Hit identification practices for positive allosteric modulators of G protein-coupled receptors: The need for multiple-mode screening approaches in dynamic Ca2+ flux assays

International Drug Discovery

Volumn 2011, Issue 2, 2011, Pages 28-33

  Burford, Neil ^a   Bertekap Jr , Robert L ^a   Banks, Martyn ^a   O'Connell, Jonathan ^a   Alt, Andrew ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ALLOSTERIC MODULATOR; CHEMICAL COMPOUND; G PROTEIN COUPLED RECEPTOR; NEGATIVE ALLOSTERIC MODULATOR; POSITIVE ALLOSTERIC MODULATOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; ASSAY; CALCIUM TRANSPORT; CHEMICAL MODIFICATION; FALSE NEGATIVE RESULT; HIGH THROUGHPUT SCREENING; STRUCTURE ACTIVITY RELATION;

EID: 79960975344     PISSN: 21504792     EISSN: 21504806     Source Type: Journal    
DOI: None     Document Type: Article

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