In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft function

Transplantation

Volumn 90, Issue 7, 2010, Pages 771-776

  Dikow, Ralf ^a   Becker, Luis E ^a   Schaier, Matthias ^a   Waldherr, Rüdiger ^a   Gross, Marie Luise ^a   Zeier, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Chemokines; Delayed graft function; Interstitial fibrosis; Renal transplantation

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CYCLOSPORIN A; METHYLPREDNISOLONE; MONOCYTE CHEMOTACTIC PROTEIN; MYCOPHENOLIC ACID; RANTES;

ADULT; ARTICLE; CLINICAL ARTICLE; COLD ISCHEMIA; DELAYED GRAFT FUNCTION; FEMALE; FOLLOW UP; HUMAN; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY CELL; KIDNEY FIBROSIS; KIDNEY FUNCTION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; BIOPSY; CADAVER; CAUSE OF DEATH; DELAYED GRAFT FUNCTION; DIABETIC NEPHROPATHIES; FEMALE; HEPATITIS B SURFACE ANTIGENS; HUMANS; IMMUNOGLOBULIN G; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; SURVIVORS; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 77958005276     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181f009ef     Document Type: Article

References (32)

1. Charo IF, Ransohoff RM. The many roles of chemokines and chemo-kine receptors in inflammation. N Engl J Med 2006; 354: 610.
2. Panzer U, Steinmetz OM, Stahl RAK, et al. Kidney diseases and chemo-kines. Curr Drug Targets 2006; 7: 65.
3. Anders HJ, Vielhauer V, Eis V, et al. Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB 2004; 18: 534.
4. Zoja C, Wang JM, Bettoni S, et al. Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells. Am J Pathol 1991; 138: 991.
5. Schmouder RL, Strieter RM, Wiggins RC, et al. In vitro and in vivo interleukin-8 production in human renal cortical epithelia. Kidney Int 1992; 41: 191.
6. Kakizaki Y, Waga S, Sugimoto K, et al. Production of monocyte che-moattractant protein-1 by bovine glomerular endothelial cells. Kidney Int 1995; 48: 1866.
7. Vielhauer V, Anders HJ, Mack M, et al. Obstructive nephropathy in the mouse: Progressive fibrosis correlates with tubulointerstitial chemo-kine expression and accumulation of CC chemokine receptor 2 and 5 positive leukocytes. J Am Soc Nephrol 2001; 12: 1173.
8. Anders HJ, Belemezova E, Eis V, et al. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. J Am Soc Nephrol 2004; 5: 1504.
9. Vielhauer V, Berning E, Linde Y, et al. A CCR1 antagonist reduces interstitial nephritis and fibrosis, but not proteinuria and glomerular pathology in murine adriamycin nephropathy. Kidney Int 2004; 66: 2264.
10. Horuk R, Shurey S, Ng HP, et al. CCR1-specific non-peptide antagonist: Efficacy in a rabbit allograft rejection model. Immunol Lett 2001; 76: 193.
11. Bedke J, Kiss E, Schaefer L, et al. Benficial effects of CCR1 blockade on the progression of chronic renal allograft damage. Am J Transplant 2007; 7: 527.
12. Furuichi K, Gao JL, Horuk R, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunology 2008; 181: 8670.
13. Anders HJ, Ninichuk V, Schloendorff D. Progression of kidney disease: Blocking leukocyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int 2006; 69: 29.
14. Gao W, Topham PS, King JA, et al. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allo-graft rejection. J Clin Invest 2000; 105: 35.
15. Eis V, Luckow B, Vielhauer V, et al. Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol 2004; 15: 337.
16. Dalton RS, Webber JN, Pead P, et al. Immunomonitoring of renal transplant recipients in the early posttransplant period by sequential analysis of chemokine and chemokine receptor gene expression in peripheral blood mononuclear cells. Transplant Proc 2005; 37: 747.
17. Segerer S, Chui Y, Eitner F, et al. Expression of chemokines and che-mokine receptors during human renal transplant rejection. Am J Kidney Dis 2001; 37: 518.
18. Ruster M, Sperschneider H, Funfstuck R, et al. Differential expression of beta-chemokines MCP-1 and RANTES and their receptors CCR1, CCR2, CCR5 in acute rejection and chronic allograft nephropathy of human renal allografts. Clin Nehrol 2004; 61: 30.
19. Mayer V, Hudkins KL, Heller F, et al. Expression of the chemokine receptor CCR1 in human allografts. Nephrol Dial Transplant 2007; 22: 1720.
20. Eddy A. Molecular basisofrenal fibrosis. Pediatr Nephrol 2000; 15: 290.
21. Birnbaum LM, Lipman M, Paraskevas S, et al. Management of chronic allograft nephropathy: A systematic review. Clin J Am Soc Nephrol 2009; 4: 860.
22. Becker GJ, Hewitson TD. The role of tubulointerstitial injury in chronic renal failure. Curr Opin Nephrol Hypertens 2000; 9: 133.
23. Kruger B, Boger CA, Obed A, et al. RANTES/CCL5 polymorphisms as a risk factor for recurrent acute rejection.Clin Transplant 2007; 21: 385.
24. Frangogiannis NG. Chemokines in ischemia and reperfusion. Thromb Haemost 2007; 97: 738.
25. Miller-Kittrell M, Sparer TE. Feeling manipulated: Cytomegalovirus immune manipulation. Virol J 2009; 6: 4.
26. Saederup N, Mocarski ES Jr. Fatal attraction: Cytomegalovirus-encoded chemokine homologs.Curr Top Microbiol Immunol2002; 269: 235.
27. Ehlin-Henriksson B, Liang W, Cagigi A, et al. Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection. Immunology 2009; 127: 549.
28. Kang SW, Park SJ, Kim YW, et al. Association of MCP-1 and CCR2 polymorphisms with the risk of late acute rejection after renal transplantation in Korean patients. Int J Immunogenet 2008; 35: 25.
29. Abdi R, Tran TB, Sahagun-Ruiz A, et al. Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. J Am Soc Nephrol 2002; 13: 754.
30. Krüger B, Schröppel B, Ashkan R, et al. A monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. J Am Soc Nephrol 2002; 13: 2585.
31. Fischereder M, Luckow B, Hocher B, et al. CC chemokine receptor 5 and renal-transplant survival. Lancet 2001; 357: 1758.
32. Horuk R. BX471: A CCR1 antagonist with anti-inflammatory activity in man. Mini Rev Med Chem 2005; 5: 791.