Common variable immunodeficiency - an update

Arthritis Research and Therapy

Volumn 14, Issue 5, 2012, Pages

  Salzer, Ulrich ^a   Warnatz, Klaus ^a   Peter, Hans H ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APRIL PROTEIN; AZATHIOPRINE; B CELL ACTIVATING FACTOR; CD19 ANTIGEN; CD27 ANTIGEN; CD38 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; CYCLOSPORIN A; IMMUNOGLOBULIN; IMMUNOGLOBULIN D ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; RITUXIMAB; STEROID; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

ANTIGEN PRESENTING CELL; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COMMON VARIABLE IMMUNODEFICIENCY; DELAYED DIAGNOSIS; DENDRITIC CELL; ENTERITIS; FAMILY HISTORY; GRANULOMATOUS INFLAMMATION; HUMAN; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOGLOBULIN DEFICIENCY; IMMUNOTHERAPY; INNATE IMMUNITY; INTERSTITIAL LUNG DISEASE; LIFE EXPECTANCY; LONG TERM CARE; LYMPHOCYTE PROLIFERATION; MULTICENTER STUDY (TOPIC); OUTCOME ASSESSMENT; PHENOTYPE; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTOPENIC PURPURA; IMMUNOLOGY; PROGNOSIS;

COMMON VARIABLE IMMUNODEFICIENCY; HUMANS; IMMUNOGLOBULINS; PROGNOSIS;

EID: 84867140960     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4032     Document Type: Review

References (74)

1. Conley ME. Diagnostic guidelines - An International Consensus document. Clin Immunol 1999, 93:189. 10.1006/clim.1999.4798, 10600328.
2. Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP, Orange JS, Routes JM, Shearer WT, Sorensen RU, , , , , , . American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology, Joint Council of Allergy, Asthma and Immunology Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol 2005, 94(5 Suppl 1):S1-63. American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology, Joint Council of Allergy, Asthma and Immunology.
3. Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 1999, 92:34-48. 10.1006/clim.1999.4725, 10413651.
4. Oksenhendler E, Gérard L, Fieschi C, Malphettes M, Mouillot G, Jaussaud R, Viallard JF, Gardembas M, Galicier L, Schleinitz N, Suarez F, Soulas-Sprauel P, Hachulla E, Jaccard A, Gardeur A, Théodorou I, Rabian C, Debré P, . DEFI Study Group Infections in 252 patients with common variable immunodeficiency. Clin Infect Dis 2008, 46:1547-1554. 10.1086/587669, 18419489, DEFI Study Group.
5. Chapel H, Lucas M, Lee M, Bjorkander J, Webster D, Grimbacher B, Fieschi C, Thon V, Abedi MR, Hammarstrom L. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 2008, 112:277-286. 10.1182/blood-2007-11-124545, 18319398.
6. Finck A, Van der Meer JW, Schaffer AA, Pfannstiel J, Fieschi C, Plebani A, Webster AD, Hammarstrom L, Grimbacher B. Linkage of autosomaldominant common variable immunodeficiency to chromosome 4q. Eur J Hum Genet 2006, 14:867-875. 10.1038/sj.ejhg.5201634, 16639407.
7. Vorechovsky I, Zetterquist H, Paganelli R, Koskinen S, Webster AD, Bjorkander J, Smith CI, Hammarstrom L. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin Immunol Immunopathol 1995, 77:185-192. 10.1006/clin.1995.1142, 7586726.
8. Espanol T, Catala M, Hernandez M, Caragol I, Bertran JM. Development of a common variable immunodeficiency in IgA-deficient patients. Clin Immunol Immunopathol 1996, 80:333-335. 10.1006/clin.1996.0132, 8811056.
9. Aghamohammadi A, Farhoudi A, Moin M, Rezaei N, Kouhi A, Pourpak Z, Yaseri N, Movahedi M, Gharagozlou M, Zandieh F, Yazadni F, Arshi S, Mohammadzadeh I, Ghazi BM, Mahmoudi M, Tahaei S, Isaeian A. Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency. Clin Diagn Lab Immunol 2005, 12:825-832. 1182213, 16002630.
10. Kralovicova J, Hammarstrom L, Plebani A, Webster AD, Vorechovsky I. Finescale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency. J Immunol 2003, 170:2765-2775.
11. Schaffer AA, Pfannstiel J, Webster AD, Plebani A, Hammarstrom L, Grimbacher B. Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q. Hum Genet 2006, 118:725-729. 10.1007/s00439-005-0101-1, 1385708, 16328471.
12. Schroeder HW, Zhu ZB, March RE, Campbell RD, Berney SM, Nedospasov SA, Turetskaya RL, Atkinson TP, Go RC, Cooper MD, Volanakis JE. Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes. Mol Med 1998, 4:72-86. 2230309, 9508785.
13. Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, Kim CE, Hou C, Wang F, Chiavacci R, Kugathasan S, Sleasman JW, Baldassano R, Perez EE, Chapel H, Cunningham-Rundles C, Hakonarson H. Genome-wide association identifies diverse causes of common variable immunodeficiency. J Allergy Clin Immunol 2011, 127:1360-1367 e1366. 10.1016/j.jaci.2011.02.039, 21497890.
14. Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW, Kroczek RA, Peter HH. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 2003, 4:261-268.
15. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet 2005, 37:829-834. 10.1038/ng1601, 16007086.
16. Salzer U, Chapel HM, Webster AD, Pan-Hammarström Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schäffer AA, Hammarström L, Grimbacher B. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet 2005, 37:820-828. 10.1038/ng1600, 16007087.
17. van Zelm MC, Reisli I, van der Burg M, Castaño D, van Noesel CJ, van Tol MJ, Woellner C, Grimbacher B, Patiño PJ, van Dongen JJ, Franco JL. An antibody-deficiency syndrome due to mutations in the CD19 gene. N Engl J Med 2006, 354:1901-1912. 10.1056/NEJMoa051568, 16672701.
18. Warnatz K, Salzer U, Rizzi M, Fischer B, Gutenberger S, Böhm J, Kienzler AK, Pan-Hammarström Q, Hammarström L, Rakhmanov M, Schlesier M, Grimbacher B, Peter HH, Eibel H. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. Proc Natl Acad Sci USA 2009, 106:13945-13950. 10.1073/pnas.0903543106, 2722504, 19666484.
19. van Zelm MC, Smet J, Adams B, Mascart F, Schandené L, Janssen F, Ferster A, Kuo CC, Levy S, van Dongen JJ, van der Burg M. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest 2010, 120:1265-1274. 10.1172/JCI39748, 2846042, 20237408.
20. Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA. CD20 deficiency in humans results in impaired T cell-independent antibody responses. J Clin Invest 2010, 120:214-222. 10.1172/JCI40231, 2798692, 20038800.
21. Thiel J, Kimmig L, Salzer U, Grudzien M, Lebrecht D, Hagena T, Draeger R, Völxen N, Bergbreiter A, Jennings S, Gutenberger S, Aichem A, Illges H, Hannan JP, Kienzler AK, Rizzi M, Eibel H, Peter HH, Warnatz K, Grimbacher B, Rump JA, Schlesier M. Genetic CD21 deficiency is associated with hypogammaglobulinemia. J Allergy Clin Immunol 2012, 129:801-810. 10.1016/j.jaci.2011.09.027, 22035880.
22. Lopez-Herrera G, Tampella G, Pan-Hammarström Q, Herholz P, Trujillo-Vargas CM, Phadwal K, Simon AK, Moutschen M, Etzioni A, Mory A, Srugo I, Melamed D, Hultenby K, Liu C, Baronio M, Vitali M, Philippet P, Dideberg V, Aghamohammadi A, Rezaei N, Enright V, Du L, Salzer U, Eibel H, Pfeifer D, Veelken H, Stauss H, Lougaris V, Plebani A, Gertz EM, et al. Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity. Am J Hum Genet 2012, 90:986-1001. 10.1016/j.ajhg.2012.04.015, 22608502.
23. Giovannetti A, Pierdominici M, Mazzetta F, Marziali M, Renzi C, Mileo AM, De Felice M, Mora B, Esposito A, Carello R, Pizzuti A, Paggi MG, Paganelli R, Malorni W, Aiuti F. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J Immunol 2007, 178:3932-3943.
24. Piqueras B, Lavenu-Bombled C, Galicier L, Bergeron-van der Cruyssen F, Mouthon L, Chevret S, Debre P, Schmitt C, Oksenhendler E. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J Clin Immunol 2003, 23:385-400. 10.1023/A:1025373601374, 14601647.
25. Warnatz K, Denz A, Drager R, Braun M, Groth C, Wolff-Vorbeck G, Eibel H, Schlesier M, Peter HH. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 2002, 99:1544-1551. 10.1182/blood.V99.5.1544, 11861266.
26. Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, Vlkova M, Hernandez M, Detkova D, Bos PR, Poerksen G, von Bernuth H, Baumann U, Goldacker S, Gutenberger S, Schlesier M, Bergeron-van der Cruyssen F, Le Garff M, Debré P, Jacobs R, Jones J, Bateman E, Litzman J, van Hagen PM, Plebani A, Schmidt RE, Thon V, Quinti I, Espanol T, Webster AD, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 2008, 111:77-85. 10.1182/blood-2007-06-091744, 17898316.
27. De Vera MJ, Al-Harthi L, Gewurz AT. Assessing thymopoiesis in patients with common variable immunodeficiency as measured by T-cell receptor excision circles. Ann Allergy Asthma Immunol 2004, 93:478-484. 10.1016/S1081-1206(10)61416-0, 15562888.
28. Isgro A, Marziali M, Mezzaroma I, Luzi G, Mazzone AM, Guazzi V, Andolfi G, Cassani B, Aiuti A, Aiuti F. Bone marrow clonogenic capability, cytokine production, and thymic output in patients with common variable immunodeficiency. J Immunol 2005, 174:5074-5081.
29. Arumugakani G, Wood PM, Carter CR. Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytes. J Clin Immunol 2010, 30:292-300. 10.1007/s10875-009-9351-3, 19997968.
30. Horn J, Manguiat A, Berglund LJ, Knerr V, Tahami F, Grimbacher B, Fulcher DA. Decrease in phenotypic regulatory T cells in subsets of patients with common variable immunodeficiency. Clin Exp Immunol 2009, 156:446-454. 10.1111/j.1365-2249.2009.03913.x, 2691973, 19438597.
31. Melo KM, Carvalho KI, Bruno FR, Ndhlovu LC, Ballan WM, Nixon DF, Kallas EG, Costa-Carvalho BT. A decreased frequency of regulatory T cells in patients with common variable immunodeficiency. PLoS One 2009, 4:e6269. 10.1371/journal.pone.0006269, 2715881, 19649263.
32. Yu GP, Chiang D, Song SJ, Hoyte EG, Huang J, Vanishsarn C, Nadeau KC. Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease. Clin Immunol 2009, 131:240-253. 10.1016/j.clim.2008.12.006, 19162554.
33. Holm AM, Sivertsen EA, Tunheim SH, Haug T, Bjerkeli V, Yndestad A, Aukrust P, Froland SS. Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cells. Clin Exp Immunol 2004, 138:278-289. 10.1111/j.1365-2249.2004.02630.x, 1809214, 15498038.
34. Viallard JF, Blanco P, Andre M, Etienne G, Liferman F, Neau D, Vidal E, Moreau JF, Pellegrin JL. CD8+HLA-DR+ T lymphocytes are increased in common variable immunodeficiency patients with impaired memory B-cell differentiation. Clin Immunol 2006, 119:51-58. 10.1016/j.clim.2005.11.011, 16413828.
35. Raeiszadeh M, Kopycinski J, Paston SJ, Diss T, Lowdell M, Hardy GA, Hislop AD, Workman S, Dodi A, Emery V, Webster AD. The T cell response to persistent herpes virus infections in common variable immunodeficiency. Clin Exp Immunol 2006, 146:234-242. 10.1111/j.1365-2249.2006.03209.x, 1942048, 17034575.
36. Holm AM, Tjonnfjord G, Yndestad A, Beiske K, Muller F, Aukrust P, Froland SS. Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropenia. Clin Exp Immunol 2006, 144:418-424. 10.1111/j.1365-2249.2006.03086.x, 1941976, 16734610.
37. Malphettes M, Gérard L, Carmagnat M, Mouillot G, Vince N, Boutboul D, Bérezné A, Nove-Josserand R, Lemoing V, Tetu L, Viallard JF, Bonnotte B, Pavic M, Haroche J, Larroche C, Brouet JC, Fermand JP, Rabian C, Fieschi C, Oksenhendler E, . DEFI Study Group Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect. Clin Infect Dis 2009, 49:1329-1338. 10.1086/606059, 19807277, DEFI Study Group.
38. Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood 2011, 119:1650-1657.
39. Herbst EW, Armbruster M, Rump JA, Buscher HP, Peter HH. Intestinal B cell defects in common variable immunodeficiency. Clin Exp Immunol 1994, 95:215-221. 1534935, 8306494.
40. Ochtrop ML, Goldacker S, May AM, Rizzi M, Draeger R, Hauschke D, Stehfest C, Warnatz K, Goebel H, Technau-Ihling K, Werner M, Salzer U, Eibel H, Schlesier M, Peter HH. T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency. Blood 2011, 118:309-318. 10.1182/blood-2010-11-321695, 21576700.
41. Taubenheim N, von Hornung M, Durandy A, Warnatz K, Corcoran L, Peter HH, Eibel H. Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients. J Immunol 2005, 175:5498-5503.
42. Berglund LJ, Wong SW, Fulcher DA. B-cell maturation defects in common variable immunodeficiency and association with clinical features. Pathology 2008, 40:288-294. 10.1080/00313020801911470, 18428049.
43. Detková D, de Gracia J, Lopes-da-Silva S, Vendrell M, Alvarez A, Guarner L, Vidaller A, Rodrigo MJ, Caragol I, Espanol T, Hernández M. Common variable immunodeficiency: association between memory B cells and lung diseases. Chest 2007, 131:1883-1889. 10.1378/chest.06-2994, 17400689.
44. Foerster C, Voelxen N, Rakhmanov M, Keller B, Gutenberger S, Goldacker S, Thiel J, Feske S, Peter HH, Warnatz K. B cell receptor-mediated calcium signaling is impaired in B lymphocytes of type Ia patients with common variable immunodeficiency. J Immunol 2010, 184:7305-7313. 10.4049/jimmunol.1000434, 20495065.
45. Goldacker S, Draeger R, Warnatz K, Huzly D, Salzer U, Thiel J, Eibel H, Schlesier M, Peter HH. Active vaccination in patients with common variable immunodeficiency (CVID). Clin Immunol 2007, 124:294-303. 10.1016/j.clim.2007.04.011, 17602874.
46. Ko J, Radigan L, Cunningham-Rundles C. Immune competence and switched memory B cells in common variable immunodeficiency. Clin Immunol 2005, 116:37-41. 10.1016/j.clim.2005.03.019, 15925830.
47. Andersen P, Permin H, Andersen V, Schejbel L, Garred P, Svejgaard A, Barington T. Deficiency of somatic hypermutation of the antibody light chain is associated with increased frequency of severe respiratory tract infection in common variable immunodeficiency. Blood 2005, 105:511-517. 10.1182/blood-2003-12-4359, 15367430.
48. Bonhomme D, Hammarstrom L, Webster D, Chapel H, Hermine O, Le Deist F, Lepage E, Romeo PH, Levy Y. Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency. J Immunol 2000, 165:4725-4730.
49. Cunningham-Rundles C, Radigan L, Knight AK, Zhang L, Bauer L, Nakazawa A. TLR9 activation is defective in common variable immune deficiency. J Immunol 2006, 176:1978-1987.
50. Yu JE, Knight AK, Radigan L, Marron TU, Zhang L, Sanchez-Ramon S, Cunningham-Rundles C. Toll-like receptor 7 and 9 defects in common variable immunodeficiency. J Allergy Clin Immunol 2009, 124:349-356. 356. e1-3, 10.1016/j.jaci.2009.05.019, 2908501, 19592080.
51. Yu JE, Zhang L, Radigan L, Sanchez-Ramon S, Cunningham-Rundles C. TLR-mediated B cell defects and IFN-alpha in common variable immunodeficiency. J Clin Immunol 2012, 32:50-60. 10.1007/s10875-011-9602-y, 3428015, 22048980.
52. He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat Immunol 2010, 11:836-845. 10.1038/ni.1914, 3047500, 20676093.
53. Treml LS, Carlesso G, Hoek KL, Stadanlick JE, Kambayashi T, Bram RJ, Cancro MP, Khan WN. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol 2007, 178:7531-7539.
54. Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Galicier L, Lepelletier Y, Webster D, Lévy Y, Eibl MM, Oksenhendler E, Hermine O, Kaveri SV. Common variable immunodeficiency is associated with defective functions of dendritic cells. Blood 2004, 104:2441-2443. 10.1182/blood-2004-04-1325, 15226176.
55. Cunningham-Rundles C, Radigan L. Deficient IL-12 and dendritic cell function in common variable immune deficiency. Clin Immunol 2005, 115:147-153. 10.1016/j.clim.2004.12.007, 15885637.
56. Wheat WH, Cool CD, Morimoto Y, Rai PR, Kirkpatrick CH, Lindenbaum BA, Bates CA, Ellison MC, Serls AE, Brown KK, Routes JM. Possible role of human herpesvirus 8 in the lymphoproliferative disorders in common variable immunodeficiency. J Exp Med 2005, 202:479-484. 10.1084/jem.20050381, 2212861, 16103407.
57. Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM. Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol 2004, 114:415-421. 10.1016/j.jaci.2004.05.057, 15316526.
58. Ardeniz O, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Clin Immunol 2009, 133:198-207. 10.1016/j.clim.2009.05.001, 2760682, 19716342.
59. Daniels JA, Lederman HM, Maitra A, Montgomery EA. Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol 2007, 31:1800-1812. 10.1097/PAS.0b013e3180cab60c, 18043034.
60. Ward C, Lucas M, Piris J, Collier J, Chapel H. Abnormal liver function in common variable immunodeficiency disorders due to nodular regenerative hyperplasia. Clin Exp Immunol 2008, 153:331-337. 10.1111/j.1365-2249.2008.03711.x, 2527366, 18647320.
61. Malamut G, Ziol M, Suarez F, Beaugrand M, Viallard JF, Lascaux AS, Verkarre V, Bechade D, Poynard T, Hermine O, Cellier C. Nodular regenerative hyperplasia: the main liver disease in patients with primary hypogammaglobulinemia and hepatic abnormalities. J Hepatol 2008, 48:74-82. 10.1016/j.jhep.2007.08.011, 17998147.
62. Boileau J, Mouillot G, Gerard L, Carmagnat M, Rabian C, Oksenhendler E, Pasquali JL, Korganow AS. Autoimmunity in common variable immunodeficiency: correlation with lymphocyte phenotype in the French DEFI study. J Autoimmun 2011, 36:25-32. 10.1016/j.jaut.2010.10.002, 21075598.
63. Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C, Claudio P, Franco D, Maria Pesce A, Borghese F, Guerra A, Rondelli R, Plebani A, . Italian Primary Immunodeficiency Network Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol 2007, 27:308-316. 10.1007/s10875-007-9075-1, 17510807, Italian Primary Immunodeficiency Network.
64. Sève P, Bourdillon L, Sarrot-Reynauld F, Ruivard M, Jaussaud R, Bouhour D, Bonotte B, Gardembas M, Poindron V, Thiercelin MF, Broussolle C, Oksenhendler E, . DEF-I Study Group Autoimmune hemolytic anemia and common variable immunodeficiency: a case-control study of 18 patients. Medicine (Baltimore) 2008, 87:177-184. DEF-I Study Group.
65. Mouillot G, Carmagnat M, Gérard L, Garnier JL, Fieschi C, Vince N, Karlin L, Viallard JF, Jaussaud R, Boileau J, Donadieu J, Gardembas M, Schleinitz N, Suarez F, Hachulla E, Delavigne K, Morisset M, Jacquot S, Just N, Galicier L, Charron D, Debré P, Oksenhendler E, Rabian C, . DEFI Study Group B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease. J Clin Immunol 2010, 30:746-755. 10.1007/s10875-010-9424-3, 20437084, DEFI Study Group.
66. Sander CA, Medeiros LJ, Weiss LM, Yano T, Sneller MC, Jaffe ES. Lymphoproliferative lesions in patients with common variable immunodeficiency syndrome. Am J Surg Pathol 1992, 16:1170-1182. 10.1097/00000478-199212000-00004, 1334378.
67. Mellemkjaer L, Hammarstrom L, Andersen V, Yuen J, Heilmann C, Barington T, Bjorkander J, Olsen JH. Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol 2002, 130:495-500. 10.1046/j.1365-2249.2002.02004.x, 1906562, 12452841.
68. Vorechovsky I, Scott D, Haeney MR, Webster DA. Chromosomal radiosensitivity in common variable immune deficiency. Mutat Res 1993, 290:255-264. 10.1016/0027-5107(93)90166-D, 7694117.
69. Seymour B, Miles J, Haeney M. Primary antibody deficiency and diagnostic delay. J Clin Pathol 2005, 58:546-547. 10.1136/jcp.2004.016204, 1770645, 15858130.
70. Rizzi M, Neumann C, Fielding AK, Marks R, Goldacker S, Thaventhiran J, Tarzi MD, Schlesier M, Salzer U, Eibel H, Warnatz K, Finke J, Grimbacher B, Peter HH. Outcome of allogeneic stem cell transplantation in adults with common variable immunodeficiency. J Allergy Clin Immunol 2011, 128:1371-1374.e2. 10.1016/j.jaci.2011.07.055, 21930294.
71. Ballow M. Immunoglobulin therapy: methods of delivery. J Allergy Clin Immunol 2008, 122:1038-1039. 10.1016/j.jaci.2008.08.012, 18804269.
72. Gardulf A. Immunoglobulin treatment for primary antibody deficiencies: advantages of the subcutaneous route. BioDrugs 2007, 21:105-116. 10.2165/00063030-200721020-00005, 17402794.
73. Gardulf A, Andersen V, Bjorkander J, Ericson D, Froland SS, Gustafson R, Hammarstrom L, Jacobsen MB, Jonsson E, Moller G, et al. Subcutaneous immunoglobulin replacement in patients with primary antibody deficiencies: safety and costs. Lancet 1995, 345:365-369. 10.1016/S0140-6736(95)90346-1, 7845120.
74. Orange JS, Hossny EM, Weiler CR, Ballow M, Berger M, Bonilla FA, Buckley R, Chinen J, El-Gamal Y, Mazer BD, Nelson RP, Patel DD, Secord E, Sorensen RU, Wasserman RL, Cunningham-Rundles C, , . Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol 2006, 117(4 Suppl):S525-553. Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology.