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Volumn 8, Issue , 2008, Pages

TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; NERVE CELL ADHESION MOLECULE; PROTEIN P53; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

EID: 47549110073     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-191     Document Type: Article
Times cited : (20)

References (56)
  • 1
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • 10.1016/S0092-8674(00)00121-5 11057902
    • Massague J Blain SW Lo RS TGFbeta signaling in growth control, cancer, and heritable disorders Cell 2000, 103:295-309. 10.1016/ S0092-8674(00)00121-5 11057902
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 3
    • 7044228192 scopus 로고    scopus 로고
    • Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice
    • 10.1002/hep.20426 15389868
    • Oe S Lemmer ER Conner EA Factor VM Leveen P Larsson J Karlsson S Thorgeirsson SS Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice Hepatology 2004, 40:1098-1105. 10.1002/hep.20426 15389868
    • (2004) Hepatology , vol.40 , pp. 1098-1105
    • Oe, S.1    Lemmer, E.R.2    Conner, E.A.3    Factor, V.M.4    Leveen, P.5    Larsson, J.6    Karlsson, S.7    Thorgeirsson, S.S.8
  • 5
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-beta 1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • 10.1053/j.gastro.2005.09.055 16285938
    • Giannelli G Bergamini C Fransvea E Sgarra C Antonaci S Laminin-5 with transforming growth factor-beta 1 induces epithelial to mesenchymal transition in hepatocellular carcinoma Gastroenterology 2005, 129:1375-1383. 10.1053/j.gastro.2005.09.055 16285938
    • (2005) Gastroenterology , vol.129 , pp. 1375-1383
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Sgarra, C.4    Antonaci, S.5
  • 6
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • 10.1074/jbc.M700998200 17513865
    • Kaimori A Potter J Kaimori JY Wang C Mezey E Koteish A Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro J Biol Chem 2007, 282:22089-22101. 10.1074/jbc.M700998200 17513865
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 7
    • 38549143883 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease
    • 10.1038/labinvest.3700704 18059363
    • Rygiel KA Robertson H Marshall HL Pekalski M Zhao L Booth TA Jones DE Burt AD Kirby JA Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease Lab Invest 2008, 88:112-123. 10.1038/labinvest.3700704 18059363
    • (2008) Lab Invest , vol.88 , pp. 112-123
    • Rygiel, K.A.1    Robertson, H.2    Marshall, H.L.3    Pekalski, M.4    Zhao, L.5    Booth, T.A.6    Jones, D.E.7    Burt, A.D.8    Kirby, J.A.9
  • 8
    • 33847025287 scopus 로고    scopus 로고
    • Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: Implications in liver carcinogenesis
    • 10.1016/j.cellsig.2006.09.002 17055226
    • Caja L Conrad O Esther B Murillo MM Miro-Obradors MJ Palacios E Fabregat I Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: Implications in liver carcinogenesis Cellular Signalling 2007, 19:683-694. 10.1016/j.cellsig.2006.09.002 17055226
    • (2007) Cellular Signalling , vol.19 , pp. 683-694
    • Caja, L.1    Conrad, O.2    Esther, B.3    Murillo, M.M.4    Miro-Obradors, M.J.5    Palacios, E.6    Fabregat, I.7
  • 9
    • 33747362847 scopus 로고    scopus 로고
    • Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands
    • 10.1016/j.yexcr.2006.05.017 16828470
    • Del Castillo G Murillo MM Alvarez-Barrientos A Bertran E Fernandez M Sanchez A Fabregat I Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands Exp Cell Res 2006, 312:2860-2871. 10.1016/j.yexcr.2006.05.017 16828470
    • (2006) Exp Cell Res , vol.312 , pp. 2860-2871
    • Del Castillo, G.1    Murillo, M.M.2    Alvarez-Barrientos, A.3    Bertran, E.4    Fernandez, M.5    Sanchez, A.6    Fabregat, I.7
  • 10
    • 0028959114 scopus 로고
    • Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers
    • 7875675
    • Bedossa P Peltier E Terris B Franco D Poynard T Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers Hepatology 1995, 21:760-766. 7875675
    • (1995) Hepatology , vol.21 , pp. 760-766
    • Bedossa, P.1    Peltier, E.2    Terris, B.3    Franco, D.4    Poynard, T.5
  • 11
    • 0037257691 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta1 and transforming growth factor-beta receptors in hepatocellular carcinoma and dysplastic nodules
    • 10.1097/01.MP.0000047308.03300.9C 12527718
    • Paik SY Park YN Kim H Park C Expression of transforming growth factor-beta1 and transforming growth factor-beta receptors in hepatocellular carcinoma and dysplastic nodules Mod Pathol 2003, 16:86-96. 10.1097/01.MP.0000047308.03300.9C 12527718
    • (2003) Mod Pathol , vol.16 , pp. 86-96
    • Paik, S.Y.1    Park, Y.N.2    Kim, H.3    Park, C.4
  • 12
    • 19544368435 scopus 로고    scopus 로고
    • Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis
    • 10.1016/j.yexcr.2005.03.009 15922743
    • Halder SK Beauchamp RD Datta PK Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis Exp Cell Res 2005, 307:231-246. 10.1016/j.yexcr.2005.03.009 15922743
    • (2005) Exp Cell Res , vol.307 , pp. 231-246
    • Halder, S.K.1    Beauchamp, R.D.2    Datta, P.K.3
  • 13
    • 1842431049 scopus 로고    scopus 로고
    • Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: Resistance mechanism to transforming growth factor-beta
    • 15086168
    • Park YN Chae KJ Oh BK Choi J Choi KS Park C Expression of Smad7 in hepatocellular carcinoma and dysplastic nodules: Resistance mechanism to transforming growth factor-beta Hepatogastroenterology 2004, 51:396-400. 15086168
    • (2004) Hepatogastroenterology , vol.51 , pp. 396-400
    • Park, Y.N.1    Chae, K.J.2    Oh, B.K.3    Choi, J.4    Choi, K.S.5    Park, C.6
  • 14
    • 0035809057 scopus 로고    scopus 로고
    • HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation
    • 10.1016/S0167-4889(00)00137-3 11341983
    • Cho J Baek W Yang S Chang J Sung YC Suh M HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation Biochim Biophys Acta 2001, 1538:59-66. 10.1016/S0167-4889(00)00137-3 11341983
    • (2001) Biochim Biophys Acta , vol.1538 , pp. 59-66
    • Cho, J.1    Baek, W.2    Yang, S.3    Chang, J.4    Sung, Y.C.5    Suh, M.6
  • 15
    • 0035118852 scopus 로고    scopus 로고
    • Hepatitis B viral X protein overcomes inhibition of E2F1 activity by pRb on the human Rb gene promoter
    • 10.1089/104454901750070274
    • Choi BH Choi M Jeon HY Rho HM Hepatitis B viral X protein overcomes inhibition of E2F1 activity by pRb on the human Rb gene promoter DNA Cell Biol 2001, 20:75-80. 10.1089/104454901750070274 11244564
    • (2001) DNA Cell Biol , vol.20 , pp. 75-80
    • Choi, B.H.1    Choi, M.2    Jeon, H.Y.3    Rho, H.M.4
  • 16
    • 29144483321 scopus 로고    scopus 로고
    • Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase
    • 1307512 16332962 10.1073/pnas.0505605102
    • Munakata T Nakamura M Liang Y Li K Lemon SM Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase Proc Natl Acad Sci U S A 2005, 102:18159-18164. 1307512 16332962 10.1073/pnas.0505605102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18159-18164
    • Munakata, T.1    Nakamura, M.2    Liang, Y.3    Li, K.4    Lemon, S.M.5
  • 17
    • 33744791738 scopus 로고    scopus 로고
    • NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner
    • 10.1099/vir.0.81735-0 16690937
    • Deng L Nagano-Fujii M Tanaka M Nomura-Takigawa Y Ikeda M Kato N Sada K Hotta H NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner J Gen Virol 2006, 87:1703-1713. 10.1099/vir.0.81735-0 16690937
    • (2006) J Gen Virol , vol.87 , pp. 1703-1713
    • Deng, L.1    Nagano-Fujii, M.2    Tanaka, M.3    Nomura-Takigawa, Y.4    Ikeda, M.5    Kato, N.6    Sada, K.7    Hotta, H.8
  • 18
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • 10.1016/0092-8674(95)90039-X 7664346
    • Deng C Zhang P Harper JW Elledge SJ Leder P Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control Cell 1995, 82:675-684. 10.1016/0092-8674(95)90039-X 7664346
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 19
    • 4344623218 scopus 로고    scopus 로고
    • HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding
    • 15259070
    • Gong GZ Jiang YF He Y Lai LY Zhu YH Su XS HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding World J Gastroenterol 2004, 10:2223-2227. 15259070
    • (2004) World J Gastroenterol , vol.10 , pp. 2223-2227
    • Gong, G.Z.1    Jiang, Y.F.2    He, Y.3    Lai, L.Y.4    Zhu, Y.H.5    Su, X.S.6
  • 20
    • 0037042205 scopus 로고    scopus 로고
    • Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein
    • 10.1016/S0014-5793(02)02694-7 11997040
    • Han HJ Jung EY Lee WJ Jang KL Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein FEBS Lett 2002, 518:169-172. 10.1016/ S0014-5793(02)02694-7 11997040
    • (2002) FEBS Lett , vol.518 , pp. 169-172
    • Han, H.J.1    Jung, E.Y.2    Lee, W.J.3    Jang, K.L.4
  • 21
    • 2342484993 scopus 로고    scopus 로고
    • Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene
    • 407832 15107488 10.1093/nar/gkh553
    • Kwun HJ Jang KL Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene Nucleic Acids Res 2004, 32:2202-2213. 407832 15107488 10.1093/nar/gkh553
    • (2004) Nucleic Acids Res , vol.32 , pp. 2202-2213
    • Kwun, H.J.1    Jang, K.L.2
  • 22
    • 38349186208 scopus 로고    scopus 로고
    • Deficiency of G1 regulators P53, P21CIP and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest
    • 2206047 18021445 10.1186/1471-2407-7-215
    • Sheahan S Bellamy CO Dunbar DR Harrison DJ Prost S Deficiency of G1 regulators P53, P21CIP and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest BMC Cancer 2007, 7:215-225. 2206047 18021445 10.1186/1471-2407-7-215
    • (2007) BMC Cancer , vol.7 , pp. 215-225
    • Sheahan, S.1    Bellamy, C.O.2    Dunbar, D.R.3    Harrison, D.J.4    Prost, S.5
  • 23
    • 1542742110 scopus 로고    scopus 로고
    • Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes
    • 10.1038/sj.onc.1207280 14647424
    • Sheahan S Bellamy CO Treanor L Harrison DJ Prost S Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes Oncogene 2004, 23:1489-1497. 10.1038/sj.onc.1207280 14647424
    • (2004) Oncogene , vol.23 , pp. 1489-1497
    • Sheahan, S.1    Bellamy, C.O.2    Treanor, L.3    Harrison, D.J.4    Prost, S.5
  • 24
    • 34548044683 scopus 로고    scopus 로고
    • Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    • 10.1158/0008-5472.CAN-07-0381 17699762
    • Chen YW Klimstra DS Mongeau ME Tatem JL Boyartchuk V Lewis BC Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells Cancer Res 2007, 67:7589-7596. 10.1158/0008-5472.CAN-07-0381 17699762
    • (2007) Cancer Res , vol.67 , pp. 7589-7596
    • Chen, Y.W.1    Klimstra, D.S.2    Mongeau, M.E.3    Tatem, J.L.4    Boyartchuk, V.5    Lewis, B.C.6
  • 25
    • 0037063164 scopus 로고    scopus 로고
    • Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells
    • te R.H. van V. 10.1038/sj.onc.1205575 12096340
    • Vooijs M te RH van V Berns A Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells Oncogene 2002, 21:4635-4645. 10.1038/ sj.onc.1205575 12096340
    • (2002) Oncogene , vol.21 , pp. 4635-4645
    • Vooijs, M.1    Berns, A.2
  • 27
    • 0018197819 scopus 로고
    • Effects of Polyriboinosinic Acid, Polyribocytidylic Acid and A Mouse Interferon Preparation on Cytochrome P-450-Dependent Mono-Oxygenase Systems in Cultures of Primary Mouse Hepatocytes
    • 683177
    • Renton KW Deloria LB Mannering GJ Effects of Polyriboinosinic Acid, Polyribocytidylic Acid and A Mouse Interferon Preparation on Cytochrome P-450-Dependent Mono-Oxygenase Systems in Cultures of Primary Mouse Hepatocytes Molecular Pharmacology 1978, 14:672-681. 683177
    • (1978) Molecular Pharmacology , vol.14 , pp. 672-681
    • Renton, K.W.1    Deloria, L.B.2    Mannering, G.J.3
  • 28
    • 0022511846 scopus 로고
    • Use of A Low-Speed, Iso-Density Percoll Centrifugation Method to Increase the Viability of Isolated Rat Hepatocyte Preparations
    • 10.1007/BF02623304
    • Kreamer BL Staecker JL Sawada N Sattler GL Hsia MTS Pitot HC Use of A Low-Speed, Iso-Density Percoll Centrifugation Method to Increase the Viability of Isolated Rat Hepatocyte Preparations In Vitro Cellular & Developmental Biology 1986, 22:201-211. 10.1007/BF02623304
    • (1986) In Vitro Cellular & Developmental Biology , vol.22 , pp. 201-211
    • Kreamer, B.L.1    Staecker, J.L.2    Sawada, N.3    Sattler, G.L.4    Hsia, M.T.S.5    Pitot, H.C.6
  • 29
    • 0030612987 scopus 로고    scopus 로고
    • UV but not gamma-irradiation induces specific transcriptional activity of p53 in primary hepatocytes
    • 10.1002/(SICI)1096-9896(199710)183:2<177::AID-PATH909>3.0.CO;2-E 9390030
    • Bellamy CO Prost S Wyllie AH Harrison DJ UV but not gamma-irradiation induces specific transcriptional activity of p53 in primary hepatocytes J Pathol 1997, 183:177-181. 10.1002/ (SICI)1096-9896(199710)183:2<177::AID-PATH909>3.0.CO;2-E 9390030
    • (1997) J Pathol , vol.183 , pp. 177-181
    • Bellamy, C.O.1    Prost, S.2    Wyllie, A.H.3    Harrison, D.J.4
  • 30
    • 38349100956 scopus 로고    scopus 로고
    • The roles of P53 in hepatocytes
    • PhD Thesis.Edinburgh University PhD thesis
    • Bellamy C The roles of P53 in hepatocytes PhD Thesis.Edinburgh University PhD thesis 1997
    • (1997)
    • Bellamy, C.1
  • 31
    • 17744404952 scopus 로고    scopus 로고
    • Adenovirus-mediated Cre deletion of floxed sequences in primary mouse cells is an efficient alternative for studies of gene deletion
    • 55864 11504888 10.1093/nar/29.16.e80
    • Prost S Sheahan S Rannie D Harrison DJ Adenovirus-mediated Cre deletion of floxed sequences in primary mouse cells is an efficient alternative for studies of gene deletion Nucleic Acids Res 2001, 29:E80. 55864 11504888 10.1093/nar/29.16.e80
    • (2001) Nucleic Acids Res , vol.29
    • Prost, S.1    Sheahan, S.2    Rannie, D.3    Harrison, D.J.4
  • 32
    • 0031913275 scopus 로고    scopus 로고
    • Altered DNA repair and dysregulation of p53 in IRF-1 null hepatocytes
    • 9472983
    • Prost S Bellamy CO Cunningham DS Harrison DJ Altered DNA repair and dysregulation of p53 in IRF-1 null hepatocytes FASEB J 1998, 12:181-188. 9472983
    • (1998) FASEB J , vol.12 , pp. 181-188
    • Prost, S.1    Bellamy, C.O.2    Cunningham, D.S.3    Harrison, D.J.4
  • 33
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • 4561027
    • Kerr JF Wyllie AH Currie AR Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 1972, 26:239-257. 4561027
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 34
    • 0026318253 scopus 로고
    • Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells
    • 51457 2014262 10.1073/pnas.88.8.3412
    • Rotello RJ Lieberman RC Purchio AF Gerschenson LE Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells Proc Natl Acad Sci U S A 1991, 88:3412-3415. 51457 2014262 10.1073/pnas.88.8.3412
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 3412-3415
    • Rotello, R.J.1    Lieberman, R.C.2    Purchio, A.F.3    Gerschenson, L.E.4
  • 36
    • 0033786378 scopus 로고    scopus 로고
    • Rb function in cell-cycle regulation and apoptosis
    • 10.1038/35008695 10783254
    • Harbour JW Dean DC Rb function in cell-cycle regulation and apoptosis Nat Cell Biol 2000, 2:E65-E67. 10.1038/35008695 10783254
    • (2000) Nat Cell Biol , vol.2
    • Harbour, J.W.1    Dean, D.C.2
  • 37
    • 1542353401 scopus 로고    scopus 로고
    • Control of apoptosis by p53
    • 10.1038/sj.onc.1207116 14663481
    • Fridman JS Lowe SW Control of apoptosis by p53 Oncogene 2003, 22:9030-9040. 10.1038/sj.onc.1207116 14663481
    • (2003) Oncogene , vol.22 , pp. 9030-9040
    • Fridman, J.S.1    Lowe, S.W.2
  • 38
    • 0026560454 scopus 로고
    • TGF-beta: Regulation of extracellular matrix
    • 10.1038/ki.1992.81 1573828
    • Roberts AB McCune BK Sporn MB TGF-beta: Regulation of extracellular matrix Kidney Int 1992, 41:557-559. 10.1038/ki.1992.81 1573828
    • (1992) Kidney Int , vol.41 , pp. 557-559
    • Roberts, A.B.1    McCune, B.K.2    Sporn, M.B.3
  • 39
  • 40
    • 0031225074 scopus 로고    scopus 로고
    • Control of the G1 phase cyclin-dependent kinases by mitogenic growth factors and the extracellular matrix
    • 10.1016/S1359-6101(97)00011-7 9462482
    • Assoian RK Control of the G1 phase cyclin-dependent kinases by mitogenic growth factors and the extracellular matrix Cytokine Growth Factor Rev 1997, 8:165-170. 10.1016/S1359-6101(97)00011-7 9462482
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 165-170
    • Assoian, R.K.1
  • 41
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • 10.1038/nrm1835 16493418
    • Thiery JP Sleeman JP Complex networks orchestrate epithelial-mesenchymal transitions Nat Rev Mol Cell Biol 2006, 7:131-142. 10.1038/nrm1835 16493418
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 42
    • 34250738303 scopus 로고    scopus 로고
    • Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-beta signaling
    • 2043381 17587819 10.1159/000101314
    • Ahmed S Nawshad A Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-beta signaling Cells Tissues Organs 2007, 185:131-145. 2043381 17587819 10.1159/000101314
    • (2007) Cells Tissues Organs , vol.185 , pp. 131-145
    • Ahmed, S.1    Nawshad, A.2
  • 43
    • 0031050451 scopus 로고    scopus 로고
    • Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression
    • 10.1016/S0955-0674(97)80157-3 9013668
    • Assoian RK Zhu X Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression Curr Opin Cell Biol 1997, 9:93-98. 10.1016/S0955-0674(97)80157-3 9013668
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 93-98
    • Assoian, R.K.1    Zhu, X.2
  • 44
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • 8714286
    • Hay ED An overview of epithelio-mesenchymal transformation Acta Anatomica 1995, 154:8-20. 8714286
    • (1995) Acta Anatomica , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 45
    • 0029157019 scopus 로고
    • Transformations Between Epithelium and Mesenchyme - Normal, Pathological, and Experimentally-Induced
    • 10.1016/0272-6386(95)90610-X 7573028
    • Hay ED Zuk A Transformations Between Epithelium and Mesenchyme - Normal, Pathological, and Experimentally-Induced American Journal of Kidney Diseases 1995, 26:678-690. 10.1016/0272-6386(95)90610-X 7573028
    • (1995) American Journal of Kidney Diseases , vol.26 , pp. 678-690
    • Hay, E.D.1    Zuk, A.2
  • 46
    • 47949121503 scopus 로고    scopus 로고
    • Involvement of epithelial-to-mesenchymal transition (EMT) in chronic renal allograft dysfunction
    • 10.1111/j.1600-6143.2004.00387.x 15023137
    • Zeisberg M Chandraker A Sayegh MH Kalluri R Involvement of epithelial-to-mesenchymal transition (EMT) in chronic renal allograft dysfunction American Journal of Transplantation 2004, 4:458-458. 10.1111/ j.1600-6143.2004.00387.x 15023137
    • (2004) American Journal of Transplantation , vol.4 , pp. 458-458
    • Zeisberg, M.1    Chandraker, A.2    Sayegh, M.H.3    Kalluri, R.4
  • 47
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • 10.1038/sj.onc.1208927 16123809
    • Zavadil J Bottinger EP TGF-beta and epithelial-to-mesenchymal transitions Oncogene 2005, 24:5764-5774. 10.1038/sj.onc.1208927 16123809
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 48
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • 10.1038/nrm1175 12923528
    • Grunert S Jechlinger M Beug H Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis Nature Reviews Molecular Cell Biology 2003, 4:657-665. 10.1038/nrm1175 12923528
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , pp. 657-665
    • Grunert, S.1    Jechlinger, M.2    Beug, H.3
  • 49
    • 0034010320 scopus 로고    scopus 로고
    • Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix
    • 10.1016/S0168-8278(00)80401-8 10735620
    • Nagaki M Sugiyama A Naiki T Ohsawa Y Moriwaki H Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix J Hepatol 2000, 32:488-496. 10.1016/S0168-8278(00)80401-8 10735620
    • (2000) J Hepatol , vol.32 , pp. 488-496
    • Nagaki, M.1    Sugiyama, A.2    Naiki, T.3    Ohsawa, Y.4    Moriwaki, H.5
  • 50
  • 51
    • 0029883399 scopus 로고    scopus 로고
    • The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells
    • 8649852
    • Fan G Ma X Kren BT Steer CJ The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells Oncogene 1996, 12:1909-1919. 8649852
    • (1996) Oncogene , vol.12 , pp. 1909-1919
    • Fan, G.1    Ma, X.2    Kren, B.T.3    Steer, C.J.4
  • 52
    • 3342982324 scopus 로고    scopus 로고
    • p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells
    • 10.1023/B:APPT.0000018803.11260.02 15004518
    • Fan G Ma X Wong PY Rodrigues CM Steer CJ p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells Apoptosis 2004, 9:211-221. 10.1023/B:APPT.0000018803.11260.02 15004518
    • (2004) Apoptosis , vol.9 , pp. 211-221
    • Fan, G.1    Ma, X.2    Wong, P.Y.3    Rodrigues, C.M.4    Steer, C.J.5
  • 53
    • 0344406127 scopus 로고    scopus 로고
    • The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes
    • 12496370
    • Valdes F Alvarez AM Locascio A Vega S Herrera B Fernandez M Benito M Nieto MA Fabregat I The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes Mol Cancer Res 2002, 1:68-78. 12496370
    • (2002) Mol Cancer Res , vol.1 , pp. 68-78
    • Valdes, F.1    Alvarez, A.M.2    Locascio, A.3    Vega, S.4    Herrera, B.5    Fernandez, M.6    Benito, M.7    Nieto, M.A.8    Fabregat, I.9
  • 54
    • 47949128042 scopus 로고    scopus 로고
    • Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: Implications in liver carcinogenesis
    • 17055226
    • Caja L Ortiz C Bertran E Murillo MM Miro-Obradors MJ Palacios E Fabregat I Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: Implications in liver carcinogenesis Cell Signal 2006. 17055226
    • (2006) Cell Signal
    • Caja, L.1    Ortiz, C.2    Bertran, E.3    Murillo, M.M.4    Miro-Obradors, M.J.5    Palacios, E.6    Fabregat, I.7
  • 55
    • 30644479959 scopus 로고    scopus 로고
    • Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
    • 1346892 16382155 10.1128/MCB.26.2.654-667.2006
    • Ju W Ogawa A Heyer J Nierhof D Yu L Kucherlapati R Shafritz DA Bottinger EP Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation Mol Cell Biol 2006, 26:654-667. 1346892 16382155 10.1128/MCB.26.2.654-667.2006
    • (2006) Mol Cell Biol , vol.26 , pp. 654-667
    • Ju, W.1    Ogawa, A.2    Heyer, J.3    Nierhof, D.4    Yu, L.5    Kucherlapati, R.6    Shafritz, D.A.7    Bottinger, E.P.8
  • 56
    • 21044445452 scopus 로고    scopus 로고
    • Apoptosis: A mechanism of acute and chronic liver injury
    • 1774601 15951554 10.1136/gut.2004.053850
    • Guicciardi ME Gores GJ Apoptosis: A mechanism of acute and chronic liver injury Gut 2005, 54:1024-1033. 1774601 15951554 10.1136/gut.2004.053850
    • (2005) Gut , vol.54 , pp. 1024-1033
    • Guicciardi, M.E.1    Gores, G.J.2


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