Gait Analysis in Rats with Single Joint Inflammation: Influence of Experimental Factors

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Ängeby Möller, Kristina ^a   Kinert, Susanne ^a   Størkson, Rolf ^b   Berge, Odd Geir ^a,c  

^a ASTRAZENECA R AND D   (Sweden)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; DICLOFENAC; FREUND ADJUVANT; IBUPROFEN; NAPROXEN; OXYCODONE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANKLE; ARTICLE; CALCULATION; CONTROLLED STUDY; DOSE RESPONSE; GAIT; KNEE; LOCOMOTION; MALE; MONARTHRITIS; NONHUMAN; RAT; SCORING SYSTEM; SENSITIVITY ANALYSIS; STANDING; VIDEORECORDING; WEIGHT BEARING;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS; AUTOMATION; GAIT; LOCOMOTION; MALE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS; RODENTIA;

EID: 84867170337     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046129     Document Type: Article

References (70)

1. Creamer P, Lethbridge-Cejku M, Hochberg MC, (1998) Where does it hurt? Pain localization in osteoarthritis of the knee. Osteoarthritis Cartilage 6: 318-323.
2. Dieppe PA, Lim K (2000) Osteoarthritis and related disorders: Clinical features and diagnostic problems. In: Dequeker J, Dieppe PA, editors Rheumatology. Mosby, London: pp 831-836.
3. Rejeski WJ, Craven T, Ettinger WH Jr, McFarlane M, Shumaker S, (1996) Self-efficacy and pain in disability with osteoarthritis of the knee. J Gerontol B Psychol Sci Soc Sci 51: P24-9.
4. van Baar ME, Dekker J, Lemmens JA, Oostendorp RA, Bijlsma JW, (1998) Pain and disability in patients with osteoarthritis of hip or knee: the relationship with articular, kinesiological, and psychological characteristics. J Rheumatol 25: 125-133.
5. McCarthy CJ, Oldham JA, (2004) The reliability, validity and responsiveness of an aggregated locomotor function (ALF) score in patients with osteoarthritis of the knee. Rheumatology (Oxford) 43: 514-517.
6. McCarthy CJ, Mills PM, Pullen R, Richardson G, Hawkins N, et al. (2004) Supplementation of a home-based exercise programme with a class-based programme for people with osteoarthritis of the knees: a randomised controlled trial and health economic analysis. Health Technol Assess 8: iii-iv, 1-61.
7. Lee C, Straus WL, Balshaw R, Barlas S, Vogel S, et al. (2004) A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis. Arthritis Rheum 51: 746-754.
8. Conrozier T, Bertin P, Bailleul F, Mathieu P, Charlot J, et al. (2006) Clinical response to intra-articular injections of hylan G-F 20 in symptomatic hip osteoarthritis: the OMERACT-OARSI criteria applied to the results of a pilot study. Joint Bone Spine 73: 705-709.
9. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V, (2009) Efficacy and Safety of Curcuma domestica Extracts in Patients with Knee Osteoarthritis. J Altern Compl Med 15: 891-987.
10. Lane NE, Schnitzer TJ, Birbara CA, Mokhtarani M, Shelton DL, et al. (2010) Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med 363: 1521-1531.
11. Coderre TJ, Wall PD, (1987) Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant. Pain 28: 379-393.
12. Schött E, Berge OG, Ängeby-Möller K, Hammarström G, Dalsgaard CJ, et al. (1994) Weight bearing as an objective measure of arthritic pain in the rat. J Pharmacol Toxicol Methods 31: 79-83.
13. Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, et al. (2003) Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarth Cart 11: 821-830.
14. Fernihough J, Gentry C, Malcangio M, Fox A, Rediske J, et al. (2004) Pain related behaviour in two models of osteoarthritis in the rat knee. Pain 112: 83-93.
15. Pomonis JD, Boulet JM, Gottshall SL, Phillips S, Sellers R, et al. (2005) Development and pharmacological characterization of a rat model of osteoarthritis pain. Pain 114: 339-346.
16. Clayton N, Oakley I, Thompson S, Wheeldon A, Sargent B, et al. (1997) Validation of the dual channel weight averager as an instrument for the measurement of clinically relevant pain. Br J Pharmacol 120: 75P.
17. Clayton N, Marshall FH, Bountra C, O'Shaughnessy CT, (2002) CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain 96: 253-260.
18. Clarke KA, Heitmeyer SA, Smith AG, Taiwo YO, (1997) Gait analysis in a rat model of osteoarthrosis. Physiol Behav 62: 951-954.
19. Ferreira-Gomes J, Adaes S, Castro-Lopes JM, (2008) Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study. J Pain 9: 945-954.
20. Hoffman MH, Hopf R, Niederreiter B, Redl H, Smolen JS, et al. (2010) Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritis. Arthr Res Ther 12: R41.
21. Ferland CE, Laverty S, Beaudry F, Vachon P, (2011) Gait analysis and pain response of two rodent models of osteoarthritis. Pharmacol Biochem Behav 97: 603-610.
22. Hamers FP, Lankhorst AJ, van Laar TJ, Veldhuis WB, Gispen WH, (2001) Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries. J Neurotrauma 18: 187-201.
23. Ängeby-Möller K, Berge OG, Hamers FP, (2008) Using the CatWalk method to assess weight-bearing and pain behaviour in walking rats with ankle joint monoarthritis induced by carrageenan: effects of morphine and rofecoxib. J Neurosci Methods 174: 1-9.
24. Clarke KA, (1995) Differential fore- and hindpaw force transmission in the walking rat. Physiol Behav 58: 415-419.
25. Betts RP, Duckworth T, (1978) A device for measuring plantar pressures under the sole of the foot. Eng Med 7: 223-228.
26. Gamaro GD, Xavier MH, Denardin JD, Pilger JA, Ely DR, et al. (1998) The effects of acute and repeated restraint stress on the nociceptive response in rats. Physiol Behav 63: 693-697.
27. King CD, Devine DP, Vierck CJ, Rodgers J, Yezierski RP, (2003) Differential effects of stress on escape and reflex responses to nociceptive thermal stimuli in the rat. Brain Res 987: 214-222.
28. Calcagnetti DJ, Holtzman SG, (1992) Potentiation of morphine analgesia in rats given a single exposure to restraint stress immobilization. Pharmacol, Biochem Behav 41: 449-453.
29. Calcagnetti DJ, Stafinsky JL, Crisp T, (1992) A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO. Brain Res 592: 305-309.
30. Carrive P, Churyukanov M, Le Bars D, (2011) A reassessment of stress-induced "analgesia" in the rat using an unbiased method. Pain 152: 676-686.
31. Butler SH, Godefroy F, Besson JM, Weil-Fugazza J, (1992) A limited arthritic model for chronic pain studies in the rat. Pain 48: 73-81.
32. Laird JM, Herrero JF, Garcia de la Rubia P, Cervero F, (1997) Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: central and peripheral components. Inflamm Res 46: 203-210.
33. Danziger N, Weil-Fugazza J, Le Bars D, Bouhassira D, (1999) Alteration of descending modulation of nociception during the course of monoarthritis in the rat. J Neurosci 19: 2394-2400.
34. Yu YC, Koo ST, Kim CH, Lyu Y, Grady JJ, et al. (2002) Two variables that can be used as pain indices in experimental animal models of arthritis. J Neurosci Methods 115: 107-113.
35. Belanger PM, Lalande M, Dore F, Labrecque G, (1987) Time-dependent variations in the organ extraction ratios of acetaminophen in rat. J Pharmacokin Biopharmaceut 15: 133-143.
36. Pini LA, Vitale G, Ottani A, Sandrini M, (1997) Naloxone-reversible antinociception by paracetamol in the rat. J Pharmacol Exp Ther 280: 934-940.
37. Huntjens DR, Spalding DJ, Danhof M, Della Pasqua OE, (2009) Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors. Europ J Pain 13: 448-457.
38. Berge OG, (2011) Predictive validity of behavioural animal models for chronic pain. Br J Pharmacol 164: 1195-1206.
39. Wilson AW, Medhurst SJ, Dixon CI, Bontoft NC, Winyard LA, et al. (2006) An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models. Europ J Pain 10: 537-549.
40. Sun S, Cao H, Han M, Li TT, Zhao ZQ, et al. (2008) Evidence for suppression of electroacupuncture on spinal glial activation and behavioral hypersensitivity in a rat model of monoarthritis. Brain Res Bull 75: 83-93.
41. Hargreaves K, Dubner R, Brown F, Flores C, Joris J, (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88.
42. Hong SK, Han JS, Min SS, Hwang JM, Kim YI, et al. (2002) Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat. Neurosci Lett 322: 21-24.
43. Finn A, Oerther SC, (2010) Can L(+)-lactate be used as a marker of experimentally induced inflammation in rats? Inflam Res 59: 315-321.
44. Coulthard P, Pleuvry BJ, Brewster M, Wilson KL, Macfarlane TV, (2002) Gait analysis as an objective measure in a chronic pain model. J Neurosci Methods 116: 197-213.
45. Kleinau S, Erlandsson H, Holmdahl R, Klareskog L, (1991) Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement. J Autoimmun 4: 871-880.
46. Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, et al. (2001) Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev 184: 184-202.
47. McDougall J, Karimian S, Ferrell W, (1995) Prolonged alteration of vasoconstrictor and vasodilator responses in rat knee joints by adjuvant monoarthritis. Exp Physiol 80: 349-357.
48. Gabriel AF, Marcus MA, Honig WM, Walenkamp GH, Joosten EA, (2007) The CatWalk method: a detailed analysis of behavioral changes after acute inflammatory pain in the rat. J Neurosci Methods 163: 9-16.
49. Grubb BD, McQueen DS, Iggo A, Birrell GJ, Dutia MB, (1988) A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints. Agents Actions 25: 216-218.
50. Grubb BD, Birrell GJ, McQueen DS, Iggo A, (1991) The role of PGE2 in the sensitization of mechanoreceptors in normal and inflamed ankle joints of the rat. Exp Brain Res 84: 383-392.
51. Donaldson LF, Seckl JR, McQueen DS, (1993) A discrete adjuvant-induced monoarthritis in the rat: effects of adjuvant dose. J Neurosci Methods 49: 5-10.
52. López-Muñoz FJ, Salazar LA, Castañeda-Hernández G, Villarreal JE, (1993) A new model to assess analgesic activity: Pain-induced functional impairment in the rat (PIFIR). Drug Dev Res 28: 169-175.
53. Orito K, Kurozumi S, Ishii I, Tanaka A, Sawada J, et al. (2007) A Sensitive Gait Parameter for Quantification of Arthritis in Rats. J Pharmacol Sci 103: 113-116.
54. Vermeirsch H, Biermans R, Salmon PL, Meert TF, (2007) Evaluation of pain behavior and bone destruction in two arthritic models in guinea pig and rat. Pharmacol Biochem Behav 87: 349-359.
55. Coulthard P, Simjee SU, Pleuvry BJ, (2003) Gait analysis as a correlate of pain induced by carrageenan intraplantar injection. J Neurosci Methods 128: 95-102.
56. Simjee SU, Pleuvry BJ, Coulthard P, (2004) Modulation of the gait deficit in arthritic rats by infusions of muscimol and bicuculline. Pain 109: 453-460.
57. Simjee SU, Jawed H, Quadri J, Saeed SA, (2007) Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat. Arthritis Res Ther 9: R91.
58. Marchand F, Bishop T, Anand R, Grist J, Hamers FP, et al. (2007) The CatWalk method: behavioral changes and effect of analgesic drugs in inflammatory and neuropathic pain models. Soc Neurosci Abstr 2007: 181.19.
59. Piesla MJ, Leventhal L, Strassle BW, Harrison JE, Cummons TA, et al. (2009) Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. Brain Res 1295: 89-98.
60. Boettger MK, Weber K, Schmidt M, Gajda M, Bräuer R, et al. (2009) Gait abnormalities differentially indicate pain or structural joint damage in monoarticular antigen-induced arthritis. Pain 145: 142-150.
61. Masocha W, Parvathy SS, (2009) Assessment of weight bearing changes and pharmacological antinociception in mice with LPS-induced monoarthritis using the Catwalk gait analysis system. Life Sci 85: 462-469.
62. Koopmans GC, Deumens R, Brook G, Gerver J, Honig WM, et al. (2007) Strain and locomotor speed affect over-ground locomotion in intact rats. Physiol Behav 92: 993-1001.
63. Ängeby-Möller K, Berge OG, Hamers FP, (2000) Locomotor behaviour in normal and monoarthritic rats assessed by a new computer assisted method. 3rd Internat Conf Meth Behav Res 2000: Abstr 8-10.
64. Kilkenny C, Parsons N, Kadyszewski E, Festing MF, Cuthill IC, et al. (2009) Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One 4 (11) (): e7824 doi:10.1371/journal.pone.0007824.
65. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG, (2010) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8 (6) (): e1000412 doi:10.1371/journal.pbio.1000412.
66. Rice AS, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, et al. (2008) Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain 139: 243-247.
67. Sena E, van der Worp HB, Howells D, Macleod M, (2007) How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci 30: 433-439.
68. Eisenach JC, Lindner MD, (2004) Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain? Anesthesiology 100: 765-767.
69. Lindner MD, Frydel BR, Francis JM, Cain CK, (2003) Analgesic effects of adrenal chromaffin allografts: contingent on special procedures or due to experimenter bias? J Pain 4: 64-73.
70. Lindner MD, (2007) Clinical attrition due to biased preclinical assessments of potential efficacy. Pharmacol Ther 115: 148-175.