Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure

Medical Hypotheses

Volumn 79, Issue 5, 2012, Pages 642-648

  McCarty, Mark F ^a  

^a NutriGuard Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BILIVERDIN; CADMIUM; CALCIUM; COPPER; ESTROGEN RECEPTOR ALPHA; HOMOCYSTEINE; IRON; MAGNESIUM; MELATONIN; MESSENGER RNA; METALLOTHIONEIN; MINERAL; MULTIVITAMIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOL GROUP; TOBACCO SMOKE; ZINC;

ANGINA PECTORIS; ARTICLE; ATHEROGENESIS; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CEREBROVASCULAR ACCIDENT; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; DIETARY INTAKE; DNA DAMAGE; HEART INFARCTION; HUMAN; IN VITRO STUDY; INGESTION; IRON DEFICIENCY; IRON OVERLOAD; IRON STORAGE; ISCHEMIC HEART DISEASE; KIDNEY DISEASE; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITIONAL STATUS; OSTEOPENIA; OSTEOPOROSIS; OXIDATIVE STRESS; PATHOGENICITY; RISK FACTOR; SHELLFISH; SPIRULINA; TOXICITY; VITAMIN SUPPLEMENTATION;

CADMIUM; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MINERALS; ZINC;

NICOTIANA TABACUM; RODENTIA; SPIRULINA;

EID: 84867334191     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.07.043     Document Type: Article

References (105)

1. Jarup L., Akesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 2009, 238(3):201-208.
2. Nawrot T.S., Staessen J.A., Roels H.A., et al. Cadmium exposure in the population: from health risks to strategies of prevention. Biometals 2010, 23(5):769-782.
3. Emmerson B.T. "Ouch-ouch" disease: the osteomalacia of cadmium nephropathy. Ann Intern Med 1970, 73(5):854-855.
4. Schutte R., Nawrot T.S., Richart T., et al. Bone resorption and environmental exposure to cadmium in women: a population study. Environ Health Perspect 2008, 116(6):777-783.
5. Menke A., Muntner P., Silbergeld E.K., Platz E.A., Guallar E. Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect 2009, 117(2):190-196.
6. Nawrot T.S., Van H.E., Thijs L., et al. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population. Environ Health Perspect 2008, 116(12):1620-1628.
7. Suwazono Y., Sand S., Vahter M., et al. Benchmark dose for cadmium-induced renal effects in humans. Environ Health Perspect 2006, 114(7):1072-1076.
8. Navas-Acien A., Tellez-Plaza M., Guallar E., et al. Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis. Am J Epidemiol 2009, 170(9):1156-1164.
9. Wu Q., Magnus J.H., Hentz J.G. Urinary cadmium, osteopenia, and osteoporosis in the US population. Osteoporos Int 2010, 21(8):1449-1454.
10. Engstrom A., Michaelsson K., Suwazono Y., Wolk A., Vahter M., Akesson A. Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women. J Bone Miner Res 2011, 26(3):486-495.
11. Everett C.J., Frithsen I.L. Association of urinary cadmium and myocardial infarction. Environ Res 2008, 106(2):284-286.
12. Agarwal S., Zaman T., Tuzcu E.M., Kapadia S.R. Heavy metals and cardiovascular disease: results from the National Health and Nutrition Examination Survey (NHANES) 1999-2006. Angiology 2011, 62(5):422-429.
13. Lee M.S., Park S.K., Hu H., Lee S. Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. Environ Res 2011, 111(1):171-176.
14. Messner B., Knoflach M., Seubert A., et al. Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance. Arterioscler, Thromb, Vasc Biol 2009, 29(9):1392-1398.
15. Messner B., Bernhard D. Cadmium and cardiovascular diseases: cell biology, pathophysiology, and epidemiological relevance. Biometals 2010, 23(5):811-822.
16. Knoflach M., Messner B., Shen Y.H., et al. Non-toxic cadmium concentrations induce vascular inflammation and promote atherosclerosis. Circ J 2011, 75(10):2491-2495.
17. Boffetta P. Methodological aspects of the epidemiological association between cadmium and cancer in humans. IARC Sci Publ 1992, 118:425-434.
18. Boffetta P. Carcinogenicity of trace elements with reference to evaluations made by the International Agency for Research on Cancer. Scand J Work Environ Health 1993, 19(Suppl 1):67-70.
19. Cuypers A., Plusquin M., Remans T., et al. Cadmium stress: an oxidative challenge. Biometals 2010, 23(5):927-940.
20. Jin Y.H., Clark A.B., Slebos R.J., et al. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet 2003, 34(3):326-329.
21. Hartwig A. Mechanisms in cadmium-induced carcinogenicity: recent insights. Biometals 2010, 23(5):951-960.
22. Sahmoun A.E., Case L.D., Jackson S.A., Schwartz G.G. Cadmium and prostate cancer: a critical epidemiologic analysis. Cancer Invest 2005, 23(3):256-263.
23. Chen Y.C., Pu Y.S., Wu H.C., et al. Cadmium burden and the risk and phenotype of prostate cancer. BMC Cancer 2009, 9:429.
24. Johnson M.D., Kenney N., Stoica A., et al. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 2003, 9(8):1081-1084.
25. Nesatyy V.J., Rutishauser B.V., Eggen R.I., Suter M.J. Identification of the estrogen receptor Cd-binding sites by chemical modification. Analyst 2005, 130(7):1087-1097.
26. Liu J., Huang H., Zhang W., Li H. Cadmium-induced increase in uterine wet weight and its mechanism. Birth Defects Res B 2010, 89(1):43-49.
27. Silva E., Lopez-Espinosa M.J., Molina-Molina J.M., Fernandez M., Olea N., Kortenkamp A. Lack of activity of cadmium in in vitro estrogenicity assays. Toxicol Appl Pharmacol 2006, 216(1):20-28.
28. McElroy J.A., Shafer M.M., Trentham-Dietz A., Hampton J.M., Newcomb P.A. Cadmium exposure and breast cancer risk. J Natl Cancer Inst 2006, 98(12):869-873.
29. Gallagher C.M., Chen J.J., Kovach J.S. Environmental cadmium and breast cancer risk. Aging (Albany NY) 2010, 2(11):804-814.
30. Adams S.V., Newcomb P.A., Shafer M.M., et al. Urinary cadmium and mammographic density in premenopausal women. Breast Cancer Res Treat 2011, 128(3):837-844.
31. Akesson A., Julin B., Wolk A. Long-term dietary cadmium intake and postmenopausal endometrial cancer incidence. a population-based prospective cohort study. Cancer Res 2008, 68(15):6435-6441.
32. Schwartz G.G., Reis I.M. Is cadmium a cause of human pancreatic cancer?. Cancer Epidemiol Biomarkers Prev 2000, 9(2):139-145.
33. Kellen E., Zeegers M.P., Hond E.D., Buntinx F. Blood cadmium may be associated with bladder carcinogenesis: the Belgian case-control study on bladder cancer. Cancer Detect Prev 2007, 31(1):77-82.
34. Il'yasova D., Schwartz G.G. Cadmium and renal cancer. Toxicol Appl Pharmacol 2005, 207(2):179-186.
35. Nawrot T., Plusquin M., Hogervorst J., et al. Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol 2006, 7(2):119-126.
36. Adams S.V., Passarelli M.N., Newcomb P.A. Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort. Occup Environ Med 2012, 69(2):153-156.
37. Schwartz G.G., Il'yasova D., Ivanova A. Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III. Diabetes Care 2003, 26(2):468-470.
38. Afridi H.I., Kazi T.G., Kazi N., et al. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pract 2008, 80(2):280-288.
39. Edwards J.R., Prozialeck W.C. Cadmium, diabetes and chronic kidney disease. Toxicol Appl Pharmacol 2009, 238(3):289-293.
40. Inoguchi T., Nawata H. NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome. Curr Drug Targets 2005, 6(4):495-501.
41. Ciesielski T., Weuve J., Bellinger D.C., Schwartz J., Lanphear B., Wright R.O. Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children. Environ Health Perspect 2012, 120(5):758-763.
42. Paniagua-Castro N., Escalona-Cardoso G., Hernandez-Navarro D., Perez-Pasten R., Chamorro-Cevallos G. Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in mice. J Med Food 2011, 14(4):398-404.
43. Chen L., Xu B., Liu L., et al. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radical Biol Med 2011, 50(5):624-632.
44. Yang Z., Yang S., Qian S.Y., et al. Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia. Toxicol Sci 2007, 98(2):488-494.
45. Johnson S. Gradual micronutrient accumulation and depletion in Alzheimer's disease. Med Hypotheses 2001, 56(6):595-597.
46. Krajcovicova-Kudladkova M., Ursinyova M., Masanova V., Bederova A., Valachovicova M. Cadmium blood concentrations in relation to nutrition. Cent Eur J Public Health 2006, 14(3):126-129.
47. Magkos F., Arvaniti F., Zampelas A. Organic food: buying more safety or just peace of mind? A critical review of the literature. Crit Rev Food Sci Nutr 2006, 46(1):23-56.
48. Ryu D.Y., Lee S.J., Park D.W., Choi B.S., Klaassen C.D., Park J.D. Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett 2004, 152(1):19-25.
49. Vesey D.A. Transport pathways for cadmium in the intestine and kidney proximal tubule: focus on the interaction with essential metals. Toxicol Lett 2010, 198(1):13-19.
50. Min K.S., Ueda H., Kihara T., Tanaka K. Increased hepatic accumulation of ingested Cd is associated with upregulation of several intestinal transporters in mice fed diets deficient in essential metals. Toxicol Sci 2008, 106(1):284-289.
51. Bannon D.I., Abounader R., Lees P.S., Bressler J.P. Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells. Am J Physiol Cell Physiol 2003, 284(1):C44-C50.
52. Apinan R., Satarug S., Ruengweerayut R., Mahavorasirikul W., Na-Bangchang K. The influence of iron stores on cadmium body burden in a Thai population. Environ Geochem Health 2010, 32(3):237-242.
53. Lee B.K., Kim Y. Iron deficiency is associated with increased levels of blood cadmium in the Korean general population: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data. Environ Res 2012, 112:155-163.
54. Gallagher C.M., Chen J.J., Kovach J.S. The relationship between body iron stores and blood and urine cadmium concentrations in US never-smoking, non-pregnant women aged 20-49years. Environ Res 2011, 111(5):702-707.
55. Toyokuni S. Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci 2009, 100(1):9-16.
56. Reeves P.G., Chaney R.L. Nutritional status affects the absorption and whole-body and organ retention of cadmium in rats fed rice-based diets. Environ Sci Technol 2002, 36(12):2684-2692.
57. Reeves P.G., Chaney R.L. Marginal nutritional status of zinc, iron, and calcium increases cadmium retention in the duodenum and other organs of rats fed rice-based diets. Environ Res 2004, 96(3):311-322.
58. Min K.S., Ueda H., Tanaka K. Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet. Toxicol Lett 2008, 176(1):85-92.
59. Himeno S., Yanagiya T., Fujishiro H. The role of zinc transporters in cadmium and manganese transport in mammalian cells. Biochimie 2009, 91(10):1218-1222.
60. Djukic-Cosic D., Ninkovic M., Malicevic Z., Plamenac-Bulat Z., Matovic V. Effect of supplemental magnesium on the kidney levels of cadmium, zinc, and copper of mice exposed to toxic levels of cadmium. Biol Trace Elem Res 2006, 114(1-3):281-291.
61. Matovic V., Plamenac B.Z., Djukic-Cosic D., Soldatovic D. Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication. Magnes Res 2010, 23(1):19-26.
62. Liu Y., Liu J., Habeebu S.M., Waalkes M.P., Klaassen C.D. Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicol Sci 2000, 57(1):167-176.
63. Klaassen C.D., Liu J., Diwan B.A. Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 2009, 238(3):215-220.
64. Sullivan V.K., Burnett F.R., Cousins R.J. Metallothionein expression is increased in monocytes and erythrocytes of young men during zinc supplementation. J Nutr 1998, 128(4):707-713.
65. Cao J., Cousins R.J. Metallothionein mRNA in monocytes and peripheral blood mononuclear cells and in cells from dried blood spots increases after zinc supplementation of men. J Nutr 2000, 130(9):2180-2187.
66. Aydemir T.B., Blanchard R.K., Cousins R.J. Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. Proc Natl Acad Sci USA 2006, 103(6):1699-1704.
67. Bulat Z.P., Djukic-Cosic D., Malicevic Z., Bulat P., Matovic V. Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. Biol Trace Elem Res 2008, 124(2):110-117.
68. Brzoska M.M., Roszczenko A., Galazyn-Sidorczuk M., Majewska K. Zinc supplementation can protect from enhanced risk of femoral neck fracture in male rats chronically exposed to cadmium. Exp Toxicol Pathol 2011, 63(5):491-498.
69. Rogalska J., Pilat-Marcinkiewicz B., Brzoska M.M. Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: a study in a rat model. Chem Biol Interact 2011, 193(3):191-203.
70. Brzoska M.M., Moniuszko-Jakoniuk J. Interactions between cadmium and zinc in the organism. Food Chem Toxicol 2001, 39(10):967-980.
71. Van W.E., Singer E.A., Palapattu G.S. Prostate-specific antigen levels in relation to cadmium exposure and zinc intake: results from the 2001-2002 National Health and Nutrition Examination Survey. Prostate 2008, 68(2):122-128.
72. Pan S.Y., Zhou J., Gibbons L., Morrison H., Wen S.W. Antioxidants and breast cancer risk- a population-based case-control study in Canada. BMC Cancer 2011, 11:372.
73. Grant W.B. An ecological study of cancer mortality rates including indices for dietary iron and zinc. Anticancer Res 2008, 28(3B):1955-1963.
74. Bao B., Prasad A.S., Beck F.W., et al. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. Am J Clin Nutr 2010, 91(6):1634-1641.
75. Jenner A., Ren M., Rajendran R., et al. Zinc supplementation inhibits lipid peroxidation and the development of atherosclerosis in rabbits fed a high cholesterol diet. Free Radical Biol Med 2007, 42(4):559-566.
76. Prasad A.S., Beck F.W., Bao B., et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 2007, 85(3):837-844.
77. Prasad A.S. Zinc in human health: effect of zinc on immune cells. Mol Med 2008, 14(5-6):353-357.
78. Age-Related Eye Disease Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001; 119(10):1417-36.
79. Clemons T.E., Kurinij N., Sperduto R.D. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the age-related eye disease study: AREDS report no. 13. Arch Ophthalmol 2004, 122(5):716-726.
80. Foster M., Petocz P., Samman S. Effects of zinc on plasma lipoprotein cholesterol concentrations in humans: a meta-analysis of randomised controlled trials. Atherosclerosis 2010, 210(2):344-352.
81. Prasad A.S., Brewer G.J., Schoomaker E.B., Rabbani P. Hypocupremia induced by zinc therapy in adults. JAMA, J Am Med Assoc 1978, 240(20):2166-2168.
82. Flora S.J., Mittal M., Mehta A. Heavy metal induced oxidative stress and its possible reversal by chelation therapy. Indian J Med Res 2008, 128(4):501-523.
83. Liu J., Qu W., Kadiiska M.B. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 2009, 238(3):209-214.
84. Patra R.C., Rautray A.K., Swarup D. Oxidative stress in lead and cadmium toxicity and its amelioration. Vet Med Int 2011, 2011:457327.
85. Matovic V., Buha A., Bulat Z., Dukic-Cosic D. Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium. Arh Hig Rada Toksikol 2011, 62(1):65-76.
86. McCarty M.F. Clinical potential of Spirulina as a source of phycocyanobilin. J Med Food 2007, 10(4):566-570.
87. Thijssen S., Cuypers A., Maringwa J., et al. Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology 2007, 236(1-2):29-41.
88. Souza V., Escobar M.C., Bucio L., Hernandez E., Gomez-Quiroz L.E., Gutierrez Ruiz M.C. NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells. Toxicol Lett 2009, 187(3):180-186.
89. Mukherjee R., Banerjee S., Joshi N., Singh P.K., Baxi D., Ramachandran A.V. A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage. Cardiovasc Toxicol 2011, 11(1):78-88.
90. El-Maraghy S.A., Nassar N.N. Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis. J Biochem Mol Toxicol 2011, 25(1):15-25.
91. Bludovska M., Kotyzova D., Koutensky J., Eybl V. The influence of alpha-lipoic acid on the toxicity of cadmium. Gen Physiol Biophys 1999, 18:28-32.
92. Sumathi R., Baskaran G., Varalakshmi P. Relationship between glutathione and dl alpha-lipoic acid against cadmium-induced hepatotoxicity. Jpn J Med Sci Biol 1996, 49(2):39-48.
93. Shagirtha K., Muthumani M., Prabu S.M. Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats. Eur Rev Med Pharmacol Sci 2011, 15(9):1039-1050.
94. El-Sokkary G.H., Nafady A.A., Shabash E.H. Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat. Ecotoxicol Environ Saf 2010, 73(3):456-463.
95. Kara H., Cevik A., Konar V., Dayangac A., Servi K. Effects of selenium with vitamin E and melatonin on cadmium-induced oxidative damage in rat liver and kidneys. Biol Trace Elem Res 2008, 125(3):236-244.
96. Onso-Gonzalez C., Gonzalez A., Mazarrasa O., et al. Melatonin prevents the estrogenic effects of sub-chronic administration of cadmium on mice mammary glands and uterus. J Pineal Res 2007, 42(4):403-410.
97. Kaplan M., Atakan I.H., Aydogdu N., et al. Influence of N-acetylcysteine on renal toxicity of cadmium in rats. Pediatr Nephrol 2008, 23(2):233-241.
98. Wang L., Chen D., Cao J., Liu Z. Protective effect of N-acetylcysteine on experimental chronic cadmium nephrotoxicity in immature female rats. Hum Exp Toxicol 2009, 28(4):221-229.
99. Odewumi C.O., Badisa V.L., Le U.T., et al. Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells. Int J Mol Med 2011, 27(2):243-248.
100. Miller A.L. Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Altern Med Rev 1998, 3(3):199-207.
101. Sompamit K., Kukongviriyapan U., Donpunha W., Nakmareong S., Kukongviriyapan V. Reversal of cadmium-induced vascular dysfunction and oxidative stress by meso-2,3-dimercaptosuccinic acid in mice. Toxicol Lett 2010, 198(1):77-82.
102. Saljooghi A.S., Fatemi S.J. Clinical evaluation of deferasirox for removal of cadmium ions in rat. Biometals 2010, 23(4):707-712.
103. Jones M.M., Singh P.K., Basinger M.A., Gale G.R., Smith A.B. Cadmium mobilization by monoaralkyl- and monoalkyl esters of meso-2,3-dimercaptosuccinic acid and by a dithiocarbamate. Pharmacol Toxicol 1994, 74(2):76-83.
104. Tasende M.S., Gale G.R., Smith A.B., Jones M.M., Singh P.K. Monoisoamyl meso-2,3-dimercaptosuccinate: interaction with metallothionein-bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo. Res Commun Chem Pathol Pharmacol 1992, 76(3):323-339.
105. Flora S.J., Mehta A. Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats. J Appl Toxicol 2003, 23(2):97-102.