Inhibitory effects of six allium species on α-amylase enzyme activity

Iranian Journal of Pharmaceutical Research

Volumn 8, Issue 1, 2009, Pages 53-57

  Nickavar, Bahman ^a   Yousefian, Nasibeh ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allium species; Antidiabetic activity; Antihyperglycemic activity; amylase inhibitory activity

Indexed keywords

ALCOHOL; ALLIUM AKAKA EXTRACT; ALLIUM AMPELOPRASUM IRANICUM EXTRACT; ALLIUM HIRTIFOLIUM EXTRACT; ALLIUM PORRUM EXTRACT; AMYLASE; GARLIC EXTRACT; ONION EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALLIUM AKAKA; ALLIUM AMPELOSPRASUM IRANICUM; ALLIUM HIRTIFOLIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; LEEK; MEDICINAL PLANT; NONHUMAN;

EID: 67649136124     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Abesundara KJ, Matsui T and Matsumoto K. alpha-Glucosidase inhibitory activity of some Sri Lanka plant extracts, one of which, Cassia auriculata, exerts a strong antihyperglycemic effect in rats comparable to the therapeutic drug acarbose. J. Agric. Food Chem. (2004) 52: 2541-2545
2. Kwon YI, Jang HD and Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia. Pac. J. Clin. Nutr. (2006) 15: 425-432
3. Ali H, Houghton PJ and Soumyanath A. alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J. Ethnopharmacol. (2006) 107: 449-455
4. Kim JS, Kwon CS and Son KH. Inhibition of alphaglucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem. (2000) 64: 2458-2461
5. Shim YJ, Doo HK, Ahn SY, Kim YS, Seong JK, Park IS and Min BH. Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. J. Ethnopharmacol. (2003) 85: 283-287
6. Kim YM, Jeong YK, Wang MH, Lee WY and Rhee HI. Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia. Nutrition (2005) 21: 756-761
7. Subramanian R, Asmawi MZ and Sadikun A. In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide. Acta Biochim. Pol. (2008) 55: 391-398
8. Schäfer A and Högger P. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res. Clin. Pract. (2007) 77: 41-46
9. Kotowaroo MI, Mahomoodally MF, Gurib-Fakim A and Subratty AH. Screening of traditional antidiabetic medicinal plants of Mauritius for possible alphaamylase inhibitory effects in vitro. Phytother. Res. (2006) 20: 228-231
10. Mai TT and Chuyen NV. Anti-hyperglycemic activity of an aqueous extract from flower buds of Cleistocalyx operculatus (Roxb.) Merr and Perry. Biosci. Biotechnol. Biochem. (2007) 71: 69-76
11. McCue P, Kwon YI and Shetty K. Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia. Pac. J. Clin. Nutr. (2005) 14: 145-152
12. Onal S, Timur S, Okutucu B and Zihnioǧlu F. Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep. Biochem. Biotechnol. (2005) 35: 29-36
13. Stajner D, Igic R, Popović BM and Malencić Dj. Comparative study of antioxidant properties of wild growing and cultivated Allium species. Phytother. Res. (2008) 22: 113-117
14. Nencini C, Cavallo F, Capasso A, Franchi GG, Giorgio G and Micheli L. Evaluation of antioxidative properties of Allium species growing wild in Italy. Phytother. Res. (2007) 21: 874-878
15. Islam MS and Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J. Med. Food (2008) 11: 152-159
16. Eidi A, Eidi M and Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocininduced diabetic rats. Phytomedicine (2006) 13: 624-629
17. Musabayane CT, Bwititi PT and Ojewole JA. Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats. Methods Find Exp. Clin. Pharmacol. (2006) 28: 223-228
18. Jelodar GA, Maleki M, Motadayen MH and Sirus S. Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Indian J. Med. Sci. (2005) 59: 64-69
19. Campos KE, Diniz YS, Cataneo AC, Faine LA, Alves MJ and Novelli EL. Hypoglycaemic and antioxidant effects of onion, Allium cepa: dietary onion addition, antioxidant activity and hypoglycaemic effects on diabetic rats. Int. J. Food Sci. Nutr. (2003) 54: 241-246
20. Roman-Ramos R, Flores-Saenz JL and Alarcon-Aguilar FJ. Anti-hyperglycemic effect of some edible plants. J. Ethnopharmacol. (1995) 48: 25-32
21. Nickavar B, Abolhasani L and Izadpanah H. α-Amylase inhibitory activities of six Salvia species. Iran. J. Pharm. Res. (2008) 7: 297-303