Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways

Toxicology and Applied Pharmacology

Volumn 262, Issue 2, 2012, Pages 205-216

  Liu, Yansong ^a   Xu, Dan ^a,b   Feng, Jianghua ^c,d   Kou, Hao ^a   Liang, Gai ^a   Yu, Hong ^b   He, Xiaohua ^b   Zhang, Baifang ^b   Chen, Liaobin ^b   Magdalou, Jacques ^e   Wang, Hui ^a,b  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c Wuhan National Laboratory for Optoelectronics   (China)

^d XIAMEN UNIVERSITY   (China)

^e Biopôle de l Université de Lorraine   (France)

Author keywords

Caffeine; Glucocorticoid; Intrauterine growth retardation; Intrauterine programming; Metabonome

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; ADIPONECTIN RECEPTOR 2; AMINO ACID; APOLIPOPROTEIN; CAFFEINE; GLUCOCORTICOID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; INSULIN RECEPTOR; LEPTIN RECEPTOR; LIPID;

AMNION FLUID; ARTICLE; CORTICOSTEROID METABOLISM; FEMALE; FETUS; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GESTATION PERIOD; GLUCOSE METABOLISM; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; METABOLISM; METABONOME; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRENATAL GROWTH; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REAL TIME POLYMERASE CHAIN REACTION; WISTAR RAT;

ANIMALS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; FEMALE; FETUS; GLUCOCORTICOIDS; GLUCOSE; LIPID METABOLISM; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MUSCLE, SKELETAL; PATERNAL EXPOSURE; PREGNANCY; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; SPECIFIC PATHOGEN-FREE ORGANISMS;

RATTUS; RATTUS NORVEGICUS;

EID: 84862245446     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.05.002     Document Type: Article

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