Jak1 plays an essential role for receptor phosphorylation and stat activation in response to granulocyte colony-stimulating factor

Blood

Volumn 90, Issue 2, 1997, Pages 597-604

  Shimoda, Kazuya ^b   Feng, Jian ^b   Murakami, Hiroshi ^b   Nagata, Shigekazu ^b   Watling, Diane ^b   Rogers, Neil C ^b   Stark, George R ^b   Kerr, Ian M ^b   Ihle, James N ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; PROTEIN TYROSINE KINASE; STAT1 PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA TRANSFECTION; FIBROSARCOMA; GENE OVEREXPRESSION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0030754121     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.2.597     Document Type: Article

References (27)

1. Demetri GD, Griffin JD: Granulocyte colony-stimulating factor and its receptor. Blood 78:2791, 1991
2. Nagata S: Granulocyte colony-stimulaing factor, in Thompson A (ed): The Cytokine Handbook. San Diego, CA, Academic, 1994, p 371
3. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934, 1990
4. Fukunaga R, Ishizaka-Ikeda E, Nagata S: Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell 74:1079, 1993
5. Nicholson SE, Oates AC, Harpur AG, Ziemiecki A, Wilks AF, Layton JE: Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proc Natl Acad Sci USA 91:2985, 1994
6. Shimoda K, Iwasaki H, Okamura S, Ohno Y, Kubota A, Arima F, Otsuka T, Niho Y: G-CSF induces tyrosine phosphorylation of the Jak2 protein in the human myeloid G-CSF responsive and proliferative cells, but not in mature neutrophiles. Biochem Biophys Res Commun 203:922, 1994
7. MAPK. Blood 86:3698, 1995
8. Barge RM, de Koning JP, Pouwels K, Dong F, Lowenberg B, Touw IP: Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route. Blood 87:2148, 1996
9. Rauprich P, Kasper G, Tidow N, Welte K: The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia. Blood 86:4500, 1995
10. Corey SJ, Burkhardt AL, Bolen JB, Geahlen R, Tkatch LS, Tweardy DJ: Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci USA 91:4683, 1994
11. Matsuda T, Hirano T: Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor. Blood 83:3457, 1994
12. de Koning JP, Dong F, Smith L, Schelen AM, Barge RMY, van der Plas DC, Hoefsloot LH, Lowenberg B, Touw IP: The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation. Blood 87:1335, 1996
13. Tian S, Lamb P, Seidel HM, Stein RB, Rosen J: Rapid activation of the Stat3 transcription factor by granulocyte colony-stimulating factor. Blood 84:1760, 1994
14. John J, McKendry R, Pellegrini S, Flavell D, Kerr IM, Stark GR: Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons. Mol Cell Biol 11:4189, 1991
15. McKendry R, John J, Flavell D, Muller M, Kerr IM, Stark GR: High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both α and γ interferons. Proc Natl Acad Sci USA 88:11455, 1991
16. Pellegrini S, John J, Shearer M, Kerr IM, Stark GR: Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol 9:4605, 1989
17. Velazquez L, Fellous M, Stark GR, Pellegrini S: A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70:313, 1992
18. Muller M, Briscoc J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, Pellegrini S, Wilks AF, Ihle JN, Stark GR, Kerr IM: The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -signal transduction. Nature 366:129, 1993
19. Watling D, Guschin D, Muller M, Silvennoinen O, Witthuhn BA, Quelle FW, Rogers NC, Schindler C, Stark GR, Ihle JN, Kerr IM: Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-γ signal transduction pathway. Nature 366:166, 1993
20. Nosaka T, van Deursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN: Defective lymphoid development in mice lacking Jak3. Science 270:800, 1995
21. Thornis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Mice lacking Jak3 have defects in B lymphocyte maturation and T lymphocyte activation. Science 270:794, 1995
22. Guschin D, Rogers N, Briscoe J, Witthuhn B, Watling D, Horn F, Pellegrini S, Yasukawa K, Heinrich P, Stark GR, Ihle JN, Kerr IM: A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J 14:1421, 1995
23. Wang D, Stravopodis D, Teglund S, Kitazawa J, Ihle JN: Naturally occurring dominant negative variants of Stat5. Mol Cell Biol 16:6141, 1996
24. Fukunaga R, Seto Y, Mizushima S, Nagata S: Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. Proc Natl Acad Sci USA 87:8702, 1990
25. Quelle FW, Thierfelder W, Witthuhn BA, Tang B, Cohen S, Ihle JN: Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein tyrosine kinases and epidermal growth factor receptor. J Biol Chem 270:20775, 1995
26. Han Y, Leaman DW, Watling D, Rogers NC, Groner B, Kerr IM, Wood WI, Stark GR: Participation of JAK and STAT proteins in growth hormone-induced signaling. J Biol Chem 271:5947, 1996
27. 1007 in the kinase activation loop. Mol Cell Biol 17:2497, 1997