Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 5, 2009, Pages

  Joo, N S ^a   Wine, J J ^a   Cuthbert, A W ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Airway submucosal glands; Airway surface epithelium; Cystic fibrosis; Human tracheas; Pig; Sheep

Indexed keywords

AMILORIDE; BUMETANIDE; FORSKOLIN; LUBIPROSTONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG BINDING; DRUG EFFECT; FIBROSING ALVEOLITIS; HUMAN; HUMAN TISSUE; MUCUS GLAND; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; SHEEP; SWINE; TRACHEA MUCOSA;

ALPROSTADIL; ANIMALS; ANIONS; CARBACHOL; CHLORIDE CHANNELS; CYSTIC FIBROSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; EXOCRINE GLANDS; HUMANS; MUCOUS MEMBRANE; MUSCLE CONTRACTION; SHEEP; SUS SCROFA; TRACHEA;

EID: 66149176927     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90636.2008     Document Type: Article

References (43)

1. Ambizas EM, Ginzburg R. Lubiprostone: a chloride channel activator for the treatment of chronic constipation. Ann Pharmacother 41: 957-964, 2007. (Pubitemid 46917622)
2. Ballard ST, Fountain JD, Inglis SK, Corboz MR, Taylor AE. Chloride secretion across distal airway epithelium: relationship to submucosal gland distribution. Am J Physiol Lung Cell Mol Physiol 268: L526-L531, 1995.
3. Ballard ST, Trout L, Bebok Z, Sorscher EJ, Crews A. CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am J Physiol Lung Cell Mol Physiol 277: L694-L699, 1999. (Pubitemid 29522634)
4. Bao HF, Liu L, Self J, Duke BJ, Ueno R, Eaton DC. A synthetic prostone activates apical chloride channels in A6 epithelial cells. Am J Physiol Gastrointest Liver Physiol 295: G234-G251, 2008.
5. Bassil AK, Borman RA, Jarvie EM, McArthur-Wilson RJ, Thangia R, Sung EZ, Lee K, Sanger GJ. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol 154: 126-135, 2008.
6. Catalan M, Niemeyer MI, Cid LP, Sepulveda FV. Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride. Gastroenterology 126: 1104-1114, 2004. (Pubitemid 38451181)
7. Cotton CU, Lawson EE, Boucher RC, Gatzy JT. Bioelectric properties an ion transport of airways excised from adult and fetal sheep. J Appl Physiol 55: 1542-1549, 1983. (Pubitemid 14231463)
8. Cuppoletti J, Malinowska DH, Tewari KP, Li QJ, Sherry AM, Patchen ML, Ueno R. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 287: C1173-C1183, 2004. (Pubitemid 39382875)
9. Cuppoletti J, Malinowska DH, Chakrabarti J, Ueno R. Effects of lubiprostone on human uterine smooth muscle cells. Prostaglandins Other Lipid Mediat 86: 56-60, 2008.
10. Donaldson SH, Boucher RC. Sodium channels and cystic fibrosis. Chest 132: 1631-1636. (Pubitemid 350156022)
11. Engelhardt JF, Yankaskas JR, Ernst SA, Yang Y, Marino CR, Boucher RC, Cohn JA, Wilson JM. Mucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet 2: 240-248, 1992.
12. - current in human intestinal T84 epithelial cells by phosphorylation. J Physiol 490: 115-128, 1996.
13. Fritsch J, Edelman A. Osmosensitivity of the hyperpolarization-activated chloride current in human intestinal T84 cells. Am J Physiol Cell Physiol 272: C778-C786, 1997. (Pubitemid 27146690)
14. Gruber AD, Schreur KD, Hong-Long JI, Fuller CM, Pauli BU. Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea and mammary gland. Am J Physiol Cell Physiol 276: C1261-C1270, 1999. (Pubitemid 29323390)
15. Gyomorey K, Yeger H, Ackerley C, Garami E, Bear CE. Expression of the chloride channel ClC-2 in the murine small intestine epithelium. Am J Physiol Cell Physiol 279: C1787-C1794, 2000.
16. Harris A. Towards an ovine model of cystic fibrosis. Hum Mol Genet 6: 2191-2193, 1997. (Pubitemid 27501068)
17. Joo NS, Irokawa T, Robbins RC, Wine JJ. Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands. J Biol Chem 281: 7392-7398, 2006. (Pubitemid 43847509)
18. Joo NS, Saenz Y, Krouse ME, Wine JJ. Mucus secretion from single submucosal glands of pig. J Biol Chem 277: 28167-28175, 2002.
19. Joo NS, Wu JV, Krouse ME, Senz Y, Wine JJ. An optical method for quantifying rates of mucus secretion from single submucosal glands. Am J Physiol Lung Cell Mol Physiol 281: L458-L468, 2001. (Pubitemid 32756058)
20. Jordt SE, Jentsch TJ. Molecular dissection of gating in the ClC-2 chloride channel. EMBO J 16: 1582-1592, 1997. (Pubitemid 27151953)
21. Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC. Charaterization of wild-type and deltaF508 cystic fibrosis transmembrane conductance regulator in human respiratory epithelia. Mol Biol Cell 16: 2154-2167, 2005. (Pubitemid 40632202)
22. Lipecka J, Bali M, Thomas A, Fanen P, Edelman A, Fritsch J. Distribution of ClC-2 chloride channel in rat and human epithelial tissues. Am J Physiol Cell Physiol 282: C805-C816, 2002. (Pubitemid 34663143)
23. MacDonald KD, McKenzie KR, Henderson MJ, Hawkins CE, Vij N, Zeitlin PL. Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol Lung Cell Mol Physiol 295: L933-L940, 2008.
24. MacVinish LJ, Cope G, Ropenga A, Cuthbert AW. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. Br J Pharmacol 150: 1055-1065, 2007. (Pubitemid 46625091)
25. Moeser AJ, Nighot PK, Engelke KJ, Ueno R, Blikslager AT. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol 292: G647-G656, 2007. (Pubitemid 46263505)
26. Moeser AJ, Haskell MM, Shifflett DE, Little D, Schultz BD, Blikslager AT. ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Gastroenterology 127: 802-815, 2004. (Pubitemid 39208413)
27. Mohammad-Panah R, Gyomorey K, Rommens J, Choudhury M, Li C, Wang Y, Bear CE. ClC-2 contributes to native chloride secretion by a human intestinal cell line, Caco-2. J Biol Chem 276: 8306-8313, 2001. (Pubitemid 37385640)
28. Mohammad-Panah R, Ackerley C, Rommens J, Choudhury M, Wang Y, Bear CE. The chloride channel ClC-4 colocalises with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia. J Biol Chem 277: 566-574, 2002.
29. Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol 124: 125-137, 2004. (Pubitemid 39038187)
30. Mummery JL, Killey J, Linsdell P. Expression of the chloride channel ClC-K in human epithelial airway cells. Can J Physiol Pharmacol 83: 1123-1128, 2005.
31. Murray CB, Morales MM, Flotte TR, McGrath-Morrow SA, Guggino WB, Zeitlin PL. ClC-2: a developmentally dependent chloride channel expressed in the fetal lung and downregulated after birth. Am J Respir Cell Mol Biol 12: 597-604, 1995.
32. Olver RE, Robinson EJ. Sodium and chloride trasport by the tracheal epithelium of fetal, new born and adult sheep. J Physiol 375: 377-390, 1986. (Pubitemid 16097613)
33. Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 15: 132-141, 1960.
34. Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCay PB, McLennon G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 295: L240-L263, 2008.
35. Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321: 1837-1841, 2008.
36. 2-receptor agonists enhances mucociliary clearance in sheep. J Appl Physiol 87: 2191-2196, 1999.
37. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson D, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J 19: 431-433, 2005. (Pubitemid 40316540)
38. Schweibert EM, Cid-Soto LP, Stafford D, Carter M, Blaisdell CJ, Zeitlin PL, Guggino WB, Cutting GR. Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells. Proc Nat Acad Sci USA 95: 3879-3884, 1998. (Pubitemid 28173222)
39. - channel. Am J Physiol Cell Physiol 273: C384-C393, 1997.
40. - channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP. Proc Natl Acad Sci USA 89: 1621-1625, 1992.
41. Tos M. Mucous glands of the trachea in man. Anat Anz 128: 136-149, 1971.
42. Wine JJ, Joo NS. Submucosal glands and airway defense. Proc Am Thorac Soc 1: 47-53, 2004.
43. Wu JV, Krouse ME, Wine JJ. Acinar origin of CFTR-dependent airway submucosal gland fluid secretion. Am J Physiol Lung Cell Mol Physiol 292: L304-L311, 2007. (Pubitemid 46103455)