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Volumn 51, Issue 5, 2012, Pages 961-968

New insights into NPP1 function: Lessons from clinical and animal studies

Author keywords

ENPP1; FGF 23; GACI; Hypophosphataemia; Insulin; Vascular calcification

Indexed keywords

CALCIUM PHOSPHATE; INSULIN; NUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84867049936     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.07.014     Document Type: Review
Times cited : (76)

References (99)
  • 1
    • 0042166167 scopus 로고    scopus 로고
    • Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification
    • Rutsch F., Ruf N., Vaingankar S., Toliat M.R., Suk A., Hohne W., et al. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat Genet 2003, 34:379-381.
    • (2003) Nat Genet , vol.34 , pp. 379-381
    • Rutsch, F.1    Ruf, N.2    Vaingankar, S.3    Toliat, M.R.4    Suk, A.5    Hohne, W.6
  • 2
    • 0035135119 scopus 로고    scopus 로고
    • PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification
    • Rutsch F., Vaingankar S., Johnson K., Goldfine I., Maddux B., Schauerte P., et al. PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol 2001, 158:543-554.
    • (2001) Am J Pathol , vol.158 , pp. 543-554
    • Rutsch, F.1    Vaingankar, S.2    Johnson, K.3    Goldfine, I.4    Maddux, B.5    Schauerte, P.6
  • 3
    • 76049121613 scopus 로고    scopus 로고
    • Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene
    • Levy-Litan V., Hershkovitz E., Avizov L., Leventhal N., Bercovich D., Chalifa-Caspi V., et al. Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. Am J Hum Genet 2010, 86:273-278.
    • (2010) Am J Hum Genet , vol.86 , pp. 273-278
    • Levy-Litan, V.1    Hershkovitz, E.2    Avizov, L.3    Leventhal, N.4    Bercovich, D.5    Chalifa-Caspi, V.6
  • 4
    • 76049105171 scopus 로고    scopus 로고
    • Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets
    • Lorenz-Depiereux B., Schnabel D., Tiosano D., Hausler G., Strom T.M. Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets. Am J Hum Genet 2010, 86:267-272.
    • (2010) Am J Hum Genet , vol.86 , pp. 267-272
    • Lorenz-Depiereux, B.1    Schnabel, D.2    Tiosano, D.3    Hausler, G.4    Strom, T.M.5
  • 5
    • 77951258759 scopus 로고    scopus 로고
    • Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population
    • Ermakov S., Toliat M.R., Cohen Z., Malkin I., Altmueller J., Livshits G., et al. Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population. Bone 2010, 46:1244-1250.
    • (2010) Bone , vol.46 , pp. 1244-1250
    • Ermakov, S.1    Toliat, M.R.2    Cohen, Z.3    Malkin, I.4    Altmueller, J.5    Livshits, G.6
  • 6
    • 0028795761 scopus 로고
    • Membrane glycoprotein PC-1 and insulin-resistance in non-insulin-dependent diabetes-mellitus
    • Maddux B.A., Sbraccia P., Kumakura S., Sasson S., Youngren J., Fisher A., et al. Membrane glycoprotein PC-1 and insulin-resistance in non-insulin-dependent diabetes-mellitus. Nature 1995, 373:448-451.
    • (1995) Nature , vol.373 , pp. 448-451
    • Maddux, B.A.1    Sbraccia, P.2    Kumakura, S.3    Sasson, S.4    Youngren, J.5    Fisher, A.6
  • 7
    • 0029759418 scopus 로고    scopus 로고
    • PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity
    • Frittitta L., Youngren J., Vigneri R., Maddux B.A., Trischitta V., Goldfine I.D. PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity. Diabetologia 1996, 39:1190-1195.
    • (1996) Diabetologia , vol.39 , pp. 1190-1195
    • Frittitta, L.1    Youngren, J.2    Vigneri, R.3    Maddux, B.A.4    Trischitta, V.5    Goldfine, I.D.6
  • 8
    • 23044493861 scopus 로고    scopus 로고
    • Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    • Meyre D., Bouatia-Naji N., Tounian A., Samson C., Lecoeur C., Vatin V., et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005, 37:863-867.
    • (2005) Nat Genet , vol.37 , pp. 863-867
    • Meyre, D.1    Bouatia-Naji, N.2    Tounian, A.3    Samson, C.4    Lecoeur, C.5    Vatin, V.6
  • 9
    • 0028228997 scopus 로고
    • Arthritis and ankylosis in TWY mice with hereditary multiple osteochondral lesions - with special reference to calcium deposition
    • Sakamoto M., Hosoda Y., Kojimahara K., Yamazaki T., Yoshimura Y. Arthritis and ankylosis in TWY mice with hereditary multiple osteochondral lesions - with special reference to calcium deposition. Pathol Int 1994, 44:420-427.
    • (1994) Pathol Int , vol.44 , pp. 420-427
    • Sakamoto, M.1    Hosoda, Y.2    Kojimahara, K.3    Yamazaki, T.4    Yoshimura, Y.5
  • 10
    • 0028969463 scopus 로고
    • Elevation of alkaline-phosphatase activity induced by parathyroid-hormone in osteoblast like cells from the spinal hyperostotic mouse TWY (twy/twy)
    • Terakado A., Tagawa M., Goto S., Yamazaki M., Moriya H., Fujimura S. Elevation of alkaline-phosphatase activity induced by parathyroid-hormone in osteoblast like cells from the spinal hyperostotic mouse TWY (twy/twy). Calcif Tissue Int 1995, 56:135-139.
    • (1995) Calcif Tissue Int , vol.56 , pp. 135-139
    • Terakado, A.1    Tagawa, M.2    Goto, S.3    Yamazaki, M.4    Moriya, H.5    Fujimura, S.6
  • 11
    • 0030733501 scopus 로고    scopus 로고
    • Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy)
    • Baba H., Furusawa N., Fukuda M., Maezawa Y., Imura S., Kawahara N., et al. Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy). Eur J Histochem 1997, 41:191-202.
    • (1997) Eur J Histochem , vol.41 , pp. 191-202
    • Baba, H.1    Furusawa, N.2    Fukuda, M.3    Maezawa, Y.4    Imura, S.5    Kawahara, N.6
  • 12
    • 0030457803 scopus 로고    scopus 로고
    • Characteristics and mechanism of the ossification of posterior longitudinal ligament in the tip-toe walking Yoshimura (twy) mouse
    • Furusawa N., Baba H., Imura S., Fukuda M. Characteristics and mechanism of the ossification of posterior longitudinal ligament in the tip-toe walking Yoshimura (twy) mouse. Eur J Histochem 1996, 40:199-210.
    • (1996) Eur J Histochem , vol.40 , pp. 199-210
    • Furusawa, N.1    Baba, H.2    Imura, S.3    Fukuda, M.4
  • 13
    • 0031859977 scopus 로고    scopus 로고
    • Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine
    • Okawa A., Nakamura I., Goto S., Moriya H., Nakamura Y., Ikegawa S. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 1998, 19:271-273.
    • (1998) Nat Genet , vol.19 , pp. 271-273
    • Okawa, A.1    Nakamura, I.2    Goto, S.3    Moriya, H.4    Nakamura, Y.5    Ikegawa, S.6
  • 14
    • 0033011551 scopus 로고    scopus 로고
    • Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse (twy/twy) in vivo
    • Okawa A., Goto S., Moriya H. Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse (twy/twy) in vivo. Calcif Tissue Int 1999, 64:239-247.
    • (1999) Calcif Tissue Int , vol.64 , pp. 239-247
    • Okawa, A.1    Goto, S.2    Moriya, H.3
  • 15
    • 0002113093 scopus 로고    scopus 로고
    • Germline deletion of the nucleoside triphosphate pyrophosphohydrolase (NTPPPH) plasma cell membrane glycoprotein-1 (PC-1) produces abnormal calcification of periarticular tissues
    • Shaker Publishing, L. Vanduffel, R. Lemmems (Eds.)
    • Sali A., Favaloro J., Terkeltaub R., Goding J. Germline deletion of the nucleoside triphosphate pyrophosphohydrolase (NTPPPH) plasma cell membrane glycoprotein-1 (PC-1) produces abnormal calcification of periarticular tissues. Ecto-ATPases and related ectoenzymes 1999, 267-282. Shaker Publishing. L. Vanduffel, R. Lemmems (Eds.).
    • (1999) Ecto-ATPases and related ectoenzymes , pp. 267-282
    • Sali, A.1    Favaloro, J.2    Terkeltaub, R.3    Goding, J.4
  • 16
    • 21144434783 scopus 로고    scopus 로고
    • Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice
    • Anderson H.C., Harmey D., Camacho N.P., Garimella R., Sipe J.B., Tague S., et al. Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. Am J Pathol 2005, 166:1711-1720.
    • (2005) Am J Pathol , vol.166 , pp. 1711-1720
    • Anderson, H.C.1    Harmey, D.2    Camacho, N.P.3    Garimella, R.4    Sipe, J.B.5    Tague, S.6
  • 17
    • 0025144935 scopus 로고
    • Plasma-cell membrane glycoprotein PC-1 - cDNA cloning of the human molecule, amino acid sequence, and chromosomal location
    • Buckley M.F., Loveland K.A., McKinstry W.J., Garson O.M., Goding J.W. Plasma-cell membrane glycoprotein PC-1 - cDNA cloning of the human molecule, amino acid sequence, and chromosomal location. J Biol Chem 1990, 265:17506-17511.
    • (1990) J Biol Chem , vol.265 , pp. 17506-17511
    • Buckley, M.F.1    Loveland, K.A.2    McKinstry, W.J.3    Garson, O.M.4    Goding, J.W.5
  • 21
    • 0034813884 scopus 로고    scopus 로고
    • Inorganic pyrophosphate generation and disposition in pathophysiology
    • Terkeltaub R.A. Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 2001, 281:C1-C11.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Terkeltaub, R.A.1
  • 22
    • 27744451970 scopus 로고    scopus 로고
    • I) in pathologic calcification of articular cartilage
    • I) in pathologic calcification of articular cartilage. Front Biosci 2005, 10:988-997.
    • (2005) Front Biosci , vol.10 , pp. 988-997
    • Johnson, K.1    Terkeltaub, R.2
  • 23
    • 0031885056 scopus 로고    scopus 로고
    • Ecto-phosphodiesterase/pyrophosphatase of lymphocytes and non-lymphoid cells: structure and function of the PC-1 family
    • Goding J.W., Terkeltaub R., Maurice M., Deterre P., Sali A., Belli S.I. Ecto-phosphodiesterase/pyrophosphatase of lymphocytes and non-lymphoid cells: structure and function of the PC-1 family. Immunol Rev 1998, 161:11-26.
    • (1998) Immunol Rev , vol.161 , pp. 11-26
    • Goding, J.W.1    Terkeltaub, R.2    Maurice, M.3    Deterre, P.4    Sali, A.5    Belli, S.I.6
  • 24
    • 34548012770 scopus 로고    scopus 로고
    • Modulation of purinergic signaling by NPP-type ectophosphodiesterases
    • Stefan C., Jansen S., Bollen M. Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal 2006, 2:361-370.
    • (2006) Purinergic Signal , vol.2 , pp. 361-370
    • Stefan, C.1    Jansen, S.2    Bollen, M.3
  • 25
    • 0031021476 scopus 로고    scopus 로고
    • Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities
    • Clair T., Lee H.Y., Liotta L.A., Stracke M.L. Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities. J Biol Chem 1997, 272:996-1001.
    • (1997) J Biol Chem , vol.272 , pp. 996-1001
    • Clair, T.1    Lee, H.Y.2    Liotta, L.A.3    Stracke, M.L.4
  • 26
    • 0027296082 scopus 로고
    • Phosphorylation and nucleotide-dependent dephosphorylation of hepatic polypeptides related to the plasma-cell differentiation antigen PC-1
    • Uriarte M., Stalmans W., Hickman S., Bollen M. Phosphorylation and nucleotide-dependent dephosphorylation of hepatic polypeptides related to the plasma-cell differentiation antigen PC-1. Biochem J 1993, 293:93-100.
    • (1993) Biochem J , vol.293 , pp. 93-100
    • Uriarte, M.1    Stalmans, W.2    Hickman, S.3    Bollen, M.4
  • 27
    • 0018084369 scopus 로고
    • 5'-Nucleotide phosphodiesterase - isolation of covalently bound 5'-monophosphate, an intermediate in catalytic mechanism
    • Landt M., Butler L.G. 5'-Nucleotide phosphodiesterase - isolation of covalently bound 5'-monophosphate, an intermediate in catalytic mechanism. Biochemistry 1978, 17:4130-4135.
    • (1978) Biochemistry , vol.17 , pp. 4130-4135
    • Landt, M.1    Butler, L.G.2
  • 28
    • 0141560730 scopus 로고    scopus 로고
    • Matrix vesicles and calcification
    • Anderson H.C. Matrix vesicles and calcification. Curr Rheumatol Rep 2003, 5:222-226.
    • (2003) Curr Rheumatol Rep , vol.5 , pp. 222-226
    • Anderson, H.C.1
  • 31
    • 0037047051 scopus 로고    scopus 로고
    • Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
    • Hessle L., Johnson K.A., Anderson H.C., Narisawa S., Sali A., Goding J.W., et al. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A 2002, 99:9445-9449.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9445-9449
    • Hessle, L.1    Johnson, K.A.2    Anderson, H.C.3    Narisawa, S.4    Sali, A.5    Goding, J.W.6
  • 32
    • 1642313676 scopus 로고    scopus 로고
    • Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1, and Ank - an integrated model of the pathogenesis of mineralization disorders
    • Harmey D., Hessle L., Narisawa S., Johnson K.A., Terkeltaub R., Millan J.L. Concerted regulation of inorganic pyrophosphate and osteopontin by Akp2, Enpp1, and Ank - an integrated model of the pathogenesis of mineralization disorders. Am J Pathol 2004, 164:1199-1209.
    • (2004) Am J Pathol , vol.164 , pp. 1199-1209
    • Harmey, D.1    Hessle, L.2    Narisawa, S.3    Johnson, K.A.4    Terkeltaub, R.5    Millan, J.L.6
  • 33
    • 33748082636 scopus 로고    scopus 로고
    • Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice
    • Harmey D., Johnson K.A., Zelken J., Camacho N.P., Hoylaerts M.F., Noda M., et al. Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. J Bone Miner Res 2006, 21:1377-1386.
    • (2006) J Bone Miner Res , vol.21 , pp. 1377-1386
    • Harmey, D.1    Johnson, K.A.2    Zelken, J.3    Camacho, N.P.4    Hoylaerts, M.F.5    Noda, M.6
  • 34
    • 78951478417 scopus 로고    scopus 로고
    • Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis
    • Sugita A., Kawai S., Hayashibara T., Amano A., Ooshima T., Michigami T., et al. Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis. J Biol Chem 2011, 286:3094-3103.
    • (2011) J Biol Chem , vol.286 , pp. 3094-3103
    • Sugita, A.1    Kawai, S.2    Hayashibara, T.3    Amano, A.4    Ooshima, T.5    Michigami, T.6
  • 35
    • 79251482785 scopus 로고    scopus 로고
    • Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification
    • Yadav M.C., Simao A.M.S., Narisawa S., Huesa C., McKee M.D., Farquharson C., et al. Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res 2011, 26:286-297.
    • (2011) J Bone Miner Res , vol.26 , pp. 286-297
    • Yadav, M.C.1    Simao, A.M.S.2    Narisawa, S.3    Huesa, C.4    McKee, M.D.5    Farquharson, C.6
  • 36
    • 0028233939 scopus 로고
    • Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma-cell membrane glycoprotein-1 - relevance to calcium pyrophosphate dihydrate deposition disease
    • Terkeltaub R., Rosenbach M., Fong F., Goding J. Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma-cell membrane glycoprotein-1 - relevance to calcium pyrophosphate dihydrate deposition disease. Arthritis Rheum 1994, 37:934-941.
    • (1994) Arthritis Rheum , vol.37 , pp. 934-941
    • Terkeltaub, R.1    Rosenbach, M.2    Fong, F.3    Goding, J.4
  • 37
    • 0034647482 scopus 로고    scopus 로고
    • Role of the mouse ank gene in control of tissue calcification and arthritis
    • Ho A.M., Johnson M.D., Kingsley D.M. Role of the mouse ank gene in control of tissue calcification and arthritis. Science 2000, 289:265-270.
    • (2000) Science , vol.289 , pp. 265-270
    • Ho, A.M.1    Johnson, M.D.2    Kingsley, D.M.3
  • 38
    • 0021733794 scopus 로고
    • Hereditary joint disorder in progressive ankylosis (ank/ank) mice. I. Association of calcium hydroxyapatite deposition with inflammatory arthropathy
    • Hakim F.T., Cranley R., Brown K.S., Eanes E.D., Harne L., Oppenheim J.J. Hereditary joint disorder in progressive ankylosis (ank/ank) mice. I. Association of calcium hydroxyapatite deposition with inflammatory arthropathy. Arthritis Rheum 1984, 27:1411-1420.
    • (1984) Arthritis Rheum , vol.27 , pp. 1411-1420
    • Hakim, F.T.1    Cranley, R.2    Brown, K.S.3    Eanes, E.D.4    Harne, L.5    Oppenheim, J.J.6
  • 39
    • 34447538396 scopus 로고    scopus 로고
    • Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity
    • Addison W.N., Azari F., Sorensen E.S., Kaartinen M.T., McKee M.D. Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. J Biol Chem 2007, 282:15872-15883.
    • (2007) J Biol Chem , vol.282 , pp. 15872-15883
    • Addison, W.N.1    Azari, F.2    Sorensen, E.S.3    Kaartinen, M.T.4    McKee, M.D.5
  • 41
    • 80655149476 scopus 로고    scopus 로고
    • Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation
    • Nam H.K., Liu J., Li Y., Kragor A., Hatch N.E. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation. J Biol Chem 2011, 286:39059-39071.
    • (2011) J Biol Chem , vol.286 , pp. 39059-39071
    • Nam, H.K.1    Liu, J.2    Li, Y.3    Kragor, A.4    Hatch, N.E.5
  • 42
    • 84855860969 scopus 로고    scopus 로고
    • Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6
    • Nitschke Y., Baujat G., Botschen U., Wittkampf T., du Moulin M., Stella J., et al. Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. Am J Hum Genet 2012, 90:25-39.
    • (2012) Am J Hum Genet , vol.90 , pp. 25-39
    • Nitschke, Y.1    Baujat, G.2    Botschen, U.3    Wittkampf, T.4    du Moulin, M.5    Stella, J.6
  • 43
    • 80052153431 scopus 로고    scopus 로고
    • Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel
    • Rutsch F., Nitschke Y., Terkeltaub R. Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel. Circ Res 2011, 109:578-592.
    • (2011) Circ Res , vol.109 , pp. 578-592
    • Rutsch, F.1    Nitschke, Y.2    Terkeltaub, R.3
  • 44
    • 0016416418 scopus 로고
    • Idiopathic arterial calcification of infancy: a clinicopathologic study
    • Moran J.J. Idiopathic arterial calcification of infancy: a clinicopathologic study. Pathol Annu 1975, 10:393-417.
    • (1975) Pathol Annu , vol.10 , pp. 393-417
    • Moran, J.J.1
  • 45
    • 0033752990 scopus 로고    scopus 로고
    • Low levels of urinary inorganic pyrophosphate indicating systemic pyrophosphate deficiency in a boy with idiopathic infantile arterial calcification
    • Rutsch F., Schauerte P., Kalhoff H., Petrarulo M., August C., Diekmann L. Low levels of urinary inorganic pyrophosphate indicating systemic pyrophosphate deficiency in a boy with idiopathic infantile arterial calcification. Acta Paediatr 2000, 89:1265-1269.
    • (2000) Acta Paediatr , vol.89 , pp. 1265-1269
    • Rutsch, F.1    Schauerte, P.2    Kalhoff, H.3    Petrarulo, M.4    August, C.5    Diekmann, L.6
  • 46
    • 68149120891 scopus 로고    scopus 로고
    • Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy
    • Rutsch F., Boeyer P., Nitschke Y., Ruf N., Lorenz-Depierieux B., Wittkampf T., et al. Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Circ Cardiovasc Genet 2008, 1:133-140.
    • (2008) Circ Cardiovasc Genet , vol.1 , pp. 133-140
    • Rutsch, F.1    Boeyer, P.2    Nitschke, Y.3    Ruf, N.4    Lorenz-Depierieux, B.5    Wittkampf, T.6
  • 48
    • 0021224880 scopus 로고
    • Generalized arterial calcification of infancy - 3 case reports, including spontaneous regression with long-term survival
    • Sholler G.F., Yu J.S., Bale P.M., Hawker R.E., Celermajer J.M., Kozlowski K. Generalized arterial calcification of infancy - 3 case reports, including spontaneous regression with long-term survival. J Pediatr 1984, 105:257-260.
    • (1984) J Pediatr , vol.105 , pp. 257-260
    • Sholler, G.F.1    Yu, J.S.2    Bale, P.M.3    Hawker, R.E.4    Celermajer, J.M.5    Kozlowski, K.6
  • 49
    • 33344454730 scopus 로고    scopus 로고
    • Generalized arterial calcification of infancy: two siblings with prolonged survival
    • Ciana G., Trappan A., Bembi B., Benettoni A., Maso G., Zennaro F., et al. Generalized arterial calcification of infancy: two siblings with prolonged survival. Eur J Pediatr 2006, 165:258-263.
    • (2006) Eur J Pediatr , vol.165 , pp. 258-263
    • Ciana, G.1    Trappan, A.2    Bembi, B.3    Benettoni, A.4    Maso, G.5    Zennaro, F.6
  • 50
    • 84860321632 scopus 로고    scopus 로고
    • Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene
    • Li Q., Schumacher W., Jablonski D., Siegel D., Uitto J. Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene. Br J Dermatol 2012, 166:1107-1111.
    • (2012) Br J Dermatol , vol.166 , pp. 1107-1111
    • Li, Q.1    Schumacher, W.2    Jablonski, D.3    Siegel, D.4    Uitto, J.5
  • 51
    • 18844465976 scopus 로고    scopus 로고
    • Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum
    • Le Saux O., Urban Z., Tschuch C., Csiszar K., Bacchelli B., Quaglino D., et al. Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet 2000, 25:223-227.
    • (2000) Nat Genet , vol.25 , pp. 223-227
    • Le Saux, O.1    Urban, Z.2    Tschuch, C.3    Csiszar, K.4    Bacchelli, B.5    Quaglino, D.6
  • 52
    • 0034705145 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
    • Ringpfeil F., Lebwohl M.G., Christiano A.M., Uitto J. Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci U S A 2000, 97:6001-6006.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6001-6006
    • Ringpfeil, F.1    Lebwohl, M.G.2    Christiano, A.M.3    Uitto, J.4
  • 54
    • 0032806520 scopus 로고    scopus 로고
    • Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)
    • Nakamura I., Ikegawa S., Okawa A., Okuda S., Koshizuka Y., Kawaguchi H., et al. Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 1999, 104:492-497.
    • (1999) Hum Genet , vol.104 , pp. 492-497
    • Nakamura, I.1    Ikegawa, S.2    Okawa, A.3    Okuda, S.4    Koshizuka, Y.5    Kawaguchi, H.6
  • 55
    • 0036133540 scopus 로고    scopus 로고
    • Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine
    • Koshizuka Y., Kawaguchi H., Ogata N., Ikeda T., Mabuchi A., Seichi A., et al. Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 2002, 17:138-144.
    • (2002) J Bone Miner Res , vol.17 , pp. 138-144
    • Koshizuka, Y.1    Kawaguchi, H.2    Ogata, N.3    Ikeda, T.4    Mabuchi, A.5    Seichi, A.6
  • 56
    • 18244378248 scopus 로고    scopus 로고
    • The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms
    • Tahara M., Aiba A., Yamazaki M., Ikeda Y., Goto S., Moriya H., et al. The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms. Spine 2005, 30:877-880.
    • (2005) Spine , vol.30 , pp. 877-880
    • Tahara, M.1    Aiba, A.2    Yamazaki, M.3    Ikeda, Y.4    Goto, S.5    Moriya, H.6
  • 57
    • 79956073084 scopus 로고    scopus 로고
    • The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells
    • Zhu D., Mackenzie N.C.W., Millan J.L., Farquharson C., MacRae V.E. The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells. PLoS One 2011, 6:e19595.
    • (2011) PLoS One , vol.6
    • Zhu, D.1    Mackenzie, N.C.W.2    Millan, J.L.3    Farquharson, C.4    MacRae, V.E.5
  • 60
    • 77953232228 scopus 로고    scopus 로고
    • Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis
    • Basta G., Corciu A.I., Vianello A., Del Turco S., Foffa I., Navarra T., et al. Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis. Atherosclerosis 2010, 210:614-618.
    • (2010) Atherosclerosis , vol.210 , pp. 614-618
    • Basta, G.1    Corciu, A.I.2    Vianello, A.3    Del Turco, S.4    Foffa, I.5    Navarra, T.6
  • 61
    • 0028301910 scopus 로고
    • Modulation of crystal-formation by bone phosphoproteins - structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation
    • Hunter G.K., Kyle C.L., Goldberg H.A. Modulation of crystal-formation by bone phosphoproteins - structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem J 1994, 300:723-728.
    • (1994) Biochem J , vol.300 , pp. 723-728
    • Hunter, G.K.1    Kyle, C.L.2    Goldberg, H.A.3
  • 62
    • 0027249892 scopus 로고
    • Osteopontin-hydroxyapatite interactions in-vitro - inhibition of hydroxyapatite formation and growth in a gelatin-gel
    • Boskey A.L., Maresca M., Ullrich W., Doty S.B., Butler W.T., Prince C.W. Osteopontin-hydroxyapatite interactions in-vitro - inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner 1993, 22:147-159.
    • (1993) Bone Miner , vol.22 , pp. 147-159
    • Boskey, A.L.1    Maresca, M.2    Ullrich, W.3    Doty, S.B.4    Butler, W.T.5    Prince, C.W.6
  • 63
    • 0037152187 scopus 로고    scopus 로고
    • Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo
    • Speer M.Y., McKee M.D., Guldberg R.E., Liaw L., Yang H.Y., Tung E., et al. Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 2002, 196:1047-1055.
    • (2002) J Exp Med , vol.196 , pp. 1047-1055
    • Speer, M.Y.1    McKee, M.D.2    Guldberg, R.E.3    Liaw, L.4    Yang, H.Y.5    Tung, E.6
  • 64
    • 0036900001 scopus 로고    scopus 로고
    • Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification
    • Steitz S.A., Speer M.Y., McKee M.D., Liaw L., Almeida M., Yang H., et al. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol 2002, 161:2035-2046.
    • (2002) Am J Pathol , vol.161 , pp. 2035-2046
    • Steitz, S.A.1    Speer, M.Y.2    McKee, M.D.3    Liaw, L.4    Almeida, M.5    Yang, H.6
  • 66
    • 0347986784 scopus 로고    scopus 로고
    • Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
    • Bruemmer D., Collins A.R., Noh G., Wang W., Territo M., Arias-Magallona S., et al. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 2003, 112:1318-1331.
    • (2003) J Clin Invest , vol.112 , pp. 1318-1331
    • Bruemmer, D.1    Collins, A.R.2    Noh, G.3    Wang, W.4    Territo, M.5    Arias-Magallona, S.6
  • 67
    • 84874242004 scopus 로고    scopus 로고
    • ATP release acts as survival signal and prevents the mineralization of aortic valve by P2Y(2) and PI3K/AKT signaling
    • Cote N., El Husseini D., Pepin A., Bosse Y., Bouvet C., Audet A., et al. ATP release acts as survival signal and prevents the mineralization of aortic valve by P2Y(2) and PI3K/AKT signaling. Circulation 2011, 124:A11911.
    • (2011) Circulation , vol.124
    • Cote, N.1    El Husseini, D.2    Pepin, A.3    Bosse, Y.4    Bouvet, C.5    Audet, A.6
  • 68
    • 57449105957 scopus 로고    scopus 로고
    • Endocrine functions of bone in mineral metabolism regulation
    • Quarles L.D. Endocrine functions of bone in mineral metabolism regulation. J Clin Invest 2008, 118:3820-3828.
    • (2008) J Clin Invest , vol.118 , pp. 3820-3828
    • Quarles, L.D.1
  • 73
    • 80051687775 scopus 로고    scopus 로고
    • Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
    • Martin A., Liu S., David V., Li H., Karydis A., Feng J.Q., et al. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J 2011, 25:2551-2562.
    • (2011) FASEB J , vol.25 , pp. 2551-2562
    • Martin, A.1    Liu, S.2    David, V.3    Li, H.4    Karydis, A.5    Feng, J.Q.6
  • 75
  • 77
    • 67650892239 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
    • Mirza M.A.I., Larsson A., Lind L., Larsson T.E. Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community. Atherosclerosis 2009, 205:385-390.
    • (2009) Atherosclerosis , vol.205 , pp. 385-390
    • Mirza, M.A.I.1    Larsson, A.2    Lind, L.3    Larsson, T.E.4
  • 79
    • 70450230670 scopus 로고    scopus 로고
    • Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    • Mirza M.A.I., Larsson A., Melhus H., Lind L., Larsson T.E. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 2009, 207:546-551.
    • (2009) Atherosclerosis , vol.207 , pp. 546-551
    • Mirza, M.A.I.1    Larsson, A.2    Melhus, H.3    Lind, L.4    Larsson, T.E.5
  • 80
    • 66349097180 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    • Gutierrez O.M., Januzzi J.L., Isakova T., Laliberte K., Smith K., Collerone G., et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation 2009, 119:2545-2552.
    • (2009) Circulation , vol.119 , pp. 2545-2552
    • Gutierrez, O.M.1    Januzzi, J.L.2    Isakova, T.3    Laliberte, K.4    Smith, K.5    Collerone, G.6
  • 81
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • Sitara D., Razzaque M.S., Hesse M., Yoganathan S., Taguchi T., Erben R.G., et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 2004, 23:421-432.
    • (2004) Matrix Biol , vol.23 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6
  • 82
    • 34250667000 scopus 로고    scopus 로고
    • Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
    • Stubbs J.R., Liu S., Tang W., Zhou J., Wang Y., Yao X., et al. Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J Am Soc Nephrol 2007, 18:2116-2124.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2116-2124
    • Stubbs, J.R.1    Liu, S.2    Tang, W.3    Zhou, J.4    Wang, Y.5    Yao, X.6
  • 83
    • 9244240970 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders
    • Bai X.Y., Miao D.S., Li J.R., Goltzman D., Karaplis A.C. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 2004, 145:5269-5279.
    • (2004) Endocrinology , vol.145 , pp. 5269-5279
    • Bai, X.Y.1    Miao, D.S.2    Li, J.R.3    Goltzman, D.4    Karaplis, A.C.5
  • 84
    • 9144248333 scopus 로고    scopus 로고
    • FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa
    • Shimada T., Urakawa I., Yamazaki Y., Hasegawa H., Hino R., Yoneya T., et al. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem Biophys Res Commun 2004, 314:409-414.
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 409-414
    • Shimada, T.1    Urakawa, I.2    Yamazaki, Y.3    Hasegawa, H.4    Hino, R.5    Yoneya, T.6
  • 85
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha 1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • Larsson T., Marsell R., Schipani E., Ohlsson C., Ljunggren O., Tenenhouse H.S., et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha 1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 2004, 145:3087-3094.
    • (2004) Endocrinology , vol.145 , pp. 3087-3094
    • Larsson, T.1    Marsell, R.2    Schipani, E.3    Ohlsson, C.4    Ljunggren, O.5    Tenenhouse, H.S.6
  • 86
    • 84860778116 scopus 로고    scopus 로고
    • Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF-23
    • Lim K.L.T., Molostvov G., Lee C., Lam F., Zehnder D., Hsiao L.L. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF-23. Circulation 2012, 125(18):2243-2255.
    • (2012) Circulation , vol.125 , Issue.18 , pp. 2243-2255
    • Lim, K.L.T.1    Molostvov, G.2    Lee, C.3    Lam, F.4    Zehnder, D.5    Hsiao, L.L.6
  • 87
    • 0031747108 scopus 로고    scopus 로고
    • Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects - evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
    • Frittitta L., Spampinato D., Solini A., Nosadini R., Goldfine I.D., Vigneri R., et al. Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects - evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling. Diabetes 1998, 47:1095-1100.
    • (1998) Diabetes , vol.47 , pp. 1095-1100
    • Frittitta, L.1    Spampinato, D.2    Solini, A.3    Nosadini, R.4    Goldfine, I.D.5    Vigneri, R.6
  • 88
    • 0033957339 scopus 로고    scopus 로고
    • Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit
    • Maddux B.A., Goldfine I.D. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 2000, 49:13-19.
    • (2000) Diabetes , vol.49 , pp. 13-19
    • Maddux, B.A.1    Goldfine, I.D.2
  • 89
    • 0029742448 scopus 로고    scopus 로고
    • Skeletal muscle content of membrane glycoprotein PC-1 in obesity - relationship to muscle glucose transport
    • Youngren J.F., Maddux B.A., Sasson S., Sbraccia P., Tapscott E.B., Swanson M.S., et al. Skeletal muscle content of membrane glycoprotein PC-1 in obesity - relationship to muscle glucose transport. Diabetes 1996, 45:1324-1328.
    • (1996) Diabetes , vol.45 , pp. 1324-1328
    • Youngren, J.F.1    Maddux, B.A.2    Sasson, S.3    Sbraccia, P.4    Tapscott, E.B.5    Swanson, M.S.6
  • 92
    • 67651085620 scopus 로고    scopus 로고
    • Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo
    • Zhou H.H., Chin C.-N., Wu M., Ni W., Quan S., Liu F., et al. Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Eur J Pharmacol 2009, 616:346-352.
    • (2009) Eur J Pharmacol , vol.616 , pp. 346-352
    • Zhou, H.H.1    Chin, C.-N.2    Wu, M.3    Ni, W.4    Quan, S.5    Liu, F.6
  • 96
    • 0032857338 scopus 로고    scopus 로고
    • A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
    • Pizzuti A., Frittitta L., Argiolas A., Baratta R., Goldfine I.D., Bozzali M., et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 1999, 48:1881-1884.
    • (1999) Diabetes , vol.48 , pp. 1881-1884
    • Pizzuti, A.1    Frittitta, L.2    Argiolas, A.3    Baratta, R.4    Goldfine, I.D.5    Bozzali, M.6
  • 97
    • 39149099952 scopus 로고    scopus 로고
    • The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities
    • Goldfine I.D., Maddux B.A., Youngren J.F., Reaven G., Accili D., Trischitta V., et al. The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev 2008, 29:62-75.
    • (2008) Endocr Rev , vol.29 , pp. 62-75
    • Goldfine, I.D.1    Maddux, B.A.2    Youngren, J.F.3    Reaven, G.4    Accili, D.5    Trischitta, V.6
  • 98
    • 33847022334 scopus 로고    scopus 로고
    • Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes
    • Willer C.J., Bonnycastle L.L., Conneely K.N., Duren W.L., Jackson A.U., Scott L.J., et al. Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes 2007, 56:256-264.
    • (2007) Diabetes , vol.56 , pp. 256-264
    • Willer, C.J.1    Bonnycastle, L.L.2    Conneely, K.N.3    Duren, W.L.4    Jackson, A.U.5    Scott, L.J.6
  • 99
    • 42449116149 scopus 로고    scopus 로고
    • The EBPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects
    • McAteer J.B., Prudente S., Bacci S., Lyon H.N., Hirschhorn J.N., Trischitta V., et al. The EBPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes 2008, 57:1125-1130.
    • (2008) Diabetes , vol.57 , pp. 1125-1130
    • McAteer, J.B.1    Prudente, S.2    Bacci, S.3    Lyon, H.N.4    Hirschhorn, J.N.5    Trischitta, V.6


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