Pharmacokinetics of 125I-labelled IgG, F(ab')2 and Fab fractions of scorpion and snake antivenins: Merits and potential for therapeutic use

Toxicon

Volumn 36, Issue 11, 1998, Pages 1523-1528

  Ismail, M ^a   Abd Elsalam, M A ^a  

^a KING FAHAD NATIONAL GUARD HOSPITAL   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IODINE 125; VENOM ANTISERUM; RADIOACTIVE IODINE; SCORPION VENOM; SNAKE VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG HALF LIFE; ENVENOMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RABBIT; RAT; SCORPION; SNAKE; SUBCUTANEOUS DRUG ADMINISTRATION; SURVIVAL; ANIMAL; ARTICLE; HUMAN; IMMUNOLOGY; METABOLISM; SNAKEBITE; SPIDER BITE; TISSUE DISTRIBUTION;

ANIMALS; ANTIVENINS; ARACHNIDISM; COBRA; COBRA VENOMS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IODINE RADIOISOTOPES; MICE; RABBITS; RATS; SCORPION VENOMS; SCORPIONS; SNAKE BITES; TISSUE DISTRIBUTION;

EID: 0031593834     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(98)00144-5     Document Type: Conference Paper

References (12)

1. Efrati P. Poisoning by scorpion stings in Israel. Am. J. Trop. Med. 29:1949;249-257.
2. Ismail M., Abd-Elsalam M. A. Are the toxicological effects of scorpion envenomation related to tissue venom concentration? Toxicon. 26:1988;233-256.
3. Ismail, M. and Abd-Elsalam, M. A. (1996) Serotheraphy of scorpion envenoming: Pharmacokinetics of antivenoms and a critical assessment of their usefulness. In Proceedings of the 1st International Congress On Envenomations and their Treatments, Paris 7-9 June, 1995, eds. C. Bon and M. Goyffon, pp. 135-153. Marcel Merieux Foundation, Lyon.
4. 125I -labelled venom from the scorpion Androctonus amoreuxi (Aud. and Sav.) Toxicon. 18:1980;301-308.
5. 125I -labelled venom from the scorpion Androctonus amoreuxi Toxicon. 21:1983;47-56.
6. Ismail M., Abd-Elsalam M. A., Morad M. A. Do changes in body temperature following envenomation by the scorpion Leiurus quinquestriatus influence the course of toxicity? Toxicon. 30:1990;1265-1284.
7. Ismail M., Fatani A. J. Y., Dabees T. T. Experimental treatment protocols for scorpion envenomation: a review of common therapies and an effect of kallikrein-kinin inhibitors. Toxicon. 30:1992;1257-1279.
8. Ismail M., And-Elsalam M. A., Al-Ahaidib M. S. Androctonus crassicauda (Olivier), a dangerous and unduly neglected scorpion. I. Pharmacological and clinical studies. Toxicon. 32:1994;1599-1618.
9. Ismail M., Aly M. H. M., Abd-Elsalam M. A., Morad M. A. A three-compartment open pharmacokinetic model can explain variable toxicities of cobra venoms and their alpha toxins. Toxicon. 34:1996;1011-1026.
10. 2 and F(ab) of the antivenin. Toxicon (in press).
11. Theakston R. D. G., Reid H. A. The development of simple standard assay procedures for the characterization of snake venoms. Bull. WHO. 61:1983;949-956.
12. World Health Organization (1981) Progress in the Characterization of Venoms and Standardization of Antivenoms. Publication No. 58. World Health Organization, Geneva.