Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates

Molecular Pharmacology

Volumn 82, Issue 4, 2012, Pages 687-699

  Yamauchi, John G ^a   Gomez, Kimberly ^a   Grimster, Neil ^c   Dufouil, Mikael ^a,c,d   Nemecz, Ákos ^a,b   Fotsing, Joseph R ^c,e   Ho, Kwok Yiu ^a   Talley, Todd T ^a,f   Sharpless, K Barry ^c   Fokin, Valery V ^c   Taylor, Palmer ^a  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITÉ LYON 1   (France)

^e Senomyx   (United States)

^f IDAHO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; BUNGAROTOXIN RECEPTOR AGONIST; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; SEROTONIN 3A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APLYSIA; ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; LYMNAEA; LYMNAEA STAGNALIS; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANIMALS; APLYSIA; AZIDES; CARRIER PROTEINS; CELL LINE; CLICK CHEMISTRY; HUMANS; LYMNAEA; MICE; MUTATION; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; RADIOLIGAND ASSAY; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TROPANES;

EID: 84866882247     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.080291     Document Type: Article

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