Lubiprostone targets prostanoid EP 4 receptors in ovine airways

British Journal of Pharmacology

Volumn 162, Issue 2, 2011, Pages 508-520

  Cuthbert, Aw ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

airway anion secretion; airway submucosal glands; CFTR; ClC 2 chloride channels; selective EP 4 agonists and antagonists

Indexed keywords

(4,4 DIFLUORO 3R HYDROXY 4 PHENYLBUT 1 EN 1 1 YL) 1 [6 (1H TETRAZOL 5 YL)HEXYL]PYRROLIDIN 2 ONE; [[N [2 [4 (4,49 DIETHOXY 1 OXO 1,3 DIHYDRO 2H BENZO[F]ISOINDOL 2 YL)PHENYL]ACETYL]BENZENE SULPHONAMIDE]]; ADENYLATE CYCLASE; G PROTEIN COUPLED RECEPTOR; GW 627368; L 092688; L 161982; LUBIPROSTONE; N [[4' [[3 BUTYL 1,5 DIHYDRO 5 OXO 1 [2 (TRIFLUOROMETHYL)PHENYL] 4H 1,2,4 TRIAZOL 4 YL]METHYL][1,1' BIPHENYL] 2YL]] 3 METHYL 2 THIOPHENECARBOXAMIDE; PROSTAGLANDIN E RECEPTOR 4; PROSTANOID RECEPTOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING; RESPIRATORY EPITHELIUM; SECRETION; SHORT CIRCUIT CURRENT;

ADENYLATE CYCLASE; ALPROSTADIL; ANIMALS; CHLORIDE CHANNELS; CYCLIC AMP; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RESPIRATORY MUCOSA; SHEEP; THIOPHENES; TRACHEA; TRIAZOLES;

EID: 78650332035     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01058.x     Document Type: Article

References (27)

1. Alexander SPH, Mathie A, Peters JA, (2009). Guide to receptors and channels (GRAC). Br J Phamacol 158: S1-S254.
2. Ballard ST, Trout L, Bebok Z, Sorscher EJ, Crews A, (1999). CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am J Physiol 277: L694-L699.
3. Bao HF, Liu L, Self J, Duke BJ, Ueno R, Eaton DC, (2008). A synthetic prostone activates apical chloride channels in A6 epithelial cells. Am J Physiol 295: G234-G251.
4. - secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology 137: 976-985.
5. Billot X, Chateauneuf A, Chauret N, Denis D, Greig GM, Mathieu M-C, et al. (2003). Discovery of a highly potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Med Chem Lett 13: 1129-1132.
6. Blikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J, (2007). Restoration of barrier function in injured intestinal mucosa. Physiol Rev 87: 545-564.
7. Catalan M, Niemeyer MI, Cid IP, Sepulveda FV, (2004). Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by direct effect of intracellular chloride. Gastroenterology 126: 1104-1114.
8. Cuppoletti J, Malinowska DH, Tewari KP, Li Q-J, Sherry AM, Patchen ML, et al. (2004). SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol 287: C1173-C1183.
9. Cuppoletti J, Malinowska DH, Tewari K, Chakrabati J, Ueno R, (2008). ClC-2 targeted siRNA inhibits lubiprostone activation of chloride currents in T84 cells. Gastroenterology 134 (Suppl.): A582,T1877.
10. Donaldson SH, Boucher RC, (2007). Sodium channels and cystic fibrosis. Chest 132: 1631-1636.
11. Fei G, Wang Y-Z, Lui S, Hu H-Z, Wang G-D, Qu M-H, et al. (2009). Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. Am J Physiol 296: G823-G832.
12. Gyomorey K, Yeger H, Ackerley C, Garami E, Bear CE, (2000). Expression of the chloride channel ClC-2 in the murine small intestine epithelium. Am J Physiol 279: C1787-C1794.
13. Harris A, (1997). Towards an ovine model of cystic fibrosis. Hum Mol Genet 6: 2191-2193.
14. Jones RL, Giembycz MA, Woodward DF, (2009). Prostanoid receptor antagonist: development strategies and therapeutic applications. Br J Pharmacol 158: 104-145.
15. Joo NS, Wu JV, Krouse ME, Senz Y, Wine JJ, (2001). An optical method for quantifying rates of mucus secretion from single submucosal glands. Am J Physiol 281: L458-L468.
16. Joo NS, Irokawa T, Robbins RC, Wine JJ, (2006). Hyposecretion, not hypoabsorbtion, is the basic defect of cystic fibrosis airway glands. J Biol Chem 281: 7392-7398.
17. Joo NS, Wine JJ, Cuthbert AW, (2009). Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs and humans. Am J Physiol 296: L811-L824.
18. Lipecka J, Bali M, Thomas A, Fanen P, Edelman A, Fritsch J, (2002). Distribution of ClC-2 chloride channels in rat and human epithelial tissues. Am J Physiol 282: C805-C816.
19. MacDonald KD, McKenzie KR, Henderson MJ, Hawkins CE, Vij N, Zeitlin PL, (2008). Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol 295: L933-L940.
20. 2. Mol Pharmacol 60: 36-41.
21. MacVinish LJ, Cope G, Ropenga A, Cuthbert AW, (2007). Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis conductance regulator, CFTR. Br J Pharmacol 150: 1055-1065.
22. 2α. Arch Int Pharmacodyn 268: 59-69. (Pubitemid 14133755)
23. Sugimoto Y, Narumiya S, (2007). Prostaglandin E receptors. J Biol Chem 282: 11613-11617.
24. Ueno R, Osama H, Habe T, Engelke K, Patchen M, (2004). Oral SPI-0211 increases intestinal fluid secretion and chloride concentration without altering serum electrolyte levels. Gastroenterology 126 (Suppl. 2): A298.
25. Verkman AS, Song Y, Thiagarajah JR, (2003). Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Am J Physiol 284: C2-C15.
26. 4 receptor antagonist. Br J Pharmacol 148: 326-339.
27. Woodward DF, Pepperl DJ, Burkey TH, Regan JW, (1995). 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem Pharmacol 50: 1731-1733.