Comparisons of the ability of human IgG3 hinge mutants, IgM, IgE, and IgA2, to form small immune complexes: A role for flexibility and geometry

Journal of Immunology

Volumn 161, Issue 8, 1998, Pages 4083-4090

  Roux, Kenneth H ^a   Strelets, Lioudmila ^a   Brekke, Ole Henrik ^b   Sandlie, Inger ^b   Michaelsen, Terje E ^c  

^a FLORIDA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A2; IMMUNOGLOBULIN E; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ARTICLE; DIMERIZATION; HUMAN; IMMUNOELECTRON MICROSCOPY; IMMUNOGLOBULIN STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIGEN-ANTIBODY COMPLEX; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032532015     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Roux, K. H., L. Strelets, and T. E. Michaelsen. 1997. Molecular flexibility of human IgG subclasses. J. Immunol. 159:3372.
2. Nezlin, R. 1990. Internal movement in Ig molecules. Adv. Immunol. 48:1.
3. Burton, D. R. 1985. IgG: functional sites. Mol. Immunol. 22:161.
4. Feinstein, A., N. Richardson, and M. J. Taussig. 1986. Ig flexibility in complement activation. Immunol. Today 7:169.
5. Michaelsen, T. E., B. Frangione, and E. C. Franklin. 1977. Primary structure of the "hinge" region of human IgG3. J. Biol. Chem. 252:883.
6. Huck, S., P. Fort, D. H. Crawford, M.-P. Lefranc, and G. Lefranc. 1986. Sequence of human γ 3 heavy chain constant region: comparison with the other human C genes. Nucleic Acids Res. 14:1779.
7. Marquart, M., J. Deisenhofer, and R. Huber. 1980. Crystallographic refinement and atomic models of the intact Ig molecule Kol and its antigen-binding fragment at 3.0 and 1.9 Å resolution. J. Mol. Biol. 141:369.
8. Endo, S., and Y. Arata. 1985. Proton nuclear magnetic resonance study of human Igs G1 and their proteolytic fragments: structure of the hinge region and effects of a hinge-region deletion on internal flexibility. Biochemistry 24:1561.
9. Phillips, M. L., M.-H. Tao, S. L. Morrison, and V. N. Schumaker. 1994. Human/mouse chimeric mAbs with human IgG1, IgG2, IgG3 and IgG4 constant domains: electron microscopic and hydrodynamic characterization. Mol. Immunol. 31:1201.
10. Gregory, L., K. G. Davis, B. Sheth, J. Boyd, R. Jefferis, C. Nave, and D. R. Burton. 1987. The solution conformations of the subclasses of human IgG deduced from sedimentation and small angle x-ray scattering studies. Mol. Immunol. 24:821.
11. Pumphrey, R. 1986. Computer models of the human Igs: shape and segmental flexibility. Immunol. Today 7:174.
12. Sjoberg, B., E. Rosenqvist, T. Michaelsen, S. Pap, and R. Osterberg. 1980. The solution shapes of IgG3 Ig and its Fch and Fc fragments. Biochim. Biophys. Acta 625:10.
13. Brekke, O. H., T. E. Michaelsen, R. H. Sandin, and I. Sandlie. 1996. Activation of complement by an IgG molecule without a genetic hinge: correction. Nature 383:103.
14. Michaelsen, T. E., O. H. Brekke, A. Aase, R. H. Sandin, B. Bremnes, and I. Sandlie. 1994. One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge. Proc. Natl. Acad. Sci. USA 91:9243.
15. Brekke, O. H., T. E. Michaelsen, R. Sandin, and I. Sandlie. 1993. Activation of complement by an IgG molecule without a genetic hinge. Nature 363:628.
16. Sandlie, I., A. Aase, C. Westby, and T. E. Michaelsen. 1989. Clq binding to chimeric monoclonal IgG3 Abs consisting of mouse variable regions and human constant regions with shortened hinge containing 15 to 47 amino acids. Eur. J. Immunol. 19:1599.
17. Michaelsen, T. E., A. Aase, C. Westby, and I. Sandlie. 1990. Enhancement of complement activation and cytolysis of human IgG3 by deletion of hinge exons. Scand. J. Immunol. 32:517.
18. Silverton, E. W., and M. D. D. Navia. 1977. Three-dimensional structure of an intact human Ig. Proc. Natl. Acad. Sci. USA 74:5140.
19. Klein, M., N. Haeffner Cavaillon, D. E. Isenman, C. Rival, M. A. Navia, D. R. Davies, and K. J. Dorrington. 1981. Expression of biologic effector functions by IgG molecules lacking the hinge region. Proc. Natl. Acad. Sci. USA 78:524.
20. Guddat, L. W., J. N. Herron, and A. B. Edmundson. 1993. Three-dimensional structure of a human Ig with a hinge deletion. Proc. Natl. Acad. Sci. USA 90:4271.
21. Sykulev, Y. K., R. Nezlin, G. P. German, E. V. Chernokhvostova, and V. V. Lavrentiev. 1984. Structural studies of human IgA1 and IgA2 Igs tagged with two different spin labels. Biofizika 29:744.
22. Beavil, A. J., R. J. Young, and B. J. Sutton. 1995. Bent domain structure of recombinant human IgE-Fc in solution by x-ray and neutron scattering in conjunction with an automated curve fitting procedure. Biochemistry 34:14449.
23. Oi, V. T., T. M. Vuong, R. Hardy, H. Reidler, J. Dangle, L. A. Herzenberg, and L. Stryer. 1984. Correlation between segmental flexibility and effector function of Abs. Nature 307:136.
24. Holowka, D., T. Wensel, and B. Baird. 1990. A nano-second fluorescence depolarization study on the segmental flexibility of receptor-bound IgE. Biochemistry 29:4607.
25. Zheng, Y., B. Shopes, and D. Holowka. 1991. Conformations of IgE bound to its receptor FcεRI and in solution. Biochemistry 30:9125.
26. Zheng, Y., B. Shopes, D. Holowka, and B. Baird. 1992. Dynamic conformations compared for IgE and IgG1 in solution and bound to receptors. Biochemistry 31: 7446.
27. Dudich, E. I., R. S. Nezlin, and F. Franek. 1980. Fluorescence polarization and spin-label study of human myeloma IgA and IgM: presence of segmental flexibility. Mol. Immunol. 17:1335.
28. Zagyansky, Y. A., L. A. Tumerman, and A. M. Egorov. 1972. Segmental flexibility of IgM molecules. Immunochemistry 9:91.
29. Sorensen, V., I. B. Rasmussen, L. Norderhaug, I. Natvig, T. E. Michaelsen, and I. Sandle. 1996. Effect of the IgM and IgA secretory tailpieces on polymerization and secretion of IgM and IgG. J. Immunol. 156:2858.
30. Johnstone, A., and R. Thorpe. 1982. Immunochemistry in Practice. Blackwell Scientific Publications, Boston, p. 298.
31. Roux, K. H. 1989. Immunoelectron microscopy of Id-anti-Id complexes. Methods Enzymol. 178:130.
32. Roux, K. H. 1996. Negative stain immunoelectron microscopic analysis of small macromolecules of immunologic significance. Methods 10:247.
33. Roux, K. H., and N. S. Greenspan. 1994. Monitoring the formation of soluble immune complexes composed of idiotype and anti-idiotype antibodies by electron microscopy. Mol. Immunol. 31:599.
34. Ravetch, J. W., and R. A. Clynes. 1998. Divergent roles for Fc receptors and complement in vivo. Annu. Rev. Immunol. 16:421.
35. Phillips, M. L., V. T. Oi, and V. N. Schumaker. 1990. Electron microscopic study of ring-shaped, bivalent hapten, bivalent antidansyl mAb complexes with identical variable domains but IgG1, IgG2a and IgG2b constant domains. Mol. Immunol. 27:181.
36. Schumaker, V. N., M. L. Phillips, and D. C. Hanson. 1991. Dynamic aspects of Ab structure. Mol. Immunol. 28:1347.
37. Moyle, W. R., C. Lin, and R. L. Corson. 1983. Quantitative explanation for increased affinity shown by mixtures of mAbs: importance of a circular complex. Mol. Immunol. 20:439.
38. Schumaker, V. N., G. W. Seegan, C. A. Smith, S. K. Ma, J. D. Rodwell, and M. F. Schumaker. 1980. The free energy of angular position of the Fab arms of IgG Ab. Mol. Immunol. 17:413.
39. Murphy, R. M., R. A. Chamberlin, P. Schurtenberger, C. K. Colton, and M. L. Yarmush. 1990. Size and structure of antigen-antibody complexes: thermodynamic parameters. Biochemistry 29:10889.
40. Dangl, J. L., T. G. Wensel, S. L. Morrison, L. Stryer, L. A. Herzenberg, and V. T. Oi. 1988. Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse Abs. EMBO J. 7:1989.
41. Schneider, W. P., T. G. Wensel, L. Stryer, and V. T. Oi. 1988. Genetically engineered Igs reveal structural features controlling segmental flexibility. Proc. Natl. Acad. Sci. USA 85:2509.
42. Roux, K. H., and D. L. Tankersley. 1990. A view of the human idiotypic repertoire: electron microscopic and immunologic analyses of spontaneous Id-anti-Id dimers in pooled human IgG. J. Immunol. 144:1387.
43. Chan, L. M., and R. E. Cathou. 1977. The role of the interheavy chain disulfide bond in modulating the flexibility of IgA Ab. J. Mol. Biol. 112:653.
44. Seegan, G. W., and C. S. V. Smith. 1979. Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond. Proc. Natl. Acad. Sci. USA 76:907.
45. Edmundson, A. B., L. W. Guddat, R. A. Rosauer, K. N. Andersen, L. Shan, and Z.-C. Fan. 1995. Three-dimensional aspects of IgG structure and function. Antibodies 1:41.
46. Horgan, C., K. Brown, and S. H. Pincus. 1993. Studies on antigen binding by intact and hinge-deleted chimeric Abs. J. Immunol. 150:5400.
47. Plaut, A. G., J. V. Gilbert, M. S. Artenstein, and J. D. Capra. 1975. Neisseria gonorrhoeae and Neisseria meningitidis: extracellular enzyme cleaves human IgA. Science 190:1103.
48. Helm, B. A., Y. Ling, and C. Tale. 1991. The nature and importance of the inter-ε chain disulfide bonds in human IgE. Eur. J. Immunol. 21:1543.
49. Nezlin, R., Y. A. Zagyansky, A. I. Kaivarainen, and D. V. Stefani. 1973. Properties of myeloma IgE(Yu): chemical, fluorescence polarization and spin-labeled studies. Immunochemistry 10:681.
50. Cathou, R. E. 1978. Solution conformation and segmental flexibility of Igs. Contemp. Topics Immunol. 5:37.
51. Burton, D. R. 1990. Ab: the flexible adaptor molecule. Trends Biochem. Sci. 15:64.
52. Keown, M. B., R. Ghirlando, R. J. Young, A. J. Beavil, S. J. Perkins, B. J. Sutton, and H. J. Gould. 1995. Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the FcεRI α chain. Proc. Natl. Acad. Sci. USA 92:1841.
53. Phillips, M. L., M.-H. Tao, S. L. Morrison, and V. N. Schumaker. 1994. Human/mouse chimeric mAbs with human IgG1, IgG2, IgG3 and IgG4 constant domains: electron microscopic and hydrodynamic characterization. Mol. Immunol. 31:1201.
54. Subramanian, K., D. Holowka, B. Baird, and B. Goldstein. 1996. The Fc segment of IgE influences the kinetics of dissociation of a symmetrical bivalent ligand from cyclic dimeric complexes. Biochemistry 35:5518.
55. Padlan, E. A. 1994. Anatomy of the Ab molecule. Mol. Immunol. 31:169.
56. 2 fragment and the intact Ig. Biochemistry 17:820.