Dietary genistein induces sex-dependent effects on murine body weight, serum profiles, and vascular function of thoracic aortae

Gender Medicine

Volumn 9, Issue 5, 2012, Pages 295-308

  Al Nakkash, Layla ^a,b   Martin, Joshua B ^b   Petty, David ^b   Lynch, Shaina M ^b   Hamrick, Cristina ^a   Lucy, Dana ^a   Robinson, John ^c   Peterson, Amity ^a   Rubin, Leona J ^d   Broderick, Tom L ^a,b  

^a MIDWESTERN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

^c GRAND CANYON UNIVERSITY   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

diet; genistein; mouse; serum markers

Indexed keywords

GENISTEIN; GLUCOSE; INSULIN; N(G) NITROARGININE METHYL ESTER; NORADRENALIN;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIET THERAPY; FEMALE; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INSULIN BLOOD LEVEL; MALE; MOUSE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; THORACIC AORTA; VASCULAR RING; WEIGHT GAIN;

ANIMALS; AORTA, THORACIC; ARTERIAL PRESSURE; BIOLOGICAL MARKERS; BODY WEIGHT; DIET; DIETARY SUPPLEMENTS; FEMALE; GENISTEIN; MALE; MICE; MICE, INBRED C57BL; RISK FACTORS; SEX FACTORS;

EID: 84867100649     PISSN: 15508579     EISSN: 18787398     Source Type: Journal    
DOI: 10.1016/j.genm.2012.07.001     Document Type: Article

References (54)

1. P.A. Murphy Phytoestrogen content of processed soybean products Food Technol 36 1982 60 64
2. M. Suetsugi, L. Su, K. Karlsberg Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors Mol Cancer Res 1 2003 981 991
3. M.S. Anthony, T.B. Clarkson, C.L. Hughes Soybean isoflavones improve cardiovasular risk factors without affecting the reproductive system or peripubertal rhesus monkeys J Nutr 126 1996 43 50
4. D. Sliva Suppression of cancer invasiveness by dietary compounds Mini Rev Med Chem 8 2008 677 688
5. S. Hulley, D. Grady, T. Bush Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women Heart and Estrogen/Progestin Replacement Study (HERS) Research Group JAMA 280 1998 605 613
6. J. Manson, J. Hsia, K. Johnson Estrogen plus progestin and the risk of coronary heart disease N Engl J Med 349 2003 523 534
7. S. Furness, H. Roberts, J. Marjoribanks Hormone therapy in postmenopausal women and risk of endometrial hyperplasia Cochrane Database Syst Rev 15 2009 1 227
8. M. Nagai, T. Hashimoto, H. Yanagawa Relationship of diet to the incidence of esophageal and stomach cancer in Japan Nutr Cancer 3 1982 257 268
9. R.K. Severson, A.M. Nomura, J.S. Grove, G.N. Stemmermann A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii Cancer Res 49 1989 1857 1860
10. H.P. Lee, L. Gourley, S.W. Duffy Dietary effects on breast cancer risk in Singapore Lancet 337 1991 1197 1200
11. M.T. Goodman, L.R. Wilkens, J.H. Hankin Association of soy and fiber consumption with the risk of endometrial cancer Am J Epidemiol 146 1997 294 306
12. T. Fotsis, M. Pepper, H. Adlercreutz Genistein, a dietary-derived inhibitor of in vitro angiogenesis Proc Natl Acad Sci USA 90 1993 2690 2694
13. E.A. Kirk, P. Sutherland, S.A. Wang Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice J Nutr 128 1998 954 959
14. W. Wong, E. Smith, J. Stuff Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men Am J Clin Nutr 68 Suppl 1998 1385S 1389S
15. A. Lichtenstein Soy protein, isoflavones and cardiovascular disease risk J Nutr 128 1998 1589 1592
16. D. Goodman-Gruen, D. Kritz-Silverstein Usual dietary isoflavone intake is associated with cardiovascular disese risk factors in postmenopausal women J Nutr 131 2001 1202 1206
17. H.J. Teede, F.S. Dalais, D. Kotsopoulos Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women J Clin Endocrinol Metab 86 2001 3053 3060
18. K. Mahn, C. Borras, G.A. Knock Dietary soy isoflavone-induced increases in antioxidant and eNOS gene expression lead to improved edothelial function and reduced blood pressure in vivo FASEB J 19 2005 1755 1757
19. H.J. Teede, D. Giannopoulos, F.S. Dalais Randomized, controlled, cross-over trial of soy protein with isoflavones on blood pressure and arterial function in hypertensive subjects J Am Coll Nutr 25 2006 533 540
20. H. Teede, B. McGrath, L. DeSilva Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women Arterioscler Thromb Vasc Biol 23 2003 1066 1071
21. F. Squadrito, D. Altavilla, G. Squadrito Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats Cardiovasc Res 45 2000 454 462
22. W. Hall, N. Formanuik, D. Harnpanich A meal enriched with soy isofalvones increases nitric oxide-mediated vasodilation in healthy postmenopausal women J Nutr 138 2008 1288 1292
23. L. Al-Nakkash, L.L. Clarke, G.E. Rottinghaus Dietary genistein stimulates anion secretion across female murine intestine J Nutr 136 2006 2785 2790
24. L.J. Rubin, L.R. Johnson, J.R. Dodam Selective transport of adenosine into porcine coronary smooth muscle Am J Physiol 279 2000 H1397 H1410
25. S.J. Bhathena, M.T. Velasquez Beneficial role of dietary phytoestrogens in obesity and diabetes Am J Clin Nutr 76 2002 1191 1201
26. R. Tissier, X. Waintraub, N. Couvreur Pharmacological postconditioning with the phytoestrogen genistein J Mol Cell Cardiol 42 2007 79 87
27. S. Hendrich, K.W. Lee, X. Xu Defining food components as new nutrients J Nutr 124 Suppl 1994 1789S 1792S
28. R.C. Santell, Y.C. Chang, M.G. Nair, W.G. Helferich Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats J Nutr 127 1997 263 269
29. A. Bhandari, S.E. Crawford, L. Huang, W.W. Reenstra Effects of oral genistein in mice Pediatr Pathol Mol Med 22 2003 131 141
30. H. Si, D. Liu Genistein, a soy phytoestrogen, upregulates the expression of human endothelial bitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats J Nutr 138 2008 297 304
31. H. Si, D. Liu Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats J Nutr 138 2008 297 304
32. S.A. Park, M.-S. Choi, S.-Y. Cho Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice Life Sci 2006 1207 1233
33. A. Orgaard, L. Jensen The effects of soy isoflavones on obesity Exp Biol Med (Maywood) 233 2008 1066 1080
34. H.-K. Kim, C. Nelson-Dooley, M.A. Della-Fera Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice J Nutr 136 2006 409 414
35. L. Al-Nakkash, B. Markus, K. Bowden Effects of acute and 2-day genistein treatment on cardiac function and ischemic tolerance in ovariectomized rats Gender Med 6 2009 488 497
36. R. Vera, M. Galisteo, I.C. Villar Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric oxide synthase, superoxide, and cyclooxygenase metabolites J Pharmacol Exp Ther 314 2005 1300 1309
37. Y.M. Seok, I. Baek, Y.-H. Kim Isoflavone attenuates vascular contraction through inhibition of the RhoA/Rho-kinase signaling pathway J Pharmacol Exp Ther 326 2008 991 998
38. H.D. Je, U.D. Sohn Inhibitory effect of genistein on agonist-induced modulation of vascular contractility Mol Cells 27 2009 191 198
39. J.M. Kim, Y. Uehara, Y.J. Choi Mechanism of attenuation of pro-inflammatory Ang II-induced NF-kB activation by genistein in the kidneys of male rats during aging Biogerontology 12 2011 537 550
40. A. Fintha, A. Sebe, A. Masszi Angiotensin II activates plasminogen activator inhibitor-I promoter in renal tubular epithelial cells via the AT1 receptor Acta Physiol Hung 94 2007 19 30
41. T. Sugiyama, T. Yoshimoto, K. Tsuchiya Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells Endocrinology 146 2005 3900 3906
42. A. Papapetropoulos, S. Andreopoulos, C.Y. Go Regulation of the nitric oxide synthase-nitric oxide-cGMP pathway in rat mesenteric endothelial cells J Appl Physiol 91 2001 2553 2560
43. T. Ogiwara, G. Murdoch, C.L. Chik, A.K. Ho Tyrosine kinase inhibitors enhance cGMP production in rat pinealocytes Biochem Biophys Res Commun 207 1995 994 1002
44. A. Friebe, D. Koesling Regulation of nitric oxide-sensitive guanylyl cyclase Circ Res 93 2003 96 105
45. R. Smith, J. Tiesinga, N. Shah Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin Arch Biochem Biophys 300 1993 238 246
46. M. Bazuine, P. van den Broek, A. Maassen Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes Biochem Biophys Res Commun 326 2005 511 514
47. M. Nomura, T. Takahashi, N. Nagata Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells Biol Pharm Bull 31 2008 1403 1409
48. M. Lee, C. Kim, D. Hoang Genistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes Biol Pharm Bull 32 2009 504 508
49. P. Villa, B. Costantini, R. Suriano The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status J Clin Endocrinol Metab 94 2009 552 558
50. S.M. Salih, P. Nallasamy, P. Muniyandi Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance J Diabetes 1 2009 278 287
51. R.L. Sorenson, T.C. Brelje, C. Roth effect of tyrosine kinase inhibitors on islets of Langerhans: evidence for tyrosine kinases in the regulation of insulin secretion Endocrinology 134 1994 1955 1958
52. R.V. Veloso, M.Q. Latorraca, V.C. Atrantes Soybean diet improves insulin secretion through activation of cAMP/PKA pathway in rats J Nutr Biochem 19 2008 778 784
53. Z. Fu, D. Liu Long term exposure to genistein improves insulin secretory function of pancreatic B-cells Eur J Pharmacol 616 2009 321 327
54. Z. Fu, W. Zhang, W. Zhen Genistein induces pancreatic B-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice Endocrinology 151 2010 3026 3037