Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function

PLoS Computational Biology

Volumn 8, Issue 9, 2012, Pages

  Jamros, Michael A ^a   Oliveira, Leandro C ^b   Whitford, Paul C ^c   Onuchic, José N ^c   Adams, Joseph A ^d   Jennings, Patricia A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^c RICE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; ENZYMES; MOLECULAR DYNAMICS; SCAFFOLDS (BIOLOGY); X RAY SCATTERING;

ACTIVE SITE RESIDUES; C-TERMINAL SRC KINASE; CONFORMATIONAL CHANGE; CONFORMATIONAL ENSEMBLE; KINASE DOMAINS; KINASE FUNCTION; MULTI-DOMAINS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN KINASE; REORGANISATION;

NUCLEOTIDES;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; C TERMINAL SRC KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SPECIFICITY; INTERACTIONS WITH NUCLEIC ACID; MOLECULAR DYNAMICS; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

EID: 84866900603     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002695     Document Type: Article

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