Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: A case series

Annals of Pharmacotherapy

Volumn 44, Issue 3, 2010, Pages 577-581

  O'Brien, Catherine E ^a   Anderson, Paula J ^b   Stowe, Cindy D ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Constipation; Cystic fibrosis; Lubiprostone

Indexed keywords

17 METHYLNALTREXONE; ALKALINE PHOSPHATASE; DIATRIZOATE; HEMOGLOBIN; HYDROMORPHONE; LUBIPROSTONE; MACROGOL 3350; MEGLUMINE DIATRIZOATE; METHADONE;

ABDOMINAL PAIN; ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; CASE REPORT; CHRONIC DRUG ADMINISTRATION; CONSTIPATION; CYSTIC FIBROSIS; FEMALE; GASTROINTESTINAL MOTILITY; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; MECONIUM ILEUS; NAUSEA; NUTRITIONAL DEFICIENCY; PANCREAS INSUFFICIENCY; PRIORITY JOURNAL; RECURRENT DISEASE; SMALL INTESTINE OBSTRUCTION; TUBE FEEDING;

ADULT; ALPROSTADIL; CHLORIDE CHANNELS; CONSTIPATION; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FEMALE; HUMANS; INTESTINAL OBSTRUCTION; MALE; RECURRENCE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77749329677     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M642     Document Type: Article

References (23)

1. Cystic Fibrosis Foundation. Cystic Fibrosis Foundation Patient Registry: Annual Report 2007. Bethesda, MD: Cystic Fibrosis Foundation, 2009.
2. Wilschanski M, Durie PR. Pathology of pancreatic and intestinal disorders in cystic fibrosis. J R Soc Med 1998;91(suppl 34):40-9.
3. Rubinstein S, Moss R, Lewiston N. Constipation and meconium ileus equivalent in patients with cystic fibrosis. Pediatrics 1986;78:473-9.
4. Yankaskas JR, Marshall BC, Sufian B, Simon RH, Rodman D. Cystic fibrosis adult care: consensus conference report. Chest 2004;125(suppl 1): 1S-39S. DOI 10.1378/chest.125.1-suppl.1S
5. Van der Doef HP, Kokke FT, Beek FJ, Woestenenk JW, Froeling SP, Houwen RH. Constipation in pediatric cystic fibrosis patients: an underestimated medical condition. J Cyst Fibros 2010;9:59-63. DOI 10.1016/j.jcf.2009.11.003
6. Davis AM, Lind CD. Acquired segmental megacolon in an adult patient with cystic fibrosis. South Med J 2000;93:229-31.
7. Houwen RH, van der Doef HP, Sermet I, et al. Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS. J Pediatr Gastroenterol Nutr 2010;50:38-42. DOI 10.1097/MPG.0b013e3181a6e01d
8. Product information. Amitiza (lubiprostone). Bethesda, MD, and Deerfield, IL: Sucampo Pharmaceuticals, Inc. and Takeda Pharmaceuticals America, Inc., April 2008.
9. Camilleri M, Bharucha AE, Ueno R, et al. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol 2006;290:G942-7. DOI 10.1152/ajpgi.00264.2005
10. Bijvelds MJ, Bot AG, Escher JC, De Jong HR. Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology 2009;137:976-85. DOI 10.1053/j.gastro.2009.05.037
11. Mizumori M, Akiba Y, Kaunitz JD. Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig Dis Sci 2009;54:2063-9. DOI 10.1007/s10620-009-0907-0
12. MacVinish LJ, Cope G, Ropenga A, Cuthbert AW. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. Br J Pharmacol 2007;150:1055-65. DOI 10.1038/sj.bjp.0707175
13. Fei G, Wang YZ, Liu S, et al. Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol 2009;296:G823-32. DOI 10.1152/ajpgi.90447.2008
14. MacDonald KD, McKenzie KR, Henderson MJ, Hawkins CE, Vij N, Zeitlin PL. Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol Lung Cell Mol Physiol 2008;295:L933-40. DOI 10.1152/ajplung.90221.2008
15. Freye HB, Kurtz SM, Spock A, Capp MP. Light and electron microscopic examination of the small bowel of children with cystic fibrosis. J Pediatr 1964;64:575-9. DOI 10.1016/S0022-3476(64)80351-6
16. Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther 2007;25:1351-61. DOI 10.1111/j.1365-2036.2007.03320.x
17. Johanson JF, Morton D, Geenen J, Ueno R. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol 2008;103:170-7. DOI 10.1111/j.1572-0241.2007. 01524.x
18. Johanson JF, Drossman DA, Panas R, Wahle A, Ueno R. Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2008;27:685-96. DOI 10.1111/j.1365-2036.2008.03629.x
19. Drossman DA, Chey WD, Johanson JF, et al. Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 2009;29:329-41. DOI 10.1111/j.1365-2036.2008.03881.x
20. Stengel JZ, Jones DP. Single-dose lubiprostone along with split-dose PEG solution without dietary restrictions for bowel cleansing prior to colonoscopy: a randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 2008;103:2224-30. DOI 10.1111/j.1572-0241.2008.02053.x
21. Johanson JF, Panas R, Holland PC, Ueno R. Long-term safety and efficacy of lubiprostone for the treatment of chronic idiopathic constipation (abstract 30). Neurogastroenterol Motil 2006;18:675. DOI 10.1111/j.1365-2982.2006.00826.x
22. Ueno R, Joswick TR, Wahle A, Zhu Y, Holland PC. Efficacy and safety of lubiprostone for the treatment of chronic idiopathic constipation in elderly patients (abstract 222). Neurogastroenterol Motil 2006;18:734. DOI 10.1111/j.1365-2982.2006.00826.x
23. Ueno R, Osama H, Engelke KJ. Lubiprostone effects on morphine-induced constipation and analgesia (abstract 225). Neurogastroenterol Motil 2006;18:735. DOI 10.1111/j.1365-2982.2006.00826.x