Investigations on the lyophilisation of MPEG-hexPLA micelle based pharmaceutical formulations

European Journal of Pharmaceutical Sciences

Volumn 40, Issue 1, 2010, Pages 38-47

  Di Tommaso, Claudia ^a   Como, Caterina ^a   Gurny, Robert ^a   Möller, Michael ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Block copolymers; Cyclosporin A; Drug delivery system; Freeze drying; Polymeric micelles

Indexed keywords

CYCLOSPORIN A; GLUCOSE; MANNITOL; METHOXY POLY(ETHYLENE GLYCOL) POLY(HEXYLLACTIDE); PHOSPHATE BUFFERED SALINE; POLYMER; SUCROSE; TREHALOSE; UNCLASSIFIED DRUG; 2-ETHYLHEXANOIC ACID; CARBOHYDRATE; CRYOPROTECTIVE AGENT; CYCLOSPORIN; DRUG CARRIER; EXCIPIENT; HEXANE; HEXANOIC ACID DERIVATIVE; MACROGOL DERIVATIVE; MICELLE; MONOMETHOXYPOLYETHYLENE GLYCOL; POLYESTER; POLYLACTIDE; WATER;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; FREEZE THAWING; GLASS TRANSITION TEMPERATURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICELLIZATION; MOISTURE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THERMAL ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; WATER CONTENT; CHEMICAL PHENOMENA; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; FREEZING; LIGHT; MEDICINAL CHEMISTRY; MICELLE; PARTICLE SIZE; PROCEDURES; RADIATION SCATTERING; TRANSITION TEMPERATURE;

CALORIMETRY, DIFFERENTIAL SCANNING; CARBOHYDRATES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYOPROTECTIVE AGENTS; CYCLOSPORINE; DRUG CARRIERS; DRUG STABILITY; EXCIPIENTS; FREEZE DRYING; FREEZING; HEXANES; HEXANOIC ACIDS; HYDROPHOBICITY; LIGHT; MICELLES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS; SCATTERING, RADIATION; TRANSITION TEMPERATURE; WATER; CAPROATES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 77951208004     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.02.006     Document Type: Article

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