CD8+HLA-DR+ T lymphocytes are increased in common variable immunodeficiency patients with impaired memory B-cell differentiation

Clinical Immunology

Volumn 119, Issue 1, 2006, Pages 51-58

  Viallard, Jean François ^a   Blanco, Patrick ^b   André, Marc ^c   Etienne, Gabriel ^d   Liferman, François ^e   Neau, Didier ^b   Vidal, Elisabeth ^f   Moreau, Jean François ^b   Pellegrin, Jean Luc ^a  

^a HAUT LÉVÊQUE HOSPITAL   (France)

^b HÔPITAL PELLEGRIN   (France)

^c SERVICE DE RHUMATOLOGIE   (France)

^d HÔPITAL SAINT ANDRÉ   (France)

^e Dax Hospital   (France)

^f DUPUYTREN UNIVERSITY HOSPITAL   (France)

Author keywords

Common variable immunodeficiency; Cytotoxic lymphocytes; Granzyme B; HLA DR; Perforin

Indexed keywords

BIOLOGICAL MARKER; CD27 ANTIGEN; CD3 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; GRANZYME B; HLA DR ANTIGEN; IMMUNOGLOBULIN D; PERFORIN;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE MARKER; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MALE; MEMORY CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD19; ANTIGENS, CD45; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; GRANZYMES; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE COUNT; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, CHEMOKINE; SERINE ENDOPEPTIDASES; T-LYMPHOCYTE SUBSETS;

EID: 33644751546     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2005.11.011     Document Type: Article

References (36)

1. M.E. Conley, L.D. Notarangelo, and A. Etzioni Diagnostic criteria for primary immunodeficiencies Clin. Immunol. 93 1999 190 197
2. G.P. Spickett, J. Farrant, M.E. North, J.G. Zhang, L. Morgan, and A.D. Webster Common variable immunodeficiency: how many diseases? Immunol. Today 18 1997 325 328
3. R.A. Hermaszewski, and A.D. Webster Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications Q. J. Med. 86 1993 31 42
4. C. Cunningham-Rundles, and C. Bodian Common variable immunodeficiency: clinical and immunological features of 248 patients Clin. Immunol. 92 1999 34 48
5. C.A. Janeway, L. Apt, and D. Gitlin Agammaglobulinemia Trans. Assoc. Am. Physicians 66 1953 200 202
6. M.B. Fasano, K.E. Sullivan, S.B. Sarpong, R.A. Wood, S.M. Jones, C.J. Johns, H.M. Lederman, M.J. Bykowsky, J.M. Greene, and J.A. Winkelstein Sarcoidosis and common variable immunodeficiency. Report of 8 cases and review of the literature Medicine (Baltimore) 75 1996 251 261
7. L.J. Mechanic, S. Dikman, and C. Cunningham-Rundles Granulomatous disease in common variable immunodeficiency Ann. Intern. Med. 127 1997 613 617
8. J.F. Viallard, J.L. Pellegrin, and J.F. Moreau Granulomatous disease in common variable immunodeficiency Ann. Intern. Med. 128 1998 781 782
9. Y.S. Choi, W.D. Biggar, and R.A. Good Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinaemia Lancet 1 1972 1149 1152
10. O. Saiki, P. Ralph, C. Cunningham-Rundles, and R.A. Good Three distinct stages of B-cell defect in common varied immunodeficiency Proc. Natl. Acad. Sci. U. S. A. 79 1982 6008 6012
11. A. Bryant, N.C. Calver, E. Toubi, A.D. Webster, and J. Farrant Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2 Clin. Immunol. Immunopathol. 56 1990 239 248
12. J.S. Jaffe, E. Eisenstein, M.C. Sneller, and W. Strober T-cell abnormalities in common variable immunodeficiency Pediatr. Res. 33 Suppl. 1 1993 S24 S27
13. S.G. Tangye, Y.J. Liu, G. Aversa, J.H. Phillips, and J.E. de Vries Identification of functional human splenic memory B cells by expression of CD148 and CD27 J. Exp. Med. 188 1998 1691 1703
14. + B cells and helper T cells in immunoglobulin production Eur. J. Immunol. 27 1997 2073 2079
15. -) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease Blood 99 2002 1544 1551
16. B. Piqueras, C. Lavenu-Bombled, L. Galicier, F. Bergeron-van der Cruyssen, L. Mouthon, S. Chevret, P. Debre, C. Schmitt, and E. Oksenhendler Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects J. Clin. Immunol. 23 2003 385 400
17. F. Sallusto, D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 1999 708 712
18. T.A. Waldmann, M. Durm, S. Broder, M. Blackman, R.M. Blaese, and W. Strober Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia Lancet 2 1974 609 613
19. E.L. Reinherz, M.D. Cooper, S.F. Schlossman, and F.S. Rosen Abnormalities of T cell maturation and regulation in human beings with immunodeficiency disorders J. Clin. Invest. 68 1981 699 705
20. A.J. Stagg, M. Funauchi, S.C. Knight, A.D. Webster, and J. Farrant Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID) Clin. Exp. Immunol. 96 1994 48 53
21. I. Kondratenko, P.L. Amlot, A.D. Webster, and J. Farrant Lack of specific antibody response in common variable immunodeficiency (CVID) associated with failure in production of antigen-specific memory T cells. MRC Immunodeficiency Group Clin. Exp. Immunol. 108 1997 9 13
22. E. Baumert, G. Wolff-Vorbeck, M. Schlesier, and H.H. Peter Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID) Clin. Exp. Immunol. 90 1992 25 30
23. M. Farrington, L.S. Grosmaire, S. Nonoyama, S.H. Fischer, D. Hollenbaugh, J.A. Ledbetter, R.J. Noelle, A. Aruffo, and H.D. Ochs CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency Proc. Natl. Acad. Sci. U. S. A. 91 1994 1099 1103
24. M. Di Renzo, Z. Zhou, I. George, K. Becker, and C. Cunningham-Rundles Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation Clin. Exp. Immunol. 120 2000 503 511
25. M.C. Sneller, and W. Strober Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency J. Immunol. 144 1990 3762 3769
26. G. Pastorelli, M.G. Roncarolo, J.L. Touraine, G. Peronne, P.A. Tovo, and J.E. de Vries Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens Clin. Exp. Immunol. 78 1989 334 340
27. E.M. Eisenstein, K. Chua, and W. Strober B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10 J. Immunol. 152 1994 5957 5968
28. G. Kruger, K. Welte, and N. Ciobanu Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency J. Clin. Immunol. 4 1984 295 303
29. W. Fiedler, K.W. Sykora, K. Welte, J.E. Kolitz, C. Cunningham-Rundles, K. Holloway, G.A. Miller, L. Souza, and R. Mertelsmann T-cell activation defect in common variable immunodeficiency: restoration by phorbol myristate acetate (PMA) or allogeneic macrophages Clin. Immunol. Immunopathol. 44 1987 206 218
30. G.P. Spickett, A.D. Webster, and J. Farrant Cellular abnormalities in common variable immunodeficiency Immunodefic. Rev. 2 1990 199 219
31. + T lymphocyte subsets in patients with common variable immunodeficiency Clin. Immunol. Immunopathol. 61 1991 83 92
32. J. Farrant, G. Spickett, N. Matamoros, D. Copas, M. Hernandez, M. North, H. Chapel, and A.D. Webster Study of B- and T-cell phenotypes in blood from patients with common variable immunodeficiency (CVID) Immunodeficiency 5 1994 159 169
33. J.J. Wright, D.K. Wagner, R.M. Blaese, C. Hagengruber, T.A. Waldmann, and T.A. Fleisher Characterization of common variable immunodeficiency: identification of a subset of patients with distinctive immunophenotypic and clinical features Blood 76 1990 2046 2051
34. + lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: possible immunopathogenic role of oxidative stress Blood 86 1995 1383 1391
35. + T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry Clin. Exp. Immunol. 105 1996 517 522
36. - effector-memory T cells Clin. Exp. Immunol. 138 2004 278 289