Does calcium intake affect cardiovascular risk factors and/or events?

Clinics

Volumn 67, Issue 7, 2012, Pages 839-844

  Torres, Márcia Regina Simas Gonçalves ^a   Sanjuliani, Antonio Felipe ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cardiovascular events; Cardiovascular risk factors; Dietary calcium; Obesity; Supplemental calcium

Indexed keywords

CALCIUM INTAKE; CARDIOVASCULAR DISEASE; DAIRY PRODUCT; HUMAN; REVIEW; RISK FACTOR;

CALCIUM, DIETARY; CARDIOVASCULAR DISEASES; DAIRY PRODUCTS; HUMANS; RISK FACTORS;

EID: 84867080551     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.6061/clinics/2012(07)22     Document Type: Review

References (74)

1. Artinian NT, Fletcher GF, Mozaffarian D, Kris-Etherton P, Van Horn L, Lichtenstein AH, et al. Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults. A Scientific Statement from the American Heart Association. Circulation. 2010;122(4):406-41.
2. Zemel MB. The role of dairy foods in weight management. J Am Coll Nutr. 2005;24(6 supl):537S-46S.
3. Dougkas A, Reynolds CK, Givens ID, Elwood PC, Minihane AM. Associations between dairy consumption and body weight: a review of the evidence and underlying mechanisms. Nutr Res Rev. 2011;15:1-24.
4. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92(6):2017-29, http://dx.doi.org/10.1210/jc.2007-0298.
5. Pittas AG, Dawson-Hughes B, Li Tricia, Van Dam RM, Willett WC, Manson JE, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006;29(3):650-6, http://dx.doi.org/10.2337/diacare.29.03.06.dc05-1961.
6. Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB. Dairy consumption and risk of type 2 diabetes mellitus in men. Arch Intern Med. 2005;165:997-1003, http://dx.doi.org/10.1001/archinte.165.9.997.
7. Villegas R, Gao YT, Dai Q, Yang G, Cai H, Li H, et al. Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study. Am J Clin Nutr. 2009;89(4):1059-67, http://dx.doi.org/10.3945/ajcn.2008.27182.
8. Fumeron F, Lamri A, Khalil AC, Jaziri R, Porchay-Baldérelli I, Lantieri O, et al. Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome. Diabetes Care. 2011;34(4):813-7, http://dx.doi.org/10.2337/dc10-1772.
9. Jacqmain M, Doucet E, Després JP, Bouchard C, Tremblay A. Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr. 2003;77(6):1448-52.
10. Ditscheid B, Keller S, Jahreis G. Cholesterol metabolism is affected by calcium phosphate supplementation in humans. J Nutr. 2005;135(7):1678-82.
11. Major GC, Alarie F, Doré J, Phouttama S, Tremblay A. Supplementation with calcium + vitamin D enhanced the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Am J Clin Nutr. 2007;85(1):54-9.
12. Lorenzen JK, Astrup A. Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet. Br J Nutr. 2011 Jan 31:1-10, http://dx.doi.org/10.1017/S0007114510005581.
13. Ruidavets J-B, Bongard V, Simon C, Dallongeville J, Ducimetière P, Arveiler D, et al. Independent contribution of dairy products and calcium intake to blood pressure variations at a population level. J Hypertens. 2006;24(4):671-81, http://dx.doi.org/10.1097/01.hjh.0000217849.10831.16.
14. Snijder MB, van der Heijden AAWA, van Dam RM, Stehouwer CDA, Hiddink GJ, Nijpels G, et al. Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Horn Study. Am J Clin Nutr. 2007;85(4):989-95.
15. Wang L, Manson JE, Buring JE, Lee IM, Sesso HD. Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middleaged and older women. Hypertension. 2008;51(1):1-7.
16. Engberink MF, Hendriksen MAH, Schouten EG, van Rooij FJA, Hofman A, Witteman JCM, et al. Inverse association between dairy intake and hypertension: the Rotterdam Study. Am J Clin Nutr. 2009;89(6):1877-83.
17. vanMierlo LA, Arends LR, Streppel MT, Zeegers MP, Kok FJ, Grobbee DE, et al. Blood pressure response to calcium supplementation: a metaanalysis of randomized controlled trials. J Hum Hypertens. 2006;20(8):571-80, http://dx.doi.org/10.1038/sj.jhh.1002038.
18. Griffith LE, Guyatt GH, Cook RJ, Bucher HC, Cook DJ. The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials. Am J Hypertens. 1999;12 (1 Pt 1):84-92, http://dx.doi.org/10.1016/S0895-7061(98)00224-6.
19. Sun X, Zemel MB. Calcium and 1,25-Dihydroxyvitamin D3 Regulation of Adipokine Expression. Obesity. 2007;15(2):340-8, http://dx.doi.org/10.1038/oby.2007.540.
20. Zemel MB, Sun X, Sobhani T, Wilson B. Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. Am J Clin Nutr. 2010;91(1):16-22, http://dx.doi.org/10.3945/ajcn.2009.28468.
21. Elwood PC, Pickering JE, Givens DI, Gallacher JE. The Consumption of milk and dairy foods and the incidence of vascular disease and diabetes: An overview of the evidence. Lipids. 2010;45(10):925-39, http://dx.doi.org/10.1007/s11745-010-3412-5.
22. Elwood PC, Givens DI, Beswick AD, Fehily AM, Pickering JE, Gallacher J. The survival advantage of milk and dairy consumption: an overview of evidence from cohort studies of vascular diseases, diabetes and cancer. J Am Coll Nutr. 2008;27(6):723S-34S.
23. Elwood PC, Pickering JE, Fehily AM. Milk and dairy consumption, diabetes and the metabolic syndrome: the Caerphilly prospective study. J Epidemiol Community Health. 2007;61(8):695-8, http://dx.doi.org/10.1136/jech.2006.053157.
24. Elwood PC, Strain JJ, Robson PJ, Fehily AM, Hughes J, Pickering J, et al. Milk consumption, stroke, and heart attack risk: evidence from the Caerphilly cohort of older men. J Epidemiol Community Health. 2005;59(6):502-5, http://dx.doi.org/10.1136/jech.2004.027904.
25. Pereira MA, Jacobs DR, Horn LV, Slattery ML, Kartashov AI, Ludwig DS. Dairy consumption, obesity, and the insulin resistance syndrome in young adults. The CARDIA study. JAMA. 2002;287(16):2081-9, http://dx.doi.org/10.1001/jama.287.16.2081.
26. Hanks LJ, Casazza K, Willig AL, Cardel MI, Beasley TM, Fernandez JR. Associations among calcium intake, resting energy expenditure, and body fat in a multiethnic sample of children. J Pediatr. 2010;157(3):473-8.
27. Bush NC, Alvarez JA, Choquette SS, Hunter GR, Oster RA, Darnell BE, et al. Dietary calcium intake is associated with less gain in intraabdominal adipose tissue over 1 year. Obesity. 2010;18(11):2101-4, http://dx.doi.org/10.1038/oby.2010.39.
28. Torres MRSG, Ferreira TS, Carvalho DC, Sanjuliani AF. Dietary calcium intake and its relationship with adiposity and metabolic profile in hypertensive patients. Nutrition. 2011;27(6):666-71, http://dx.doi.org/10.1016/j.nut.2010.07.012.
29. Torres MRSG, Gioseffi G, Guimarães SSMS, Cardoso LG, Barroso SG, Sanjuliani AF, et al. A Pilot study on the relation between dietary calcium and clinical parameters in renal transplant recipients. J Ren Nutr. 2011;21(5):418-25, http://dx.doi.org/10.1053/j.jrn.2010.08.007.
30. Shahar DR, Schwarzfuchs D, Fraser D, Vardi H, Thiery J, Fiedler GM, et al. Dairy calcium intake, serum vitamin D, and successful weight loss. Am J Clin Nutr. 2010;92(5):1017-22, http://dx.doi.org/10.3945/ajcn.2010.29355.
31. Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res. 2004;12(4):582-90, http://dx.doi.org/10.1038/oby.2004.67.
32. Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes Relat Metab Disord. 2005;29(4):391-7, http://dx.doi.org/10.1038/sj.ijo.0802880.
33. Zemel MB, Richards J, Milstead A, Campbell P. Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res. 2005;13(7):1218-25, http://dx.doi.org/10.1038/oby.2005.144.
34. Harvey-Berino J, Gold BC, Lauber R, Starinski A. The impact of calcium and dairy product consumption on weight loss. Obes Res. 2005;13(10):1720-6, http://dx.doi.org/10.1038/oby.2005.210.
35. Thompson WG, Holdman NR, Janzow DJ, Slezak JM, Morris KL, Zemel MB. Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults. Obes Res. 2005;13(8):1344-53, http://dx.doi.org/10.1038/oby.2005.163.
36. Torres MRSG, Francischetti EA, Genelhu V, Sanjuliani AF. Effect of a high-calcium energy-reduced diet on abdominal obesity and cardiometabolic risk factors in obese Brazilian subjects. Int J Clin Pract. 2010;64(8):1076-83, http://dx.doi.org/10.1111/j.1742-1241.2009.02312.x.
37. Shapses SA, Heshka S, Heymsfield SB. Effect of calcium supplementation on weight and fat loss in women. J Clin Endocrinol Metab. 2004;89(2):632-7, http://dx.doi.org/10.1210/jc.2002-021136.
38. Reid IR, Horne A, Mason B, Ames R, Bava U, Gamble GD. Effects of calcium supplementation on body weight and blood pressure in normal older women. J Clin Endocrinol Metab. 2005;90(7):3824-9, http://dx.doi.org/10.1210/jc.2004-2205.
39. Reid IR, Ames R, Mason B, Bolland MJ, Bacon CJ, Reid HE, et al. Effects of calcium supplementation on lipids, blood pressure, and body composition in healthy older men: a randomized controlled trial. Am J Clin Nutr. 2010;91(1):131-9, http://dx.doi.org/10.3945/ajcn.2009.28097.
40. Shalileh M, Shidfar F, Haghani H, Eghtesadi S, Heydari I. The influence of calcium supplement on body composition, weight loss and insulin resistance in obese adults receiving low calorie diet. J Res Med Sci. 2010;15(4):191-201.
41. Palacios C, Bertrán JJ, Ríos RE, Soltero S. No effects of low and high consumption of dairy products and calcium supplements on body composition and serum lipids in Puerto Rican obese adults. Nutrition. 2011;27(5):520-5, http://dx.doi.org/10.1016/j.nut.2010.02.011.
42. Eagan MS, Lyle RM, Gunther CW, Peacock M, Teegarden D. Effect of 1-year dairy product intervention on fat mass in young women: 6-month follow-up. Obesity. 2006;14(12):2242-8, http://dx.doi.org/10.1038/oby.2006.263.
43. Zemel MB, Donnelly JE, Smith BK, Sullivan DK, Richards J, Morgan-Hanusa D, et al. Effects of dairy intake on weight maintenance. Nutr Metab (Lond). 2008;5:28, http://dx.doi.org/10.1186/1743-7075-5-28.
44. Faghih SH, Abadi AR, Hedayati M, Kimiagar SM. Comparison of the effects of cows' milk, fortified soy milk, and calcium supplement on weight and fat loss in premenopausal overweight and obese women. Nutr Metab Cardiovasc Dis. 2011;21(7):499-503, http://dx.doi.org/10.1016/j.numecd.2009.11.013.
45. Van Loan M. The role of dairy foods and dietary calcium in weight management. J Am Coll Nutr. 2009;28(Suppl1):120S-9S.
46. Astrup A, Kristensen M, Gregersen NT, Belza A, Lorenzen JK, Due A, et al. Can bioactive foods affect obesity? Ann N Y Acad Sci. 2010;1190:25-41, http://dx.doi.org/10.1111/j.1749-6632.2009.05272.x.
47. MajorGC, Chaput JP, Ledoux M, St-Pierre S, AndersonGH, ZemelMB, et al. Recent developments in calcium-related obesity research. Obes Reviews. 2008;9(5):428-45, http://dx.doi.org/10.1111/j.1467-789X.2007.00465.x.
48. Jacobsen R, Lorenzen JK, Toubro S, Krog-Mikkelsen I, Astrup A. Effects of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion. Int J Obes (Lond). 2005;29(3):292-301, http://dx.doi.org/10.1038/sj.ijo.0802785.
49. Christensen R, Lorenzen JK, Svith CR, Bartels EM, Melanson EL, Saris WH, et al. Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials. Obes Rev. 2009;10(4):475-86, http://dx.doi.org/10.1111/j.1467-789X.2009.00599.x.
50. Major GC, Alarie FP, Tremblay A. Calcium plus vitamin D supplementation and fat mass loss in female very low-calcium consumers: potential link with a calcium-specific appetite control. Br J Nutr. 2009;101(5):659-63, http://dx.doi.org/10.1017/S0007114508030808.
51. Lorenzen JK, Nielsen S, Holst JJ, Tetens I, Rehfeld JF, Astrup A. Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake. Am J Clin Nutr. 2007;85(3):678-87.
52. Morris KL, Zemel MB. 1,25-dihydroxyvitmin D3 modulation of adipocyte glucocorticoid function. Obes Res. 2005;13(4):670-7, http://dx.doi.org/10.1038/oby.2005.75.
53. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The Effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007;30(4):980-6, http://dx.doi.org/10.2337/dc06-1994.
54. Zemel MB. Insulin resistance vs. hyperinsulinemia in hypertension: insulin regulation of Ca2+ transport and Ca(2+)-regulation of insulin sensitivity. J Nutr. 1995;125(6 Suppl):1738S-43S.
55. Rajpathak SN, Xue X, Wassertheil-Smoller S, Horn LV, Robinson JG, Liu S, et al. Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids. Am J Clin Nutr. 2010;91(4):894-9, http://dx.doi.org/10.3945/ajcn.2009.28579.
56. Vaskonen T. Dietary minerals and modification of cardiovascular risk factors. J Nutr Biochem. 2003;14(9):492-506, http://dx.doi.org/10.1016/S0955-2863(03)00074-3.
57. Miller GD, DiRienzo DD, Reusser ME, McCarron DA. Benefits of dairy product consumption on blood pressure in humans: a summary of the biomedical literature. J Am Coll Nutr. 2000;19(suppl):147S-64S.
58. Zemel MB. Calcium modulation of hypertension and obesity: Mechanisms and implications. J Am Coll Nutr. 2001;20(suppl):428S-35S.
59. Hoe SZ, Lee CN, Mok SL, Kamaruddin MY, Lami SK. Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels. CLINICS. 2011;66(1):143-50.
60. van Meijl LEC, Mensink RP. Effects of low-fat dairy consumption on markers of low-grade systemic inflammation and endothelial function in overweight and obese subjects: an intervention study. Br J Nutr. 2010;104(10):1523-7, http://dx.doi.org/10.1017/S0007114510002515.
61. Sun X, Zemel MB. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids. 2007;42(4):297-305, http://dx.doi.org/10.1007/s11745-007-3029-5.
62. Reid IR, Bolland MJ, Grey A. Does calcium supplementation increase cardiovascular risk? Clinical Endocrinology. 2010;73(6):689-95, http://dx.doi.org/10.1111/j.1365-2265.2010.03792.x.
63. Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, Ames R, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ. 2008;336(7638):262-6, http://dx.doi.org/10.1136/bmj.39440.525752.BE.
64. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events. BMJ. 2011;342:d2040, http://dx.doi.org/10.1136/bmj.d2040.
65. Lewis JR, Calver J, Zhu K, Flicker L, Prince RL. Calcium supplementation and risk of atherosclerotic vascular disease in older women. J Bone Miner Res. 2011;26(1):35-41, http://dx.doi.org/10.1002/jbmr.176.
66. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010;341:doi:10.1136/bmj.c3691.
67. Jackson G. Calcium supplements and cardiovascular disease-A response. Int J Clin Pract. 2011;65(2):227-8, http://dx.doi.org/10.1111/j.1742-1241.2010.02605.x.
68. Nordin BE, Daly RM, Horowitz J, Metcalfe AV. Calcium and heart attacks. Making too much of a weak case. BMJ. 2010;341:c4997, http://dx.doi.org/10.1136/bmj.c4997.
69. Grove ML, Cook D. Calcium and heart attacks. Doesnt apply to most calcium prescriptions. BMJ. 2010;341:c5003, http://dx.doi.org/10.1136/bmj.c5003.
70. Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR. Dietary supplements and mortality rate in older women. The Iowa Women's Health Study. Arch Intern Med. 2011;171(18):1625-33.
71. Shah SM, Carey IM, Harris T, DeWilde S, Cook DG. Calcium supplementation, cardiovascular disease and mortality in older women. Pharmacoepidemiol Drug Saf. 2010;19(1):59-64, http://dx.doi.org/10.1002/pds.1859.
72. LaCroix AZ, Kotchen J, Anderson G, Brzyski R, Cauley JA, Cummings SR, et al. Calcium plus vitamin D supplementation and mortality in postmenopausal women: The Women's Health Initiative Calcium-Vitamin D Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2009;64(5):559-67, http://dx.doi.org/10.1093/gerona/glp006.
73. Neuhouser ML, Wassertheil-Smoller S, Thomson C, Aragaki A, Anderson GL, Manson JE, et al. Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative Cohorts. Arch Intern Med. 2009;169(3):294-304, http://dx.doi.org/10.1001/archinternmed.2008.540.
74. Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007;115(7):846-54, http://dx.doi.org/10.1161/CIRCUL ATIONAHA.106.673491.