Relationship between glutathione and DL α-lipoic acid against cadmium-induced hepatotoxicity

Japanese Journal of Medical Science and Biology

Volumn 49, Issue 2, 1996, Pages 39-48

  Sumathi, Ramachandran ^a   Baskaran, Govindasamy ^a   Varalakshmi, Palaninathan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; CADMIUM; GLUTATHIONE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; RAT;

EID: 0029890646     PISSN: 00215112     EISSN: None     Source Type: Journal    
DOI: 10.7883/yoken1952.49.39     Document Type: Article

References (29)

1. Singhal, R. L., Anderson, M. E. and Meister, A. (1987): Glutathione, a first line of defense against cadmium toxicity. FASEB J., 1, 220-223.
2. Ochi, T., Otsuka, F., Takahashi, K. and Ohsawa, M. (1988): Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells. Chem. Biol. Interact., 65, 1-12.
3. Chan, H. M. and Cherian, M. G. (1992): Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicology, 72, 281-290.
4. Scholich, H., Murphy, M. E. and Sies, H. (1989): Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol. Biochim. Biophys. Acta, 1001, 256-261.
5. Griffith, O. W. and Meister, A. (1979): Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (s-n-butyl homocysteine sulfoximine). J. Biol. Chem., 254, 7558-7560.
6. Hogberg, J., Larson, R. E., Kristoferson, A. and Orrenius, S. (1974): NADPH-dependent reductase solubilized from microsomes by peroxidation and its activity. Biochem. Biophys. Res. Commun., 56, 836-842.
7. Moron, M. S., Defierre, J. W. and Mannervik, K. B. (1979): Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim. Biophys. Acta, 582, 67-78.
8. Omaye, S. T., Turnball, J. D. and Sauberlich, H. E. (1971): Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol., 62, 1-11.
9. Sedlack, J. and Lindsay, R. H. (1968): Estimation of total, protein bound and nonprotein-bound sulfhydryl groups in the tissues with Ellman's reagent. Anal. Biochem., 25, 192-205.
10. Rotruck, J. T., Pope, A. L. and Ganther, H. E. (1973): Selenium - Biochemical roles as a component of glutathione peroxidase. Science, 179, 588-590.
11. Beutler, E. (1983): Active transport of glutathione disulfide from erythrocytes. p.60-65. In A. Larson, S. Orrenius, A. Holmgren and B. Mannerwik (eds.), Functions of glutathione: Biochemical, physiological and clinical aspects. Raven Press, New York.
12. Beutler, E. (1984): In Red cell metabolism. A manual of biochemical methods. Third edition, Grune and Stratton, Orlando.
13. Habig, W. H., Pabst, U. J. and Jakoby, W. B. (1973): Glutathione-S-transferase. J. Biol. Chem., 249, 7130-7139.
14. Mooz, E. D. and Meister, A. (1969): Glutathione biosyntheis. p.483-486. In T. Herbest and W. T. Celia (eds.), Methods Enzymol., Vol 17, Academic Press, New York.
15. Lowry, O. H., Rosebrough, N. J., Farr, A. I. and Randall, R. J. (1951): Protein measument with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
16. Din, W. S. and Frazier, J. M. (1985): Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes. Biochem, J., 230, 395-398.
17. Sumathi, R., Baskaran, G. and Varalakshmi, P. (1995): Therapeutic effectiveness of DL α-lipoic acid on the redox status in acute cadmium intoxicated rat tissues. J. Nutr. Biochem., in press.
18. Sumathi, R., Kalpana Devi, V. and Varalakshmi, P. (1994): DL α-Lipoic acid protection against cadmium-induced tissue lipid peroxidation. Med. Sci. Res., 22, 23-25.
19. Bast, A. and Haenen, G. R. M. M. (1988): Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochim. Biophys. Acta, 963, 558-561.
20. Mrtensson, J. and Meister, A. (1991): Glutathione deficiency decreases tissue ascorbate levels in newborn rats: Ascorbate spares glutathione and protects. Proc. Natl. Acad. Sci. USA, 88, 4656-4660.
21. Haenen, G. R. M. M. and Bast, A. (1989): Modulation of microsomal lipid peroxidation by dihydrolipoate in interplay with vitamin E, vitamin C and glutathione. p.137-150. In H. O. Borbe and H. Ulrich (eds.), Thioctsaure, Verlag, Frankfurt.
22. Zimmer, G., Mainka, L. and Kruger, E. (1991): Dihydrolipoic acid activates oligomycin - sensitive thiol groups and increases ATP synthesis in mitochondria. Arch. Biochem. Biophys., 288, 609-613.
23. Valle, B. L. and Ulmer, D. D. (1972): Biochemical effects of mercury, cadmium and lead. Ann. Rev. Biochem., 41, 91-128.
24. Pool, M. L. (1981): Exposure and health effects of cadmium Part III. Effects of cadmium on enzyme activities. Toxicol. Environ. Chem. Rev., 4, 179-203.
25. Meister, A. and Tate, S. S. (1976): Glutathione and related γ-glutamyl compounds. Biosynthesis and utilization. Ann. Rev. Biochem., 45, 559-563.
26. Kosower, N. S. and Kosower, E. M. (1976): The glutathione-glutathione disulfide system. p.55-84. In W. A. Pryor (ed.), Free radicals in biology, Vol. 2, Academic Press, New York.
27. James, R. C. and Harbison, D. (1982): Hepatic glutathione and hepatotoxicity: Effect of cytochrome P-450 complexing compounds SKF 525-A, L-γ-acetylmethadol (LAAM), nor LAAM and piperonyl butaoxide. Biochem. Pharmacol., 31, 1829-1835.
28. Sumathi, R., Jayanthi, S. and Varalakshmi, P. (1995): Impaired lipid metabolism in calcium oxalalte stone forming rats and DL α-lipoic acid supplementation. Nutr. Res., 15, 59-70.
29. Sumathi, R., Jayanthi, S., Kalpana Devi, V. and Varalakshmi, P. (1993): Effect of DL α-lipoic acid on tissue lipid peroxidation and antioxidant systems in normal and glycollate-treated rats. Pharmacol. Res., 27, 309-318.