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Volumn 94, Issue 7, 2012, Pages 729-737

Cellular infiltrates and NFκB subunit c-rel signaling in kidney allografts of patients with clinical operational tolerance

Author keywords

c Rel; FOXP3; NFJB; PI3K; Tolerance

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR REL;

EID: 84867263974     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31826032be     Document Type: Article
Times cited : (22)

References (47)
  • 1
    • 70450223522 scopus 로고    scopus 로고
    • Clinical transplantation tolerance: A myth no more, butI
    • Azzi J, Sayegh MH. Clinical transplantation tolerance: a myth no more, butI. Am J Kidney Dis 2009; 54: 1005.
    • (2009) Am J Kidney Dis , vol.54 , pp. 1005
    • Azzi, J.1    Sayegh, M.H.2
  • 2
    • 78650179150 scopus 로고    scopus 로고
    • Clinical operational tolerance after renal transplantation: Current status and future challenges
    • Orlando G, Hematti P, Stratta RJ, et al. Clinical operational tolerance after renal transplantation: current status and future challenges. Ann Surg 2010; 252: 915.
    • (2010) Ann Surg , vol.252 , pp. 915
    • Orlando, G.1    Hematti, P.2    Stratta, R.J.3
  • 3
    • 38449100017 scopus 로고    scopus 로고
    • Spontaneous operational tolerance after immunosuppressive drug withdrawal in clinical renal allotransplantation
    • Ashton-Chess J, Giral M, Brouard S, et al. Spontaneous operational tolerance after immunosuppressive drug withdrawal in clinical renal allotransplantation. Transplantation 2007; 84: 1215.
    • (2007) Transplantation , vol.84 , pp. 1215
    • Ashton-Chess, J.1    Giral, M.2    Brouard, S.3
  • 4
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353.
    • (2008) N Engl J Med , vol.358 , pp. 353
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 6
    • 0033610680 scopus 로고    scopus 로고
    • Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function
    • Kirk AD, Jacobson LM, Heisey DM, et al. Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function. Transplantation 1999; 68: 1578.
    • (1999) Transplantation , vol.68 , pp. 1578
    • Kirk, A.D.1    Jacobson, L.M.2    Heisey, D.M.3
  • 7
    • 49149099012 scopus 로고    scopus 로고
    • Spontaneous renal allograft acceptance associated with WregulatoryW dendritic cells and IDO
    • Cook CH, Bickerstaff AA, Wang JJ, et al. Spontaneous renal allograft acceptance associated with WregulatoryW dendritic cells and IDO. J Immunol 2008; 180: 3103.
    • (2008) J Immunol , vol.180 , pp. 3103
    • Cook, C.H.1    Bickerstaff, A.A.2    Wang, J.J.3
  • 8
    • 38349018193 scopus 로고    scopus 로고
    • 3+ T cells within tolerant renal allografts shows infiltration of tubules mimicking rejection
    • 3+ T cells within tolerant renal allografts shows infiltration of tubules mimicking rejection. Am J Pathol 2007; 171: 1915.
    • (2007) Am J Pathol , vol.171 , pp. 1915
    • Brown, K.1    Moxham, V.2    Karegli, J.3
  • 9
    • 54049126955 scopus 로고    scopus 로고
    • 3+ regulatory T cells predicts outcome of subclinical rejection of renal allografts
    • 3+ regulatory T cells predicts outcome of subclinical rejection of renal allografts. J Am Soc Nephrol 2008; 19: 2020.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2020
    • Bestard, O.1    Cruzado, J.M.2    Rama, I.3
  • 10
    • 33947210002 scopus 로고    scopus 로고
    • Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance
    • Xu Q, Lee J, Jankowska-Gan E, et al. Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol 2007; 178: 3983.
    • (2007) J Immunol , vol.178 , pp. 3983
    • Xu, Q.1    Lee, J.2    Jankowska-Gan, E.3
  • 11
    • 3843141628 scopus 로고    scopus 로고
    • Tuning the volume of the immune response: Strength and persistence of stimulation determine migration and cytokine secretion in dentritic cells
    • Luft TH, Maraskovsky E, Schnur M, et al. Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion in dentritic cells. Blood 2004; 104: 1066.
    • (2004) Blood , vol.104 , pp. 1066
    • Luft, T.H.1    Maraskovsky, E.2    Schnur, M.3
  • 12
    • 79951516904 scopus 로고    scopus 로고
    • Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments
    • Wang C, Cordoba S, Hu M, et al. Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transpl Immunol 2011; 24: 149.
    • (2011) Transpl Immunol , vol.24 , pp. 149
    • Wang, C.1    Cordoba, S.2    Hu, M.3
  • 13
    • 33846903837 scopus 로고    scopus 로고
    • Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-JB pathways
    • Liu Q, Chen T, Chen G, et al. Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-JB pathways. Mol Immunol 2007; 44: 2686.
    • (2007) Mol Immunol , vol.44 , pp. 2686
    • Liu, Q.1    Chen, T.2    Chen, G.3
  • 14
    • 35948934636 scopus 로고    scopus 로고
    • Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    • Isermann B, Vinnikov IA, Madhusudhan T, et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 2007; 13: 1349.
    • (2007) Nat Med , vol.13 , pp. 1349
    • Isermann, B.1    Vinnikov, I.A.2    Madhusudhan, T.3
  • 15
    • 68549098129 scopus 로고    scopus 로고
    • Protective effects and antiinflammatory pathways of exogenous calcitonin geneYrelated peptide in severe necrotizing pancreatitis
    • Schneider L, Hartwig W, Flemming T, et al. Protective effects and antiinflammatory pathways of exogenous calcitonin geneYrelated peptide in severe necrotizing pancreatitis. Pancreatology 2009; 9: 662.
    • (2009) Pancreatology , vol.9 , pp. 662
    • Schneider, L.1    Hartwig, W.2    Flemming, T.3
  • 16
    • 60849117518 scopus 로고    scopus 로고
    • Critical role of class IA PI3K for c-Rel expression in B lymphocytes
    • Matsuda S, Mikami Y, Ohtani M, et al. Critical role of class IA PI3K for c-Rel expression in B lymphocytes. Blood 2009; 113: 1037.
    • (2009) Blood , vol.113 , pp. 1037
    • Matsuda, S.1    Mikami, Y.2    Ohtani, M.3
  • 17
    • 77952767221 scopus 로고    scopus 로고
    • Cutting edge: CD28 and c-RelY dependent pathways initiate regulatory T cell development
    • Vang KB, Yang J, Pagán AJ, et al. Cutting edge: CD28 and c-RelY dependent pathways initiate regulatory T cell development. J Immunol 2010; 184: 4074.
    • (2010) J Immunol , vol.184 , pp. 4074
    • Vang, K.B.1    Yang, J.2    Pagán, A.J.3
  • 18
    • 77957298442 scopus 로고    scopus 로고
    • A distinct subset of HLADR+ Yregulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation
    • Kisielewicz A, Schaier M, Schmitt E, et al. A distinct subset of HLADR+ Yregulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation. Clin Immunol 2010; 137: 209.
    • (2010) Clin Immunol , vol.137 , pp. 209
    • Kisielewicz, A.1    Schaier, M.2    Schmitt, E.3
  • 19
    • 33644677802 scopus 로고    scopus 로고
    • Predicting subsequent decline in kidney allograft function from early surveillance biopsies
    • Cosio FG, Grande JP, Wadei H, et al. Predicting subsequent decline in kidney allograft function from early surveillance biopsies. Am J Transplant 2005; 5: 2464.
    • (2005) Am J Transplant , vol.5 , pp. 2464
    • Cosio, F.G.1    Grande, J.P.2    Wadei, H.3
  • 20
    • 1842577508 scopus 로고    scopus 로고
    • Prope tolerance: The future of organ transplantationVfrom the laboratory to the clinic
    • Calne RY. Prope tolerance: the future of organ transplantationVfrom the laboratory to the clinic. Transplantation 2004; 77: 930.
    • (2004) Transplantation , vol.77 , pp. 930
    • Calne, R.Y.1
  • 21
    • 34848857054 scopus 로고    scopus 로고
    • Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
    • Brouard S, Mansfield E, Braud C, et al. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci USA 2007; 104: 15448.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15448
    • Brouard, S.1    Mansfield, E.2    Braud, C.3
  • 23
    • 79954615159 scopus 로고    scopus 로고
    • Donor antigenYspecific regulatory Tcell function affects outcome in kidney transplant recipients
    • Tsaur I, Gasser M, Aviles B, et al. Donor antigenYspecific regulatory Tcell function affects outcome in kidney transplant recipients. Kidney Int 2011; 79: 1005.
    • (2011) Kidney Int , vol.79 , pp. 1005
    • Tsaur, I.1    Gasser, M.2    Aviles, B.3
  • 24
    • 79952165892 scopus 로고    scopus 로고
    • T-cell phenotype in protocol renal biopsy from transplant recipients treated with belatacept-mediated costimulatory blockade
    • Grimbert P, Audard V, Diet C, et al. T-cell phenotype in protocol renal biopsy from transplant recipients treated with belatacept-mediated costimulatory blockade. Nephrol Dial Transplant 2011; 26: 1087.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1087
    • Grimbert, P.1    Audard, V.2    Diet, C.3
  • 25
    • 65649117029 scopus 로고    scopus 로고
    • Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients
    • Ashton-Chess J, Dugast E, Colvin RB, et al. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. J Am Soc Nephrol 2009; 20: 1113.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1113
    • Ashton-Chess, J.1    Dugast, E.2    Colvin, R.B.3
  • 26
    • 39649107089 scopus 로고    scopus 로고
    • Monocyte infiltration and kidney allograft dysfunction during acute rejection
    • Girlanda R, Kleiner DE, Duan Z, et al. Monocyte infiltration and kidney allograft dysfunction during acute rejection. Am J Transplant 2008; 8: 600.
    • (2008) Am J Transplant , vol.8 , pp. 600
    • Girlanda, R.1    Kleiner, D.E.2    Duan, Z.3
  • 27
    • 77955665719 scopus 로고    scopus 로고
    • Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype
    • Pallier A, Hillion S, Danger R, et al. Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype. Kidney Int 2010; 78: 503.
    • (2010) Kidney Int , vol.78 , pp. 503
    • Pallier, A.1    Hillion, S.2    Danger, R.3
  • 28
    • 77953178765 scopus 로고    scopus 로고
    • Identification of a B cell signature associated with renal transplant tolerance in humans
    • Newell KA, Asare A, Kirk AD, et al. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010; 120: 1836.
    • (2010) J Clin Invest , vol.120 , pp. 1836
    • Newell, K.A.1    Asare, A.2    Kirk, A.D.3
  • 29
    • 77953209236 scopus 로고    scopus 로고
    • Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
    • Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120: 1848.
    • (2010) J Clin Invest , vol.120 , pp. 1848
    • Sagoo, P.1    Perucha, E.2    Sawitzki, B.3
  • 30
    • 33947587323 scopus 로고    scopus 로고
    • Induction of donor specific cellular hyporesponse is feasible after renal transplantation by a calcineurin-inhibitor and steroid-free immunosuppressive protocol
    • Bestard O, Cruzado JM, Mestres M, et al. Induction of donor specific cellular hyporesponse is feasible after renal transplantation by a calcineurin-inhibitor and steroid-free immunosuppressive protocol. Am J Transplant 2006; 6: 170.
    • (2006) Am J Transplant , vol.6 , pp. 170
    • Bestard, O.1    Cruzado, J.M.2    Mestres, M.3
  • 31
    • 47249084696 scopus 로고    scopus 로고
    • FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes
    • Bunnag S, Allanach K, Jhangri GS, et al. FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. Am J Transplant 2008; 8: 1423.
    • (2008) Am J Transplant , vol.8 , pp. 1423
    • Bunnag, S.1    Allanach, K.2    Jhangri, G.S.3
  • 32
    • 33750139444 scopus 로고    scopus 로고
    • Urinary HLA-DR and CD54 expressionVindicators for inflammatory activity in decoy cell shedding patients
    • Kim SH, Ahn HJ, Kim YS, et al. Urinary HLA-DR and CD54 expressionVindicators for inflammatory activity in decoy cell shedding patients. Nephrol Dial Transplant 2006; 21: 2601.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2601
    • Kim, S.H.1    Ahn, H.J.2    Kim, Y.S.3
  • 33
    • 73449115685 scopus 로고    scopus 로고
    • Allograft rejectionYrelated gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection
    • Li Y, Yan H, Xue WJ, et al. Allograft rejectionYrelated gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection. J Zhejiang Univ Sci 2009; 10: 820.
    • (2009) J Zhejiang Univ Sci , vol.10 , pp. 820
    • Li, Y.1    Yan, H.2    Xue, W.J.3
  • 34
    • 3943111609 scopus 로고    scopus 로고
    • Relationship of HLA-DR expression to rejection and mononuclear cell infiltration in renal allograft biopsies
    • Ozdemir BH, Aksoy PK, Haberal AN, et al. Relationship of HLA-DR expression to rejection and mononuclear cell infiltration in renal allograft biopsies. Ren Fail 2004; 26: 247.
    • (2004) Ren Fail , vol.26 , pp. 247
    • Ozdemir, B.H.1    Aksoy, P.K.2    Haberal, A.N.3
  • 35
    • 34248348232 scopus 로고    scopus 로고
    • Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions
    • Woltman AM, de Fijter JW, Zuidwijk K, et al. Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions. Kidney Int 2007; 71: 1001.
    • (2007) Kidney Int , vol.71 , pp. 1001
    • Woltman, A.M.1    De Fijter, J.W.2    Zuidwijk, K.3
  • 36
    • 77957288035 scopus 로고    scopus 로고
    • Expanding therapeutic targets in bladder cancer: The PI3K/Akt/mTOR pathway
    • Ching CB, Hansel DE. Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest 2010; 90: 1406.
    • (2010) Lab Invest , vol.90 , pp. 1406
    • Ching, C.B.1    Hansel, D.E.2
  • 37
    • 78650059541 scopus 로고    scopus 로고
    • Calcineurin signaling regulates human islet {beta}-cell survival
    • Soleimanpour SA, Crutchlow MF, Ferrari AM, et al. Calcineurin signaling regulates human islet {beta}-cell survival. J Biol Chem 2010; 285: 40050.
    • (2010) J Biol Chem , vol.285 , pp. 40050
    • Soleimanpour, S.A.1    Crutchlow, M.F.2    Ferrari, A.M.3
  • 38
    • 78651265551 scopus 로고    scopus 로고
    • AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance
    • Jovanovic V, Giacomelli L, Sivozhelezov V, et al. AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance. J Cell Biochem 2010; 111: 709.
    • (2010) J Cell Biochem , vol.111 , pp. 709
    • Jovanovic, V.1    Giacomelli, L.2    Sivozhelezov, V.3
  • 39
    • 40849118049 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-JB pathway
    • Zhao L, Lee JY, Hwang DH. The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-JB pathway. Biochem Pharmacol 2008; 75: 1515.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1515
    • Zhao, L.1    Lee, J.Y.2    Hwang, D.H.3
  • 40
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005; 9: 59.
    • (2005) J Cell Mol Med , vol.9 , pp. 59
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 41
    • 0029150389 scopus 로고
    • Mice lacking the c-rel protooncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Köntgen F, Grumont RJ, Strasser A, et al. Mice lacking the c-rel protooncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 1995; 9: 1965.
    • (1995) Genes Dev , vol.9 , pp. 1965
    • Köntgen, F.1    Grumont, R.J.2    Strasser, A.3
  • 42
    • 0033917674 scopus 로고    scopus 로고
    • Distinct roles for the NF-JB1 (p50) and c-Rel transcription factors in inflammatory arthritis
    • Campbell IK, Gerondakis S, O'Donnell K, et al. Distinct roles for the NF-JB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest 2000; 105: 1799.
    • (2000) J Clin Invest , vol.105 , pp. 1799
    • Campbell, I.K.1    Gerondakis, S.2    O'Donnell, K.3
  • 43
    • 77749245810 scopus 로고    scopus 로고
    • C-Rel: A pioneer in directing regulatory T-cell lineage commitment?
    • Hori S. c-Rel: a pioneer in directing regulatory T-cell lineage commitment? Eur J Immunol 2010; 40: 664.
    • (2010) Eur J Immunol , vol.40 , pp. 664
    • Hori, S.1
  • 44
    • 79551677401 scopus 로고    scopus 로고
    • Local renal autoantibody production in lupus nephritis
    • Espeli M, Bökers S, Giannico G, et al. Local renal autoantibody production in lupus nephritis. J Am Soc Nephrol 2011; 22: 296.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 296
    • Espeli, M.1    Bökers, S.2    Giannico, G.3
  • 45
    • 40449101372 scopus 로고    scopus 로고
    • Banff 07 classification of renal allograft pathology: Updates and future directions
    • Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753.
    • (2008) Am J Transplant , vol.8 , pp. 753
    • Solez, K.1    Colvin, R.B.2    Racusen, L.C.3
  • 46
    • 77958005276 scopus 로고    scopus 로고
    • In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft function
    • Dikow R, Becker LE, Schaier M, et al. In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft function. Transplantation 2010; 90: 771.
    • (2010) Transplantation , vol.90 , pp. 771
    • Dikow, R.1    Becker, L.E.2    Schaier, M.3
  • 47
    • 33846243266 scopus 로고    scopus 로고
    • Infiltrates in protocol biopsies from renal allografts
    • Mengel M, Gwinner W, Schwarz A, et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007; 7: 356.
    • (2007) Am J Transplant , vol.7 , pp. 356
    • Mengel, M.1    Gwinner, W.2    Schwarz, A.3


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