Pre-clinical studies of toxin-specific Nanobodies: Evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming

Toxicology and Applied Pharmacology

Volumn 264, Issue 2, 2012, Pages 222-231

  Hmila, Issam ^a   Cosyns, Bernard ^b   Tounsi, Hayfa ^a   Roosens, Bram ^b   Caveliers, Vicky ^b   Abderrazek, Rahma Ben ^a   Boubaker, Samir ^a   Muyldermans, Serge ^b,c   El Ayeb, Mohamed ^a   Bouhaouala Zahar, Balkiss ^a,d   Lahoutte, Tony ^b  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

99mTc Nanobody; Biodistribution; Scorpion antivenom; SPECT; Tissue damage; Toxin

Indexed keywords

ANTISERUM; NBAAHIF12; NBAAHII10; NBF12 0; SCORPION VENOM; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANDROCTONUS AUSTRALIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE VARIABILITY; CONTROLLED STUDY; DRUG DISTRIBUTION; ECHOCARDIOGRAPHY; ENVENOMATION; HEART HEMODYNAMICS; HEART INJURY; HISTOPATHOLOGY; IN VIVO STUDY; LUNG LESION; MALE; MOUSE; NONHUMAN; POISONOUS SCORPION; RAT;

ANIMALS; ANTIBODY SPECIFICITY; ANTIVENINS; ARACHNIDISM; CAMELS; HEART DISEASES; HEMODYNAMICS; IMMUNOGLOBULIN FAB FRAGMENTS; LUNG; MALE; MYOCARDIUM; NANOPARTICLES; RATS; SCORPION VENOMS; SCORPIONS; TECHNETIUM; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

ANDROCTONUS; ANDROCTONUS AUSTRALIS HECTOR; ANIMALIA; MUS; RATTUS; RODENTIA; SCORPIONES;

EID: 84866870590     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.07.033     Document Type: Article

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