Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-κB pathways

Molecular Immunology

Volumn 44, Issue 10, 2007, Pages 2686-2696

  Liu, Qiuyan ^a,b   Chen, Taoyong ^a   Chen, Guoyou ^a   Shu, Xiaoli ^b   Sun, Anna ^b   Ma, Pengcheng ^c   Lu, Liwei ^d   Cao, Xuetao ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

CCR7; Dendritic cell; Immunosuppression; Migration; Signal transduction

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEIN KINASE B; TRIPTOLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; DENDRITIC CELL; DOWN REGULATION; DRUG INHIBITION; DRUG MANUFACTURE; ENZYME ACTIVATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LYMPHOID ORGAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL MOVEMENT; CHEMOKINES, CC; CYCLOOXYGENASE 2; CYTOKINES; DENDRITIC CELLS; DINOPROSTONE; DITERPENES; EPOXY COMPOUNDS; IMMUNOSUPPRESSIVE AGENTS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CHEMOKINE;

TRIPTERYGIUM WILFORDII;

EID: 33846903837     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.12.003     Document Type: Article

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