-
1
-
-
52649131951
-
Lung cancer
-
Herbst, R.S.; Heymach, J.V.; Lippman, S.M. Lung cancer. N. Engl. J. Med. 2008, 359, 1367-1380.
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 1367-1380
-
-
Herbst, R.S.1
Heymach, J.V.2
Lippman, S.M.3
-
2
-
-
0003964363
-
-
American cancer society, Available online, accessed on 24 June 2012
-
American cancer society. Cancer facts & figures 2011. Available online: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-029771.pdf (accessed on 24 June 2012).
-
Cancer Facts & Figures 2011
-
-
-
3
-
-
79952232216
-
Global cancer statistics, 2011
-
Jemal, A.; Bray, F.; Center, M.M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics, 2011. CA. Cancer J. Clin. 2011, 61, 69-90.
-
(2011)
CA. Cancer J. Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
4
-
-
84878084822
-
-
National Comprehensive Cancer Network. Available online, accessed on 10 September 2012
-
National Comprehensive Cancer Network. Available online: http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf (accessed on 10 September 2012).
-
-
-
-
5
-
-
39649116928
-
EGFR tyrosine kinase inhibitors in lung cancer: An evolving story
-
Sequist, L.V.; Lynch, T.J. EGFR tyrosine kinase inhibitors in lung cancer: An evolving story. Annu. Rev. Med. 2008, 59, 429-442.
-
(2008)
Annu. Rev. Med
, vol.59
, pp. 429-442
-
-
Sequist, L.V.1
Lynch, T.J.2
-
6
-
-
84860582939
-
Advances in treatment of lung cancer with targeted therapy
-
Cagle, P.T.; Chirieac, L.R. Advances in treatment of lung cancer with targeted therapy. Arch. Pathol. Lab. Med. 2012, 136, 504-509.
-
(2012)
Arch. Pathol. Lab. Med
, vol.136
, pp. 504-509
-
-
Cagle, P.T.1
Chirieac, L.R.2
-
7
-
-
85041203037
-
Cancer genetics: Initially complex, always heterogeneous
-
Burgess, D.J. Cancer genetics: Initially complex, always heterogeneous. Nat. Rev. Cancer 2011, 11, 153.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 153
-
-
Burgess, D.J.1
-
8
-
-
79551700566
-
Will we be able to care for cancer patients in the future?
-
Bunnell, C.A.; Shulman, L.N. Will we be able to care for cancer patients in the future? Oncology (Williston Park) 2010, 14, 1343-1348.
-
(2010)
Oncology (Williston Park)
, vol.14
, pp. 1343-1348
-
-
Bunnell, C.A.1
Shulman, L.N.2
-
9
-
-
84860455486
-
Discovery of small molecule cancer drugs: Successes, challenges and opportunities
-
Hoelder, S.; Clarke, P.A.; Workman, P. Discovery of small molecule cancer drugs: Successes, challenges and opportunities. Mol. Oncol. 2012, 6, 155-176.
-
(2012)
Mol. Oncol
, vol.6
, pp. 155-176
-
-
Hoelder, S.1
Clarke, P.A.2
Workman, P.3
-
10
-
-
78649681592
-
Head and neck squamous cell carcinoma: New translational therapies
-
Prince, A.; Aguirre-Ghizo, J.; Genden, E.; Posner, M.; Sikora, A. Head and neck squamous cell carcinoma: New translational therapies. Mt. Sinai. J. Med. 2010, 77, 684-699.
-
(2010)
Mt. Sinai. J. Med
, vol.77
, pp. 684-699
-
-
Prince, A.1
Aguirre-Ghizo, J.2
Genden, E.3
Posner, M.4
Sikora, A.5
-
11
-
-
84860172731
-
Patient-tailored treatments with anti-EGFR monoclonal antibodies in advanced colorectal cancer: KRAS and beyond
-
Ballestrero, A.; Garuti, A.; Cirmena, G.; Rocco, I.; Palermo, C.; Nencioni, A.; Scabini, S.; Zoppoli, G.; Parodi, S.; Patrone, F. Patient-tailored treatments with anti-EGFR monoclonal antibodies in advanced colorectal cancer: KRAS and beyond. Curr. Cancer Drug Targets 2012, 12, 316-328.
-
(2012)
Curr. Cancer Drug Targets
, vol.12
, pp. 316-328
-
-
Ballestrero, A.1
Garuti, A.2
Cirmena, G.3
Rocco, I.4
Palermo, C.5
Nencioni, A.6
Scabini, S.7
Zoppoli, G.8
Parodi, S.9
Patrone, F.10
-
12
-
-
59849124142
-
Personalized medicine for pancreatic cancer: A step in the right direction
-
Ko, A.H.; Tempero, M.A. Personalized medicine for pancreatic cancer: A step in the right direction. Gastroenterology 2009, 136, 43-45.
-
(2009)
Gastroenterology
, vol.136
, pp. 43-45
-
-
Ko, A.H.1
Tempero, M.A.2
-
13
-
-
58149359606
-
Advances in breast cancer: Pathways to personalized medicine
-
Olopade, O.I.; Grushko, T.A.; Nanda, R.; Huo, D. Advances in breast cancer: Pathways to personalized medicine. Clin. Cancer Res. 2008, 14, 7988-7999.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 7988-7999
-
-
Olopade, O.I.1
Grushko, T.A.2
Nanda, R.3
Huo, D.4
-
14
-
-
35548962203
-
Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
-
Mitsudomi, T.; Yatabe, Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci. 2007, 98, 1817-1824.
-
(2007)
Cancer Sci
, vol.98
, pp. 1817-1824
-
-
Mitsudomi, T.1
Yatabe, Y.2
-
15
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma, S.V.; Bell, D.W.; Settleman, J.; Haber, D.A. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 2007, 7, 169-181.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
Haber, D.A.4
-
16
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello, F.; Tortora, G. EGFR antagonists in cancer treatment. N. Engl. J. Med. 2008, 358, 1160-1174.
-
(2008)
N. Engl. J. Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
17
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
Scaltriti, M.; Baselga, J. The epidermal growth factor receptor pathway: A model for targeted therapy. Clin. Cancer Res. 2006, 12, 5268-5272.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
18
-
-
33745828702
-
EGF-ERBB signalling: Towards the systems level
-
Citri, A.; Yarden, Y. EGF-ERBB signalling: Towards the systems level. Nat. Rev. Mol. Cell Biol. 2006, 7, 505-516.
-
(2006)
Nat. Rev. Mol. Cell Biol
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
19
-
-
61749090015
-
Deregulated EGFR signaling during lung cancer progression: Mutations, amplicons, and autocrine loops
-
Gazdar, A.F.; Minna, J.D. Deregulated EGFR signaling during lung cancer progression: Mutations, amplicons, and autocrine loops. Cancer Prev. Res. (Phila) 2008, 1, 156-160.
-
(2008)
Cancer Prev. Res. (Phila)
, vol.1
, pp. 156-160
-
-
Gazdar, A.F.1
Minna, J.D.2
-
20
-
-
33845645365
-
Oncogenic shock: Turning an activated kinase against the tumor cell
-
Sharma, S.V.; Settleman, J. Oncogenic shock: Turning an activated kinase against the tumor cell. Cell Cycle 2006, 5, 2878-2880.
-
(2006)
Cell Cycle
, vol.5
, pp. 2878-2880
-
-
Sharma, S.V.1
Settleman, J.2
-
21
-
-
84878039322
-
Molecular Biology and Genetics of Lung Cancer
-
Jeremić, B., Ed.; Springer-Verlag Berlin: Heidelberg, Germany
-
Martine, E.N.; Hahn, M.S.; McKenna, G.W. Molecular Biology and Genetics of Lung Cancer. In Advances in Radiation Oncology in Lung Cancer; Jeremić, B., Ed.; Springer-Verlag Berlin: Heidelberg, Germany, 2005; p. 6.
-
(2005)
Advances In Radiation Oncology In Lung Cancer
, pp. 6
-
-
Martine, E.N.1
Hahn, M.S.2
McKenna, G.W.3
-
22
-
-
84857658325
-
Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC)
-
Belani, C.P.; Goss, G.; Blumenschein, G., Jr. Recent clinical developments and rationale for combining targeted agents in non-small cell lung cancer (NSCLC). Cancer Treat. Rev. 2012, 38, 173-184.
-
(2012)
Cancer Treat. Rev
, vol.38
, pp. 173-184
-
-
Belani, C.P.1
Goss, G.2
Blumenschein Jr., G.3
-
23
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T.J.; Bell, D.W.; Sordella, R.; Gurubhagavatula, S.; Okimoto, R.A.; Brannigan, B.W.; Harris, P.L.; Haserlat, S.M.; Supko, J.G.; Haluska, F.G. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350, 2129-2139.
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
24
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J.G.; Jänne, P.A.; Lee, J.C.; Tracy, S.; Greulich, H.; Gabriel, S.; Herman, P.; Kaye, F.J.; Lindeman, N.; Boggon, T.J. et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004, 304, 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
25
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao, W.; Miller, V.; Zakowski, M.; Doherty, J.; Politi, K.; Sarkaria, I.; Singh, B.; Heelan, R.; Rusch, V.; Fulton, L. et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl. Acad. Sci.USA 2004, 101, 13306-13311.
-
(2004)
Proc. Natl. Acad. Sci.USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
-
26
-
-
79960702788
-
Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
-
Fukuoka, M.; Wu, Y.L.; Thongprasert, S.; Sunpaweravong, P.; Leong, S.S.; Sriuranpong, V.; Chao, T.Y.; Nakagawa, K.; Chu, D.T.; Saijo, N. et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J. Clin. Oncol. 2011, 29, 2866-2874.
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.L.2
Thongprasert, S.3
Sunpaweravong, P.4
Leong, S.S.5
Sriuranpong, V.6
Chao, T.Y.7
Nakagawa, K.8
Chu, D.T.9
Saijo, N.10
-
27
-
-
78649919343
-
Predictive molecular markers for EGFR-TKI in non-small cell lung cancer patients: New insights and critical aspects
-
Ulivi, P.; Calistri, D.; Zoli, W.; Amadori, D. Predictive molecular markers for EGFR-TKI in non-small cell lung cancer patients: New insights and critical aspects. J. Nucleic Acids Investig. 2010, 1, 47-54.
-
(2010)
J. Nucleic Acids Investig
, vol.1
, pp. 47-54
-
-
Ulivi, P.1
Calistri, D.2
Zoli, W.3
Amadori, D.4
-
28
-
-
84857414572
-
Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: A meta-analysis of 13 randomized trials
-
Petrelli, F.; Borgonovo, K.; Cabiddu, M.; Barni, S. Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: A meta-analysis of 13 randomized trials. Clin. Lung Cancer 2012, 13, 107-114.
-
(2012)
Clin. Lung Cancer
, vol.13
, pp. 107-114
-
-
Petrelli, F.1
Borgonovo, K.2
Cabiddu, M.3
Barni, S.4
-
29
-
-
80155150303
-
Personalized medicine in lung cancer: What we need to know
-
Mok, T.S. Personalized medicine in lung cancer: What we need to know. Nat. Rev. Clin. Oncol. 2011, 8, 661-668.
-
(2011)
Nat. Rev. Clin. Oncol
, vol.8
, pp. 661-668
-
-
Mok, T.S.1
-
30
-
-
79957492069
-
American Society of Clinical Oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy
-
Keedy, V.L.; Temin, S.; Somerfield, M.R.; Beasley, M.B.; Johnson, D.H.; McShane, L.M.; Milton, D.T.; Strawn, J.R.; Wakelee, H.A.; Giaccone, G. American Society of Clinical Oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. J. Clin. Oncol. 2011, 29, 2121-2127.
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2121-2127
-
-
Keedy, V.L.1
Temin, S.2
Somerfield, M.R.3
Beasley, M.B.4
Johnson, D.H.5
McShane, L.M.6
Milton, D.T.7
Strawn, J.R.8
Wakelee, H.A.9
Giaccone, G.10
-
31
-
-
84655167293
-
Targeting EGFR in non-small-cell lung cancer: Lessons, experiences, strategies
-
Stella, G.M.; Luisetti, M.; Inghilleri, S.; Cemmi, F.; Scabini, R.; Zorzetto, M.; Pozzi, E. Targeting EGFR in non-small-cell lung cancer: Lessons, experiences, strategies. Respir. Med. 2012, 106, 173-183.
-
(2012)
Respir. Med
, vol.106
, pp. 173-183
-
-
Stella, G.M.1
Luisetti, M.2
Inghilleri, S.3
Cemmi, F.4
Scabini, R.5
Zorzetto, M.6
Pozzi, E.7
-
32
-
-
33947498978
-
Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
-
Sequist, L.V.; Bell, D.W.; Lynch, T.J.; Haber, D.A. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J. Clin. Oncol. 2007, 25, 587-595.
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 587-595
-
-
Sequist, L.V.1
Bell, D.W.2
Lynch, T.J.3
Haber, D.A.4
-
33
-
-
84862823259
-
Molecular pathology of lung cancer: Key to personalized medicine
-
Cheng, L.; Alexander, R.E.; Maclennan, G.T.; Cummings, O.W.; Montironi, R.; Lopez-Beltran, A.; Cramer, H.M.; Davidson, D.D.; Zhang, S. Molecular pathology of lung cancer: Key to personalized medicine. Mod. Pathol. 2012, 25, 347-369.
-
(2012)
Mod. Pathol
, vol.25
, pp. 347-369
-
-
Cheng, L.1
Alexander, R.E.2
Maclennan, G.T.3
Cummings, O.W.4
Montironi, R.5
Lopez-Beltran, A.6
Cramer, H.M.7
Davidson, D.D.8
Zhang, S.9
-
34
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu, H.; Lin, L.; Takahashi, T.; Nomura, M.; Suzuki, M.; Wistuba, I.I.; Fong, M.K.; Lee, H.; Toyooka, S.; Shimizu, N. et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J. Natl. Cancer Inst. 2005, 97, 339-346.
-
(2005)
J. Natl. Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, M.K.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
-
35
-
-
33846187218
-
Update on epidermal growth factor receptor mutations in non-small cell lung cancer
-
Riely, G.J.; Politi, K.A.; Miller, V.A.; Pao, W. Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin. Cancer Res. 2006, 12, 7232-7241.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 7232-7241
-
-
Riely, G.J.1
Politi, K.A.2
Miller, V.A.3
Pao, W.4
-
36
-
-
84861336752
-
Lung cancer in never smokers-A review
-
Couraud, S.; Zalcman, G.; Milleron, B.; Morin, F.; Souquet, P.J. Lung cancer in never smokers-A review. Eur. J. Cancer 2012, 48, 1299-1311.
-
(2012)
Eur. J. Cancer
, vol.48
, pp. 1299-1311
-
-
Couraud, S.1
Zalcman, G.2
Milleron, B.3
Morin, F.4
Souquet, P.J.5
-
37
-
-
84855310079
-
EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
-
Yasuda, H.; Kobayashi, S.; Costa, D.B. EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications. Lancet Oncol. 2012, 13, e23-e31.
-
(2012)
Lancet Oncol
, vol.13
-
-
Yasuda, H.1
Kobayashi, S.2
Costa, D.B.3
-
38
-
-
42549089715
-
Lung adenocarcinoma: Guiding EGFR-targeted therapy and beyond
-
Ladanyi, M.; Pao, W. Lung adenocarcinoma: Guiding EGFR-targeted therapy and beyond. Mod. Pathol. 2008, 21, S16-S22.
-
(2008)
Mod. Pathol
, vol.21
-
-
Ladanyi, M.1
Pao, W.2
-
39
-
-
28844501639
-
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
-
Shigematsu, H.; Gazdar, A.F. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int. J. Cancer 2006, 118, 257-262.
-
(2006)
Int. J. Cancer
, vol.118
, pp. 257-262
-
-
Shigematsu, H.1
Gazdar, A.F.2
-
40
-
-
84863275566
-
High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma
-
Lee, Y.; Shim, H.S.; Park, M.S.; Kim, J.H.; Ha, S.J.; Kim, S.H.; Cho, B.C. High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma. Clin. Cancer Res. 2012, 18, 1760-1768.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 1760-1768
-
-
Lee, Y.1
Shim, H.S.2
Park, M.S.3
Kim, J.H.4
Ha, S.J.5
Kim, S.H.6
Cho, B.C.7
-
41
-
-
27244443759
-
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study
-
Hirsch, F.R.; Varella-Garcia, M.; McCoy, J.; West, H.; Xavier, A.C.; Gumerlock, P.; Bunn, P.A., Jr.; Franklin, W.A.; Crowley, J.; Gandara, D.R. et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study. J. Clin. Oncol. 2005, 23, 6838-6845.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 6838-6845
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
McCoy, J.3
West, H.4
Xavier, A.C.5
Gumerlock, P.6
Bunn Jr., P.A.7
Franklin, W.A.8
Crowley, J.9
Gandara, D.R.10
-
42
-
-
20444498630
-
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
-
Cappuzzo, F.; Hirsch, F.R.; Rossi, E.; Bartolini, S.; Ceresoli, G.L.; Bemis, L.; Haney, J.; Witta, S.; Danenberg, K.; Domenichini, I. et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J. Natl. Cancer Inst. 2005, 97, 643-655.
-
(2005)
J. Natl. Cancer Inst
, vol.97
, pp. 643-655
-
-
Cappuzzo, F.1
Hirsch, F.R.2
Rossi, E.3
Bartolini, S.4
Ceresoli, G.L.5
Bemis, L.6
Haney, J.7
Witta, S.8
Danenberg, K.9
Domenichini, I.10
-
43
-
-
77953000554
-
EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry
-
Sholl, L.M.; Xiao, Y.; Joshi, V.; Yeap, B.Y.; Cioffredi, L.A.; Jackman, D.M.; Lee, C.; Jänne, P.A.; Lindeman, N.I. EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry. Am. J. Clin. Pathol. 2010, 133, 922-934.
-
(2010)
Am. J. Clin. Pathol
, vol.133
, pp. 922-934
-
-
Sholl, L.M.1
Xiao, Y.2
Joshi, V.3
Yeap, B.Y.4
Cioffredi, L.A.5
Jackman, D.M.6
Lee, C.7
Jänne, P.A.8
Lindeman, N.I.9
-
44
-
-
77956691818
-
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain
-
Lee, C.C.; Jia, Y.; Li, N.; Sun, X.; Ng, K.; Ambing, E.; Gao, M.Y.; Hua, S.; Chen, C.; Kim, S. et al. Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain. Biochem. J. 2010, 430, 425-437.
-
(2010)
Biochem. J
, vol.430
, pp. 425-437
-
-
Lee, C.C.1
Jia, Y.2
Li, N.3
Sun, X.4
Ng, K.5
Ambing, E.6
Gao, M.Y.7
Hua, S.8
Chen, C.9
Kim, S.10
-
45
-
-
0031008896
-
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
-
Morris, S.W.; Naeve, C.; Mathew, P.; James, P.L.; Kirstein, M.N.; Cui, X.; Witte, D.P. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 1997, 14, 2175-2188.
-
(1997)
Oncogene
, vol.14
, pp. 2175-2188
-
-
Morris, S.W.1
Naeve, C.2
Mathew, P.3
James, P.L.4
Kirstein, M.N.5
Cui, X.6
Witte, D.P.7
-
46
-
-
84859508816
-
ALK translocation and crizotinib in non-small cell lung cancer: An evolving paradigm in oncology drug development
-
Scagliotti, G.; Stahel, R.A.; Rosell, R.; Thatcher, N.; Soria, J.C. ALK translocation and crizotinib in non-small cell lung cancer: An evolving paradigm in oncology drug development. Eur. J. Cancer 2012, 48, 961-973.
-
(2012)
Eur. J. Cancer
, vol.48
, pp. 961-973
-
-
Scagliotti, G.1
Stahel, R.A.2
Rosell, R.3
Thatcher, N.4
Soria, J.C.5
-
47
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda, M.; Choi, Y.L.; Enomoto, M.; Takada, S.; Yamashita, Y.; Ishikawa, S.; Fujiwara, S.; Watanabe, H.; Kurashina, K.; Hatanaka, H. et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007, 448, 561-566.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
-
48
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak, E.L.; Bang, Y.J.; Camidge, D.R.; Shaw, A.T.; Solomon, B.; Maki, R.G.; Ou, S.H.; Dezube, B.J.; Jänne, P.A.; Costa, D.B. et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 2010, 363, 1693-1703.
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
Maki, R.G.6
Ou, S.H.7
Dezube, B.J.8
Jänne, P.A.9
Costa, D.B.10
-
49
-
-
84866934255
-
Clinical significance of the EML4-ALK fusion gene and association with EGFR and KRAS gene mutation in 208 Chinese patients with non-small cell lung cancer
-
Chen, J.; Liu, H.; Yang, T.; Wei, S.; Zhou, Q. Clinical significance of the EML4-ALK fusion gene and association with EGFR and KRAS gene mutation in 208 Chinese patients with non-small cell lung cancer. J. Clin. Oncol. 2012, 30, e17514.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Chen, J.1
Liu, H.2
Yang, T.3
Wei, S.4
Zhou, Q.5
-
50
-
-
78049515002
-
Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases
-
Sun, Y.; Ren, Y.; Fang, Z.; Li, C.; Fang, R.; Gao, B.; Han, X.; Tian, W.; Pao, W.; Chen, H. et al. Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J. Clin. Oncol. 2010, 28, 4616-4620.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 4616-4620
-
-
Sun, Y.1
Ren, Y.2
Fang, Z.3
Li, C.4
Fang, R.5
Gao, B.6
Han, X.7
Tian, W.8
Pao, W.9
Chen, H.10
-
51
-
-
79960042770
-
Targeted therapy in non-small-cell lung cancer-Is it becoming a reality?
-
Janku, F.; Stewart, D.J.; Kurzrock, R. Targeted therapy in non-small-cell lung cancer-Is it becoming a reality? Nat. Rev. Clin. Oncol. 2010, 7, 401-414.
-
(2010)
Nat. Rev. Clin. Oncol
, vol.7
, pp. 401-414
-
-
Janku, F.1
Stewart, D.J.2
Kurzrock, R.3
-
52
-
-
79251490374
-
New driver mutations in non-small-cell lung cancer
-
Pao, W.; Girard, N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011, 12, 175-180.
-
(2011)
Lancet Oncol
, vol.12
, pp. 175-180
-
-
Pao, W.1
Girard, N.2
-
53
-
-
52749099497
-
Assessment of somatic K-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
Linardou, H.; Dahabreh, I.J.; Kanaloupiti, D.; Siannis, F.; Bafaloukos, D.; Kosmidis, P.; Papadimitriou, C.A.; Murray, S. Assessment of somatic K-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008, 9, 962-972.
-
(2008)
Lancet Oncol
, vol.9
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
Siannis, F.4
Bafaloukos, D.5
Kosmidis, P.6
Papadimitriou, C.A.7
Murray, S.8
-
54
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao, W.; Wang, T.Y.; Riely, G.J.; Miller, V.A.; Pan, Q.; Ladanyi, M.; Zakowski, M.F.; Heelan, R.T.; Kris, M.G.; Varmus, H.E. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2005, 2, e17.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
Miller, V.A.4
Pan, Q.5
Ladanyi, M.6
Zakowski, M.F.7
Heelan, R.T.8
Kris, M.G.9
Varmus, H.E.10
-
55
-
-
77949902069
-
Epidermal growth factor receptor biomarkers in non-small-cell lung cancer: A riddle, wrapped in a mystery, inside an enigma
-
Shepherd, F.A.; Tsao, M.S. Epidermal growth factor receptor biomarkers in non-small-cell lung cancer: A riddle, wrapped in a mystery, inside an enigma. J. Clin. Oncol. 2010, 28, 903-905.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 903-905
-
-
Shepherd, F.A.1
Tsao, M.S.2
-
56
-
-
84861312838
-
The mTOR pathway in lung cancer and implications for therapy and biomarker analysis
-
Ekman, S.; Wynes, M.W.; Hirsch, F.R. The mTOR pathway in lung cancer and implications for therapy and biomarker analysis. J. Thorac. Oncol. 2012, 7, 947-953.
-
(2012)
J. Thorac. Oncol
, vol.7
, pp. 947-953
-
-
Ekman, S.1
Wynes, M.W.2
Hirsch, F.R.3
-
57
-
-
84878104947
-
Amplification of fibroblast growth factor receptor type 1 gene (FGFR1) in samples from 101 NSCLC patients (pts) with squamous cell carcinoma (SCC) histology
-
abstr7041
-
Marti, M.A.; Martinez, P.; Aura, C.; Cedres, S.; Sullivan, I.; Jimenez, J.; Prudkin, L.; Montero, A.M.; Murtra-Garrell, N.; Zamora, E. et al. Amplification of fibroblast growth factor receptor type 1 gene (FGFR1) in samples from 101 NSCLC patients (pts) with squamous cell carcinoma (SCC) histology. J. Clin. Oncol. 2012, 30, abstr7041.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Marti, M.A.1
Martinez, P.2
Aura, C.3
Cedres, S.4
Sullivan, I.5
Jimenez, J.6
Prudkin, L.7
Montero, A.M.8
Murtra-Garrell, N.9
Zamora, E.10
-
58
-
-
84866948375
-
Preclinical investigation of the antitumor efficacy in lung cancer of Y15, a novel focal adhesion kinase inhibitor
-
Dy, K.G.; Shao, H.; Ho, B.; Yemma, M.; Adjei, A.; Golubovskaya, V.; Cance, V. Preclinical investigation of the antitumor efficacy in lung cancer of Y15, a novel focal adhesion kinase inhibitor. Mol. Cancer Ther. 2011, 10, S1.
-
(2011)
Mol. Cancer Ther
, vol.10
-
-
Dy, K.G.1
Shao, H.2
Ho, B.3
Yemma, M.4
Adjei, A.5
Golubovskaya, V.6
Cance, V.7
-
59
-
-
84866709500
-
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
-
Hammerman, P.S.; Sos, M.L.; Ramos, A.H.; Xu, C.; Dutt, A.; Zhou, W.; Brace, L.E.; Woods, B.A.; Lin, W.; Zhang, J. et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011, 1, 78-89.
-
(2011)
Cancer Discov
, vol.1
, pp. 78-89
-
-
Hammerman, P.S.1
Sos, M.L.2
Ramos, A.H.3
Xu, C.4
Dutt, A.5
Zhou, W.6
Brace, L.E.7
Woods, B.A.8
Lin, W.9
Zhang, J.10
-
60
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao, W.; Miller, V.A.; Politi, K.A.; Riely, G.J.; Somwar, R.; Zakowski, M.F.; Kris, M.G.; Varmus, H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005, 2, e73.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
Kris, M.G.7
Varmus, H.8
-
61
-
-
84861977785
-
T790M and acquired resistance of EGFR TKI: A literature review of clinical reports
-
Ma, C.; Wei, S.; Song, Y. T790M and acquired resistance of EGFR TKI: A literature review of clinical reports. J. Thorac. Dis. 2011, 3, 10-18.
-
(2011)
J. Thorac. Dis
, vol.3
, pp. 10-18
-
-
Ma, C.1
Wei, S.2
Song, Y.3
-
62
-
-
84860319366
-
Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance
-
Ogawa, T.; Liggett, T.E.; Melnikov, A.A.; Monittom, C.L.; Kusuke, D.; Shiga, K.; Kobayashi, T.; Horii, A.; Chatterjee, A.; Levenson, V.V. et al. Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance. Cell Cycle 2012, 11, 1656-1663.
-
(2012)
Cell Cycle
, vol.11
, pp. 1656-1663
-
-
Ogawa, T.1
Liggett, T.E.2
Melnikov, A.A.3
Monittom, C.L.4
Kusuke, D.5
Shiga, K.6
Kobayashi, T.7
Horii, A.8
Chatterjee, A.9
Levenson, V.V.10
-
63
-
-
84858408937
-
Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors
-
Ghosh, G.; Lian, X.; Kron, S.J.; Palecek, S.P. Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors. BMC Cancer 2012, 12, 95.
-
(2012)
BMC Cancer
, vol.12
, pp. 95
-
-
Ghosh, G.1
Lian, X.2
Kron, S.J.3
Palecek, S.P.4
-
64
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
ALK Lung Cancer Study Group
-
Choi, Y.L.; Soda, M.; Yamashita, Y.; Ueno, T.; Takashima, J.; Nakajima, T.; Yatabe, Y.; Takeuchi, K.; Hamada, T.; Haruta, H. et al. ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N. Engl. J. Med. 2010, 363, 1734-1739.
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
Ueno, T.4
Takashima, J.5
Nakajima, T.6
Yatabe, Y.7
Takeuchi, K.8
Hamada, T.9
Haruta, H.10
-
65
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
doi: 10.1126/scitranslmed.3002003
-
Sequist, L.V.; Waltman, B.A.; Dias-Santagata, D.; Digumarthy, S.; Turke, A.B.; Fidias, P.; Bergethon, K.; Shaw, A.T.; Gettinger, S.; Cosper, A.K. et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 2011, 3, doi: 10.1126/scitranslmed.3002003.
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
Digumarthy, S.4
Turke, A.B.5
Fidias, P.6
Bergethon, K.7
Shaw, A.T.8
Gettinger, S.9
Cosper, A.K.10
-
66
-
-
84878082512
-
-
Gefitinib (marketed as Iressa) Information. Available online, accessed on 07 July 2012
-
Gefitinib (marketed as Iressa) Information. Available online: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm110473.htm (accessed on 07 July 2012).
-
-
-
-
67
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher, N.; Chang, A.; Parikh, P.; Rodrigues Pereira, J.; Ciuleanu, T.; von Pawel, J.; Thongprasert, S.; Tan, E.H.; Pemberton, K.; Archer, V. et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005, 366, 1527-1537.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Rodrigues, P.J.4
Ciuleanu, T.5
von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
-
68
-
-
84866167321
-
Advances on EGFR mutation for lung cancer
-
Metro, G.; Crinò, L. Advances on EGFR mutation for lung cancer. Transl. Lung Cancer Res. 2012, 1, 5-13.
-
(2012)
Transl. Lung Cancer Res
, vol.1
, pp. 5-13
-
-
Metro, G.1
Crinò, L.2
-
69
-
-
84859418112
-
The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor
-
Kim, Y.; Ko, J.; Cui, Z.; Abolhoda, A.; Ahn, J.S.; Ou, S.H.; Ahn, M.J.; Park, K. The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor. Mol. Cancer Ther. 2012, 11, 784-791.
-
(2012)
Mol. Cancer Ther
, vol.11
, pp. 784-791
-
-
Kim, Y.1
Ko, J.2
Cui, Z.3
Abolhoda, A.4
Ahn, J.S.5
Ou, S.H.6
Ahn, M.J.7
Park, K.8
-
70
-
-
77958011527
-
Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy (CT)
-
Boyer, J.M.; Blackhall, H.F.; Park, K.; Barrios, H.C.; Krzakowski, J.M.; Taylor, I.; Liang, Q.J.; Denis, J.L.; O'Connell, P.J.; Ramalingam, S.S. Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy (CT). J. Clin. Oncol. 2010, 28, 18s.
-
(2010)
J. Clin. Oncol
, vol.28
-
-
Boyer, J.M.1
Blackhall, H.F.2
Park, K.3
Barrios, H.C.4
Krzakowski, J.M.5
Taylor, I.6
Liang, Q.J.7
Denis, J.L.8
O'Connell, P.J.9
Ramalingam, S.S.10
-
71
-
-
84878070269
-
-
ARIAD. Available online, accessed on 24 June 2012
-
ARIAD. Available online: http://www.ariad.com/wt/tertiarypage/alk_inhibitor (accessed on 24 June 2012).
-
-
-
-
72
-
-
84866901075
-
First-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumors
-
abstr 3007
-
Mehra, R.; Camidge, D.R.; Sharma, S.; Felip, E.; Tan, D.S.; Vansteenkiste, J.F.; de Pas, T.M.; Kim, D.W.; Santoro, A.; Liu, G. et al. First-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumors. J. Clin. Oncol. 2012, 30, abstr 3007.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Mehra, R.1
Camidge, D.R.2
Sharma, S.3
Felip, E.4
Tan, D.S.5
Vansteenkiste, J.F.6
de Pas, T.M.7
Kim, D.W.8
Santoro, A.9
Liu, G.10
-
73
-
-
33745085747
-
A prospective study to correlate EGFR mutations with gefitinib response
-
abstr7091
-
Rizvi, A.N.; Pao, W.; Kris, G.M.; Rusch, V.; Ladanyi, M.; Ginex, K.P.; Zakowski, F.M.; Tyson, B.L.; Heelan, T.R.; Varmus, H. A prospective study to correlate EGFR mutations with gefitinib response. J. Clin. Oncol. 2005, 23, abstr7091.
-
(2005)
J. Clin. Oncol
, vol.23
-
-
Rizvi, A.N.1
Pao, W.2
Kris, G.M.3
Rusch, V.4
Ladanyi, M.5
Ginex, K.P.6
Zakowski, F.M.7
Tyson, B.L.8
Heelan, T.R.9
Varmus, H.10
-
74
-
-
84858766310
-
EGFR molecular profiling in advanced NSCLC: A prospective phase II study in molecularly/clinically selected patients pretreated with chemotherapy
-
Milella, M.; Nuzzo, C.; Bria, E.; Sperduti, I.; Visca, P.; Buttitta, F.; Antoniani, B.; Merola, R.; Gelibter, A.; Cuppone, F. et al. EGFR molecular profiling in advanced NSCLC: A prospective phase II study in molecularly/clinically selected patients pretreated with chemotherapy. J. Thorac. Oncol. 2012, 7, 672-680.
-
(2012)
J. Thorac. Oncol
, vol.7
, pp. 672-680
-
-
Milella, M.1
Nuzzo, C.2
Bria, E.3
Sperduti, I.4
Visca, P.5
Buttitta, F.6
Antoniani, B.7
Merola, R.8
Gelibter, A.9
Cuppone, F.10
-
75
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
Kim, E.S.; Herbst, R.S.; Wistuba, I.I.; Lee, J.J.; Blumenschein, G.R., Jr.; Tsao, A.; Stewart, D.J.; Hicks, M.E.; Erasmus, J., Jr.; Gupta, S. et al. The BATTLE trial: Personalizing therapy for lung cancer. Cancer Discov. 2011, 1, 44-53.
-
(2011)
Cancer Discov
, vol.1
, pp. 44-53
-
-
Kim, E.S.1
Herbst, R.S.2
Wistuba, I.I.3
Lee, J.J.4
Blumenschein Jr., G.R.5
Tsao, A.6
Stewart, D.J.7
Hicks, M.E.8
Erasmus Jr., J.9
Gupta, S.10
-
76
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell, R.; Carcereny, E.; Gervais, R.; Vergnenegre, A.; Massuti, B.; Felip, E.; Palmero, R.; Garcia-Gomez, R.; Pallares, C.; Sanchez, J.M. et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012, 13, 239-246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
Vergnenegre, A.4
Massuti, B.5
Felip, E.6
Palmero, R.7
Garcia-Gomez, R.8
Pallares, C.9
Sanchez, J.M.10
-
77
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou, C.; Wu, Y.L.; Chen, G.; Feng, J.; Liu, X.Q.; Wang, C.; Zhang, S.; Wang, J.; Zhou, S.; Ren, S. et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011, 12, 735-742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.Q.5
Wang, C.6
Zhang, S.7
Wang, J.8
Zhou, S.9
Ren, S.10
-
78
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi, T.; Morita, S.; Yatabe, Y.; Negoro, S.; Okamoto, I.; Tsurutani, J.; Seto, T.; Satouchi, M.; Tada, H.; Hirashima, T. et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol. 2010, 11, 121-128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
Negoro, S.4
Okamoto, I.5
Tsurutani, J.6
Seto, T.7
Satouchi, M.8
Tada, H.9
Hirashima, T.10
-
79
-
-
84866655838
-
LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
-
Yang, C.J.; Schuler, H.M.; Yamamoto, N.; O'Byrne, J.K.; Hirsh, V.; Mok, T.; Geater, L.S.; Orlov, V.S.; Tsai, C.; Boyer, J.M. et al. LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J. Clin. Oncol. 2012, 30, LBA7500.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Yang, C.J.1
Schuler, H.M.2
Yamamoto, N.3
O'Byrne, J.K.4
Hirsh, V.5
Mok, T.6
Geater, L.S.7
Orlov, V.S.8
Tsai, C.9
Boyer, J.M.10
-
80
-
-
83455167490
-
Final overall survival results of NEJ002, a phase III trial comparing gefitinib to carboplatin (CBDCA) plus paclitaxel (TXL) as the first-line treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations
-
abstr 7519
-
Inoue, A.; Kobayashi, K.; Maemondo, M.; Sugawara, S.; Oizumi, S.; Isobe, H.; Gemma, A.; Saijo, Y.; Yoshizawa, H.; Morita, S. et al. Final overall survival results of NEJ002, a phase III trial comparing gefitinib to carboplatin (CBDCA) plus paclitaxel (TXL) as the first-line treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutations. J. Clin. Oncol. 2011, 29, abstr 7519.
-
(2011)
J. Clin. Oncol
, vol.29
-
-
Inoue, A.1
Kobayashi, K.2
Maemondo, M.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
Gemma, A.7
Saijo, Y.8
Yoshizawa, H.9
Morita, S.10
-
81
-
-
78650189256
-
A multicenter phase II study to evaluate the efficacy and safety of gefitinib as first-line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations
-
Kim, D.W.; Lee, S.H.; Lee, J.S.; Lee, M.A.; Kang, J.H.; Kim, S.Y.; Shin, S.W.; Kim, H.K.; Heo, D.S. A multicenter phase II study to evaluate the efficacy and safety of gefitinib as first-line treatment for Korean patients with advanced pulmonary adenocarcinoma harboring EGFR mutations. Lung Cancer 2011, 71, 65-69.
-
(2011)
Lung Cancer
, vol.71
, pp. 65-69
-
-
Kim, D.W.1
Lee, S.H.2
Lee, J.S.3
Lee, M.A.4
Kang, J.H.5
Kim, S.Y.6
Shin, S.W.7
Kim, H.K.8
Heo, D.S.9
-
82
-
-
40349111048
-
Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: Results of the West Japan Thoracic Oncology Group trial (WJTOG0403)
-
Tamura, K.; Okamoto, I.; Kashii, T.; Negoro, S.; Hirashima, T.; Kudoh, S.; Ichinose, Y.; Ebi, N.; Shibata, K.; Nishimura, T. et al. Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: Results of the West Japan Thoracic Oncology Group trial (WJTOG0403). Br. J. Cancer. 2008, 98, 907-914.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 907-914
-
-
Tamura, K.1
Okamoto, I.2
Kashii, T.3
Negoro, S.4
Hirashima, T.5
Kudoh, S.6
Ichinose, Y.7
Ebi, N.8
Shibata, K.9
Nishimura, T.10
-
83
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist, L.V.; Martins, R.G.; Spigel, D.; Grunberg, S.M.; Spira, A.; Jänne, P.A.; Joshi, V.A.; McCollum, D.; Evans, T.L.; Muzikansky, A. et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J. Clin. Oncol. 2008, 26, 2442-2449.
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
Grunberg, S.M.4
Spira, A.5
Jänne, P.A.6
Joshi, V.A.7
McCollum, D.8
Evans, T.L.9
Muzikansky, A.10
-
84
-
-
63049132774
-
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
-
Inoue, A.; Kobayashi, K.; Usui, K.; Maemondo, M.; Okinaga, S.; Mikami, I.; Ando, M.; Yamazaki, K.; Saijo, Y.; Gemma, A. et al. First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J. Clin. Oncol. 2009, 27, 1394-1400.
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 1394-1400
-
-
Inoue, A.1
Kobayashi, K.2
Usui, K.3
Maemondo, M.4
Okinaga, S.5
Mikami, I.6
Ando, M.7
Yamazaki, K.8
Saijo, Y.9
Gemma, A.10
-
85
-
-
67349144683
-
Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations
-
Sugio, K.; Uramoto, H.; Onitsuka, T.; Mizukami, M.; Ichiki, Y.; Sugaya, M.; Yasuda, M.; Takenoyama, M.; Oyama, T.; Hanagiri, T. et al. Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. Lung Cancer 2009, 64, 314-318.
-
(2009)
Lung Cancer
, vol.64
, pp. 314-318
-
-
Sugio, K.1
Uramoto, H.2
Onitsuka, T.3
Mizukami, M.4
Ichiki, Y.5
Sugaya, M.6
Yasuda, M.7
Takenoyama, M.8
Oyama, T.9
Hanagiri, T.10
-
86
-
-
84866927444
-
Erlotinib as neoadjuvant treatment in patients with stage IIIA-N2 non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation (NCT01217619, ESTERN)
-
abstr e17551
-
Han, B.; Xiong, L.; Sun, J.; Li, R.; Lou, Y.; Zhang, Y. Erlotinib as neoadjuvant treatment in patients with stage IIIA-N2 non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation (NCT01217619, ESTERN). J. Clin. Oncol. 2012, 30, abstr e17551.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Han, B.1
Xiong, L.2
Sun, J.3
Li, R.4
Lou, Y.5
Zhang, Y.6
-
87
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase II trial
-
Yang, J.C.; Shih, J.Y.; Su, W.C.; Hsia, T.C.; Tsai, C.M.; Ou, S.H.; Yu, C.J.; Chang, G.C.; Ho, C.L.; Sequist, L.V. et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase II trial. Lancet Oncol. 2012, 13, 539-548.
-
(2012)
Lancet Oncol
, vol.13
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
Hsia, T.C.4
Tsai, C.M.5
Ou, S.H.6
Yu, C.J.7
Chang, G.C.8
Ho, C.L.9
Sequist, L.V.10
-
88
-
-
84866709146
-
First-line dacomitinib (PF-00299804), an irreversible pan-HER tyrosine kinase inhibitor, for patients with EGFR-mutant lung cancers
-
abstr 7530
-
Kris, G.M.; Mok, T.; Ou, S.H.; Martins, R.; Kim, W.D.; Goldberg, Z.; Zhang, H.; Taylor, I.; Letrent, P.S.; Janne, A.P. First-line dacomitinib (PF-00299804), an irreversible pan-HER tyrosine kinase inhibitor, for patients with EGFR-mutant lung cancers. J. Clin. Oncol. 2012, 30, abstr 7530.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Kris, G.M.1
Mok, T.2
Ou, S.H.3
Martins, R.4
Kim, W.D.5
Goldberg, Z.6
Zhang, H.7
Taylor, I.8
Letrent, P.S.9
Janne, A.P.10
-
89
-
-
84866908443
-
Induction erlotinib or gemcitabine/carboplatin factorial assignment therapy in stage IIIA-N2 non-small cell lung cancer
-
abstr e17512
-
Zhong, W.; Yang, X.; Liao, R.; Nie, Q.; Dong, S.; Su, J.; Zhang, X.; Zhou, Q.; Yang, J.; Wu, L.Y. Induction erlotinib or gemcitabine/carboplatin factorial assignment therapy in stage IIIA-N2 non-small cell lung cancer. J. Clin. Oncol. 2011, 29, abstr e17512.
-
(2011)
J. Clin. Oncol
, vol.29
-
-
Zhong, W.1
Yang, X.2
Liao, R.3
Nie, Q.4
Dong, S.5
Su, J.6
Zhang, X.7
Zhou, Q.8
Yang, J.9
Wu, L.Y.10
-
90
-
-
67649431893
-
Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
-
Rosell, R.; Perez-Roca, L.; Sanchez, J.J.; Cobo, M.; Moran, T.; Chaib, I.; Provencio, M.; Domine, M.; Sala, M.A.; Jimenez, U. et al. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS One 2009, 4, e5133.
-
(2009)
PLoS One
, vol.4
-
-
Rosell, R.1
Perez-Roca, L.2
Sanchez, J.J.3
Cobo, M.4
Moran, T.5
Chaib, I.6
Provencio, M.7
Domine, M.8
Sala, M.A.9
Jimenez, U.10
-
91
-
-
84862115744
-
Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer
-
Pietanza, M.C.; Gadgeel, S.M.; Dowlati, A.; Lynch, T.J.; Salgia, R.; Rowland, K.M., Jr.; Wertheim, M.S.; Price, K.A.; Riely, G.J.; Azzoli, C.G. et al. Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer. J. Thorac. Oncol. 2012, 7, 856-865.
-
(2012)
J. Thorac. Oncol
, vol.7
, pp. 856-865
-
-
Pietanza, M.C.1
Gadgeel, S.M.2
Dowlati, A.3
Lynch, T.J.4
Salgia, R.5
Rowland Jr., K.M.6
Wertheim, M.S.7
Price, K.A.8
Riely, G.J.9
Azzoli, C.G.10
-
92
-
-
77954584507
-
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: Results of a phase II trial in patients with advanced non-small-cell lung cancer
-
Sequist, L.V.; Besse, B.; Lynch, T.J.; Miller, V.A.; Wong, K.K.; Gitlitz, B.; Eaton, K.; Zacharchuk, C.; Freyman, A.; Powell, C. et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: Results of a phase II trial in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 2010, 28, 3076-3083.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 3076-3083
-
-
Sequist, L.V.1
Besse, B.2
Lynch, T.J.3
Miller, V.A.4
Wong, K.K.5
Gitlitz, B.6
Eaton, K.7
Zacharchuk, C.8
Freyman, A.9
Powell, C.10
-
93
-
-
84866928412
-
PROSE: Randomized proteomic stratified phase III study of second line erlotinib versus chemotherapy in patients with inoperable non-small cell lung cancer (NSCLC)
-
abstr TPS214
-
Sorlini, C.; Barni, S.; Petrelli, F.; Novello, S.; de Marinis, F.; de Pas, M.T.; Grossi, F.; Bearz, A.; Mencoboni, M.; Aieta, M. et al. PROSE: Randomized proteomic stratified phase III study of second line erlotinib versus chemotherapy in patients with inoperable non-small cell lung cancer (NSCLC). J. Clin. Oncol. 2011, 29, abstr TPS214.
-
(2011)
J. Clin. Oncol
, vol.29
-
-
Sorlini, C.1
Barni, S.2
Petrelli, F.3
Novello, S.4
de Marinis, F.5
de Pas, M.T.6
Grossi, F.7
Bearz, A.8
Mencoboni, M.9
Aieta, M.10
-
94
-
-
84878073999
-
A phase II trial of induction gefitinib monotherapy followed by cisplatin-docetaxel and concurrent thoracic irradiation in patients with EGFR-mutant locally advanced non-small-cell lung cancer (LA-NSCLC): LOGIK0902/OLCSG0905 intergroup trial
-
abstr 7045
-
Hisamoto, A.; Sasaki, J.; Takigawa, N.; Shioyama, Y.; Kishimoto, J.; Takemoto, M.; Hotta, K.; Tanimoto, M.; Ichinose, Y.; Kiura, K. et al. A phase II trial of induction gefitinib monotherapy followed by cisplatin-docetaxel and concurrent thoracic irradiation in patients with EGFR-mutant locally advanced non-small-cell lung cancer (LA-NSCLC): LOGIK0902/OLCSG0905 intergroup trial. J. Clin. Oncol. 2012, 30, abstr 7045.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Hisamoto, A.1
Sasaki, J.2
Takigawa, N.3
Shioyama, Y.4
Kishimoto, J.5
Takemoto, M.6
Hotta, K.7
Tanimoto, M.8
Ichinose, Y.9
Kiura, K.10
-
95
-
-
84862271634
-
A phase II trial of erlotinib in patients with EGFR wild-type advanced non-small-cell lung cancer
-
Kobayashi, T.; Koizumi, T.; Agatsuma, T.; Yasuo, M.; Tsushima, K.; Kubo, K.; Eda, S.; Kuraishi, H.; Koyama, S.; Hachiya, T. et al. A phase II trial of erlotinib in patients with EGFR wild-type advanced non-small-cell lung cancer. Cancer Chemother. Pharmacol. 2012, 69, 1241-1246.
-
(2012)
Cancer Chemother. Pharmacol
, vol.69
, pp. 1241-1246
-
-
Kobayashi, T.1
Koizumi, T.2
Agatsuma, T.3
Yasuo, M.4
Tsushima, K.5
Kubo, K.6
Eda, S.7
Kuraishi, H.8
Koyama, S.9
Hachiya, T.10
-
96
-
-
79961071748
-
Phase II study of erlotinib as third-line monotherapy in patients with advanced non-small-cell lung cancer without epidermal growth factor receptor mutations
-
Matsuura, S.; Inui, N.; Ozawa, Y.; Nakamura, Y.; Toyoshima, M.; Yasuda, K.; Yamada, T.; Shirai, T.; Suganuma, H.; Yokomura, K. et al. Phase II study of erlotinib as third-line monotherapy in patients with advanced non-small-cell lung cancer without epidermal growth factor receptor mutations. Jpn. J. Clin. Oncol. 2011, 41, 959-963.
-
(2011)
Jpn. J. Clin. Oncol
, vol.41
, pp. 959-963
-
-
Matsuura, S.1
Inui, N.2
Ozawa, Y.3
Nakamura, Y.4
Toyoshima, M.5
Yasuda, K.6
Yamada, T.7
Shirai, T.8
Suganuma, H.9
Yokomura, K.10
-
97
-
-
76149100579
-
A phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705
-
Yoshioka, H.; Hotta, K.; Kiura, K.; Takigawa, N.; Hayashi, H.; Harita, S.; Kuyama, S.; Segawa, Y.; Kamei, H.; Umemura, S. et al. A phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705. J. Thorac. Oncol. 2010, 5, 99-104.
-
(2010)
J. Thorac. Oncol
, vol.5
, pp. 99-104
-
-
Yoshioka, H.1
Hotta, K.2
Kiura, K.3
Takigawa, N.4
Hayashi, H.5
Harita, S.6
Kuyama, S.7
Segawa, Y.8
Kamei, H.9
Umemura, S.10
-
98
-
-
84866927445
-
TAILOR: A phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild-type (wt) EGFR
-
abstr LBA7501
-
Garassino, C.M.; Martelli, O.; Bettini, A.; Floriani, I.; Copreni, E.; Lauricella, C.; Ganzinelli, M.; Marabese, M.; Broggini, M.; Veronese, S. et al. TAILOR: A phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild-type (wt) EGFR. J. Clin. Oncol. 2012, 30, abstr LBA7501.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Garassino, C.M.1
Martelli, O.2
Bettini, A.3
Floriani, I.4
Copreni, E.5
Lauricella, C.6
Ganzinelli, M.7
Marabese, M.8
Broggini, M.9
Veronese, S.10
-
99
-
-
84866147012
-
Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype
-
in press
-
Metro, G.; Chiari, R.; Duranti, S.; Siggillino, A.; Fischer, M.J.; Giannarelli, D.; Ludovini, V.; Bennati, C.; Marcomigni, L.; Baldi, A. et al. Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype. Lung Cancer, 2012, in press.
-
(2012)
Lung Cancer
-
-
Metro, G.1
Chiari, R.2
Duranti, S.3
Siggillino, A.4
Fischer, M.J.5
Giannarelli, D.6
Ludovini, V.7
Bennati, C.8
Marcomigni, L.9
Baldi, A.10
-
100
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok, T.S.; Wu, Y.L.; Thongprasert, S.; Yang, C.H.; Chu, D.T.; Saijo, N.; Sunpaweravong, P.; Han, B.; Margono, B.; Ichinose, Y. et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 2009, 361, 947-957.
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
Sunpaweravong, P.7
Han, B.8
Margono, B.9
Ichinose, Y.10
-
101
-
-
52049090365
-
Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
-
Zhu, C.Q.; da Cunha Santos, G.; Ding, K.; Sakurada, A.; Cutz, J.C.; Liu, N.; Zhang, T.; Marrano, P.; Whitehead, M.; Squire, J.A. et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J. Clin. Oncol. 2008, 26, 4268-4275.
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 4268-4275
-
-
Zhu, C.Q.1
da Cunha, S.G.2
Ding, K.3
Sakurada, A.4
Cutz, J.C.5
Liu, N.6
Zhang, T.7
Marrano, P.8
Whitehead, M.9
Squire, J.A.10
-
102
-
-
84866182159
-
Phase II double-blind, randomized study of selumetinib (SEL) plus docetaxel (DOC) versus DOC plus placebo as second-line treatment for advanced KRAS mutant non-small cell lung cancer (NSCLC)
-
abstr 7503
-
Janne, A.P.; Shaw, T.A.; Pereira, J.R.; Jeannin, G.; Vansteenkiste, J.; Barrios, H.C.; Franke, A.F.; Grinsted, L.; Smith, D.P.; Zazulina, V. et al. Phase II double-blind, randomized study of selumetinib (SEL) plus docetaxel (DOC) versus DOC plus placebo as second-line treatment for advanced KRAS mutant non-small cell lung cancer (NSCLC). J. Clin. Oncol. 2012, 30, abstr 7503.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Janne, A.P.1
Shaw, T.A.2
Pereira, J.R.3
Jeannin, G.4
Vansteenkiste, J.5
Barrios, H.C.6
Franke, A.F.7
Grinsted, L.8
Smith, D.P.9
Zazulina, V.10
-
103
-
-
84866169938
-
A randomized discontinuation phase II trial of ridaforolimus in non-small cell lung cancer (NSCLC) patients with KRAS mutations
-
abstr 7531
-
Riely, J.G.; Brahmer, R.J.; Planchard, D.; Crinò, L.; Doebele, C.R.; Mas Lopez, L.; Gettinger, N.S.; Schumann, C.; Li, X.; Atkins B.M. et al. A randomized discontinuation phase II trial of ridaforolimus in non-small cell lung cancer (NSCLC) patients with KRAS mutations. J. Clin. Oncol. 2012, 30, abstr 7531.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Riely, J.G.1
Brahmer, R.J.2
Planchard, D.3
Crinò, L.4
Doebele, C.R.5
Mas, L.L.6
Gettinger, N.S.7
Schumann, C.8
Li, X.9
Atkins, B.M.10
-
104
-
-
80051780280
-
Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005
-
abstr 7514
-
Crinò, L.; Kim, D.; Riely, J.G.; Janne, A.P.; Blackhall, H.F.; Camidge, R.D.; Hirsh, V.; Mok, T.; Solomon, J.B.; Park, K. et al. Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005. J. Clin. Oncol. 2011, 29, abstr 7514.
-
(2011)
J. Clin. Oncol
, vol.29
-
-
Crinò, L.1
Kim, D.2
Riely, J.G.3
Janne, A.P.4
Blackhall, H.F.5
Camidge, R.D.6
Hirsh, V.7
Mok, T.8
Solomon, J.B.9
Park, K.10
-
105
-
-
84865431278
-
Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
-
abstr 7533
-
Kim, D.W.; Ahn, M.J.; Shi, Y.; De Pas, T.M.; Yang, P.C.; Riely, J.G.; Crinò, L.; Evans, L.T.; Liu, X.; Han, J.Y. et al. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). J. Clin. Oncol. 2012, 30, abstr 7533.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Kim, D.W.1
Ahn, M.J.2
Shi, Y.3
de Pas, T.M.4
Yang, P.C.5
Riely, J.G.6
Crinò, L.7
Evans, L.T.8
Liu, X.9
Han, J.Y.10
-
106
-
-
80053386829
-
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
-
Shaw, A.T.; Yeap, B.Y.; Solomon, B.J.; Riely, G.J.; Gainor, J.; Engelman, J.A.; Shapiro, G.I.; Costa, D.B.; Ou, S.H.; Butaney, M. et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis. Lancet Oncol. 2011, 12, 1004-1012.
-
(2011)
Lancet Oncol
, vol.12
, pp. 1004-1012
-
-
Shaw, A.T.1
Yeap, B.Y.2
Solomon, B.J.3
Riely, G.J.4
Gainor, J.5
Engelman, J.A.6
Shapiro, G.I.7
Costa, D.B.8
Ou, S.H.9
Butaney, M.10
-
107
-
-
84863645360
-
Emerging personalized oncology: Sequencing and systems strategies
-
Cho, W.; Ziogas, D.E.; Katsios, C.; Roukos, D.H. Emerging personalized oncology: Sequencing and systems strategies. Futur. Oncol. 2012, 8, 637-641.
-
(2012)
Futur. Oncol
, vol.8
, pp. 637-641
-
-
Cho, W.1
Ziogas, D.E.2
Katsios, C.3
Roukos, D.H.4
-
108
-
-
84861976984
-
Whole genome sequencing for lung cancer
-
Daniels, M.; Goh, F.; Wright, C.M.; Sriram, K.B.; Relan, V.; Clarke, B.E.; Duhig, E.E.; Bowman, R.V.; Yang, I.A.; Fong, K.M. et al. Whole genome sequencing for lung cancer. J. Thorac. Dis. 2012, 4, 155-163.
-
(2012)
J. Thorac. Dis
, vol.4
, pp. 155-163
-
-
Daniels, M.1
Goh, F.2
Wright, C.M.3
Sriram, K.B.4
Relan, V.5
Clarke, B.E.6
Duhig, E.E.7
Bowman, R.V.8
Yang, I.A.9
Fong, K.M.10
-
109
-
-
84866750638
-
Comprehensive genomic characterization of squamous cell carcinoma of the lung
-
abstr 7006
-
Govindan, R.; Hammerman, S.P.; Hayes, N.D.; Wilkerson, D.M.; Baylin, S.; Meyerson, M.; Comprehensive genomic characterization of squamous cell carcinoma of the lung. J. Clin. Oncol. 2012, 30, abstr 7006.
-
(2012)
J. Clin. Oncol
, vol.30
-
-
Govindan, R.1
Hammerman, S.P.2
Hayes, N.D.3
Wilkerson, D.M.4
Baylin, S.5
Meyerson, M.6
-
110
-
-
77953006634
-
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
-
Lee, W.; Jiang, Z.; Liu, J.; Haverty, P.M.; Guan, Y.; Stinson, J.; Yue, P.; Zhang, Y.; Pant, K.P.; Bhatt, D. et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature 2010, 465, 473-477.
-
(2010)
Nature
, vol.465
, pp. 473-477
-
-
Lee, W.1
Jiang, Z.2
Liu, J.3
Haverty, P.M.4
Guan, Y.5
Stinson, J.6
Yue, P.7
Zhang, Y.8
Pant, K.P.9
Bhatt, D.10
-
111
-
-
84863230117
-
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
-
Ju, Y.S.; Lee, W.C.; Shin, J.Y.; Lee, S.; Bleazard, M.T.; Won, J.K.; Kim, Y.T.; Kim, J.I.; Kang, J.H.; Seo, J.S. A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res. 2012, 22, 436-445.
-
(2012)
Genome Res
, vol.22
, pp. 436-445
-
-
Ju, Y.S.1
Lee, W.C.2
Shin, J.Y.3
Lee, S.4
Bleazard, M.T.5
Won, J.K.6
Kim, Y.T.7
Kim, J.I.8
Kang, J.H.9
Seo, J.S.10
-
112
-
-
84855188616
-
A computational index derived from whole-genome copy number analysis is a novel tool for prognosis in early stage lung squamous cell carcinoma
-
Belvedere, O.; Berri, S.; Chalkley, R.; Conway, C.; Barbone, F.; Pisa, F.; MacLennan, K.; Daly, C.; Alsop, M.; Morgan, J. et al. A computational index derived from whole-genome copy number analysis is a novel tool for prognosis in early stage lung squamous cell carcinoma. Genomics 2012, 99, 18-24.
-
(2012)
Genomics
, vol.99
, pp. 18-24
-
-
Belvedere, O.1
Berri, S.2
Chalkley, R.3
Conway, C.4
Barbone, F.5
Pisa, F.6
Maclennan, K.7
Daly, C.8
Alsop, M.9
Morgan, J.10
-
113
-
-
84863393678
-
Cancer genomics: Technology, discovery, and translation
-
Tran, B.; Dancey, J.E.; Kamel-Reid, S.; McPherson, J.D.; Bedard, P.L.; Brown, A.M.; Zhang, T.; Shaw, P.; Onetto, N.; Stein, L. et al. Cancer genomics: Technology, discovery, and translation. J. Clin. Oncol. 2012, 30, 647-660.
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 647-660
-
-
Tran, B.1
Dancey, J.E.2
Kamel-Reid, S.3
McPherson, J.D.4
Bedard, P.L.5
Brown, A.M.6
Zhang, T.7
Shaw, P.8
Onetto, N.9
Stein, L.10
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