Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function

Environmental Toxicology and Pharmacology

Volumn 32, Issue 3, 2011, Pages 356-363

  Xu, Dan ^a,b   Chen, Man ^a   Pan, Xiao liang ^a   Xia, Li ping ^a   Wang, Hui ^a,b  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

11 Hydroxysteroid dehydrogenase; Cytochrome P450 cholesterol side chain cleavage; Dexamethasone; Intrauterine growth retardation; Steroidogenic acute regulatory protein

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTICOSTERONE; CYTOCHROME P450; DEXAMETHASONE; MESSENGER RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ADRENAL FUNCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PLACENTA BARRIER; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; FEMALE; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRAUTERINE GROWTH RETARDATION; MALE; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; WEIGHT GAIN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADRENAL GLANDS; ANIMALS; CELLS, CULTURED; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CORTICOSTERONE; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEVELOPMENT; FETAL GROWTH RETARDATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MALE; MICE; PHOSPHOPROTEINS; PLACENTA; PREGNANCY; WEIGHT GAIN;

MUS;

EID: 80054105847     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.08.003     Document Type: Article

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