Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP4)

Biochemical and Biophysical Research Communications

Volumn 426, Issue 3, 2012, Pages 374-379

  Norimatsu, Yohei ^a   Moran, Aurelia R ^a   MacDonald, Kelvin D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

CFTR; Chloride channel; ClC 2; Lubiprostone; Prostaglandin

Indexed keywords

BETA ADRENERGIC RECEPTOR; CHLORIDE CHANNEL; CHLORIDE CHANNEL 2; ISOPRENALINE; LUBIPROSTONE; PROSTAGLANDIN RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHLORIDE TRANSPORT; FEMALE; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; XENOPUS;

ALPROSTADIL; ANIMALS; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FEMALE; OOCYTES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; XENOPUS LAEVIS;

EID: 84866905969     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.097     Document Type: Article

References (30)

1. Lacy B.E., Levy L.C. Lubiprostone: a chloride channel activator. J. Clin. Gastroenterol. 2007, 41:345-351.
2. Cuppoletti J., Malinowska D.H., Tewari K.P., Li Q.J., Sherry A.M., Patchen M.L., Ueno R. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am. J. Physiol. Cell Physiol. 2004, 287:C1173-C1183.
3. Bao H.F., Liu L., Self J., Duke B.J., Ueno R., Eaton D.C. A synthetic prostone activates apical chloride channels in A6 epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G234-G251.
4. Bijvelds M.J., Bot A.G., Escher J.C., De Jonge H.R. Activation of intestinal Cl-secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology 2009, 137:976-985.
5. Ao M., Venkatasubramanian J., Boonkaewwan C., Ganesan N., Syed A., Benya R.V., Rao M.C. Lubiprostone activates Cl-secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84. Dig. Dis. Sci. 2011, 56:339-351.
6. Pilewski J.M., Frizzell R.A. Role of CFTR in airway disease. Physiol. Rev. 1999, 79:S215-S255.
7. Thiemann A., Grunder S., Pusch M., Jentsch T.J. A chloride channel widely expressed in epithelial and non-epithelial cells. Nature 1992, 356:57-60.
8. Jentsch T.J., Gunther W., Pusch M., Schwappach B. Properties of voltage-gated chloride channels of the ClC gene family. J. Physiol. 1995, 482:19S-25S.
9. Lipecka J., Bali M., Thomas A., Fanen P., Edelman A., Fritsch J. Distribution of ClC-2 chloride channel in rat and human epithelial tissues. Am. J. Physiol. Cell Physiol. 2002, 282:C805-C816.
10. Murray C.B., Morales M.M., Flotte T.R., McGrath-Morrow S.A., Guggino W.B., Zeitlin P.L. CIC-2: a developmentally dependent chloride channel expressed in the fetal lung and downregulated after birth. Am. J. Respir. Cell Mol. Biol. 1995, 12:597-604.
11. Schwiebert E.M., Cid-Soto L.P., Stafford D., Carter M., Blaisdell C.J., Zeitlin P.L., Guggino W.B., Cutting G.R. Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells. Proc. Natl. Acad. Sci. USA 1998, 95:3879-3884.
12. Bassil A.K., Borman R.A., Jarvie E.M., McArthur-Wilson R.J., Thangiah R., Sung E.Z., Lee K., Sanger G.J. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br. J. Pharmacol. 2008, 154:126-135.
13. Regan J.W. EP2 and EP4 prostanoid receptor signaling. Life Sci. 2003, 74:143-153.
14. Cuthbert A.W. Lubiprostone targets prostanoid EP receptors in ovine airways. Br. J. Pharmacol. 2011, 162:508-520.
15. Furukawa T., Horikawa S., Terai T., Ogura T., Katayama Y., Hiraoka M. Molecular cloning and characterization of a novel truncated from (ClC-2 beta) of ClC-2 alpha (ClC-2G) in rabbit heart. FEBS Lett. 1995, 375:56-62.
16. Jordt S.E., Jentsch T.J. Molecular dissection of gating in the ClC-2 chloride channel. EMBO J. 1997, 16:1582-1592.
17. - channel. J. Gen. Physiol. 2003, 122:605-620.
18. Niemeyer M.I., Cid L.P., Zúñiga L., Catalán M., Sepúlveda F.V. A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel. J. Physiol. 2003, 553:873-879.
19. Cunningham S.A., Worrell R.T., Benos D.J., Frizzell R.A. CAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA. Am. J. Physiol. Cell Physiol. 1992, 262:C783-C788.
20. Cuppoletti J., Tewari K.P., Sherry A.M., Kupert E.Y., Malinowska D.H. ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole. Am. J. Physiol. Cell Physiol. 2001, 281:C46-C54.
21. Tewari K.P., Malinowska D.H., Sherry A.M., Cuppoletti J. PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels. Am. J. Physiol. Cell Physiol. 2000, 279:C40-C50.
22. Park K., Begenisich T., Melvin J.E. Protein kinase A activation phosphorylates the rat ClC-2 Cl- channel but does not change activity. J. Membr. Biol. 2001, 182:31-37.
23. Furukawa T., Ogura T., Katayama Y., Hiraoka M. Characteristics of rabbit ClC-2 current expressed in Xenopus oocytes and its contribution to volume regulation. Am. J. Physiol. Cell Physiol. 1998, 274:C500-C512.
24. Jentsch T.J. To the editor. CLC chloride channels and transporters: from genes to protein structure, pathology and physiology. Crit. Rev. Biochem. Mol. Biol. 2009, 44:64.
25. Joo N.S., Wine J.J., Cuthbert A.W. Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am. J. Physiol. Lung Cell. Mol. Physiol. 2009, 296:L811-L824.
26. MacVinish L.J., Cope G., Ropenga A., Cuthbert A.W. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator CFTR. Br. J. Pharmacol. 2007, 150:1055-1065.
27. MacDonald K.D., McKenzie K.R., Henderson M.J., Hawkins C.E., Vij N., Zeitlin P.L. Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L933-L940.
28. De Lisle R.C., Mueller R., Roach E. Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype. BMC Gastroenterol. 2010, 10:107.
29. O'Brien C.E., Anderson P.J., Stowe C.D. Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series. Ann. Pharmacother. 2010, 44:577-581.
30. O'Brien C.E., Anderson P.J., Stowe C.D. Lubiprostone for constipation in adults with cystic fibrosis: a pilot study. Ann. Pharmacother. 2011, 45:1061-1066.