Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene

Journal of Experimental Medicine

Volumn 189, Issue 4, 1999, Pages 683-691

  Hermans, Mirjam H A ^a,b   Antonissen, Claudia ^a   Ward, Alister C ^a   Mayen, Angelique E M ^a   Ploemacher, Rob E ^a   Touw, Ivo P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Acute myeloid leukemia; Granulocyte colony stimulating factor receptor; Mutations; Neutropenia; Severe congenital neutropenia

Indexed keywords

AMINO ACID; GRANULOCYTE COLONY STIMULATING FACTOR; RECEPTOR; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE; GENE MUTATION; INTERNALIZATION; MOUSE; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; BONE MARROW; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; COLONY-FORMING UNITS ASSAY; DNA-BINDING PROTEINS; ENDOCYTOSIS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; KINETICS; LEUKEMIA, MYELOID; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MILK PROTEINS; NEUTROPENIA; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; SEQUENCE DELETION; SPECIFIC PATHOGEN-FREE ORGANISMS; STAT1 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0033557171     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.4.683     Document Type: Article

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