G-CSF receptor structure, function, and intracellular signal transduction

Milestones in Drug Therapy

Volumn 43, Issue , 2012, Pages 83-105

  Nguyen Jackson, Hoainam T ^a,b   Zhang, Huiyuan ^a   Watowich, Stephanie S ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; JANUS KINASE; MESSENGER RNA; STAT PROTEIN; STAT3 PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL TYPE; DIMERIZATION; DISEASE ASSOCIATION; GENE EXPRESSION; GENE MUTATION; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR GENE; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HYPER IGE SYNDROME; INTRACELLULAR SIGNALING; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR PATHOLOGY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; RECEPTOR GENE; RECEPTOR UPREGULATION; SEVERE CONGENITAL NEUTROPENIA; TRANSCRIPTION REGULATION;

EID: 84866984433     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-0348-0218-5_6     Document Type: Article

References (100)

1. Larsen A, Davis T, Curtis BM et al (1990) Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immuno- globulin, and fibronectin domains. J Exp Med 172:1559-1570.
2. Fukunaga R, Ishizaka-Ikeda E, Seto Y, Nagata S (1990) Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell 61:341-350.
3. Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y (1997) Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand. Nat Struct Biol 4:498-504.
4. Fukunaga R, Ishizaka-Ikeda E, Pan CX, Seto Y, Nagata S (1991) Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 10:2855-2865.
5. Nicola NA, Peterson L (1986) Identification of distinct receptors for two hemopoietic growth factors (granulocyte colony-stimulating factor and multipotential colony-stimulating factor) by chemical cross-linking. J Biol Chem 261:12384-12389.
6. Tamada T, Honjo E, Maeda Y et al (2006) Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. Proc Natl Acad Sci U S A 103:3135-3140.
7. McKinstry WJ, Li CL, Rasko JE, Nicola NA, Johnson GR, Metcalf D (1997) Cytokine receptor expression on hematopoietic stem and progenitor cells. Blood 89:65-71.
8. Nicola NA, Metcalf D (1985) Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol 124:313-321.
9. Manz MG, Miyamoto T, Akashi K, Weissman IL (2002) Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A 99:11872-11877.
10. Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC (1996) Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 5:491-501.
11. Lieschke GJ, Grail D, Hodgson G et al (1994) Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84:1737-1746.
12. Boneberg EM, Hareng L, Gantner F, Wendel A, Hartung T (2000) Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-gamma. Blood 95:270-276.
13. Morikawa K, Morikawa S, Nakamura M, Miyawaki T (2002) Characterization of granulocyte colony-stimulating factor receptor expressed on human lymphocytes. Br J Haematol 118:296-304.
14. Shimoda K, Okamura S, Harada N, Kondo S, Okamura T, Niho Y (1993) Identification of a functional receptor for granulocyte colony-stimulating factor on platelets. J Clin Invest 91:1310-1313.
15. Semerad CL, Christopher MJ, Liu F et al (2005) G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 106:3020-3027.
16. Liu F, Poursine-Laurent J, Link DC (2000) Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF. Blood 95:3025-3031.
17. Budel LM, Touw IP, Delwel R, Lowenberg B (1989) Granulocyte colony-stimulating factor receptors in human acute myelocytic leukemia. Blood 74:2668-2673.
18. Corcione A, Corrias MV, Daniele S, Zupo S, Spriano M, Pistoia V (1996) Expression of granulocyte colony-stimulating factor and granulocyte colony-stimulating factor receptor genes in partially overlapping monoclonal B-cell populations from chronic lymphocytic leukemia patients. Blood 87:2861-2869.
19. Trumpp A, Essers M, Wilson A (2010) Awakening dormant haematopoietic stem cells. Nat Rev Immunol 10:201-209.
20. Calhoun DA, Donnelly WH Jr, Du Y, Dame JB, Li Y, Christensen RD (1999) Distribution of granulocyte colony-stimulating factor (G-CSF) and G-CSF-receptor mRNA and protein in the human fetus. Pediatr Res 46:333-338.
21. Fukunaga R, Seto Y, Mizushima S, Nagata S (1990) Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. Proc Natl Acad Sci U S A 87:8702-8706.
22. Schneider A, Kruger C, Steigleder T et al (2005) The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 115:2083-2098.
23. Harada M, Qin Y, Takano H et al (2005) G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 11:305-311.
24. Bussolino F, Wang JM, Defilippi P et al (1989) Granulocyte- and granulocyte-macrophage- colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 337:471-473.
25. Seto Y, Fukunaga R, Nagata S (1992) Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor. J Immunol 148:259-266.
26. Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG (1996) PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88:1234-1247.
27. Anderson KL, Smith KA, Conners K, McKercher SR, Maki RA, Torbett BE (1988) Myeloid development is selectively disrupted in PU.1 null mice. Blood 91:3702-3710.
28. Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K (1999) Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme. Nature 401:713-717.
29. Nicholson SE, Oates AC, Harpur AG, Ziemiecki A, Wilks AF, Layton JE (1994) Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proc Natl Acad Sci U S A 91:2985-2988.
30. Tian SS, Lamb P, Seidel HM, Stein RB, Rosen J (1994) Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. Blood 84:1760-1764.
31. Shimoda K, Feng J, Murakami H et al (1997) Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor. Blood 90:597-604.
32. Rodig SJ, Meraz MA, White JM et al (1998) Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93:373-383.
33. Parganas E, Wang D, Stravopodis D et al (1998) Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93:385-395.
34. Dong F, van Buitenen C, Pouwels K, Hoefsloot LH, Lowenberg B, Touw IP (1993) Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation. Mol Cell Biol 13:7774-7781.
35. Ziegler SF, Bird TA, Morella KK, Mosley B, Gearing DP, Baumann H (1993) Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction. Mol Cell Biol 13:2384-2390.
36. Fukunaga R, Ishizaka-Ikeda E, Nagata S (1993) Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell 74:1079-1087.
37. Nicholson SE, Novak U, Ziegler SF, Layton JE (1995) Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK. Blood 86:3698-3704.
38. Tanner JW, Chen W, Young RL, Longmore GD, Shaw AS (1995) The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J Biol Chem 270:6523-6530.
39. Yoshikawa A, Murakami H, Nagata S (1995) Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor. EMBO J 14:5288-5296.
40. Akbarzadeh S, Ward AC, McPhee DO, Alexander WS, Lieschke GJ, Layton JE (2002) Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells. Blood 99:879-887.
41. Aaronson DS, Horvath CM (2002) A road map for those who don't know JAK-STAT. Science 296:1653-1655.
42. Tian SS, Tapley P, Sincich C, Stein RB, Rosen J, Lamb P (1996) Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes. Blood 88:4435-4444.
43. Chakraborty A, Dyer KF, Cascio M, Mietzner TA, Tweardy DJ (1999) Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood 93:15-24.
44. Ward AC, Hermans MH, Smith L et al (1999) Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G- CSF) receptor are differentially utilized depending on G-CSF concentration. Blood 93:113-124.
45. Shimozaki K, Nakajima K, Hirano T, Nagata S (1997) Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J Biol Chem 272:25184-25189.
46. Panopoulos AD, Bartos D, Zhang L, Watowich SS (2002) Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. J Biol Chem 277:19001-19007.
47. McLemore ML, Grewal S, Liu F et al (2001) STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14:193-204.
48. de Koning JP, Soede-Bobok AA, Schelen AM et al (1998) Proliferation signaling and activation of Shc, p21Ras, and Myc via tyrosine 764 of human granulocyte colonystimulating factor receptor. Blood 91:1924-1933.
49. de Koning JP, Schelen AM, Dong F et al (1996) Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes. Blood 87:132-140.
50. Ward AC, Smith L, de Koning JP, van Aesch Y, Touw IP (1999) Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells. J Biol Chem 274:14956-14962.
51. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA (1993) Associ- ation of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduc- tion and transformation. Nature 363:45-51.
52. Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ (1994) Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A 91:4683-4687.
53. Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (1998) The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor. Biochem Biophys Res Commun 251:117-123.
54. Dong F, Larner AC (2000) Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the Janus kinases. Blood 95:1656-1662.
55. Mermel CH, McLemore ML, Liu F et al (2006) Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood 108:2562-2568.
56. Wormald S, Hilton DJ (2004) Inhibitors of cytokine signal transduction. J Biol Chem 279:821-824.
57. Hortner M, Nielsch U, Mayr LM, Johnston JA, Heinrich PC, Haan S (2002) Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J Immunol 169:1219-1227.
58. Irandoust MI, Aarts LH, Roovers O, Gits J, Erkeland SJ, Touw IP (2007) Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor. EMBO J 26:1782-1793.
59. Roberts AW, Robb L, Rakar S et al (2001) Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A 98:9324-9329.
60. Croker BA, Metcalf D, Robb L et al (2004) SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20:153-165.
61. Auernhammer CJ, Bousquet C, Melmed S (1999) Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci USA96:6964-6969.
62. Lee CK, Raz R, Gimeno R et al (2002) STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17:63-72.
63. Tapley P, Shevde NK, Schweitzer PA et al (1997) Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice. Exp Hematol 25:122-131.
64. Ward AC, Oomen SP, Smith L et al (2000) The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte colony-stimulating factor (G-CSF) and modulates signaling from the G-CSF receptor. Leukemia 14:1284-1291.
65. Dong F, Qiu Y, Yi T, Touw IP, Larner AC (2001) The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/ acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J Immunol 167:6447-6452.
66. Hunter MG, Avalos BR (1999) Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia. Blood 93:440-446.
67. Richards MK, Liu F, Iwasaki H, Akashi K, Link DC (2003) Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid path- way. Blood 102:3562-3568.
68. Liu F, Poursine-Laurent J, Wu HY, Link DC (1997) Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 90:2583-2590.
69. Betsuyaku T, Liu F, Senior RM et al (1999) A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation. J Clin Invest 103:825-832.
70. Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS (2010) STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115:3354-3363.
71. Panopoulos AD, Zhang L, Snow JW et al (2006) STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108:3682-3690.
72. Germeshausen M, Skokowa J, Ballmaier M, Zeidler C, Welte K (2008) G-CSF receptor mutations in patients with congenital neutropenia. Curr Opin Hematol 15:332-337.
73. von Vietinghoff S, Ley K (2008) Homeostatic regulation of blood neutrophil counts. J Immunol 181:5183-5188.
74. Rosenberg PS, Alter BP, Bolyard AA et al (2006) The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. Blood 107:4628-4635.
75. Skokowa J, Cario G, Uenalan M et al (2006) LEF-1 is crucial for neutrophil granulocytopoie- sis and its expression is severely reduced in congenital neutropenia. Nat Med 12:1191-1197.
76. Klein C, Grudzien M, Appaswamy G et al (2007) HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet 39:86-92.
77. Dale DC, Person RE, Bolyard AA et al (2000) Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96:2317-2322.
78. Dong F, Brynes RK, Tidow N, Welte K, Lowenberg B, Touw IP (1995) Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leuke- mia preceded by severe congenital neutropenia. N Engl J Med 333:487-493.
79. Dong F, Dale DC, Bonilla MA et al (1997) Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Leukemia 11:120-125.
80. Germeshausen M, Ballmaier M, Welte K (2007) Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey. Blood 109:93-99.
81. McLemore ML, Poursine-Laurent J, Link DC (1998) Increased granulocyte colonystimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia. J Clin Invest 102:483-492.
82. Hermans MH, Antonissen C, Ward AC, Mayen AE, Ploemacher RE, Touw IP (1999) Sustained receptor activation and hyperproliferation in response to granulocyte colony- stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene. J Exp Med 189:683-692.
83. Liu F, Kunter G, Krem MM et al (2008) Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest 118:946-955.
84. Kimura A, Rieger MA, Simone JM et al (2009) The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood 114:4721-4728.
85. Bunting KD (2007) STAT5 signaling in normal and pathologic hematopoiesis. Front Biosci 12:2807-2820.
86. Silver RT, Tefferi, A (eds) (2008) Myeloproliferative disorders: biology and management. Informa Healthcare USA, Inc., New York.
87. Plo I, Zhang Y, Le Couedic JP et al (2009) An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J Exp Med 206:1701-1707.
88. Forbes LV, Gale RE, Pizzey A, Pouwels K, Nathwani A, Linch DC (2002) An activating mutation in the transmembrane domain of the granulocyte colony-stimulating factor receptor in patients with acute myeloid leukemia. Oncogene 21:5981-5989.
89. Takeda K, Noguchi K, Shi W et al (1997) Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A 94:3801-3804.
90. Durbin JE, Hackenmiller R, Simon MC, Levy DE (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443-450.
91. Meraz MA, White JM, Sheehan KC et al (1996) Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
92. Kamezaki K, Shimoda K, Numata A et al (2005) Roles of Stat3 and ERK in G-CSF signaling. Stem Cells 23:252-263.
93. Welte T, Zhang SS, Wang T et al (2003) STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 100:1879-1884.
94. Cheers C, Haigh AM, Kelso A, Metcalf D, Stanley ER, Young AM (1988) Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs. Infect Immun 56:247-251.
95. Lord BI, Molineux G, Pojda Z, Souza LM, Mermod JJ, Dexter TM (1991) Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo. Blood 77:2154-2159.
96. Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS (2010) STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood 116:2462-2471.
97. Hirai H, Zhang P, Dayaram T et al (2006) C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol 7:732-739.
98. Paslin D, Norman ME (1977) Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome. Arch Dermatol 113:801-805.
99. Holland SM, DeLeo FR, Elloumi HZ et al (2007) STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 357:1608-1619.
100. Mintz R, Garty BZ, Meshel T et al (2010) Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients. Immunol Lett 130:97-106.