Pathophysiological effects of Androctonus australis hector scorpion venom: Tissue damages and inflammatory response

Experimental and Toxicologic Pathology

Volumn 60, Issue 4-5, 2008, Pages 373-380

  Adi Bessalem, Sonia ^a,b   Hammoudi Triki, Djelila ^a,b   Laraba Djebari, Fatima ^a,b  

^a UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI BOUMEDIENE   (Algeria)

^b Institut Pasteur d'Algerie   (Algeria)

Author keywords

Cytokines; Lungs; Myocardium; Pathophysiology; Venom

Indexed keywords

CREATINE KINASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; LACTATE DEHYDROGENASE; SCORPION VENOM; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; CELL INFILTRATION; CONTROLLED STUDY; ENVENOMATION; ENZYME ACTIVITY; HEART EDEMA; INFLAMMATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; TISSUE INJURY;

ANIMALS; CREATINE KINASE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEART; INFLAMMATION; L-LACTATE DEHYDROGENASE; LUNG; MICE; MYOCARDIUM; SCORPION VENOMS; SCORPIONS;

ANDROCTONUS AUSTRALIS HECTOR; ANIMALIA; MUS; SCORPIONES;

EID: 46649112693     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2008.03.006     Document Type: Article

References (35)

1. Amaral C.F., and Rezende N.A. Both cardiogenic and non-cardiogenic factors are involved in the pathogenesis of pulmonary edema after scorpion envenoming. Toxicon 35 (1997) 997-998
2. Andus T., Bauer J., and Gerok W. Effects of cytokines on the liver. Hepatology 13 (1991) 364-369
3. Barbouche M.R., Haguiga H., Nouira S., Krifi M.N., Abroug F., and Bouchoucha S. Inflammatory cytokines and scorpionic envenomation: analysis of serological levels in 46 Tunisian patients. Toxicon 34 (1996) 156 [Abstract]
4. Bertazzi D.T., Assis-Pandochi A.I., Azzolini A.E., Talhaferro V.L., Lazzarini M., and Arantes E.C. Effect of Tityus serrulatus scorpion venom and its major toxin, TsTX-I, on the complement system in vivo. Toxicon 41 (2003) 501-508
5. Bertazzi D.T., Assis-Pandochi A.I., Talhaferro V.L., Azzolini A.E.C.S., Crott L.S.P., and Arantes E.C. Activation of complement system and leukocyte recruitment by Tityus serrulatus scorpion venom. Int Immunopharmacol 5 (2005) 1077-1084
6. 2. Toxicon 37 (1999) 771-782
7. Corrêa M.M., Sampaio S.V., Lopez R.A., Mancuso L.C., Cunha O.A.B., Franco J.J., and Giglio J.R. Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin Tityustoxin-I. Toxicon 35 (1997) 1035-1067
8. Daisley H., Alexander D., and Pitt-Miller P. Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics. Toxicon 37 (1999) 159-165
9. De Dàvila C.A.M., Dàvila D.F., Donis J.H., De Bellarbarba G.A., Villarreal V., and Barbosa J.S. Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation. Toxicon 40 (2002) 1339-1346
10. De-Matos I.M., Talvani A.O.O.A., Freira-Maia L., and Teixiera M.M. Evidence for the role of mast cells in the lung edema induced by Tityus serrulatus venom in rats. Toxicon 39 (2001) 861-867
11. D'Suze G., Monceda S., Gonzalez C., Sevcik C., Aguilar V., and Alagon A. Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentrations following Tityus scorpion sting. Toxicon 41 (2003) 367-375
12. D'Suze G., Salazar V., Diaz P., Sevcik C., Azpurua H., and Bracho N. Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams. Toxicon 44 (2004) 851-860
13. Faccioli L.H., Souza G.E.P., Cunha F.Q.S., Poole S., and Ferreira S.H. Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration in vivo by indirect mechanisms. Agents Actions 30 (1990) 344-349
14. Farsky S.H.P., Costa-Cruz J.W.M., Cury Y., and Teixeira C.F.P. Leukocyte response induced by Bothrops jararaca crude venom. In vivo and in vitro studies. Toxicon 35 (1997) 185-193
15. Freire-Maia L., and De Matos I.M. Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion in the rat. Toxicon 31 (1993) 1207-1220
16. Fukahara Y.D.M., Reis M.L., Dellalibera-Joviliani R., Cunha F.Q.C., and Donadi E.A. Increased levels of IL-1β, IL-6, IL-8, IL-10 and TNF-α in patients moderately or severely envenomed by Tityus serrulatus scorpion sting. Toxicon 41 (2003) 49-55
17. Ghazal A., Ismail M., Abdel-Rahman A.A., and El-Asmar M.F. Pharmacological studies of scorpion (Androctonus amoreuxi Aud. & Sav.) venom. Toxicon 13 (1975) 253-259
18. Gueron M., Ilia R., and Sofer S. The cardiovascular system after scorpion envenomation. A review. J Toxicol Clin 30 (1992) 245-258
19. Hammoudi-Triki D., Ferquiel E., Robbe-Vincent A., Bon C., Choumet V., and Laraba-Djebari F. Epidemiological data, clinical admission gradation and biological quantification by ELISA of scorpion envenomations in Algeria: effect of immunotherapy. J R Soc Trop Med Hyg 98 (2004) 240-250
20. Hammoudi-Triki D., Lefort J., Rougeot C., Robbe-Vincent A., Bon C., Laraba-Djebari F., et al. Toxicokinetic and Toxicodynamic analyses of Androctonus australis hector venom in rats: optimization of antivenom. Ther Toxocol Appl Pharmacol 218 3 (2007) 205-214
21. Hering E.S., Jurca M., Vichi F.L., Azevedo-Marques M.M., and Cupo P. Reversible cardiomyopathy in patients with severe scorpion envenoming by Tityus serrulatus; evolution of enzymatic, electrocardiographic and echocardiographic alterations. Ann Trop Paediatr 13 (1993) 173-182
22. Ismail M. Review article: the scorpion envenoming syndrome. Toxicon 33 (1995) 825-858
23. Ismail M., and Abd-Elsalam M.A. Are the toxicological effects of scorpion envenoming related to tissue venom concentration?. Toxicon 26 (1988) 233-256
24. 125I-labelled venom from the scorpion Androctonus amoreuxi (Aud. and Sav.). Toxicon 18 (1980) 301-308
25. Kishimoto T. The biology of interleukin-6. Blood 74 (1989) 1-10
26. Laraba-Djebari F., and Hammoudi D. Utilisation de la Fraction toxique majoritaire isolée à partir du venin d' Androctonus australis hector d'Algérie dans la valorisation du sérum anti-scorpionique. Arch Inst Pasteur Algérie 62 (1998) 254-266
27. Lomonte B., Tarkowski A., and Hanson L.A. Host response to Bothrops asper snake. Analysis of edema formation, inflammatory cells and cytokine release in mouse model. Inflammation 17 (1993) 93-105
28. Magalhaes M.M., Pereira M.E., Amaral C.F., Rezende N.A., Campolina D., Bucaretchi F., et al. Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting. Toxicon 37 (1999) 1155-1164
29. Martin M.C., Gomez J.J., Esteban F., Saur R., Mourelle M.I., and Salgado A. Cytokines and nitric oxide in streptococcal toxic shock syndrome. Med Clin 104 (1995) 458-464
30. Meki A.R.M.A., and Mohey El-Dean Z.M. Serum interleukin 1β, interleukin-6, nitric oxide and α1-antitrypsin in scorpion envenomed children. Toxicon 36 (1998) 1851-1859
31. Possani L.D., Becerril B., Delpierre M., and Tytgat J. Scorpion toxins specific for sodium channels. Eur J Biochem 264 (1999) 287-300
32. Smith J.A. Neutrophils, host defence, and inflammation: a double-edged sword. J Leukocyte Biol 56 (1994) 672-686
33. Sofer S., and Gueron M. Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects. Toxicon 26 (1988) 931-939
34. Sofer S., Gueron M., White R.M., Lifshitz M., and Apte R.N. Interleukin-6 release following scorpion sting in children. Toxicon 34 (1996) 389-392
35. Teixeira A.L., Fontoura B.F., Freira-Maia L., Machado C.R.S., Camargo E.R.S., and Teixeira M.M. Evidence for a direct action of Tityus serralutus on the cardiac muscle. Toxicon 39 (2001) 703-709