A novel method for the large-scale production of PG-CNP37, a C-type natriuretic peptide analogue

Journal of Biotechnology

Volumn 164, Issue 2, 2012, Pages 196-201

  Long, Shinong ^a   Wendt, Daniel J ^a   Bell, Sean M ^a   Taylor, Timothy W ^a   Dewavrin, Jean Yves ^a   Vellard, Michel C ^a  

^a BIOMARIN PHARMACEUTICAL INC   (United States)

Author keywords

CNP; E. coli; Formic acid cleavage; Fusion protein; Inclusion body; Large scale

Indexed keywords

CNP; E. COLI; FUSION PROTEINS; INCLUSION BODIES; LARGE-SCALE;

BONE; ESCHERICHIA COLI; FORMIC ACID;

PEPTIDES;

FORMIC ACID; PEPTIDE DERIVATIVE; PG CNP37; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CULTURE MEDIUM; DRUG MANUFACTURE; DRUG PURIFICATION; DRUG SOLUBILITY; DRUG SYNTHESIS; ESCHERICHIA COLI; FIBROBLAST; GENE OVEREXPRESSION; IN VITRO STUDY; LARGE SCALE PRODUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

CHROMATOGRAPHY, ION EXCHANGE; CLONING, MOLECULAR; ESCHERICHIA COLI; FORMATES; INCLUSION BODIES; NATRIURETIC PEPTIDE, C-TYPE; RECOMBINANT FUSION PROTEINS;

ESCHERICHIA COLI;

EID: 84866868392     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2012.08.001     Document Type: Article

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