Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation

Toxicology Letters

Volumn 214, Issue 3, 2012, Pages 279-287

  Tan, Yang ^a,b   Liu, Jin ^a   Deng, Yu ^b   Cao, Hong ^b   Xu, Dan ^a,d   Cu, Fenglong ^b   Lei, Youying ^a   Magdalou, Jacques ^c   Wu, Min ^d   Chen, Liaobin ^b   Wang, Hui ^a,d  

^a WUHAN UNIVERSITY   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c Biopôle de l Université de Lorraine   (France)

^d WUHAN UNIVERSITY   (China)

Author keywords

Caffeine; Glucocorticoids; Growth plate; Histone methylation; Insulin like growth factor 1; Skeletal growth retardation

Indexed keywords

CAFFEINE; COLLAGEN TYPE 2; COLLAGEN TYPE 2A1; CORTICOSTERONE; GLUCOCORTICOID; HISTONE; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; PROTEIN AKT1; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEOGLYCAN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CHONDROGENESIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; FEMUR; FETUS; FETUS GROWTH; FETUS LIVER; FETUS WEIGHT; GENE EXPRESSION; GESTATIONAL AGE; GROWTH PLATE; HISTONE METHYLATION; IMMUNOHISTOCHEMISTRY; INTRAUTERINE GROWTH RETARDATION; MALE; NONHUMAN; OSTEOARTHRITIS; OSTEOPOROSIS; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; FEMALE; FEMUR; FETAL DEVELOPMENT; FETAL GROWTH RETARDATION; FETAL WEIGHT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOCORTICOIDS; GROWTH PLATE; HISTONES; INSULIN-LIKE GROWTH FACTOR I; LIVER; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; METHYLATION; PREGNANCY; RATS; RATS, WISTAR; RNA, MESSENGER;

RATTUS; RATTUS NORVEGICUS;

EID: 84867122115     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.09.007     Document Type: Article

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