In vitro antidiabetes and antihypertension properties of phenolic extracts from bitter leaf (vernonia amygdalina del.)

Journal of Food Biochemistry

Volumn 36, Issue 5, 2012, Pages 569-576

  Saliu, J A ^a,b   Ademiluyi, A O ^a,c   Akinyemi, A J ^a   Oboh, G ^a,b  

^a FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

^b ADEKUNLE AJASIN UNIVERSITY   (Nigeria)

^c OSUN STATE UNIVERSITY   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

ACE-INHIBITORY ACTIVITY; ANTI-HYPERTENSION; ANTIOXIDANT ACTIVITIES; BOUND PHENOLS; CONVERTING ENZYME; DOSE-DEPENDENT; GLUCOSIDASE; GLUCOSIDASE ACTIVITY; IN-VITRO; INHIBITORY ACTIVITY; INHIBITORY EFFECT; KEY ENZYMES; PHENOL CONTENT; STRONG CORRELATION; TYPE-2 DIABETES;

PHENOLS;

AMYLASES;

GYMNANTHEMUM AMYGDALINUM; VERNONIA AMYGDALINA;

EID: 84867193758     PISSN: 01458884     EISSN: 17454514     Source Type: Journal    
DOI: 10.1111/j.1745-4514.2011.00576.x     Document Type: Article

References (44)

1. AHNFELT-RONNE, I. 1991. Enzyme inhibitors as drugs. In A Textbook of Drug Design and Development (P. Krogsgaard-Larsen and H. Bundgaard, eds.) pp. 302-307, Harvood Academic Publishers, Chur, Switzerland.
2. AKAH, P.A. and OKAFOR, C.I. 1992. Blood sugar lowering effect of Vernonia amygdalina (del) in an experimental rabbit model. Phytother. Res. 6, 171-173.
3. APOSTOLIDIS, E., KWON, Y.I. and SHETTY, K. 2007. Inhibitory potential of herb, fruit, and fungal enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Innov. Food Sci. Emerg. Technol. 8, 46-54.
4. BAGRI, P., ALI, M., AERI, V., BHOWMIK, M. and SULTANA, S. 2009. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem. Toxicol. 47, 50-54.
5. BAILEY, C.J. and DAY, C. 2004. Avandamet: Combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes. Int. J. Clin. Pract. 58, 867-876.
6. BAKRIS, G.L., WILLIAMS, M., DWORKIN, L., ELLIOTT, W.J., EPSTEIN, M., TOTO, R., TUTTLE, K., DOUGLAS, J., HSUEH, W. and SOWERS, J. 2000. Preserving renal function in adults with hypertension and diabetes: A consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group.
7. BRUNNER, H.R., LARAGH, J.H., BAER, L., NEWTON, M.A., GOODWIN, F.T., KRAKOFF, L.R., BARD, R.H. and BUHLER, F.R. 1972. Essential hypertension: Renin and aldosterone, heart attack and stroke. N. Engl. J. Med. 286, 441-449.
8. CHU, Y., SUN, J., WU, X. and LIU, R.H. 2002. Antioxidant and antiproliferative activity of common vegetables. J. Agric. Food Chem. 50, 6910-6916.
9. CUSHMAN, D.W. and CHEUNG, H.S. 1971. Spectrophotometric assay and properties of the angiotensin I converting enzyme of rabbit lung. Biochem. Pharmacol. 20, 1637-1648.
10. DASTMALCHI, K., DORMAN, H.J.D., KOSAR, M. and HILTUNEN, R. 2007. Chemical composition and in vitro antioxidant evaluation of a water soluble Moldavian balm (Dracocephalum moldavica L.) extract. Lebensm. Wiss. Technol. 40, 239-248.
11. ERASTO, P., ADEBOLA, P.O., GRIERSON, D.S. and AFOLAYAN, A.J. 2005. An ethnobotanical study of the plants used for the treatment of diabetes in the Eastern Cape Province, South Africa. Afr. J Biotechnol. 4, 1458-1460.
12. 2 muscle and 3T3-L1 cells. Pharm. Biol. 47(2), 175-181.
13. ERDOS, E.G. and SKIDGEL, R.A. 1987. The angiotensin I-converting enzyme. Lab. Investig. 56, 345-348.
14. FAROMBI, E.O. 2003. African indigenous plants with chemotherapeutic potentials and biotechnological approach to the production of bioactive prophylactic agents. Afr. J. Biotechnol. 2(12), 662-671.
15. HALVORSEN, B.L., HOLTE, K., MYHRSTAD, M.C.W., BARIKMO, I., HVATTUM, E., REMBERG, S.F., WOLD, A.B., HAFFNER, K., BAUGERØD, H., ANDERSEN, L.F. etal. 2002. Systematic screening of total antioxidants in dietary plants. J. Nutr. 132, 461-471.
16. KWON, Y.I., JANG, H.D. and SHETTY, K. 2006. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac. J. Clin. Nutr. 15, 425-432.
17. KWON, Y.I., APOSTOLIDIS, E., KIM, Y.C. and SHETTY, K. 2007. Health benefits of traditional corn, beans and pumpkin: In vitro studies for hyperglycemia and hypertension management. J. Med. Food 10, 266-275.
18. KWON, Y.I., APOSTOLIDIS, E. and SHETTY, K. 2008. In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresour. Technol. 99, 2981-2988.
19. LEONARD, B.S., KAREN, L.L., BRUCE, B., THOMAS, F.K. and JAY, H.H. 2002. Complementary and alternative medicine in chronic liver disease. Hepatology 34(3), 595-603.
20. LI, W.L., ZHENG, H.C., BUKURU, J. and DE KIMPE, N. 2004. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J. Ethnopharmacol. 92, 1-21.
21. MAITI, R., JANA, D., DAS, U.K. and GHOSH, D. 2004. Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. J. Ethnopharmacol. 92, 85-91.
22. MARIN, A., FERRERES, F., TOMAS-BARBERAN, F.A. and GIL, M.J. 2004. Characterization and quantitation of antioxidant constituents of sweet pepper (Capsicum annuum L). J. Agric. Food Chem. 52, 3861-3869.
23. MARLES, R.J. and FARNSWORTH, N.R. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2, 137-189.
24. MATERSKA, M. and PERUCKA, I. 2005. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruits (Capsicum annuum L.). J. Agric. Food Chem. 53, 1730-1758.
25. MEDA, A., LAMIEN, C.E., ROMITO, M., MILLOGO, J. and NACOULMA, O.G. 2005. Determination of the total phenolic, flavonoid and proline contents in Burkina Faso honey, as well as their radical scavenging activity. Food Chem. 91, 571-577.
26. MEMNUNE, S., AILAL, Y., NEVA, G., BULENT, C., ZAYNEP, E. and SEZAL, E. 2009. Total phenolic content, antioxidant and antimicrobial activities of some medicinal plants. Pak. J. Pharm. Sci. 22, 102-106.
27. NICKAVAR, B. and YOUSEFIAN, N. 2009. Inhibitory effects of six Allium species on α-amylase enzyme activity. Iran. J. Pharm. Res. 8, 53-57.
28. OBERLEY, L.W. 1988. Free radicals and diabetes. Free Radic. Biol. Med. 5, 113-124.
29. OBOH, G. and ADEMOSUN, A.O. 2011. Phenolic rich extracts from orange peels (citrus sinensis) inhibits key enzyme linked to non-insulin dependent diabetes mellitus (NIDDM) and hypertension. Riv. Ital. Sostanze Gr. 88, 16-23.
30. OBOH, G. and ROCHA, J.B.T. 2007. Polyphenols in red pepper (Capsicum annuum var. aviculare [Tepin]) and their protective effect on some pro-oxidants induced lipid peroxidation in brain and liver. Eur. Food Res. Technol. 225, 239-247.
31. OBOH, G., PUNTEL, R.L. and ROCHA, J.B.T. 2007. Hot pepper (Capsicum annuum, Tepin and Capsicum chinese, Habanero) prevents Fe2+-induced lipid peroxidation in brain -in vitro. Food Chem. 102, 178-185.
32. OBOH, G., AKINYEMI, A.J., ADEMILUYI, A.O. and ADEFEGHA, S.A. 2010. Inhibitory effects of aqueous extract of two varieties of ginger on some key enzymes linked to type-2 diabetes in vitro. J. Food Nutr. Res. 49, 14-20.
33. ORTIZ-ANDRADE, R.R., GARCIA-JIMENEZ, S., CASTILLO-ESPANA, P., RAMIREZAVILA, G., VILLALOBOS-MOLINA, R. and ESTRADA-SOTO, S. 2007. Alphaglucosidase inhibitory activity of the methanolic extract from Tourneforia hartwegiana: An anti-hyperglycemic agent. J. Ethnopharmacol. 109, 48-53.
34. PULIDO, R., BRAVO, L. and SAURA-CALIXTO, F. 2000. Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. J. Agric. Food Chem. 48, 3396-3402.
35. RE, R., PELLEGRINI, N., PROTEGGENTE, A., PANNALA, A., YANG, M. and RICEEVANS, C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorisation assay. Free Radic. Biol. Med. 26, 1231-1237.
36. RICE-EVANS, C., MILLER, N.J. and PAGANGA, G. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20, 933-956.
37. SHIM, Y.J., DOO, H.K., AHN, S.Y., KIM, Y.S., SEONG, J.K., PARK, I.S. and MIN, B.H. 2003. Inhibitory effect of aqueous extract from the gall of Rhuz chinensis on alphaglucosidase activity and postprandial blood glucose. J. Ethnopharmacol. 85, 283-287.
38. SINGLETON, V.L., ORTHOFER, R. and LAMUELA-RAVENTOS, R.M. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin- Ciocalteu reagent. In Methods in Enzymology, Vol. 299: Oxidants and antioxidants, Part A (L. Packer, ed.) pp. 152-178, Academic Press, San Diego, CA.
39. SOWERS, J.R. and EPSTEIN, M. 1995. Diabetes mellitus and associated hypertension, vascular disease, and nephropathy. An update. Hypertension 26, 869-879.
40. SUN, J., CHU, Y.F., WU, X. and LIU, R.H. 2002. Antioxidant and antiproliferation activities of common fruits. J. Agric. Food Chem. 50, 7449-7454.
41. UHEGBU, F.O. 2004. Effect of aqueous extract (crude) of leaves of Vernonia amygdalina (Del.) on blood glucose, serum albumin and cholesterol levels in diabetic albino rats. Glob. J. Pure Appl. Sci. 10, 189-194.
42. VILLAR, A., PAYA, M. and TERENCIO, M.C. 1986. Plants with antihypertensive action. Fitoterapy 57, 131-145.
43. WORTHINGTON, V., ed. 1993. Alpha amylase. In Worthington Enzyme Manual, pp. 36-41, Worthington Biochemical Corp, Freehold, NJ.
44. ZHANG, J. and KASHKET, S. 1998. Inhibtion of salivary amylase black and green teas. Caries Res. 32, 233-238.