Decrease in phenotypic regulatory T cells in subsets of patients with common variable immunodeficiency

Clinical and Experimental Immunology

Volumn 156, Issue 3, 2009, Pages 446-454

  Horn, J ^b   Manguiat, A ^c   Berglund, L J ^a   Knerr, V ^c   Tahami, F ^c   Grimbacher, B ^c   Fulcher, D A ^a  

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autoimmunity; Common variable immunodeficiency; Granuloma; Regulatory T cells

Indexed keywords

INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; AUSTRALIA; AUTOIMMUNITY; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL FEATURE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOPENIA; EUROPE; FLOW CYTOMETRY; GRANULOMATOSIS; HUMAN; INFECTION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; CELL SEPARATION; COMMON VARIABLE IMMUNODEFICIENCY; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MIDDLE AGED; PILOT PROJECTS; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 66149088095     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.03913.x     Document Type: Article

References (27)

1. Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 1999 92 : 34 48. (Pubitemid 29315984)
2. Chapel H, Lucas M, Lee M et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 2008 112 : 277 86.
3. Cunningham-Rundles C, Cooper DL, Duffy TP, Strauchen J. Lymphomas of mucosal-associated lymphoid tissue in common variable immunodeficiency. Am J Hematol 2002 69 : 171 8. (Pubitemid 34177470)
4. Knight AK, Cunningham-Rundles C. Inflammatory and autoimmune complications of common variable immune deficiency. Autoimmun Rev 2006 5 : 156 9. (Pubitemid 43129551)
5. Warnatz K, Denz A, Drager R et al. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 2002 99 : 1544 51. (Pubitemid 34533024)
6. Agematsu K, Futatani T, Hokibara S et al. Absence of memory B cells in patients with common variable immunodeficiency. Clin Immunol 2002 103 : 34 42. (Pubitemid 34478418)
7. Piqueras B, Lavenu-Bombled C, Galicier L et al. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J Clin Immunol 2003 23 : 385 400. (Pubitemid 37083193)
8. Giovannetti A, Pierdominici M, Mazzetta F et al. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J Immunol 2007 178 : 3932 43. (Pubitemid 46417664)
9. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005 6 : 345 52. (Pubitemid 41716771)
10. Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006 203 : 1701 11. (Pubitemid 44036276)
11. Fevang B, Yndestad A, Sandberg WJ et al. Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivo. Clin Exp Immunol 2007 147 : 521 5. (Pubitemid 46208054)
12. Geha RS, Notarangelo LD, Casanova J-L et al. International Union of Immunological Societies Primary Immunodeficiency Diseases Classification C, Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol 2007 120 : 776 94.
13. Wehr C, Kivioja T, Schmitt C et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 2008 111 : 77 85.
14. Ferry BL, Jones J, Bateman EA et al. Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method. Clin Exp Immunol 2005 140 : 532 9. (Pubitemid 40813965)
15. Berglund LJ, Wong SWJ, Fulcher DA. B-cell maturation defects in common variable immunodeficiency and association with clinical features. Pathology 2008 40 : 288 94.
16. Warnatz K, Schlesier M. Flowcytometric phenotyping of common variable immunodeficiency. Cytometry Part B 2008 74B : 261 71.
17. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self tolerance causes various autoimmune diseases. J Immunol 1995 155 : 1151 64.
18. Banham AH, Powrie FM, Suri-Payer E. FOX P3+ regulatory T cells: current controversies and future perspectives. Eur J Immunol 2006 36 : 2832 6.
19. Rouse BT. Regulatory T cells in health and disease. J Intern Med 2007 262 : 78 95. (Pubitemid 47000634)
20. Brandt D, Gershwin ME. Common variable immune deficiency and autoimmunity. Autoimmun Rev 2006 5 : 465 70. (Pubitemid 44236281)
21. Miyara M, Amoura Z, Parizot C et al. The immune paradox of sarcoidosis and regulatory T cells erratum appears in J Exp Med 2006 Feb 20;203(2):477 J Exp Med 2006 203 : 359 70. (Pubitemid 43290845)
22. Idali F, Wahlström J, Müller-Suur C, Eklund A, Grunewald J. Analysis of regulatory T cell-associated forkhead box P3 expression in the lungs of patients with sarcoidosis. Clin Exp Immunol 2008 152 : 127 37.
23. Ling Y, Cao X, Yu Z, Ruan C. Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome. Eur J Haematol 2007 79 : 310 6. (Pubitemid 47390130)
24. Liu B, Zhao H, Poon M-C et al. Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura. Eur J Haematol 2007 78 : 139 43. (Pubitemid 46058876)
25. Sakakura M, Wada H, Tawara I et al. Reduced CD4+CD25+ T cells in patients with idiopathic thrombocytopenic purpura. Thromb Res 2007 120 : 187 93.
26. Stasi R, Cooper N, Del Poeta G et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab see comment Blood 2008 112 : 1147 50.
27. Yu J, Heck S, Patel V et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura see comment Blood 2008 112 : 1325 8.