Donor antigen-specific regulatory T-cell function affects outcome in kidney transplant recipients

Kidney International

Volumn 79, Issue 9, 2011, Pages 1005-1012

  Tsaur, Igor ^a   Gasser, Martin ^b   Aviles, Beatriz ^b   Lutz, Jens ^c   Lutz, Lydia ^c   Grimm, Martin ^b   Lange, Volkmar ^b   Lopau, Kai ^b   Heemann, Uwe ^c   Germer, Christoph Thomas ^b   Chandraker, Anil ^d   Waaga Gasser, Ana Maria ^b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

chronic allograft dysfunction; kidney transplantation; mycophenolate mofetil; regulatory T cells; tacrolimus

Indexed keywords

CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; KIDNEY DONOR; KIDNEY TRANSPLANTATION; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

EID: 79954615159     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.533     Document Type: Article

References (28)

1. Fehervari Z, Sakaguchi S. Development and function of CD25+CD4+ regulatory T cells. Curr Opin Immunol 2004; 16: 203-208. (Pubitemid 38332029)
2. Sakaguchi S, Sakaguchi N. Regulatory T cells in immunologic selftolerance and autoimmune disease. Int Rev Immunol 2005; 24: 211-226. (Pubitemid 40991002)
3. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199-210. (Pubitemid 37323205)
4. Najafian N, Salama AD, Fedoseyeva EV et al. Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients. J Am Soc Nephrol 2002; 13: 252-259. (Pubitemid 34042035)
5. Salama AD, Najafian N, Clarkson MR et al. Regulatory CD25+ T cells in human kidney transplant recipients. J Am Soc Nephrol 2003; 14: 1643-1651. (Pubitemid 36687068)
6. Noris M, Casiraghi F, Todeschini M et al. Regulatory T cells and T cell depletion: role of immunosuppressive drugs. J Am Soc Nephrol 2007; 18: 1007-1018. (Pubitemid 46434518)
7. Meloni F, Morosini M, Solari N et al. Peripheral CD4+ CD25+ Treg cell expansion in lung transplant recipients is not affected by calcineurin inhibitors. Int Immunopharmacol 2006; 6: 2002-2010. (Pubitemid 44855695)
8. Calvo-Turrubiartes M, Romano-Moreno S, Garcia-Hernandez M et al. Quantitative analysis of regulatory T cells in kidney graft recipients: A relationship with calcineurin inhibitor level. Transpl Immunol 2009; 21: 43-49.
9. Ekberg H, Tedesco-Silva H, Demirbas A et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562-2575. (Pubitemid 350294223)
10. Caproni M, Torchia D, Antiga E et al. The effects of tacrolimus ointment on regulatory T lymphocytes in atopic dermatitis. J Clin Immunol 2006; 26: 370-375. (Pubitemid 44051384)
11. Khattri R, Cox T, Yasayko SA et al. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4: 337-342. (Pubitemid 36432315)
12. Wu Y, Borde M, Heissmeyer V et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006; 126: 375-387. (Pubitemid 44092960)
13. Kist-van Holthe JE, Gasser M, Womer K et al. Regulatory functions of alloreactive Th2 clones in human renal transplant recipients. Kidney Int 2002; 62: 627-631. (Pubitemid 34779777)
14. Waaga AM, Gasser M, Kist-van Holthe JE et al. Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest 2001; 107: 909-916. (Pubitemid 32274044)
15. Webster AC, Woodroffe RC, Taylor RS et al. Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data. BMJ 2005; 331: 810.
16. Waaga AM, Gasser M, Laskowski I et al. Mechanisms of chronic rejection. Curr Opin Immunol 2000; 12: 517-521.
17. Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005; 105: 4743-4748.
18. Fontenot JD, Rasmussen JP, Williams LM et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22: 329-341. (Pubitemid 40387475)
19. Ng WF, Duggan PJ, Ponchel F et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001; 98: 2736-2744.
20. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000; 101: 455-458.
21. Sakaguchi S, Ono M, Setoguchi R et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006; 212: 8-27. (Pubitemid 44116697)
22. Valencia X, Lipsky PE. CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Nat Clin Pract Rheumatol 2007; 3: 619-626.
23. Meloni F, Vitulo P, Bianco AM et al. Regulatory CD4+CD25+ T cells in the peripheral blood of lung transplant recipients: correlation with transplant outcome. Transplantation 2004; 77: 762-766. (Pubitemid 38366987)
24. Louis S, Braudeau C, Giral M et al. Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation 2006; 81: 398-407. (Pubitemid 43255726)
25. Bolton EM. Regulatory T cells in transplantation: natural or induced? Transplantation 2005; 79: 643-645. (Pubitemid 40463168)
26. Waaga-Gasser AM, Grimm MR, Lutz J et al. Regulatory allospecific T cell clones abrogate chronic allograft rejection. J Am Soc Nephrol 2009; 20: 820-830.
27. Baan CC, van der Mast BJ, Klepper M et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 2005; 80: 110-117. (Pubitemid 40980903)
28. Korczak-Kowalska G, Wierzbicki P, Bocian K et al. The influence of immuosuppressive therapy on the development of CD4+CD25+ T cells after renal transplantation. Transplant Proc 2007; 39: 2721-2723. (Pubitemid 350088119)