Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 5, 2008, Pages

  Momoi, Nobuo ^a   Tinney, Joseph P ^a   Liu, Li J ^a   Elshershari, Huda ^a   Hoffmann, Paul J ^a   Ralphe, John C ^a   Keller, Bradley B ^a   Tobita, Kimimasa ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Adenosine A2A receptor; Cardiovascular development; Carotid artery; Pregnancy

Indexed keywords

ADENOSINE A2A RECEPTOR; CAFFEINE; 1,3 DIMETHYL 8 CYCLOPENTYLXANTHINE; 1,3-DIMETHYL-8-CYCLOPENTYLXANTHINE; ADENOSINE A1 RECEPTOR; CENTRAL STIMULANT AGENT; MESSENGER RNA; MSX 3 COMPOUND; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA FLOW; ARTERY BLOOD FLOW; ARTICLE; CARDIOVASCULAR FUNCTION; CAROTID ARTERY; CONTROLLED STUDY; CROWN RUMP LENGTH; ECHOCARDIOGRAPHY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FETUS WEIGHT; GENE EXPRESSION; HEART DEVELOPMENT; HEART FUNCTION; HEMODYNAMICS; MOUSE; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL ARTERY; ANIMAL; AORTA; BLOOD; BLOOD FLOW; BLOOD FLOW VELOCITY; CARDIOVASCULAR SYSTEM; CHEMICALLY INDUCED DISORDER; DOPPLER ECHOCARDIOGRAPHY; DRUG ANTAGONISM; DRUG EFFECT; ECHOGRAPHY; EMBRYO DEATH; ENVIRONMENTAL EXPOSURE; GENETICS; GESTATIONAL AGE; INTRAUTERINE GROWTH RETARDATION; METABOLISM; METHODOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; AORTA; BLOOD FLOW VELOCITY; CAFFEINE; CARDIOVASCULAR SYSTEM; CAROTID ARTERIES; CENTRAL NERVOUS SYSTEM STIMULANTS; CROWN-RUMP LENGTH; ECHOCARDIOGRAPHY, DOPPLER, PULSED; EMBRYO LOSS; FEMALE; FETAL GROWTH RETARDATION; FETAL WEIGHT; GESTATIONAL AGE; HEMODYNAMICS; INJECTIONS, SUBCUTANEOUS; MATERNAL EXPOSURE; MICE; PREGNANCY; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; REGIONAL BLOOD FLOW; RNA, MESSENGER; ULTRASONOGRAPHY, PRENATAL; UMBILICAL ARTERIES; XANTHINES;

EID: 44949116156     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.91469.2007     Document Type: Article

References (51)

1. Abdi F, Pollard I, Wilkinson J. Placental transfer and foetal disposition of caffeine and its immediate metabolites in the 20-day pregnant rat: function of dose. Xenobiotica 23: 449-456, 1993.
2. 2b adenosine receptor during implantation chamber development. Dev Dyn 216: 127-136, 1999.
3. Blood AB, Hunter CJ, Power GG. The role of adenosine in regulation of cerebral blood flow during hypoxia in the near-term fetal sheep. J Physiol 543: 1015-1023, 2002.
4. Bonati M, Latini R, Tognoni G, Young JF, Garattini S. Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouse. Drug Metab Rev 15: 1355-1383, 1984.
5. Chalothorn D, McCune DF, Edelmann SE, Tobita K, Keller BB, Lasley RD, Perez DM, Tanoue A, Tsujimoto G, Post GR, Piascik MT. Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes. J Pharmacol Exp Ther 305: 1045-1053, 2003.
6. Chorostowska-Wynimko J, Skopinska-Rozewska E, Sommer E, Rogala E, Skopinski P, Wojtasik E. Multiple effects of theobromine on fetus development and postnatal status of the immune system. Int J Tissue React 26: 53-60, 2004.
7. Chou CC, Vickroy TW. Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. Am J Vet Res 64: 216-224, 2003.
8. Christian MS, Brent RL. Teratogen update: evaluation of the reproductive and developmental risks of caffeine. Teratology 64: 51-78, 2001.
9. Cnattingius S, Signorello LB, Anneren G, Clausson B, Ekbom A, Ljunger E, Blot WJ, McLaughlin JK, Petersson G, Rane A, Granath F. Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med 343: 1839-1845, 2000.
10. Conover WB, Key TC, Resnik R. Maternal cardiovascular response to caffeine infusion in the pregnant ewe. Am J Obstet Gynecol 145: 534-538, 1983.
11. Cook DG, Peacock JL, Feyerabend C, Carey IM, Jarvis MJ, Anderson HR, Bland JM. Relation of caffeine intake and blood caffeine concentrations during pregnancy to fetal growth: prospective population based study. BMJ 313: 1358-1362, 1996.
12. Edwards LJ, McMillen IC. Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo-pituitary adrenal axis in sheep during late gestation. Biol Reprod 66: 1562-1569, 2002.
13. Fernandes O, Sabharwal M, Smiley T, Pastuszak A, Koren G, Einarson T. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 12: 435-444, 1998.
14. Frary CD, Johnson RK, Wang MQ. Food sources and intakes of caffeine in the diets of persons in the United States. J Am Diet Assoc 105: 110-113, 2005.
15. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51: 83-133, 1999.
16. Galli C, Spano PF, Szyszka K. Accumulation of caffeine and its metabolites in rat fetal brain and liver. Pharmacol Res Commun 7: 217-221, 1975.
17. Golding J. Reproduction and caffeine consumption - a literature review. Early Hum Dev 43: 1-14, 1995.
18. Goldstein A, Warren R. Passage of caffeine into human gonadal and fetal tissue. Biochem Pharmacol 11: 166-168, 1962.
19. Grosso LM, Triche EW, Belanger K, Benowitz NL, Holford TR, Bracken MB. Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction. Am J Epidemiol 163: 1035-1041, 2006.
20. Hawkins JA, Hu N, Clark EB. Effect of caffeine on cardiovascular function in the stage 24 chick embryo. Dev Pharmacol Ther 7: 334 -343, 1984.
21. Hey E. Coffee and pregnancy. BMJ 334: 377, 2007.
22. Infante-Rivard C, Fernandez A, Gauthier R, David M, Rivard GE. Fetal loss associated with caffeine intake before and during pregnancy. JAMA 270: 2940-2943, 1993.
23. Jacombs A, Ryan J, Loupis A, Pollard I. Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos. Reprod Fertil Dev 11: 211-218, 1999.
24. Kimmel CA, Kimmel GL, White CG, Grafton TF, Young JF, Nelson CJ. Blood flow changes and conceptual development in pregnant rats in response to caffeine. Fundam Appl Toxicol 4: 240-247, 1984.
25. Kirkinen P, Jouppila P, Koivula A, Vuori J, Puukka M. The effect of caffeine on placental and fetal blood flow in human pregnancy. Am J Obstet Gynecol 147: 939-942, 1983.
26. Klebanoff MA, Levine RJ, Clemens JD, Wilkins DG. Maternal serum caffeine metabolites and small-for-gestational age birth. Am J Epidemiol 155: 32-37, 2002.
27. 2A receptors. Biochem Pharmacol 57: 65-75, 1999.
28. León D, Albasanz JL, Ruíz MA, Iglesias I, Martín M. Effect of chronic gestational treatment with caffeine or theophylline on group I metabotropic glutamate receptors in maternal and fetal brain. J Neurochem 94: 440-451, 2005.
29. Miller RC, Watson WJ, Hackney AC, Seeds JW. Acute maternal and fetal cardiovascular effects of caffeine ingestion. Am J Perinatol 11: 132-136, 1994.
30. Nakazawa M, Miyagawa S, Ohno T, Miura S, Takao A. Developmental hemodynamic changes in rat embryos at 11 to 15 days of gestation: normal data of blood pressure and the effect of caffeine compared to data from chick embryo. Pediatr Res 23: 200-205, 1988.
31. Nehlig A, Debry G. Potential teratogenic and neurodevelopmental consequences of coffee and caffeine exposure: a review on human and animal data. Neurotoxicol Teratol 16: 531-543, 1994.
32. Parazzini F, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G. Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation. Hum Reprod 13: 2286-2291, 1998.
33. Phoon CK, Aristizabal O, Turnbull DH. 40 MHz Doppler characterization of umbilical and dorsal aortic blood flow in the early mouse embryo. Ultrasound Med Biol 26: 1275-1283, 2000.
34. Pollard I, Murray JF, Hiller R, Scaramuzzi RJ, Wilson CA. Effects of preconceptual caffeine exposure on pregnancy and progeny viability. J Matern Fetal Med 8: 220-224, 1999.
35. Salvador HS, Koos BJ. Effects of regular and decaffeinated coffee on fetal breathing and heart rate. Am J Obstet Gynecol 160: 1043-1047, 1989.
36. Savitz DA, Chan RL, Herring AH, Howards PP, Hartmann KE. Caffeine and miscarriage risk. Epidemiology 19: 55-62, 2008.
37. 2A subtype receptor agonists. Br J Pharmacol 144: 642-650, 2005.
38. Shen Y, Leatherbury L, Rosenthal J, Yu Q, Pappas MA, Wessels A, Lucas J, Siegfried B, Chatterjee B, Svenson K, Lo CW. Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects. Physiol Genomics 24: 23-36, 2005.
39. Sissman NJ. Developmental landmarks in cardiac morphogenesis: comparative chronology. Am J Cardiol 25: 141-148, 1970.
40. Stevens AD, Lumbers ER. Effects of reduced uterine blood flow on fetal cardiovascular, renal, and lung function. Am J Physiol Regul Integr Comp Physiol 259: R1004-R1011, 1990.
41. Tobita K, Tinney JP, Keller BB. Analysis of murine embryonic cardiovascular phenotype. In: Cardiovascular Physiology in the Genetically Engineered Mouse, edited by Hoit BD, Walsh RA. Norwell, MA: Kluwer Academic, 2003.
42. Tomimatsu T, Lee SJ, Peña JP, Ross JM, Lang JA, Longo LD. Maternal caffeine administration and cerebral oxygenation in near-term fetal sheep. Reprod Sci 14: 588-594, 2007.
43. Tsai EM, Lea JN, Chiang PH, Huang MS. Adenosine modulation of neurotransmission in human uterine arteries. Mol Hum Reprod 2: 105-109, 1996.
44. Watson ED, Cross JC. Development of structures and transport functions in the mouse placenta. Physiology (Bethesda) 20: 180 -193, 2005.
45. Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 198: 279.e1-279.e8, 2008.
46. Wilson SJ, Ayromlooi J, Errick JK. Pharmacokinetic and hemodynamic effects of caffeine in the pregnant sheep. Obstet Gynecol 61: 486-492, 1983.
47. Xu D, Kong HY, Liang BT. Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes. Circ Res 70: 56-65, 1992.
48. Yoneyama Y, Sawa R, Suzuki S, Shin S, Power GG, Araki T. The relationship between uterine artery Doppler velocimetry and umbilical venous adenosine levels in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 174: 267-271, 1996.
49. Yoneyama Y, Wakatsuki M, Sawa R, Kamoi S, Takahashi H, Shin S, Kawamura T, Power GG, Araki T. Plasma adenosine concentration in appropriate- and small-for-gestational-age fetuses. Am J Obstet Gynecol 170: 684-688, 1994.
50. Yoshigi M, Hu N, Keller BB. Dorsal aortic impedance in stage 24 chick embryo following acute changes in circulating blood volume. Am J Physiol Heart Circ Physiol 270: H1597-H1606, 1996.
51. Zhou YQ, Foster FS, Qu DW, Zhang M, Harasiewicz KA, Adamson SL. Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics 10: 113-126, 2002.