A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: A meta-analysis

Arthritis Care and Research

Volumn 51, Issue 5, 2004, Pages 746-754

  Lee, Chin ^a   Straus, Walter L ^b   Balshaw, Robert ^c   Barlas, Suna ^b   Vogel, Suzanne ^b   Schnitzer, Thomas J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Health Dialog Data Services   (United States)

^c SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Acetaminophen; Nonsteroidal antiinflammatory agents; Osteoarthritis; Therapy

Indexed keywords

ACEMETACIN; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; FLOCTAFENIC ACID; IBUPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; ROFECOXIB;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; EMBASE; FEMALE; HIP OSTEOARTHRITIS; HUMAN; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; MEDLINE; META ANALYSIS; OSTEOARTHRITIS; OUTCOMES RESEARCH; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; REST; SIDE EFFECT; SYSTEMATIC REVIEW; WALKING;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE INHIBITORS; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; TREATMENT OUTCOME;

EID: 5644294351     PISSN: 21514658     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20698     Document Type: Article

References (46)

1. Altman RD, Hochberg MC, Moskowitz RW, Schnitzer, TJ. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000;43:1905-15.
2. Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, et al. Guidelines for the medical management of osteoarthritis. Part I. Osteoarthritis of the hip. Arthritis Rheum 1995;38:1535-40.
3. Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, et al. Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. Arthritis Rheum 1995;38:1541-6.
4. Pincus T, Koch G, Sokka T, Lefkowith J, Wolfe F, Jordan JM, et al. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum 2001; 44:1587-98.
5. Altman RD, The IAP Study Group. Ibuprofen, acetaminophen and placebo in osteoarthritis of the knee: a six-day double-blind study. Arthritis Rheum 1999;42 Suppl 9:S404.
6. Pincus T, Swearingen C, Cummins P, Callahan LF. Preference for nonsteroidal anti-inflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. J Rheumatol 2000;27:1020-7.
7. Lanza FL, Simon TJ, Quan H, Bolognese JA, Hoover MF, Wilson FR, et al. Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. Aliment Pharmacol Ther 1999;13: 761-7.
8. Simon LS, Weaver AL, Graham DY, Kivitz AJ, Lipsky PE, Hubbard RC, et al. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA 1999;282:1921-8.
9. Langman MJ, Jensen DM, Watsoin DJ, Harper SE, Zhao PL, Quan H, et al. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. JAMA 1999;282:1929-33.
10. Laine L, Harper S, Simon T, Bath R, Johanson J, Schwartz H, et al, Rofecoxib Osteoarthritis Endoscopy Study Group. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofan on the gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 1999;117:776-83.
11. Bensen WG, Zhao SZ, Burke TA, Zabinski RA, Makuch RW, Maurath CJ, et al. Upper gastrointestinal tolerability of celecoxib, a COX-2 specific inhibitor, compared to naproxen and placebo. J Rheumatol 2000;27:1876-83.
12. Goldstein JL, Silverstein E, Agrawal NM, Hubbard RC, Kaiser J, Maurath CJ, et al. Reduced risk of upper gastrointestinal ulcer complications with celecoxib, a novel COX-2 inhibitor. Am J Gastroenterol 2000;95:1681-90.
13. Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med 2000;343:1520-8.
14. Felson DT. The verdict favors nonsteroidal anti-inflammatory drugs for treatment of osteoarthritis and a plea for more evidence on other treatments. Arthritis Rheum 2001;44:1477-80.
15. Schnitzer TJ. Osteoarthritis management: the role of cyclooxygenase-2- selective inhibitors. Clin Ther 2001;23:313-26.
16. Schnitzer TJ. Update of ACR guidelines for osteoarthritis: role of the coxibs. J Pain Symptom Manage 2002;23(4 Suppl):S24-30; discussion S31-4.
17. Eccles M, Freemantle N, Mason J, The North of England Non-Steroidal Anti-Inflammatory Drug Guideline Development Group. North of England evidence based guideline development project: summary guideline for non-steroidal anti-inflammatory drugs versus basic analgesia in treating the pain of degenerative arthritis. BMJ 1998;317:526-30.
18. Parr G, Darekar B, Fletcher A, Bulpitt CJ. Joint pain and quality of life; results of a randomised trial. Br J Clin Pharmacol 1989;27:235-42.
19. PubMed Website. URL: http://www.ncbi.nlm.nih.gov/entrez/ query/static/overview.html.
20. Ovid Website. URL: http://www.ovid.com/site/index.jsp.
21. Case JP, Baliunas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003;163:169-78.
22. Williams HJ, Ward JR, Egger MJ, Neuner R, Brooks RH, Clegg DO, et al. Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. Arthritis Rheum 1993;36:1196-206.
23. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12.
24. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
25. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Erlbaum Associates; 1988.
26. Gotzsche PC. Non-steroidal anti-inflammatory drugs. BMJ 2000;320:1058-61.
27. Seideman P, Samuelson P, Neander G. Naproxen and paracetamol compared with naproxen only in coxarthrosis: increased effect of the combination in 18 patients. Acta Orthop Scand 1993;64:285-8.
28. Brooks PM, Dougan MA, Mugford S, Meffin E. Comparative effectiveness of 5 analgesics in patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 1982;9:723-6.
29. Solomon L, Abrams G. Orudis in the management of osteoarthritis of the knee: a double-blind trial. S Afr Med J 1974; 48:1526-9.
30. Wojtulewski JA, Hart FD, Huskisson EC. Fenoprofen in treatment of osteoarthrosis of hip and knee. BMJ 1974;2:475-6.
31. Wojtulewski JA. Fenoprofen in the treatment of osteoarthrosis. Curr Med Res Opin 1974;2:551-5.
32. Maneksha S. 'Safapryn' and benorylate-a comparative trial of two new preparations of aspirin and paracetamol in the treatment of rheumatoid arthritis and osteoarthritis. Curr Med Res Opin 1973;1:563-8.
33. Rovetta G, Monteforte P. Dexketoprofen-trometamol in patients with osteoarthritis of the hands. Minerva Ortopedica e Traumatologica 2001;52:27-30.
34. Whitehead J, Thomas P. A sequential trial of pain killers in arthritis: issues of multiple comparisons with control and of interval-censored survival data. J Biopharmaceutical Stat 1997;7:333-55.
35. Hackenthal E. Paracetamol and metamizol in the treatment of chronic pain syndromes. Schmerz 1997;11:269-75.
36. Nikles CJ, Glasziou PP, Del Mar CB, Duggan CM, Clavarino A, Yelland MJ. Preliminary experiences with a single-patient trials service in general practice. Med J Aust 2000;173:100-3.
37. March L, Irwig L, Schwarz J, Simpson J, Chock C, Brooks P. n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis. BMJ 1994;309:1041-5; discussion 1045-6.
38. Bradley JD, Brant KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991; 325:87-91.
39. Lequesne M, Fannius J, Reginster J-Y, Verdickt W, Vincent du Laurier M. Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Rev Rhum [Engl Ed] 1997;64:327-33.
40. Erturk H, Celker R, Aydin M, Ugur O. Comparison of efficacy and tolerability of acemetacin and acetaminophen in the treatment of knee osteoarthritis. J Rheum Med Rehab 1998;9: 157-61.
41. Geba GP, Weaver AL, Polis AB, Dixon ME, Schnitzer TJ, Vioxx, Acetaminophen, Celecoxib Trial (VACT) Group. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. JAMA 2002;287:64-71.
42. Petitti DB. Information retrieval. In: Meta-analysis, decision analysis, and cost-effectiveness analysis. 2nd ed. New York: Oxford University Press; 2000. p. 43-67.
43. Ehrich EW, Davies GM, Watson DJ, Bolognese JA, Seidenberg BC, Bellamy N. Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire and global assessments in patients with osteoarthritis. J Rheumatol 2000;27:2635-41.
44. Gotzsche PC. Non-steroidal anti-inflammatory drugs. Clin Evid 2002;7:1063-70.
45. Davidson RA. Source of funding and outcome of clinical trials. J Gen Intern Med 1986;1:155-8.
46. Rochon PA, Gurwitz JH, Simms RW, Fortin PR, Felson DT, Minaker KL, et al. A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis. Arch Intern Med 1994;154:157-63.