Plasma half-life extension of small recombinant antibodies by fusion to immunoglobulin-binding domains

Journal of Biological Chemistry

Volumn 287, Issue 7, 2012, Pages 4462-4469

  Hutt, Meike ^a   Färber Schwarz, Aline ^a   Unverdorben, Felix ^a   Richter, Fabian ^a   Kontermann, Roland E ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ANTIBODY MOLECULES; ANTIGEN-BINDING; C TERMINUS; COMPARATIVE ANALYSIS; DIABODY; EXTENSION PROPERTIES; FUSION PROTEINS; HALF LIVES; MAMMALIAN CELLS; PROTEIN A; PROTEIN G; PROTEIN THERAPEUTICS; RECOMBINANT ANTIBODY; SINGLE-CHAIN FV; SMALL SIZE; THERAPEUTIC PROTEIN;

AMINO ACIDS; BINDING ENERGY; RECOMBINANT PROTEINS;

ANTIBODIES;

FINEGOLDIA PROTEIN L IMMUNOGLOBULIN BINDING DOMAIN SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; STAPHYLOCOCCUS PROTEIN A IMMUNOGLOBULIN BINDING DOMAIN SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY FUSION PROTEIN; STREPTOCOCCUS PROTEIN G IMMUNOGLOBULIN BINDING DOMAIN SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY FUSION PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIGEN BINDING; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; SINGLE DRUG DOSE;

ANIMALS; BACTERIAL PROTEINS; HALF-LIFE; HUMANS; JURKAT CELLS; MICE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES;

BACTERIA (MICROORGANISMS); FINEGOLDIA; MAMMALIA; MUS; PEPTOSTREPTOCOCCUS; STAPHYLOCOCCUS; STREPTOCOCCUS;

EID: 84856876300     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.311522     Document Type: Article

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