Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: Role of oxidative stress from Microglia

Toxicological Sciences

Volumn 98, Issue 2, 2007, Pages 488-494

  Yang, Zhengqin ^a,b   Yang, Sufen ^a   Qian, Steven Y ^a,c   Hong, Jau Shyong ^a   Kadiiska, Maria B ^a   Tennant, Raymond W ^a   Waalkes, Michael P ^d   Liu, Jie ^d  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b ZHENGZHOU UNIVERSITY   (China)

^c NORTH DAKOTA STATE UNIVERSITY   (United States)

^d NCI   (United States)

Author keywords

Cadmium; Gene expression; Neuron glia cultures; Neurotoxicity; NF B and AP 1; Oxidative stress

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CADMIUM CHLORIDE; CARRIER PROTEIN; DICHLOROFLUORESCEIN; GLUTATHIONE TRANSFERASE P1; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METAL TRANSPORT PROTEIN 1; METALLOTHIONEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ELECTRON SPIN RESONANCE; GEL ELECTROPHORESIS; GLIA CELL; IC 50; MICROGLIA; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPIN TRAPPING;

ANIMALS; CADMIUM; CATION TRANSPORT PROTEINS; CELLS, CULTURED; DOPAMINE; GENE EXPRESSION; GLUTATHIONE S-TRANSFERASE PI; HEME OXYGENASE-1; MESENCEPHALON; METALLOTHIONEIN; NEUROGLIA; NF-KAPPA B; OXIDATIVE STRESS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR AP-1;

RATTUS;

EID: 34547839626     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm106     Document Type: Article

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