메뉴 건너뛰기




Volumn 67, Issue 9, 2012, Pages 781-788

Preparation, characterization and anticancer activity of norcantharidin-loaded poly(ethylene glycol)-poly(caprolactone) amphiphilic block copolymer micelles

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; COPOLYMER; MACROGOL; NORCANTHARIDIN; ORGANIC SOLVENT; PHOSPHATE BUFFERED SALINE; POLYCAPROLACTONE;

EID: 84867213870     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2012.1151     Document Type: Article
Times cited : (15)

References (36)
  • 1
    • 34548609979 scopus 로고    scopus 로고
    • β-Lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells
    • DOI 10.1016/j.jconrel.2007.04.014, PII S0168365907001897, Proceedings of the Thirtheenth International Symposium on Recent Advances in Drug Delivery Systems
    • Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA, Gao JM (2007) β-Lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. J Control Release 122: 365-374. (Pubitemid 47404665)
    • (2007) Journal of Controlled Release , vol.122 , Issue.3 , pp. 365-374
    • Blanco, E.1    Bey, E.A.2    Dong, Y.3    Weinberg, B.D.4    Sutton, D.M.5    Boothman, D.A.6    Gao, J.7
  • 2
    • 34848839868 scopus 로고    scopus 로고
    • Micelles of different morphologies - Advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery
    • DOI 10.1007/s11095-007-9335-z
    • Cai S, Vijayan K, Cheng D, Lima EM, Discher DE (2007) Micelles of different morphologies - advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm Res 24: 2099-2109. (Pubitemid 47493571)
    • (2007) Pharmaceutical Research , vol.24 , Issue.11 , pp. 2099-2109
    • Cai, S.1    Vijayan, K.2    Cheng, D.3    Lima, E.M.4    Discher, D.E.5
  • 3
    • 70249142794 scopus 로고    scopus 로고
    • A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloprote-inase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells
    • Chen YJ, Chang WM, Liu YW, Lee CY, Jang YH, Kuo CD, Liao HF (2009) A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloprote-inase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. Chem Biol Interact 181: 440-446.
    • (2009) Chem Biol Interact , vol.181 , pp. 440-446
    • Chen, Y.J.1    Chang, W.M.2    Liu, Y.W.3    Lee, C.Y.4    Jang, Y.H.5    Kuo, C.D.6    Liao, H.F.7
  • 4
    • 0142184964 scopus 로고    scopus 로고
    • 2-terminal kinase signaling pathways in human hepatoma HepG2 cells
    • DOI 10.1038/sj.bjp.0705461
    • Chen YN, Cheng CC, Chen JC, Tsauer W, Hsu SL (2003) Norcantharidin- induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells. Br J Pharmacol 140: 461-470. (Pubitemid 37330490)
    • (2003) British Journal of Pharmacology , vol.140 , Issue.3 , pp. 461-470
    • Chen, Y.-N.1    Cheng, C.-C.2    Chen, J.-C.3    Tsauer, W.4    Hsu, S.-L.5
  • 6
    • 77951208004 scopus 로고    scopus 로고
    • Investigations on the lyophilisation of MPEG-hexPLA micelle based pharmaceutical formulations
    • Di Tommaso C, Como C, Gurny R, Möller M (2010) Investigations on the lyophilisation of MPEG-hexPLA micelle based pharmaceutical formulations. Eur J Pharm Sci 40: 38-47.
    • (2010) Eur J Pharm Sci , vol.40 , pp. 38-47
    • Di Tommaso, C.1    Como, C.2    Gurny, R.3    Möller, M.4
  • 7
    • 1042264211 scopus 로고    scopus 로고
    • Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs
    • DOI 10.1016/j.biomaterials.2003.09.055
    • Dong Y, Feng SS (2004) Methoxy poly(ethylene glycol)- poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. Biomaterials 25: 2843-2849. (Pubitemid 38201309)
    • (2004) Biomaterials , vol.25 , Issue.14 , pp. 2843-2849
    • Dong, Y.1    Feng, S.-S.2
  • 8
    • 0037020525 scopus 로고    scopus 로고
    • Paclitaxel-loaded PLGA nanoparticles: Preparration, physicochemical characterization and in vitro antitumoral activity
    • Fonseca C, Simões S, Gaspar R (2002) Paclitaxel-loaded PLGA nanoparticles: preparration, physicochemical characterization and in vitro antitumoral activity. J Control Release 83: 273-286.
    • (2002) J Control Release , vol.83 , pp. 273-286
    • Fonseca, C.1    Simões, S.2    Gaspar, R.3
  • 10
    • 0032952283 scopus 로고    scopus 로고
    • PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug
    • DOI 10.1016/S0168-3659(98)00116-3, PII S0168365998001163
    • Govender T, Stolnik S, Garnett MC, Davis SS, Stolnik S (1999) PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J Control Release 99: 171-185. (Pubitemid 29062869)
    • (1999) Journal of Controlled Release , vol.57 , Issue.2 , pp. 171-185
    • Govender, T.1    Stolnik, S.2    Garnett, M.C.3    Illum, L.4    Davis, S.S.5
  • 11
    • 38749120897 scopus 로고    scopus 로고
    • A new hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel
    • Huh KM, Min HS, Lee SC, Lee HJ, Kim S, Park K (2008) A new hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel. J Control Release 126: 122-129.
    • (2008) J Control Release , vol.126 , pp. 122-129
    • Huh, K.M.1    Min, H.S.2    Lee, S.C.3    Lee, H.J.4    Kim, S.5    Park, K.6
  • 12
    • 0027180686 scopus 로고
    • Block copolymer micelles as vehicles for drug delivery
    • Kataoka K, KWon GS, Yokoyama M (1993) Block copolymer micelles as vehicles for drug delivery. J Control Release 24: 119-132.
    • (1993) J Control Release , vol.24 , pp. 119-132
    • Kataoka, K.1    KWon, G.S.2    Yokoyama, M.3
  • 13
    • 0035937592 scopus 로고    scopus 로고
    • Block copolymer micelles for drug delivery: Design, characterization and biological significance
    • DOI 10.1016/S0169-409X(00)00124-1, PII S0169409X00001241
    • Kataoka K, Harada A, Nagasaki Y (2001) Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 47: 113-131. (Pubitemid 32209236)
    • (2001) Advanced Drug Delivery Reviews , vol.47 , Issue.1 , pp. 113-131
    • Kataoka, K.1    Harada, A.2    Nagasaki, Y.3
  • 15
    • 0035858296 scopus 로고    scopus 로고
    • In vivo evaluation of polymeric micellar paclitaxel formulation: Toxicity and efficacy
    • DOI 10.1016/S0168-3659(01)00275-9, PII S0168365901002759
    • Kim SC, Kim DW, Shim YH, Oh HS, Kim SW, Seo MH, Kim DW (2001) In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J Control Release 72: 191-202. (Pubitemid 32522357)
    • (2001) Journal of Controlled Release , vol.72 , Issue.1-3 , pp. 191-202
    • Kim, S.C.1    Kim, D.W.2    Shim, Y.H.3    Bang, J.S.4    Oh, H.S.5    Kim, S.W.6    Seo, M.H.7
  • 16
    • 0037211088 scopus 로고    scopus 로고
    • Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes
    • DOI 10.1016/S1368-8375(01)00129-4, PII S1368837501001294
    • Kok SH, Hong CY, Kuo MY, Lee CH, Lee JJ, Lou IU, Lee MS, Hsiao M, Lin SK. (2003) Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes. Oral Oncol 39: 19-26. (Pubitemid 35385638)
    • (2003) Oral Oncology , vol.39 , Issue.1 , pp. 19-26
    • Kok, S.H.1    Hong, C.Y.2    Kuo, M.Y.P.3    Lee, C.H.K.4    Lee, J.J.5    Lou, I.U.6    Lee, M.S.7    Hsiao, M.8    Lin, S.K.9
  • 19
    • 0036803285 scopus 로고    scopus 로고
    • Polyethylene glycol-diacyllipid micelles demonstrate increased acculumation in subcutaneous tumors in mice
    • DOI 10.1023/A:1020488012264
    • Lukyanov AN, Gao Z, Mazzola L, Torchilin VP (2002) Polyethylene glycoldiacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice. Pharm Res 19: 1424-1429. (Pubitemid 35266545)
    • (2002) Pharmaceutical Research , vol.19 , Issue.10 , pp. 1424-1429
    • Lukyanov, A.N.1    Gao, Z.2    Mazzola, L.3    Torchilin, V.P.4
  • 20
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • DOI 10.1016/S0168-3659(99)00248-5, PII S0168365999002485
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K (2003) Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65: 271-284. (Pubitemid 30122932)
    • (2000) Journal of Controlled Release , vol.65 , Issue.1-2 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 21
    • 0031844605 scopus 로고    scopus 로고
    • Pentamidine-loaded poly(D,L-lactide) nanoparticles: Adsorption and drug release
    • DOI 10.1002/(SICI)1098-2299(199802)43:2<98::AID-DDR2>3.0.CO;2-K
    • Paul M, Laatiris A, Fessi H, Dufeu B, Durand R, Deniau M, Astier A (1998) Pentamidine-loaded poly (D,L-lactide) nanoparticles: Adsorption and drug release. Drug Dev Res 43: 98-104. (Pubitemid 28281218)
    • (1998) Drug Development Research , vol.43 , Issue.2 , pp. 98-104
    • Paul, M.1    Laatiris, A.2    Fessi, H.3    Dufeu, B.4    Durand, R.5    Deniau, M.6    Astier, A.7
  • 23
    • 33750041061 scopus 로고    scopus 로고
    • Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs
    • DOI 10.1016/j.ejpb.2006.06.003, PII S0939641106001548
    • Sezgin Z, Yüksel N, Baykara T (2006) Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur J Pharm Biopharm 64: 261-268. (Pubitemid 44585209)
    • (2006) European Journal of Pharmaceutics and Biopharmaceutics , vol.64 , Issue.3 , pp. 261-268
    • Sezgin, Z.1    Yuksel, N.2    Baykara, T.3
  • 24
    • 33748685215 scopus 로고    scopus 로고
    • A less irritant norcantharidin lipid microspheres: Formulation and drug distribution
    • DOI 10.1016/j.ijpharm.2006.05.060, PII S0378517306004455
    • Wang LX, He HB, Tang X, Ruiying S, Dawei C (2006) A less irritant norcantharidin lipid microspheres: Formulation and drug distribution. Int J Pharm 323: 161-167. (Pubitemid 44397374)
    • (2006) International Journal of Pharmaceutics , vol.323 , Issue.1-2 , pp. 161-167
    • Lixin, W.1    Haibing, H.2    Xing, T.3    Ruiying, S.4    Dawei, C.5
  • 25
    • 84867210588 scopus 로고    scopus 로고
    • Spectroscopic characterization of cantharidin and its derivatives
    • Wang J, Xu QM, Sun XF (2009) Spectroscopic characterization of cantharidin and its derivatives. Chin J Magnetic Resonance 26: 126-135.
    • (2009) Chin J Magnetic Resonance , vol.26 , pp. 126-135
    • Wang, J.1    Xu, Q.M.2    Sun, X.F.3
  • 26
    • 34249876647 scopus 로고    scopus 로고
    • Preparation and characterization of 7-ethyl-10-hydroxycam ptothecin loaded hypomicron of amphiphilic block copolymer
    • Wu QL, Luan LB (2007) Preparation and characterization of 7-ethyl-10-hydroxycam ptothecin loaded hypomicron of amphiphilic block copolymer. Acta Pharm Sin 42: 440-444.
    • (2007) Acta Pharm Sin , vol.42 , pp. 440-444
    • Wu, Q.L.1    Luan, L.B.2
  • 27
    • 33846490802 scopus 로고    scopus 로고
    • A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer
    • DOI 10.1016/j.jconrel.2006.11.014, PII S0168365906006717
    • Xie ZG, Guan HL, Chen XS, Lu CH, Chen L, Hu XL, Shi Q, Jing XB (2007) A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer. J Control Release 117: 210-216. (Pubitemid 46161883)
    • (2007) Journal of Controlled Release , vol.117 , Issue.2 , pp. 210-216
    • Xie, Z.1    Guan, H.2    Chen, X.3    Lu, C.4    Chen, L.5    Hu, X.6    Shi, Q.7    Jing, X.8
  • 28
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • Yamagata M, Hasuda K, Stamato T, Tannock1 IF (1998) The contribution of lactic acid to acidification of tumors: studies of variant cells lacking lactate dehydrogenase. Br J Cancer 77: 1726-1731. (Pubitemid 28254604)
    • (1998) British Journal of Cancer , vol.77 , Issue.11 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4
  • 29
    • 69949169645 scopus 로고    scopus 로고
    • Novel biodegradable polylactide/poly (ethylene glycol) micelles prepared by direct dissolution method for controlled delivery of anticancer drugs
    • Yang L, Wu X, Liu F, Duan Y, Li S (2009) Novel biodegradable polylactide/poly (ethylene glycol) micelles prepared by direct dissolution method for controlled delivery of anticancer drugs. Pharm Res 26: 2332-2342.
    • (2009) Pharm Res , vol.26 , pp. 2332-2342
    • Yang, L.1    Wu, X.2    Liu, F.3    Duan, Y.4    Li, S.5
  • 30
    • 79952043014 scopus 로고    scopus 로고
    • Norcantharidin induces apoptosis of breast cancer cells: Involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription
    • Yang PY, Chen MF, Kao YH, Hu DN, Chang FR, Wu YC (2011) Norcantharidin induces apoptosis of breast cancer cells: Involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription. Toxicol In Vitro 25: 699-707.
    • (2011) Toxicol in Vitro , vol.25 , pp. 699-707
    • Yang, P.Y.1    Chen, M.F.2    Kao, Y.H.3    Hu, D.N.4    Chang, F.R.5    Wu, Y.C.6
  • 31
    • 42149102217 scopus 로고    scopus 로고
    • Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: Preparation, freeze-drying, and in vitro release
    • DOI 10.1002/jbm.a.31504
    • Yang ZL, Yang KW, LI XR, Liu Y (2008) Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: Preparation, freeze-drying, and in vitro release. J. Biomed Mater Res A 85: 539-546. (Pubitemid 351535336)
    • (2008) Journal of Biomedical Materials Research - Part A , vol.85 , Issue.2 , pp. 539-546
    • Yang, Z.L.1    Xin, R.L.2    Ke, W.Y.3    Liu, Y.4
  • 32
    • 4644316820 scopus 로고    scopus 로고
    • Polymer design and incorporation methods for polymeric micelle carrier system containing water-insoluble anti-cancer agent camptothecin
    • DOI 10.1080/10611860412331285251
    • Yokoyama M, Opanasopit P, OkanoT, Kawano K, Maitani Y (2004) Polymer design and incorporation methods for polymeric micelle carrier system containingwater-insoluble anti-cancer agent camptothecin. J Drug Target 12: 373-384. (Pubitemid 39294835)
    • (2004) Journal of Drug Targeting , vol.12 , Issue.6 , pp. 373-384
    • Yokoyama, M.1    Opanasopit, P.2    Okano, T.3    Kawano, K.4    Maitani, Y.5
  • 33
    • 8144225129 scopus 로고    scopus 로고
    • Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system
    • DOI 10.1016/j.colsurfb.2004.09.002, PII S0927776504002772
    • Zhang C, Qineng P, Zhang H (2004) Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system. Colloids Surf B Biointerfaces. 39: 69-75. (Pubitemid 39473356)
    • (2004) Colloids and Surfaces B: Biointerfaces , vol.39 , Issue.1-2 , pp. 69-75
    • Zhang, C.1    Qineng, P.2    Zhang, H.3
  • 34
    • 25144498368 scopus 로고    scopus 로고
    • An investigation on liver-targeting microemulsio ns of norcantharidin
    • Zhang L, Sun X, Zhang ZR (2005a) An investigation on liver-targeting microemulsio ns of norcantharidin. Drug Deliv 12: 289-295.
    • (2005) Drug Deliv , vol.12 , pp. 289-295
    • Zhang, L.1    Sun, X.2    Zhang, Z.R.3
  • 35
    • 9644266802 scopus 로고    scopus 로고
    • Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate
    • DOI 10.1016/j.biomaterials.2004.06.024, PII S0142961204005630
    • Zhang X, Li Y, Chen X, Wang X, Xu X, Liang Q, Hu J, Jing X (2005b) Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate. Biomaterials 26: 2121-2128. (Pubitemid 39575355)
    • (2005) Biomaterials , vol.26 , Issue.14 , pp. 2121-2128
    • Zhang, X.1    Li, Y.2    Chen, X.3    Wang, X.4    Xu, X.5    Liang, Q.6    Hu, J.7    Jing, X.8
  • 36
    • 24644459310 scopus 로고    scopus 로고
    • Nanoparticles of poly(lactide)/vitamin e TPGS copolymer for cancer chemotherapy: Synthesis, formulation, characterization and in vitro drug release
    • Zhang ZP, Feng SS (2006) Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: Synthesis, formulation, characterization and in vitro drug release. Biomaterials 27: 262-270.
    • (2006) Biomaterials , vol.27 , pp. 262-270
    • Zhang, Z.P.1    Feng, S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.