Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state

Journal of the American Chemical Society

Volumn 132, Issue 51, 2010, Pages 18292-18300

  Bourne, Yves ^a   Radić, Zoran ^b   Taylor, Palmer ^b   Marchot, Pascale ^c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b San Diego   (United States)

^c University of Mediterranée   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CONFORMATIONS; DISSOCIATION; LIGANDS;

ACETYLCHOLINESTERASE; AROMATIC RESIDUES; CRYSTALLINE COMPLEXES; CRYSTALLINE STATE; DIFFUSION LIMITED; ORDERS OF MAGNITUDE; STABLE COMPLEXES; THERMODYNAMIC EQUILIBRIA;

CRYSTALLINE MATERIALS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; MUTANT PROTEIN;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFUSION; DISSOCIATION; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; PROTEIN FOLDING; THERMODYNAMICS; TIME; WILD TYPE;

EID: 78650603475     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106820e     Document Type: Article

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