood DH, Pato CN, Malhotra AK, Purcell S, Dudbridge F, Neale BM, Rossin L, Visscher PM, Posthuma D, Ruderfer DM, Fanous A, Stefansson H, Steinberg S, Mowry BJ, Golimbet V, De Hert M, Jonsson EG, Bitter I, Pietilainen OP, Collier DA, Tosato S, Agartz I, Albus M, Alexander M, Amdur RL, Amin F, Bass N, Bergen SE, Black DW, Borglum AD, Brown MA, Bruggeman R, Buccola NG, Byerley WF, Cahn W, Cantor RM, Carr VJ, Catts SV, Choudhury K, Cloninger CR, Cormican P, Craddock N, Danoy PA, Datta S, de Haan L, Demontis D, Dikeos D, Djurovic S, Donnelly P, Donohoe G, Duong L, Dwyer S, Fink-Jensen A, Freedman R, Freimer NB, Friedl M, Georgieva L, Giegling I, Gill M, Glenthoj B, Godard S, Hamshere M, Hansen M, Hansen T, Hartmann AM, Henskens FA, Hougaard DM, Hultman CM, Ingason A, Jablensky AV, Jakobsen KD, Jay M, Jurgens G, Kahn RS, Keller MC, Kenis G, Kenny E, Kim Y, Kirov GK, Konnerth H, Konte B, Krabbendam L, Krasucki R, Lasseter VK, Laurent C, Lawrence J, Lencz T, Lerer FB, Liang KY, Lichtenstein P, Lieberman JA, Linszen DH, Lonnqvist J, Loughland CM, Maclean AW, Maher BS, Maier W, Mallet J, Malloy P, Mattheisen M, Mattingsdal M, McGhee KA, McGrath JJ, McIntosh A, McLean DE, McQuillin A, Melle I, Michie PT, Milanova V, Morris DW, Mors O, Mortensen PB, Moskvina V, Muglia P, Myin-Germeys I, Nertney DA, Nestadt G, Nielsen J, Nikolov I, Nordentoft M, Norton N, Nothen MM, O'Dushlaine CT, Olincy A, Olsen L, O'Neill FA, Orntoft TF, Owen MJ, Pantelis C, Papadimitriou G, Pato MT, Peltonen L, Petursson H, Pickard B, Pimm J, Pulver AE, Puri V, Quested D, Quinn EM, Rasmussen HB, Rethelyi JM, Ribble R, Rietschel M, Riley BP, Ruggeri M, Schall U, Schulze TG, Schwab SG, Scott RJ, Shi J, Sigurdsson E, Silverman JM, Spencer CC, Stefansson K, Strange A, Strengman E, Stroup TS, Suvisaari J, Terenius L, Thirumalai S, Thygesen JH, Timm S, Toncheva D, van den Oord E, van Os J, van Winkel R, Veldink J, Walsh D, Wang AG, Wiersma D, Wildenauer DB, Williams HJ, Williams NM, Wormley B, Zammit S, Sullivan PF, O'Donovan MC, Daly MJ, Gejman PV (2011) Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43:969-976
149. Roehrs T, Roth T (2001a) Sleep, sleepiness, sleep disorders and alcohol use and abuse. Sleep Med Rev 5:287-297
150. Roehrs T, Roth T (2001b) Sleep, sleepiness, and alcohol use. Alcohol Res Health 25:101-109
151. Roehrs T, Hyde M, Blaisdell B, Greenwald M, Roth T (2006) Sleep loss and REM sleep loss are hyperalgesic. Sleep 29:145-151
152. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA (2007) Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 104:6406-6411
153. Sams-Dodd F (1996) Phencyclidine-induced stereotyped behaviour and social isolation in rats: A possible animal model of schizophrenia. Behav Pharmacol 7:3-23
154. Sanderson DJ, Bannerman DM (2010) The role of habituation in hippocampus-dependent spatial working memory tasks: Evidence from GluA1 AMPA receptor subunit knockout mice. Hippocampus 22:981-994
155. Savelyev SA, Larsson KC, Johansson AS, Lundkvist GB (2011) Slice preparation, organotypic tissue culturing and luciferase recording of clock gene activity in the suprachiasmatic nucleus. J Vis Exp 48:2439
156. Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch LA, Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, Tomoda T, Hai T, Furukubo-Tokunaga K, Sawa A (2008) Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol Psychiatry 13(1138-1148):1069
157. Scott JP, McNaughton LR, Polman RC (2006) Effects of sleep deprivation and exercise on cognitive, motor performance and mood. Physiol Behav 87:396-408
158. Scott LD, Hwang WT, Rogers AE, Nysse T, Dean GE, Dinges DF (2007) The relationship between nurse work schedules, sleep duration, and drowsy driving. Sleep 30:1801-1807
159. Selvi Y, Gulec M, Agargun MY, Besiroglu L (2007) Mood changes after sleep deprivation in morningness-eveningness chronotypes in healthy individuals. J Sleep Res 16:241-244
160. Sharif A, Duhem-Tonnelle V, Allet C, Baroncini M, Loyens A, Kerr-Conte J, Collier F, Blond S, Ojeda SR, Junier MP, Prevot V (2009) Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain. Glia 57:362-379
161. Sharma V, Mazmanian D (2003) Sleep loss and postpartum psychosis. Bipolar Disord 5:98-105
162. Shimazoe T, Morita M, Ogiwara S, Kojiya T, Goto J, Kamakura M, Moriya T, Shinohara K, Takiguchi S, Kono A, Miyasaka K, Funakoshi A, Ikeda M (2008) Cholecystokinin-A receptors regulate photic input pathways to the circadian clock. FASEB J 22:1479-1490
163. Snodgrass-Belt P, Gilbert JL, Davis FC (2005) Central administration of transforming growth factor-Alpha and neuregulin-1 suppressactive behaviors and cause weight loss in hamsters. Brain Res 1038:171-182
164. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K (2002) Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71:877-892
165. Stickgold R (2005) Sleep-dependent memory consolidation. Nature 437:1272-1278
166. Swerdlow NR, Weber M, Qu Y, Light GA, Braff DL (2008) Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology (Berl) 199:331-388
167. Tachikawa H, Harada S, Kawanishi Y, Okubo T, Shiraishi H (2000) Novel polymorphisms of the human cholecystokinin A receptor gene: An association analysis with schizophrenia. Am J Med Genet 96:141-145
168. Tachikawa H, Harada S, Kawanishi Y, Okubo T, Suzuki T (2001) Linked polymorphisms (-333G[T and-286A[G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia. Psychiatry Res 103:147-155
169. Tobler I (1995) Is sleep fundamentally different between mammalian species? Behav Brain Res 69:35-41
170. TohKL, Jones CR,He Y, Eide EJ, HinzWA,VirshupDM,Ptacek LJ, Fu YH (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291:1040-1043
171. Toirac I, Sanjuan J, Aguilar EJ, Gonzalez JC, Artigas F, Rivero O, Najera C, Molto MD, de Frutos R (2007) Association between CCK-AR gene and schizophrenia with auditory hallucinations. Psychiatr Genet 17:47-53
172. Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio-Henriksson A, Suvisaari J, Partonen T, Ekelund J, Lonnqvist J, Peltonen L (2009) Association between genes of disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry 65:1055-1062
173. Tsujino N, Yamanaka A, Ichiki K, Muraki Y, Kilduff TS, Yagami K, Takahashi S, Goto K, Sakurai T (2005) Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci 25:7459-7469
174. Tunbridge EM, Weinberger DR, Harrison PJ (2006) A novel protein isoform of catechol O-methyltransferase (COMT): Brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype. Mol Psychiatry 11:116-117
175. Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J (2005) Obesity and metabolic syndrome in circadian clock mutant mice. Science 308:1043-1045
176. Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandar A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, DellAquila M, Morris DW, Gill M, Corvin A, Insel PA, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J (2011) Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature 471:499-503
177. Van Dongen HP, Maislin G, Mullington JM, Dinges DF (2003) The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26:117-126
178. Venkatraman V, Chuah YM, Huettel SA, Chee MW (2007) Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions. Sleep 30:603-609
179. Verrall L, Burnet PW, Betts JF, Harrison PJ (2010) The neurobiology of D-Amino acid oxidase and its involvement in schizophrenia. Mol Psychiatry 15:122-137
180. Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS (1994) Mutagenesis and mapping of a mouse gene, clock, essential for circadian behavior. Science 264:719-725
181. Wei J, Hemmings GP (1999) The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. Eur Psychiatry 14:67-70
182. Weinberger DR, DeLisi LE, Perman GP, Targum S, Wyatt RJ (1982) Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 39:778-783
183. Weinberger DR, Harrison PJ (2011) Schizophrenia, Vol. Wiley-Blackwell, Chichester; Hoboken, NJ
184. Williams NM, O'Donovan MC, Owen MJ (2005) Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? Schizophr Bull 31:800-805
185. Wulff K, Joyce E, Middleton B, Dijk DJ, Foster RG (2006) The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: A case report. Chronobiol Int 23:485-495
186. Wulff K, Porcheret K, Cussans E, Foster RG (2009) Sleep and circadian rhythm disturbances: Multiple genes and multiple phenotypes. Curr Opin Genet Dev 19:237-246
187. Wulff K, Gatti S, Wettstein JG, Foster RG (2010) Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci 11:589-599
188. Wulff K, Dijk DJ, Middleton B, Foster RG, Joyce EM (2012) Sleep and circadian rhythm disruption in schizophrenia. Br J Psychiatry 200:308-316
189. Wulff K, Joyce E (2011) Circadian rhythms and cognition in schizophrenia. Br J Psychiatry 198:250-252
190. Yamashita H, Mori K, Nagao M, Okamoto Y, Morinobu S, Yamawaki S (2004) Effects of changing from typical to atypical antipsychotic drugs on subjective sleep quality in patients with schizophrenia in a Japanese population. J Clin Psychiatry 65:1525-1530
191. Yang C, Winkelman JW (2006) Clinical significance of sleep EEG abnormalities in chronic schizophrenia. Schizophr Res 82:251-260
192. Yin L, Wang J, Klein PS, Lazar MA (2006) Nuclear receptor Reverbalpha is a critical lithium-sensitive component of the circadian clock. Science 311:1002-1005
193. Young ME, Bray MS (2007) Potential role for peripheral circadian clock dyssynchrony in the pathogenesis of cardiovascular dysfunction. Sleep Med 8:656-667
194. Zachrisson O, de Belleroche J, Wendt KR, Hirsch S, Lindefors N (1999) Cholecystokinin CCK(B) receptor mRNA isoforms: Expression in schizophrenic brains. Neuroreport 10:3265-3268
195. Zhang HT, Zhao Y, Huang Y, Dorairaj NR, Chandler LJ, O'Donnell JM (2004) Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus. Neuropsychopharmacology 29:1432-1439
196. Zhang HT, Zhao Y, Huang Y, Deng C, Hopper AT, De Vivo M, Rose GM, O'Donnell JM (2006) Antidepressant-like effects of PDE4 inhibitors mediated by the high-Affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats. Psychopharmacology (Berl) 186:209-217
197. Zheng X, Sehgal A (2010) AKT and TOR signaling set the pace of the circadian pacemaker. Curr Biol 20:1203-1208