α-Synuclein modifies huntingtin aggregation in living cells

FEBS Letters

Volumn 586, Issue 1, 2012, Pages 7-12

  Herrera, Federico ^a   Outeiro, Tiago Fleming ^a,b,c  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Synuclein; Bimolecular fluorescence complementation assay; Co aggregation; Huntingtin

Indexed keywords

ALPHA SYNUCLEIN; HUNTINGTIN;

ARTICLE; BIMOLECULAR FLUORESCENCE COMPLEMENTATION ASSAY; CELL COUNT; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; FLUORESCENCE ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NONHUMAN; OLIGOMERIZATION; PARKINSON DISEASE; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ALPHA-SYNUCLEIN; CELL LINE, TUMOR; CYTOSOL; EXONS; HUMANS; HUNTINGTON DISEASE; MICROSCOPY, FLUORESCENCE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PARKINSON DISEASE;

EID: 84655176749     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.11.019     Document Type: Article

References (30)

1. E.I. Agorogiannis, G.I. Agorogiannis, A. Papadimitriou, and G.M. Hadjigeorgiou Protein misfolding in neurodegenerative diseases Neuropathol. Appl. Neurobiol. 30 2004 215 224 (Pubitemid 38789243)
2. J.C. Rochet Novel therapeutic strategies for the treatment of protein-misfolding diseases Expert Rev. Mol. Med. 9 2007 1 34
3. R. Tarawneh, and J.E. Galvin Potential future neuroprotective therapies for neurodegenerative disorders and stroke Clin. Geriatr. Med. 26 2010 125 147
4. C.F. Lippa, J.E. Duda, M. Grossman, H.I. Hurtig, D. Aarsland, B.F. Boeve, D.J. Brooks, D.W. Dickson, B. Dubois, M. Emre, S. Fahn, J.M. Farmer, D. Galasko, J.E. Galvin, C.G. Goetz, J.H. Growdon, K.A. Gwinn-Hardy, J. Hardy, P. Heutink, T. Iwatsubo, K. Kosaka, V.M. Lee, J.B. Leverenz, E. Masliah, I.G. McKeith, R.L. Nussbaum, C.W. Olanow, B.M. Ravina, A.B. Singleton, C.M. Tanner, J.Q. Trojanowski, and Z.K. Wszolek DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers Neurology 68 2007 812 819 (Pubitemid 46568532)
5. R.J. Perry, and J.R. Hodges Spectrum of memory dysfunction in degenerative disease Curr. Opin. Neurol. 9 1996 281 285 (Pubitemid 26273287)
6. M. Tsolaki, K. Kokarida, V. Iakovidou, E. Stilopoulos, J. Meimaris, and A. Kazis Extrapyramidal symptoms and signs in Alzheimer's disease: prevalence and correlation with the first symptom Am. J. Alzheimers Dis. Other Demen. 16 2001 268 278 (Pubitemid 32946241)
7. M. Yoshimoto, A. Iwai, D. Kang, D.A. Otero, Y. Xia, and T. Saitoh NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation Proc. Natl. Acad. Sci. USA 92 1995 9141 9145
8. K.C. Wilhelmsen, M.S. Forman, H.J. Rosen, L.I. Alving, J. Goldman, J. Feiger, J.V. Lee, S.K. Segall, J.H. Kramer, C. Lomen-Hoerth, K.P. Rankin, J. Johnson, H.S. Feiler, M.W. Weiner, V.M. Lee, J.Q. Trojanowski, and B.L. Miller 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions Arch. Neurol. 61 2004 398 406 (Pubitemid 38332000)
9. R.L. Hamilton Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry Brain Pathol. 10 2000 378 384 (Pubitemid 30431290)
10. R. Raghavan, C. Khin-Nu, A. Brown, D. Irving, P.G. Ince, K. Day, S.P. Tyrer, and R.H. Perry Detection of Lewy bodies in Trisomy 21 (Down's syndrome) Can. J. Neurol. Sci. 20 1993 48 51 (Pubitemid 23056946)
11. A.R. Judkins, M.S. Forman, K. Uryu, D.A. Hinkle, A.K. Asbury, V.M. Lee, and J.Q. Trojanowski Co-occurrence of Parkinson's disease with progressive supranuclear palsy Acta Neuropathol. 103 2002 526 530 (Pubitemid 36075351)
12. W.R. Galpern, and A.E. Lang Interface between tauopathies and synucleinopathies: a tale of two proteins Ann. Neurol. 59 2006 449 458 (Pubitemid 43358065)
13. J. Clarimon, L. Molina-Porcel, T. Gomez-Isla, R. Blesa, C. Guardia-Laguarta, A. Gonzalez-Neira, M. Estorch, G.J. Ma, L. Barraquer, C. Roig, I. Ferrer, and A. Lleo Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study J. Neuropathol. Exp. Neurol. 68 2009 73 82
14. P.G. Galloway, I. Grundke-Iqbal, K. Iqbal, and G. Perry Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles J. Neuropathol. Exp. Neurol. 47 1988 654 663
15. B.I. Giasson, M.S. Forman, M. Higuchi, L.I. Golbe, C.L. Graves, P.T. Kotzbauer, J.Q. Trojanowski, and V.M. Lee Initiation and synergistic fibrillization of tau and alpha-synuclein Science 300 2003 636 640 (Pubitemid 36520587)
16. T. Ishizawa, P. Mattila, P. Davies, D. Wang, and D.W. Dickson Colocalization of tau and alpha-synuclein epitopes in Lewy bodies J. Neuropathol. Exp. Neurol. 62 2003 389 397 (Pubitemid 36403039)
17. J. Wills, J. Jones, T. Haggerty, V. Duka, J.N. Joyce, and A. Sidhu Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia Exp. Neurol. 225 2010 210 218
18. T. Haggerty, J. Credle, O. Rodriguez, J. Wills, A.W. Oaks, E. Masliah, and A. Sidhu Hyperphosphorylated Tau in an alpha-synuclein-overexpressing transgenic model of Parkinson's disease Eur. J. Neurosci. 33 2011 1598 1610
19. N. Badiola, R.M. de Oliveira, F. Herrera, C. Guardia-Laguarta, S.A. Gonalves, M. Pera, M. Suarez-Calvet, J. Clarimon, T.F. Outeiro, and A. Lleó Tau enhances a-Synuclein aggregation and toxicity in cellular models of synucleinopathy PLoS One 6 2011 e26609
20. E. Masliah, A. Iwai, M. Mallory, K. Ueda, and T. Saitoh Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease Am. J. Pathol. 148 1996 201 210 (Pubitemid 26019656)
21. L.K. Clinton, M. Blurton-Jones, K. Myczek, J.Q. Trojanowski, and F.M. LaFerla Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline J. Neurosci. 30 2010 7281 7289
22. V. Charles, E. Mezey, P.H. Reddy, A. Dehejia, T.A. Young, M.H. Polymeropoulos, M.J. Brownstein, and D.A. Tagle Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models Neurosci. Lett. 289 2000 29 32 (Pubitemid 30433838)
23. R.A. Furlong, Y. Narain, J. Rankin, A. Wyttenbach, and D.C. Rubinsztein Alpha-synuclein overexpression promotes aggregation of mutant huntingtin Biochem. J. 346 3 2000 577 581 (Pubitemid 30171015)
24. F. Herrera, S. Tenreiro, L. Miller-Fleming, and T.F. Outeiro Visualization of cell-to-cell transmission of mutant huntingtin oligomers PLoS Curr. 3 2011 RRN1210
25. T.F. Outeiro, P. Putcha, J.E. Tetzlaff, R. Spoelgen, M. Koker, F. Carvalho, B.T. Hyman, and P.J. McLean Formation of toxic oligomeric alpha-synuclein species in living cells PLoS One 3 2008 e1867
26. T.F. Outeiro, and S. Lindquist Yeast cells provide insight into alpha-synuclein biology and pathobiology Science 302 2003 1772 1775 (Pubitemid 37505742)
27. S. Krobitsch, and S. Lindquist Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins Proc. Natl. Acad. Sci. USA 97 2000 1589 1594 (Pubitemid 30118486)
28. F. Herrera, Q. Chen, W.H. Fishcer, P. Maher, and D.R. Schubert Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome Cell Death Differ. 16 2009 910 920
29. Y. Yan, D. Peng, J. Tian, J. Chi, J. Tan, X. Yin, J. Pu, K. Xia, and B. Zhang Essential sequence of the N-terminal cytoplasmic localization-related domain of Huntingtin and its effect on Huntingtin aggregates Sci. China Life Sci. 54 2011 342 350
30. C.F. Lippa, H. Fujiwara, D.M. Mann, B. Giasson, M. Baba, M.L. Schmidt, L.E. Nee, B. O'Connell, D.A. Pollen, P. St George-Hyslop, B. Ghetti, D. Nochlin, T.D. Bird, N.J. Cairns, V.M. Lee, T. Iwatsubo, and J.Q. Trojanowski Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes Am. J. Pathol. 153 1998 1365 1370 (Pubitemid 28509891)